{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T13:38:19Z","timestamp":1769261899014,"version":"3.49.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1038\/ki.2012.308","type":"journal-article","created":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T12:47:26Z","timestamp":1345034846000},"page":"41-49","source":"Crossref","is-referenced-by-count":36,"title":["Ezrin, a membrane cytoskeletal cross-linker, is essential for the regulation of phosphate and calcium homeostasis"],"prefix":"10.1016","volume":"83","author":[{"given":"Ryo","family":"Hatano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiko","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Segawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Mukaisho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsunobu","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichi","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Sugihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Asano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2012.308_bb0010","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00424-008-0580-8","article-title":"Regulation of phosphate transport in proximal tubules","volume":"458","author":"Biber","year":"2009","journal-title":"Pflugers Arch"},{"key":"10.1038\/ki.2012.308_bb0015","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1152\/physrev.2000.80.4.1373","article-title":"Proximal tubular phosphate reabsorption: molecular mechanisms","volume":"80","author":"Murer","year":"2000","journal-title":"Physiol Rev"},{"key":"10.1038\/ki.2012.308_bb0020","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/sj.ki.5001813","article-title":"Proximal tubular handling of phosphate: a molecular perspective","volume":"70","author":"Forster","year":"2006","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.308_bb0025","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1111\/j.1523-1755.2004.09102.x","article-title":"Novel aspects in regulated expression of the renal type IIa Na\/Pi-cotransporter","volume":"91","author":"Bacic","year":"2004","journal-title":"Kidney Int Suppl"},{"key":"10.1038\/ki.2012.308_bb0030","doi-asserted-by":"crossref","first-page":"F231","DOI":"10.1152\/ajprenal.00532.2010","article-title":"Dynamics of PTH-induced disassembly of Npt2a\/NHERF-1 complexes in living OK cells","volume":"300","author":"Weinman","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2012.308_bb0035","doi-asserted-by":"crossref","first-page":"C159","DOI":"10.1152\/ajpcell.00456.2004","article-title":"Parathyroid hormone treatment induces dissociation of type IIa Na+-P(i) cotransporter-Na+\/H+ exchanger regulatory factor-1 complexes","volume":"289","author":"D\u00e9liot","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1038\/ki.2012.308_bb0040","doi-asserted-by":"crossref","first-page":"11470","DOI":"10.1073\/pnas.162232699","article-title":"Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting","volume":"99","author":"Shenolikar","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2012.308_bb0045","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nrm882","article-title":"ERM proteins and merlin: integrators at the cell cortex","volume":"3","author":"Bretscher","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1038\/ki.2012.308_bb0050","doi-asserted-by":"crossref","first-page":"17705","DOI":"10.1073\/pnas.0407974101","article-title":"Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 organizes ERM proteins at the apical membrane of polarized epithelia","volume":"101","author":"Morales","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2012.308_bb0055","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1111\/j.1523-1755.2005.00505.x","article-title":"Role of membrane microdomains in PTH-mediated down-regulation of NaPi-IIa in opossum kidney cells","volume":"68","author":"Nashiki","year":"2005","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.308_bb0060","doi-asserted-by":"crossref","first-page":"F667","DOI":"10.1152\/ajprenal.00276.2007","article-title":"Ezrin promotes functional expression and parathyroid hormone- mediated regulation of the sodium-phosphate cotransporter 2a in LLC-PK1 cells","volume":"294","author":"Mahon","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2012.308_bb0065","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.devcel.2004.05.007","article-title":"Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine","volume":"6","author":"Saotome","year":"2004","journal-title":"Dev Cell"},{"key":"10.1038\/ki.2012.308_bb0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1083\/jcb.200410083","article-title":"Achlorhydria by ezrin knockdown: defects in the formation\/expansion of apical canaliculi in gastric parietal cells","volume":"169","author":"Tamura","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2012.308_bb0075","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1152\/physrev.00003.2004","article-title":"Calcium absorption across epithelia","volume":"85","author":"Hoenderop","year":"2005","journal-title":"Physiol Rev"},{"key":"10.1038\/ki.2012.308_bb0080","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1073\/pnas.95.9.5372","article-title":"Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities","volume":"95","author":"Beck","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2012.308_bb0085","doi-asserted-by":"crossref","first-page":"F671","DOI":"10.1152\/ajprenal.00156.2009","article-title":"Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development","volume":"297","author":"Segawa","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2012.308_bb0090","doi-asserted-by":"crossref","first-page":"11957","DOI":"10.1073\/pnas.182412699","article-title":"PDZ-domain interactions and apical expression of type IIa Na\/Pi cotransporters","volume":"99","author":"Hernando","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2012.308_bb0095","doi-asserted-by":"crossref","first-page":"9206","DOI":"10.1074\/jbc.M008745200","article-title":"Interaction of the type IIa Na\/Pi cotransporter with PDZ protein","volume":"276","author":"Gisler","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2012.308_bb0100","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/sj.ki.5002703","article-title":"Interactions of the growth-related, type IIc renal sodium\/phosphate cotransporter with PDZ proteins","volume":"73","author":"Villa-Bellosta","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.308_bb0105","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s00424-002-0865-2","article-title":"Na\/Pi cotransporter (Npt2) gene disruption increases duodenal calcium absorption and expression of epithelial calcium channels 1 and 2","volume":"444","author":"Tenenhouse","year":"2002","journal-title":"Pflugers Arch"},{"key":"10.1038\/ki.2012.308_bb0110","doi-asserted-by":"crossref","first-page":"13324","DOI":"10.1073\/pnas.231474698","article-title":"Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects","volume":"98","author":"Van Cromphaut","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2012.308_bb0115","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00424-006-0051-z","article-title":"Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4","volume":"452","author":"Van de Graaf","year":"2006","journal-title":"Pflugers Arch"},{"key":"10.1038\/ki.2012.308_bb0120","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrneph.2010.121","article-title":"Hereditary disorders of renal phosphate wasting","volume":"6","author":"Alizadeh Naderi","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"10.1038\/ki.2012.308_bb0125","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1073\/pnas.94.18.9831","article-title":"Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia","volume":"94","author":"Li","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2012.308_bb0130","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1083\/jcb.139.3.749","article-title":"ERM (ezrin\/radixin\/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis","volume":"139","author":"Kondo","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2012.308_bb0135","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1038\/nprot.2007.156","article-title":"Isolation of renal proximal tubular brush-border membranes","volume":"2","author":"Biber","year":"2007","journal-title":"Nat Protoc"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815556901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815556901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T15:39:12Z","timestamp":1656171552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815556901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0085253815556901"],"URL":"https:\/\/doi.org\/10.1038\/ki.2012.308","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}