{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:40:19Z","timestamp":1792676419784,"version":"4.5.0"},"reference-count":97,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":1461,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1038\/ki.2012.65","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T22:11:26Z","timestamp":1332454286000},"page":"270-277","source":"Crossref","is-referenced-by-count":265,"title":["The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli"],"prefix":"10.1016","volume":"82","author":[{"given":"Richard J.","family":"Glassock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Rule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2012.65_bb0010","series-title":"A Dictionary of Epidemiology","year":"2001"},{"key":"10.1038\/ki.2012.65_bb0015","series-title":"National Kidney Disease Education Program","author":"Suggestions for Laboratories","year":"2003"},{"key":"10.1038\/ki.2012.65_bb0020","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0531-5565(86)90044-6","article-title":"Anatomic and physiologic age changes in the kidney","volume":"21","author":"Lindeman","year":"1986","journal-title":"Exp Gerontol"},{"key":"10.1038\/ki.2012.65_bb0025","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0272-6386(12)80002-3","article-title":"Overview: renal physiology and pathophysiology of aging","volume":"16","author":"Lindeman","year":"1990","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2012.65_bb0030","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1681\/ASN.V781106","article-title":"Aging and the kidney","volume":"7","author":"Epstein","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.65_bb0035","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/ki.2008.319","article-title":"The aging kidney","volume":"74","author":"Zhou","year":"2008","journal-title":"Kidney Int"},{"issue":"Suppl 1","key":"10.1038\/ki.2012.65_bb0040","first-page":"1","article-title":"Aging and physiological changes of the kidneys including changes in GFR","volume":"119","author":"Musso","year":"2011","journal-title":"Nephron Clin Pract"},{"key":"10.1038\/ki.2012.65_bb0045","doi-asserted-by":"crossref","first-page":"c19","DOI":"10.1159\/000314545","article-title":"Chronic kidney disease in older people: physiology, pathology or both","volume":"116","author":"Abdelhafiz","year":"2010","journal-title":"Nephron Clin Pract"},{"key":"10.1038\/ki.2012.65_bb0050","first-page":"419","article-title":"Ageing and the glomerular filtration rate: truths and consequences","volume":"120","author":"Glassock","year":"2008","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"10.1038\/ki.2012.65_bb0055","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/S0041-1345(03)00573-6","article-title":"Importance of kidney biopsy in graft selection","volume":"35","author":"Vazquez Martul","year":"2003","journal-title":"Transplant Proc"},{"key":"10.1038\/ki.2012.65_bb0060","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1046\/j.1523-1755.63.s83.8.x","article-title":"A stereological study of glomerular number and volume: preliminary findings in a multiracial study of kidneys at autopsy","volume":"63","author":"Hoy","year":"2003","journal-title":"Kidney Int Suppl"},{"key":"10.1038\/ki.2012.65_bb0065","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1046\/j.1523-1755.2003.00886.x","article-title":"Risk factors for renal glomerular and vascular changes in an autopsy-based population survey: the Hisayama study","volume":"63","author":"Kubo","year":"2003","journal-title":"Kidney Intl"},{"key":"10.1038\/ki.2012.65_bb0070","first-page":"227","article-title":"Age-related incidence of sclerotic glomeruli in human kidneys","volume":"80","author":"Kaplan","year":"1975","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.2012.65_bb0075","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/path.1711090304","article-title":"The parameters of the ageing kidney","volume":"109","author":"Darmady","year":"1973","journal-title":"J Pathol"},{"key":"10.1038\/ki.2012.65_bb0080","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF00454830","article-title":"Cortical interstitial tissue and sclerosed glomeruli in the normal human kidney, related to age and sex. A quantitative study","volume":"387","author":"Kappel","year":"1980","journal-title":"Virchows Archiv"},{"key":"10.1038\/ki.2012.65_bb0085","doi-asserted-by":"crossref","first-page":"561","DOI":"10.7326\/0003-4819-152-9-201005040-00006","article-title":"The association between age and nephrosclerosis on renal biopsy among healthy adults","volume":"152","author":"Rule","year":"2010","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.2012.65_bb0090","series-title":"The Aging Kidney in Health and Disease","first-page":"39","article-title":"Anatomical changes in the aging kidney","author":"Zhou","year":"2008"},{"key":"10.1038\/ki.2012.65_bb0095","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1681\/ASN.2005050488","article-title":"Podocyte hypertrophy, \u2018adaptation,\u2019 and \u2018decompensation\u2019 associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction","volume":"16","author":"Wiggins","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.65_bb0100","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/ki.1972.98","article-title":"Intrarenal vascular changes with age and disease","volume":"2","author":"Takazakura","year":"1972","journal-title":"Kidney Intl"},{"key":"10.1038\/ki.2012.65_bb0105","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1097\/TP.0b013e3181906150","article-title":"Time-zero renal biopsy in living kidney transplantation: a valuable opportunity to correlate predonation clinical data with histological abnormalities","volume":"86","author":"Mancilla","year":"2008","journal-title":"Transplantation"},{"key":"10.1038\/ki.2012.65_bb0110","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/path.2111","article-title":"Renal ageing","volume":"211","author":"Martin","year":"2007","journal-title":"J Pathol"},{"key":"10.1038\/ki.2012.65_bb0115","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/ar.1092320205","article-title":"Glomerular number and size in relation to age, kidney weight, and body surface in normal man","volume":"232","author":"Nyengaard","year":"1992","journal-title":"Anat Rec"},{"key":"10.1038\/ki.2012.65_bb0120","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0531-5565(82)90032-8","article-title":"Changes with age in the human kidney","volume":"17","author":"Goyal","year":"1982","journal-title":"Exp Gerontol"},{"key":"10.1038\/ki.2012.65_bb0125","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1053\/ajkd.1998.v32.pm9669422","article-title":"Heterogeneity of glomerular size in normal donor kidneys: impact of race","volume":"32","author":"Abdi","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2012.65_bb0130","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1097\/01.ASN.0000088025.33462.B0","article-title":"Estimation of total glomerular number in stable renal transplants","volume":"14","author":"Fulladosa","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.65_bb0135","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0140-6736(78)91522-2","article-title":"The ageing kidney","volume":"312","author":"McLachlan","year":"1978","journal-title":"Lancet"},{"key":"10.1038\/ki.2012.65_bb0140","doi-asserted-by":"crossref","first-page":"282","DOI":"10.4065\/mcp.2010.0821","article-title":"Association of kidney function and metabolic risk factors with density of glomeruli on renal biopsy samples from living donors","volume":"86","author":"Rule","year":"2011","journal-title":"Mayo Clinic Proc"},{"key":"10.1038\/ki.2012.65_bb0145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2215\/CJN.04680709","article-title":"Glomerular density in renal biopsy specimens predicts the long-term prognosis of IgA nephropathy","volume":"5","author":"Tsuboi","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.65_bb0150","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1093\/ndt\/gfr399","article-title":"Low glomerular density is a risk factor for progression in idiopathic membranous nephropathy","volume":"26","author":"Tsuboi","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.65_bb0155","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000211811","article-title":"Age changes in the human kidney of the different races","volume":"17","author":"Tauchi","year":"1971","journal-title":"Gerontologia"},{"key":"10.1038\/ki.2012.65_bb0160","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1148\/102.2.337","article-title":"Normal weights of human organs","volume":"102","author":"Rao","year":"1972","journal-title":"Radiology"},{"key":"10.1038\/ki.2012.65_bb0165","first-page":"55","article-title":"The influence of age, sex, race, and body habitus on kidney weight in humans","volume":"110","author":"Kasiske","year":"1986","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/ki.2012.65_bb0170","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2215\/CJN.00030110","article-title":"Determinants and functional significance of renal parenchymal volume in adults","volume":"6","author":"Johnson","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.65_bb0175","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1148\/radiol.2521081873","article-title":"Estimating glomerular filtration rate in kidney donors: a model constructed with renal volume measurements from donor CT scans","volume":"252","author":"Herts","year":"2009","journal-title":"Radiology"},{"key":"10.1038\/ki.2012.65_bb0180","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.juro.2010.04.079","article-title":"Predictors of kidney volume change and delayed kidney function recovery after donor nephrectomy","volume":"184","author":"Jeon","year":"2010","journal-title":"J Urol"},{"key":"10.1038\/ki.2012.65_bb0185","first-page":"541","article-title":"The thickness of the renal parenchyma decreases with age: a CT study of 360 patients","volume":"155","author":"Gourtsoyiannis","year":"1990","journal-title":"Am J Radiol"},{"key":"10.1038\/ki.2012.65_bb0190","first-page":"83","article-title":"Kidney dimensions at sonography: correlation with age, sex, and habitus in 665 adult volunteers","volume":"160","author":"Emamian","year":"1993","journal-title":"Am J Radiol"},{"key":"10.1038\/ki.2012.65_bb0195","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2490-9-19","article-title":"Normal kidney size and its influencing factors\u2014a 64-slice MDCT study of 1.040 asymptomatic patients","volume":"9","author":"Glodny","year":"2009","journal-title":"BMC Urology"},{"key":"10.1038\/ki.2012.65_bb0200","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1365-2362.2003.01091.x","article-title":"Influence of atherosclerosis on age-related changes in renal size and function","volume":"33","author":"Bax","year":"2003","journal-title":"Eur J Clin Invest"},{"key":"10.1038\/ki.2012.65_bb0205","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1259\/0007-1285-54-642-488","article-title":"Changes in sizes and distensibility of the aging kidney","volume":"54","author":"McLachlan","year":"1981","journal-title":"Brit J Radiol"},{"key":"10.1038\/ki.2012.65_bb0210","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1093\/ndt\/gfq769","article-title":"Clinical characteristics of potential kidney donors with asymptomatic kidney stones","volume":"26","author":"Lorenz","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.65_bb0215","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0009-9260(83)80238-4","article-title":"The incidence of simple renal cyst by computed tomography","volume":"34","author":"Tada","year":"1983","journal-title":"Clin Radiol"},{"key":"10.1038\/ki.2012.65_bb0220","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1681\/ASN.2008040441","article-title":"A clinical view of simple and complex renal cysts","volume":"20","author":"Eknoyan","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.65_bb0225","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0022-5347(17)58167-7","article-title":"Is the diverticulum of the distal and collecting tubules a preliminary stage of the simple cyst in the adult?","volume":"118","author":"Baert","year":"1977","journal-title":"J Urol"},{"key":"10.1038\/ki.2012.65_bb0230","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1046\/j.1523-1755.2003.00207.x","article-title":"Determinants of glomerular hypofiltration in aging humans","volume":"64","author":"Hoang","year":"2003","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.65_bb0235","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/ki.2010.128","article-title":"Effects of aging on glomerular function and number in living kidney donors","volume":"78","author":"Tan","year":"2010","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.65_bb0240","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1681\/ASN.2008030306","article-title":"Glomerular function, structure, and number in renal allografts from older deceased donors","volume":"20","author":"Tan","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.65_bb0245","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1046\/j.1523-1755.2000.00225.x","article-title":"Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study","volume":"58","author":"Manalich","year":"2000","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.65_bb0250","series-title":"The Kidney: Structure and Function in Health and Disease","first-page":"552","author":"Smith","year":"1951"},{"key":"10.1038\/ki.2012.65_bb0255","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1172\/JCI102286","article-title":"Age changes in glomerular filtration rate, effective renal plasma flow and tubular excretory capacity in adult males","volume":"29","author":"Davies","year":"1950","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2012.65_bb0260","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1532-5415.1985.tb07117.x","article-title":"Longitudinal studies on the rate of decline in renal function with age","volume":"33","author":"Lindeman","year":"1985","journal-title":"J Am Geriatr Soc"},{"key":"10.1038\/ki.2012.65_bb0265","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/geronj\/31.2.155","article-title":"The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study","volume":"31","author":"Rowe","year":"1976","journal-title":"J Gerontol"},{"key":"10.1038\/ki.2012.65_bb0270","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1093\/ndt\/12.8.1553","article-title":"Renal function in the elderly- is the dogma of an inexorable decline of renal function correct?","volume":"12","author":"Fliser","year":"1997","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.65_bb0275","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/ndt\/gfh710","article-title":"Ren sanus in corpore sano: the myth of the inevitable decline of renal function with senescence","volume":"20","author":"Fliser","year":"2005","journal-title":"Nephrol Dial Transplant"},{"issue":"Supplement 9","key":"10.1038\/ki.2012.65_bb0280","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/ndt\/11.supp9.2","article-title":"Renal hemodynamics in the elderly","volume":"11","author":"Fliser","year":"1996","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.65_bb0285","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000021995","article-title":"Relationship between hypertension and renal function and its therapeutic implications in the elderly","volume":"44","author":"Fliser","year":"1998","journal-title":"Gerontol"},{"key":"10.1038\/ki.2012.65_bb0290","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/ki.1997.163","article-title":"Renal function in the elderly: impact of hypertension and cardiac function","volume":"51","author":"Fliser","year":"1997","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.65_bb0295","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/ndt\/gfh689","article-title":"Ageing as a determinant of renal and vascular disease: role of endothelial factors","volume":"20","author":"Barton","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.65_bb0300","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/01.RES.34.3.309","article-title":"Senescence and the renal vasculature in normal man","volume":"34","author":"Hollenberg","year":"1974","journal-title":"Circ Res"},{"key":"10.1038\/ki.2012.65_bb0305","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1532-5415.1994.tb06550.x","article-title":"Age and the renal blood supply: renal vascular responses to angiotensin converting enzyme inhibition in healthy humans","volume":"42","author":"Hollenberg","year":"1994","journal-title":"J Am Geriatric Soc"},{"key":"10.1038\/ki.2012.65_bb0310","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1093\/ndt\/gfg183","article-title":"Functional changes in the ageing kidney: is there a role for asymmetric dimethylarginine?","volume":"18","author":"Kielstein","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.65_bb0315","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/ki.1984.229","article-title":"Association between blood pressure and the rate of decline in renal function with age","volume":"26","author":"Lindeman","year":"1984","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.65_bb0320","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1161\/01.HYP.29.1.171","article-title":"Aging, acculturation, salt intake and hypertension in the Kuna of Panama","volume":"29","author":"Hollenberg","year":"1997","journal-title":"Hypertension"},{"key":"10.1038\/ki.2012.65_bb0325","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000045389","article-title":"Age, renal perfusion and function in island dwelling indigenous Kuna Amerinds of Panama","volume":"82","author":"Hollenberg","year":"1999","journal-title":"Nephron"},{"key":"10.1038\/ki.2012.65_bb0330","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1097\/01.hjh.0000239293.40507.2a","article-title":"Aging and vascular responses to flavanol-rich cocoa","volume":"24","author":"Fisher","year":"2006","journal-title":"J Hypertens"},{"key":"10.1038\/ki.2012.65_bb0335","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/ki.2009.11","article-title":"Demographic and clinical characteristics associated with glomerular filtration rates in living kidney donors","volume":"75","author":"Poggio","year":"2009","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.65_bb0340","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1053\/j.ajkd.2003.09.026","article-title":"Measured and estimated GFR in healthy potential kidney donors","volume":"43","author":"Rule","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2012.65_bb0345","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/TP.0b013e3181e64237","article-title":"Definition of chronic kidney disease after uni-nephrectomy in living donors: what are the implications?","volume":"15","author":"Barri","year":"2010","journal-title":"Transplantation"},{"key":"10.1038\/ki.2012.65_bb0350","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","article-title":"Prediction of creatinine clearance from serum creatinine","volume":"16","author":"Cockcroft","year":"1976","journal-title":"Nephron"},{"key":"10.1038\/ki.2012.65_bb0355","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Group","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.2012.65_bb0360","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.2012.65_bb0365","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/sj.ki.5002755","article-title":"Age and gender-specific reference values of estimated glomerular filtration rate in a Caucasian population: results of the Nijmegen Biomedical Study","volume":"73","author":"Wetzels","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.65_bb0370","doi-asserted-by":"crossref","first-page":"c40","DOI":"10.1159\/000319646","article-title":"Estimation of the age-dependent decline of glomerular filtration rate from formulas based on creatinine and cystatin C in the general elderly population","volume":"117","author":"Christerensson","year":"2011","journal-title":"Nephron Clin Pract"},{"key":"10.1038\/ki.2012.65_bb0375","doi-asserted-by":"crossref","first-page":"c307","DOI":"10.1159\/000319166","article-title":"The conundrum of chronic kidney disease classification and end stage renal risk prediction in the elderly- what is the right approach?","volume":"116","author":"Hallan","year":"2010","journal-title":"Nephron Clin Pract"},{"key":"10.1038\/ki.2012.65_bb0380","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ki.2009.49","article-title":"Dissecting and refining the staging of chronic kidney disease","volume":"75","author":"Winearls","year":"2009","journal-title":"Kidney Int"},{"issue":"Supplement 1","key":"10.1038\/ki.2012.65_bb0385","first-page":"s1","article-title":"Clinical Practice Guidelines for chronic kidney disease- evaluation, classification, and stratification","volume":"39","author":"National Kidney Foundation- Kidney Disease Outcomes Quality Initiative","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2012.65_bb0390","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.2215\/CJN.02300311","article-title":"Relative performance of the MDRD and CKD-EPI equations for estimating glomerular filtration rate among patients with varied clinical presentations","volume":"6","author":"Murata","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.65_bb0395","doi-asserted-by":"crossref","first-page":"937","DOI":"10.2215\/CJN.09241010","article-title":"The clinician and estimation of glomerular filtration rate by creatinine-based formulas: current limitations and quo vadis","volume":"6","author":"Botev","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.65_bb0400","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/S0140-6736(09)62004-3","article-title":"Early recognition and prevention of chronic kidney disease","volume":"375","author":"James","year":"2010","journal-title":"Lancet"},{"key":"10.1038\/ki.2012.65_bb0405","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/ki.2010.531","article-title":"Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high risk population cohorts","volume":"80","author":"Gansevoort","year":"2011","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.65_bb0410","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.2215\/CJN.02030311","article-title":"Age-specific association of reduced estimated glomerular filtration rate and albuminuria with all cause mortality","volume":"6","author":"Muntner","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.65_bb0415","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1053\/j.ajkd.2010.05.017","article-title":"Kidney function, albuminuria and all-cause mortality in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study","volume":"56","author":"Warnock","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2012.65_bb0420","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1001\/jama.2010.39","article-title":"Relation between kidney function, proteinuria and adverse outcomes","volume":"303","author":"Hemmelgarn","year":"2010","journal-title":"JAMA"},{"key":"10.1038\/ki.2012.65_bb0425","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1681\/ASN.2008070730","article-title":"Combining GFR and albuminuria to classify CKD improves prediction of ESRD","volume":"20","author":"Hallan","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.65_bb0430","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/ki.2010.550","article-title":"Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts","volume":"79","author":"Astor","year":"2011","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.65_bb0435","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ki.2010.483","article-title":"The definition, classification and prognosis of chronic kidney disease: a KDIGO Controversies Conference Report","volume":"80","author":"Levey","year":"2011","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.65_bb0440","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.semnephrol.2009.06.006","article-title":"Interaction of aging and CKD","volume":"29","author":"Prakash","year":"2009","journal-title":"Semin Nephrol"},{"key":"10.1038\/ki.2012.65_bb0445","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1681\/ASN.2007040422","article-title":"Age affects outcome in chronic kidney disease","volume":"18","author":"O\u2019Hare","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.65_bb0450","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1681\/ASN.2005090986","article-title":"Mortality risk stratification in chronic kidney disease: one size for all ages?","volume":"17","author":"O\u2019Hare","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.65_bb0455","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/S0140-6736(10)61271-8","article-title":"Glomerular filtration rate, proteinuria and the incidence and consequences of acute kidney injury: a cohort study","volume":"376","author":"James","year":"2010","journal-title":"Lancet"},{"key":"10.1038\/ki.2012.65_bb0460","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1093\/ndt\/gfr323","article-title":"Epidemiology and prognostic significance of chronic kidney disease in the elderly\u2014the three cities prospective cohort study","volume":"26","author":"Stengel","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.65_bb0465","doi-asserted-by":"crossref","first-page":"310","DOI":"10.7326\/0003-4819-154-5-201103010-00005","article-title":"Estimated glomerular filtration rate and albuminuria as predictors of outcomes in patients with high cardio-vascular risk: a cohort study","volume":"154","author":"Clase","year":"2010","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.2012.65_bb0470","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/ki.2008.698","article-title":"For estimating creatinine clearance measuring muscle mass gives better results than those based on demographics","volume":"75","author":"Rule","year":"2009","journal-title":"Kidney Intl"},{"key":"10.1038\/ki.2012.65_bb0475","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1093\/ndt\/gfq848","article-title":"The combined contribution of albuminuria and glomerular filtration rate in the prediction of cardiovascular mortality in elderly men","volume":"26","author":"Nerpin","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.65_bb0480","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1681\/ASN.2010050483","article-title":"Cystatin C identifies chronic kidney disease patients at higher risk for complications","volume":"22","author":"Peralta","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.65_bb0485","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/ki.2008.638","article-title":"Factors other than glomerular filtration rate affect serum cystatin C levels","volume":"75","author":"Stevens","year":"2009","journal-title":"Kidney Int"},{"issue":"Suppl 1","key":"10.1038\/ki.2012.65_bb0490","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000328012","article-title":"Senile nephrosclerosis - does it explain the decline in glomerular filtration rate with aging","volume":"119","author":"Rule","year":"2011","journal-title":"Nephron Physiol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381555552X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381555552X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T03:53:09Z","timestamp":1641441189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S008525381555552X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":97,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S008525381555552X"],"URL":"https:\/\/doi.org\/10.1038\/ki.2012.65","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}