{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:56:26Z","timestamp":1792425386450,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"vor","delay-in-days":1462,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1038\/ki.2012.63","type":"journal-article","created":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T08:44:11Z","timestamp":1332924251000},"page":"454-464","source":"Crossref","is-referenced-by-count":531,"title":["Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies"],"prefix":"10.1016","volume":"82","author":[{"given":"Aude","family":"Servais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure-H\u00e9l\u00e8ne","family":"No\u00ebl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubka T.","family":"Roumenina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moglie","family":"Le Quintrec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Agn\u00e8s","family":"Dragon-Durey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Alice","family":"Macher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Zuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Karras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Provot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Moulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Gr\u00fcnfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Niaudet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lesavre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Fr\u00e9meaux-Bacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2012.63_bb0010","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1681\/ASN.2005010078","article-title":"Membranoproliferative glomerulonephritis type II (dense deposit disease): an update","volume":"16","author":"Appel","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.63_bb0015","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/jmg.2006.045328","article-title":"Primary glomerulonephritis with isolated C3 deposits: a new entity which shares common genetic risk factors with haemolytic uraemic syndrome","volume":"44","author":"Servais","year":"2007","journal-title":"J Med Genet"},{"key":"10.1038\/ki.2012.63_bb0020","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nrneph.2010.85","article-title":"C3 glomerulopathy: a new classification","volume":"6","author":"Fakhouri","year":"2007","journal-title":"Nat Rev Nephrol"},{"key":"10.1038\/ki.2012.63_bb0025","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/modpathol.3800773","article-title":"Dense deposit disease is not a membranoproliferative glomerulonephritis","volume":"20","author":"Walker","year":"2007","journal-title":"Mod Pathol"},{"key":"10.1038\/ki.2012.63_bb0030","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/ki.2008.657","article-title":"Glomeruli of Dense Deposit Disease contain components of the alternative and terminal complement pathway","volume":"75","author":"Sethi","year":"2009","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.63_bb0035","series-title":"Advances in Nephrology","first-page":"37","article-title":"Complement deposition in the kidney","volume":"vol 4","author":"Berger","year":"1974"},{"key":"10.1038\/ki.2012.63_bb0040","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1053\/j.ajkd.2007.11.032","article-title":"Complement factor H deficiency and posttransplantation glomerulonephritis with isolated C3 deposits","volume":"51","author":"Boyer","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2012.63_bb0045","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2215\/CJN.07110810","article-title":"Proliferative glomerulonephritis secondary to dysfunction of the alternative pathway of complement","volume":"6","author":"Sethi","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.63_bb0050","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.humpath.2010.11.023","article-title":"Heterogeneous pattern of renal disease associated with homozygous Factor H deficiency","volume":"42","author":"Servais","year":"2011","journal-title":"Hum Pathol"},{"key":"10.1038\/ki.2012.63_bb0055","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1172\/JCI43343","article-title":"Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation","volume":"120","author":"Martinez-Barricarte","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2012.63_bb0060","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00467-006-0299-8","article-title":"MPGN II--genetically determined by defective complement regulation?","volume":"22","author":"Licht","year":"2007","journal-title":"Pediatr Nephrol"},{"key":"10.1038\/ki.2012.63_bb0065","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1084\/jem.20070301","article-title":"Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains","volume":"204","author":"Pickering","year":"2007","journal-title":"J Exp Med"},{"key":"10.1038\/ki.2012.63_bb0070","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1136\/jmg.2005.038315","article-title":"Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)","volume":"43","author":"Abrera-Abeleda","year":"2006","journal-title":"J Med Genet"},{"key":"10.1038\/ki.2012.63_bb0075","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2215\/CJN.03480708","article-title":"Dense deposit disease: clinicopathologic study of 32 pediatric and adult patients","volume":"4","author":"Nasr","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.63_bb0080","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1681\/ASN.2010060647","article-title":"Complement factor H deficiency accelerates development of lupus nephritis","volume":"22","author":"Bao","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.63_bb0085","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1681\/ASN.2006080811","article-title":"Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome","volume":"18","author":"Sellier-Leclerc","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.63_bb0090","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1681\/ASN.2009070706","article-title":"Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations","volume":"21","author":"Fakhouri","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.63_bb0095","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/ni.1755","article-title":"Structure of complement fragment C3b-factor H and implications for host protection by complement regulators","volume":"10","author":"Wu","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1038\/ki.2012.63_bb0100","doi-asserted-by":"crossref","first-page":"e432","DOI":"10.1371\/journal.pmed.0030432","article-title":"Complement factor h gene abnormalities in haemolytic uraemic syndrome: from point mutations to hybrid gene","volume":"3","author":"Noris","year":"2006","journal-title":"PLoS Med"},{"key":"10.1038\/ki.2012.63_bb0105","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.4049\/jimmunol.0804031","article-title":"The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome","volume":"182","author":"Ferreira","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/ki.2012.63_bb0110","doi-asserted-by":"crossref","first-page":"27657","DOI":"10.1074\/jbc.M002903200","article-title":"Each of the three binding sites on complement factor H interacts with a distinct site on C3b","volume":"275","author":"Jokiranta","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2012.63_bb0115","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/ki.2009.472","article-title":"Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome","volume":"77","author":"Bienaime","year":"2010","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.63_bb0120","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/eji.200939280","article-title":"Mutations in complement factor I as found in atypical hemolytic uremic syndrome lead to either altered secretion or altered function of factor I","volume":"40","author":"Nilsson","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1038\/ki.2012.63_bb0125","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1182\/blood-2005-10-007252","article-title":"Genetics of HUS: the impact of MCP, CFH and IF mutations on clinical presentation, response to treatment, and outcome","volume":"108","author":"Caprioli","year":"2006","journal-title":"Blood"},{"key":"10.1038\/ki.2012.63_bb0130","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.molimm.2006.10.005","article-title":"A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation","volume":"44","author":"Nilsson","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1038\/ki.2012.63_bb0135","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1182\/blood-2007-04-084533","article-title":"Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome","volume":"111","author":"Fang","year":"2008","journal-title":"Blood"},{"key":"10.1038\/ki.2012.63_bb0140","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/sj.ki.5000084","article-title":"Severity of primary MPGN, rather than MPGN type, determines renal survival and post-transplantation recurrence risk","volume":"69","author":"Little","year":"2006","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.63_bb0145","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0002-9343(83)90606-X","article-title":"Idiopathic mesangiocapillary glomerulonephritis. Comparison of types I and II in children and adults and long-term prognosis","volume":"74","author":"Cameron","year":"1983","journal-title":"Am J Med"},{"key":"10.1038\/ki.2012.63_bb0150","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/path.1711410404","article-title":"Mesangiocapillary glomerulonephritis: a long-term study of 40 cases","volume":"141","author":"Swainson","year":"1983","journal-title":"J Pathol"},{"key":"10.1038\/ki.2012.63_bb0155","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000180897","article-title":"The prognostic value of some clinical and histological parameters in membranoproliferative glomerulonephritis (MPGN): report of 112 cases","volume":"19","author":"di Belgiojoso","year":"1977","journal-title":"Nephron"},{"key":"10.1038\/ki.2012.63_bb0160","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1034\/j.1399-3038.2001.012003166.x","article-title":"Complement analysis in children with idiopathic membranoproliferative glomerulonephritis: a long-term follow-up","volume":"12","author":"Schwertz","year":"2001","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1038\/ki.2012.63_bb0165","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/ndt\/17.9.1603","article-title":"Prognostic factors in mesangioproliferative glomerulonephritis","volume":"17","author":"Vikse","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.63_bb0170","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/eji.1830141209","article-title":"Protection of the classical and alternative complement pathway C3 convertases, stabilized by nephritic factors, from decay by the human C3b receptor","volume":"14","author":"Fischer","year":"1984","journal-title":"Eur J Immunol"},{"key":"10.1038\/ki.2012.63_bb0175","first-page":"240","article-title":"Biological significance of the C3 nephritic factor in membranoproliferative glomerulonephritis","volume":"18","author":"Schena","year":"1982","journal-title":"Clin Nephrol"},{"key":"10.1038\/ki.2012.63_bb0180","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1172\/JCI117751","article-title":"Hereditary porcine membranoproliferative glomerulonephritis type II is caused by factor H deficiency","volume":"95","author":"Hogasen","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2012.63_bb0185","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/ng912","article-title":"Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H","volume":"31","author":"Pickering","year":"2002","journal-title":"Nat Genet"},{"key":"10.1038\/ki.2012.63_bb0190","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/humu.20435","article-title":"The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models","volume":"28","author":"Saunders","year":"2007","journal-title":"Hum Mutat"},{"key":"10.1038\/ki.2012.63_bb0195","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1073\/pnas.0501536102","article-title":"A common haplotype in the complement regulatory gene factor H (HF1\/CFH) predisposes individuals to age-related macular degeneration","volume":"102","author":"Hageman","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2012.63_bb0200","doi-asserted-by":"crossref","first-page":"24713","DOI":"10.1074\/jbc.M605083200","article-title":"His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form","volume":"281","author":"Clark","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2012.63_bb0205","doi-asserted-by":"crossref","first-page":"18960","DOI":"10.1074\/jbc.M609636200","article-title":"Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism","volume":"282","author":"Herbert","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2012.63_bb0210","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1016\/j.molimm.2007.02.012","article-title":"Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration","volume":"44","author":"Skerka","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1038\/ki.2012.63_bb0215","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bbadis.2010.09.002","article-title":"Lessons from functional and structural analyses of disease-associated genetic variants in the complement alternative pathway","volume":"1812","author":"Rodriguez de Cordoba","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/ki.2012.63_bb0220","first-page":"608","article-title":"Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice","volume":"118","author":"Rose","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2012.63_bb0225","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1136\/jmg.2005.030783","article-title":"The development of atypical HUS is influenced by susceptibility factors in factor H and membrane cofactor protein- evidence from two independent cohorts","volume":"42","author":"Fremeaux-Bacchi","year":"2005","journal-title":"J Med Genet"},{"key":"10.1038\/ki.2012.63_bb0230","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/hmg\/ddi066","article-title":"Predisposition to atypical hemolytic uremic syndrome involves the concurrence of different susceptibility alleles in the regulators of complement activation gene cluster in 1q32","volume":"14","author":"Esparza-Gordillo","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1038\/ki.2012.63_bb0235","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jim.2010.12.020","article-title":"Alternative complement pathway assessment in patients with atypical HUS","volume":"365","author":"Roumenina","year":"2011","journal-title":"J Immunol Methods"},{"key":"10.1038\/ki.2012.63_bb0240","first-page":"811","article-title":"Selective disappearance of C3NeF IgG autoantibody in the plasma of a patient with membranoproliferative glomerulonephritis following renal transplantation","volume":"9","author":"Fremeaux-Bacchi","year":"1994","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.63_bb0245","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1111\/j.1523-1755.2005.00365.x","article-title":"Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)","volume":"67","author":"Levey","year":"2005","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.63_bb0250","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0022-3476(84)80479-5","article-title":"A simple estimate of glomerular filtration rate in full-term infants during the first year of life","volume":"104","author":"Schwartz","year":"1984","journal-title":"J Pediatr"},{"key":"10.1038\/ki.2012.63_bb0255","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0022-3476(85)80697-1","article-title":"A simple estimate of glomerular filtration rate in adolescent boys","volume":"106","author":"Schwartz","year":"1985","journal-title":"J Pediatr"},{"key":"10.1038\/ki.2012.63_bb0260","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1542\/peds.58.2.259","article-title":"A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine","volume":"58","author":"Schwartz","year":"1976","journal-title":"Pediatrics"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815555828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815555828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T04:28:31Z","timestamp":1641616111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815555828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0085253815555828"],"URL":"https:\/\/doi.org\/10.1038\/ki.2012.63","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}