{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:44:25Z","timestamp":1769607865485,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":1461,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1038\/ki.2014.107","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T12:41:23Z","timestamp":1398861683000},"page":"757-767","source":"Crossref","is-referenced-by-count":47,"title":["Early targets of lithium in rat kidney inner medullary collecting duct include p38 and ERK1\/2"],"prefix":"10.1016","volume":"86","author":[{"given":"Francesco","family":"Trepiccione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trairak","family":"Pisitkun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason D.","family":"Hoffert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren B.","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovambattista","family":"Capasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Knepper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Fenton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte M.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl 16","key":"10.1038\/ki.2014.107_bb0010","first-page":"S43","article-title":"Lithium-induced nephrogenic diabetes insipidus: new clinical and experimental findings","volume":"23","author":"Trepiccione","year":"2010","journal-title":"J Nephrol"},{"key":"10.1038\/ki.2014.107_bb0015","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1172\/JCI112465","article-title":"Inhibition by lithium of the hydroosmotic action of vasopressin in the isolated perfused cortical collecting tubule of the rabbit","volume":"77","author":"Cogan","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2014.107_bb0020","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/00365510310001005","article-title":"Effect of an acute oral lithium intake on urinary Aquaporin-2 in healthy humans with and without simultaneous stimulation with hypertonic saline infusion","volume":"63","author":"Pedersen","year":"2003","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1038\/ki.2014.107_bb0025","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1073\/pnas.0800001105","article-title":"Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation","volume":"105","author":"Nielsen","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2014.107_bb0030","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1681\/ASN.2005080884","article-title":"Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity","volume":"17","author":"Li","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.107_bb0035","doi-asserted-by":"crossref","first-page":"F461","DOI":"10.1152\/ajprenal.00389.2009","article-title":"Metabolic profiling of kidney and urine in rats with lithium-induced nephrogenic diabetes insipidus by (1)H-NMR-based metabonomics","volume":"298","author":"Hwang","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.107_bb0040","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1172\/JCI117863","article-title":"Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla","volume":"95","author":"Marples","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2014.107_bb0045","doi-asserted-by":"crossref","first-page":"C952","DOI":"10.1152\/ajpcell.00266.2003","article-title":"Changes in cellular composition of kidney collecting duct cells in rats with lithium-induced NDI","volume":"286","author":"Christensen","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1038\/ki.2014.107_bb0050","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1021\/pr050406g","article-title":"Label-free protein quantification using LC-coupled ion trap or FT mass spectrometry: reproducibility, linearity, and application with complex proteomes","volume":"5","author":"Wang","year":"2006","journal-title":"J Proteome Res"},{"key":"10.1038\/ki.2014.107_bb0055","doi-asserted-by":"crossref","first-page":"F642","DOI":"10.1152\/ajprenal.00287.2004","article-title":"Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria","volume":"288","author":"Rao","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.107_bb0060","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.3390\/ijms14047089","article-title":"Roles of rho GTPases in intracellular transport and cellular transformation","volume":"14","author":"Chi","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1038\/ki.2014.107_bb0065","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.ejcb.2006.04.011","article-title":"Rho GTPase signaling in Dictyostelium discoideum: insights from the genome","volume":"85","author":"Vlahou","year":"2006","journal-title":"Eur J Cell Biol"},{"key":"10.1038\/ki.2014.107_bb0070","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1242\/jcs.018044","article-title":"Paxillin comes of age","volume":"121","author":"Deakin","year":"2008","journal-title":"J Cell Sci"},{"key":"10.1038\/ki.2014.107_bb0075","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev.cellbio.19.050103.103356","article-title":"Ena\/VASP proteins: regulators of the actin cytoskeleton and cell migration","volume":"19","author":"Krause","year":"2003","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1038\/ki.2014.107_bb0080","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4161\/sgtp.1.1.12672","article-title":"Rho-guanine nucleotide exchange factors during development: force is nothing without control","volume":"1","author":"Mulinari","year":"2010","journal-title":"Small GTPases"},{"key":"10.1038\/ki.2014.107_bb0085","first-page":"3290","article-title":"Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice","volume":"119","author":"Jeong","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2014.107_bb0090","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1681\/ASN.2012121183","article-title":"Salt and pepper distribution of cell types in the collecting duct","volume":"24","author":"Sampogna","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.107_bb0095","doi-asserted-by":"crossref","first-page":"F919","DOI":"10.1152\/ajprenal.00152.2012","article-title":"Evaluation of cellular plasticity in the collecting duct during recovery from lithium-induced nephrogenic diabetes insipidus","volume":"305","author":"Trepiccione","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.107_bb0100","doi-asserted-by":"crossref","first-page":"F1030","DOI":"10.1152\/ajprenal.90339.2008","article-title":"Akt and ERK1\/2 pathways are components of the vasopressin signaling network in rat native IMCD","volume":"295","author":"Pisitkun","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.107_bb0105","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1038\/ki.2014.107_bb0110","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/ki.1984.197","article-title":"Osmotic activity of dimethyl sulfoxide in the renal distal tubule","volume":"26","author":"Ellison","year":"1984","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.107_bb0115","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1073\/pnas.0910646107","article-title":"Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells","volume":"107","author":"Rinschen","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2014.107_bb0120","doi-asserted-by":"crossref","first-page":"F290","DOI":"10.1152\/ajprenal.00072.2008","article-title":"The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells","volume":"295","author":"Lu","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.107_bb0125","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1073\/pnas.0910683107","article-title":"Phosphorylation of aquaporin-2 regulates its endocytosis and protein-protein interactions","volume":"107","author":"Moeller","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2014.107_bb0130","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1681\/ASN.2009111190","article-title":"Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase","volume":"21","author":"Nedvetsky","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.107_bb0135","doi-asserted-by":"crossref","first-page":"C636","DOI":"10.1152\/ajpcell.00433.2009","article-title":"Regulation of AQP2 localization by S256 and S261 phosphorylation and ubiquitination","volume":"300","author":"Tamma","year":"2011","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1038\/ki.2014.107_bb0140","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1734-1140(09)70026-X","article-title":"Pharmacology of dimethyl sulfoxide in cardiac and CNS damage","volume":"61","author":"Jacob","year":"2009","journal-title":"Pharmacol Rep"},{"key":"10.1038\/ki.2014.107_bb0145","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s002130050642","article-title":"Prevention of lithium nephrotoxicity in a novel one-hour model in rats","volume":"138","author":"Levine","year":"1998","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1038\/ki.2014.107_bb0150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/toxsci\/kfr263","article-title":"Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney","volume":"125","author":"Diaz","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1038\/ki.2014.107_bb0155","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0022-3565(25)21307-6","article-title":"Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein\/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function","volume":"279","author":"Badger","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/ki.2014.107_bb0160","doi-asserted-by":"crossref","first-page":"76ra27","DOI":"10.1126\/scitranslmed.3001069","article-title":"A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice","volume":"3","author":"Lyubynska","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1038\/ki.2014.107_bb0165","first-page":"F251","article-title":"Purification of rat papillary collecting duct cells: functional and metabolic assessment","volume":"253","author":"Stokes","year":"1987","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.2014.107_bb0170","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1152\/physiolgenomics.00214.2005","article-title":"High-throughput identification of IMCD proteins using LC-MS\/MS","volume":"25","author":"Pisitkun","year":"2006","journal-title":"Physiol Genomics"},{"key":"10.1038\/ki.2014.107_bb0175","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1021\/ac050102d","article-title":"InsPecT: identification of posttranslationally modified peptides from tandem mass spectra","volume":"77","author":"Tanner","year":"2005","journal-title":"Anal Chem"},{"key":"10.1038\/ki.2014.107_bb0180","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1021\/ac980122y","article-title":"Method to compare collision-induced dissociation spectra of peptides: potential for library searching and subtractive analysis","volume":"70","author":"Yates","year":"1998","journal-title":"Anal Chem"},{"key":"10.1038\/ki.2014.107_bb0185","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1021\/pr0499491","article-title":"Open mass spectrometry search algorithm","volume":"3","author":"Geer","year":"2004","journal-title":"J Proteome Res"},{"key":"10.1038\/ki.2014.107_bb0190","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nmeth1019","article-title":"Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry","volume":"4","author":"Elias","year":"2007","journal-title":"Nat Methods"},{"key":"10.1038\/ki.2014.107_bb0195","doi-asserted-by":"crossref","first-page":"M111","DOI":"10.1074\/mcp.M111.014613","article-title":"Dynamics of the G protein-coupled vasopressin V2 receptor signaling network revealed by quantitative phosphoproteomics","volume":"11","author":"Hoffert","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"10.1038\/ki.2014.107_bb0200","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1002\/pmic.201200189","article-title":"CPhos: a program to calculate and visualize evolutionarily conserved functional phosphorylation sites","volume":"12","author":"Zhao","year":"2012","journal-title":"Proteomics"},{"key":"10.1038\/ki.2014.107_bb0205","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nbt1146","article-title":"An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets","volume":"23","author":"Schwartz","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1038\/ki.2014.107_bb0210","doi-asserted-by":"crossref","first-page":"D561","DOI":"10.1093\/nar\/gkq973","article-title":"The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored","volume":"39","author":"Szklarczyk","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/ki.2014.107_bb0215","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1186\/1756-0500-4-384","article-title":"Medusa: A tool for exploring and clustering biological networks","volume":"4","author":"Pavlopoulos","year":"2011","journal-title":"BMC Res Notes"},{"key":"10.1038\/ki.2014.107_bb0220","doi-asserted-by":"crossref","first-page":"F29","DOI":"10.1152\/ajprenal.2000.278.1.F29","article-title":"Localization and regulation of PKA-phosphorylated AQP2 in response to V(2)-receptor agonist\/antagonist treatment","volume":"278","author":"Christensen","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.107_bb0225","doi-asserted-by":"crossref","first-page":"F691","DOI":"10.1152\/ajprenal.00284.2006","article-title":"Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct","volume":"292","author":"Hoffert","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.107_bb0230","doi-asserted-by":"crossref","first-page":"24617","DOI":"10.1074\/jbc.M803074200","article-title":"Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2","volume":"283","author":"Hoffert","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2014.107_bb0235","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1681\/ASN.2010070734","article-title":"{alpha}ENaC-mediated lithium absorption promotes nephrogenic diabetes insipidus","volume":"22","author":"Christensen","year":"2011","journal-title":"J Am Soc Nephrol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815303689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815303689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T16:38:01Z","timestamp":1746203881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815303689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0085253815303689"],"URL":"https:\/\/doi.org\/10.1038\/ki.2014.107","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}