{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:01:17Z","timestamp":1792213277831,"version":"4.4.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1038\/ki.2014.119","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T13:01:21Z","timestamp":1398258081000},"page":"954-964","source":"Crossref","is-referenced-by-count":28,"title":["Minocycline prevents osmotic demyelination associated with aquaresis"],"prefix":"10.1016","volume":"86","author":[{"given":"Hiroshi","family":"Takagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Sugimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Iwama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisakazu","family":"Izumida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ochiai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kiyota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Suga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motomitsu","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Banno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Arima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Oiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2014.119_bb0010","doi-asserted-by":"crossref","first-page":"164","DOI":"10.7326\/0003-4819-102-2-164","article-title":"Hyponatremia: a prospective analysis of its epidemiology and the pathogenetic role of vasopressin","volume":"102","author":"Anderson","year":"1985","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.2014.119_bb0015","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.amjmed.2013.07.006","article-title":"Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations","volume":"126","author":"Verbalis","year":"2013","journal-title":"Am J Med"},{"key":"10.1038\/ki.2014.119_bb0020","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1681\/ASN.V481522","article-title":"Neurologic sequelae after treatment of severe hyponatremia: a multicenter perspective","volume":"4","author":"Sterns","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.119_bb0025","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1126\/science.7466381","article-title":"Rapid correction of hyponatremia causes demyelination: relation to central pontine myelinolysis","volume":"211","author":"Kleinschmidt-DeMasters","year":"1981","journal-title":"Science"},{"key":"10.1038\/ki.2014.119_bb0030","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/ki.2009.251","article-title":"Overcorrection of hyponatremia is a medical emergency","volume":"76","author":"Sterns","year":"2009","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.119_bb0035","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1681\/ASN.2010101062","article-title":"Managing overly rapid correction of chronic hyponatremia: an ounce of prevention or a pound of cure?","volume":"21","author":"Kamel","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.119_bb0040","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1093\/ndt\/gfr790","article-title":"The importance of distal delivery of filtrate and residual water permeability in the pathophysiology of hyponatremia","volume":"27","author":"Kamel","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2014.119_bb0045","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1056\/NEJMoa065181","article-title":"Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia","volume":"355","author":"Schrier","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2014.119_bb0050","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1530\/EJE-10-1078","article-title":"Efficacy and safety of oral tolvaptan therapy in patients with the syndrome of inappropriate antidiuretic hormone secretion","volume":"164","author":"Verbalis","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"10.1038\/ki.2014.119_bb0055","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1001\/jama.297.12.1332","article-title":"Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials","volume":"297","author":"Gheorghiade","year":"2007","journal-title":"JAMA"},{"key":"10.1038\/ki.2014.119_bb0060","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jhep.2007.03.007","article-title":"Vaptans: a promising therapy in the management of advanced cirrhosis","volume":"46","author":"Gines","year":"2007","journal-title":"J Hepatol"},{"key":"10.1038\/ki.2014.119_bb0065","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1681\/ASN.2009080857","article-title":"Oral tolvaptan is safe and effective in chronic hyponatremia","volume":"21","author":"Berl","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.119_bb0070","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/ki.2011.78","article-title":"Vaptans are not the mainstay of treatment in hyponatremia: perhaps not yet","volume":"80","author":"Gross","year":"2011","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.119_bb0075","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1056\/NEJM200005253422107","article-title":"Hyponatremia","volume":"342","author":"Adrogue","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2014.119_bb0080","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/ki.2009.254","article-title":"Re-induction of hyponatremia after rapid overcorrection of hyponatremia reduces mortality in rats","volume":"76","author":"Gankam Kengne","year":"2009","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.119_bb0085","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/ki.1994.23","article-title":"Prevention of brain demyelination in rats after excessive correction of chronic hyponatremia by serum sodium lowering","volume":"45","author":"Soupart","year":"1994","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.119_bb0090","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/01.jnen.0000195938.02292.39","article-title":"Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats","volume":"65","author":"Silver","year":"2006","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1038\/ki.2014.119_bb0095","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1172\/JCI115292","article-title":"Study of brain electrolytes and organic osmolytes during correction of chronic hyponatremia. Implications for the pathogenesis of central pontine myelinolysis","volume":"88","author":"Lien","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2014.119_bb0100","doi-asserted-by":"crossref","first-page":"742","DOI":"10.2215\/CJN.06990711","article-title":"Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH","volume":"7","author":"Soupart","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.119_bb0105","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1681\/ASN.2010040438","article-title":"Minocycline prevents osmotic demyelination syndrome by inhibiting the activation of microglia","volume":"21","author":"Suzuki","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.119_bb0110","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1681\/ASN.2010050467","article-title":"Minocycline protects against neurologic complications of rapid correction of hyponatremia","volume":"21","author":"Gankam-Kengne","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.119_bb0115","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/exnr.2000.7474","article-title":"Blood-brain barrier disruption and complement activation in the brain following rapid correction of chronic hyponatremia","volume":"165","author":"Baker","year":"2000","journal-title":"Exp Neurol"},{"key":"10.1038\/ki.2014.119_bb0120","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.expneurol.2004.10.018","article-title":"Protective effect of dexamethasone on osmotic-induced demyelination in rats","volume":"192","author":"Sugimura","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1038\/ki.2014.119_bb0125","doi-asserted-by":"crossref","first-page":"13532","DOI":"10.1073\/pnas.0605796103","article-title":"Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice","volume":"103","author":"Frydenlund","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2014.119_bb0130","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neulet.2011.08.049","article-title":"Aquaporins AQP1 and AQP4 in the cerebrospinal fluid of bacterial meningitis patients","volume":"504","author":"Blocher","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1038\/ki.2014.119_bb0135","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/glia.21114","article-title":"Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome","volume":"59","author":"Iwama","year":"2011","journal-title":"Glia"},{"key":"10.1038\/ki.2014.119_bb0140","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1681\/ASN.2010111127","article-title":"Astrocytes are an early target in osmotic demyelination syndrome","volume":"22","author":"Gankam Kengne","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.119_bb0145","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1210\/en.2004-1590","article-title":"Therapeutic effects of tolvaptan, a potent, selective nonpeptide vasopressin V2 receptor antagonist, in rats with acute and chronic severe hyponatremia","volume":"146","author":"Miyazaki","year":"2005","journal-title":"Endocrinology"},{"key":"10.1038\/ki.2014.119_bb0150","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0022-3565(24)37873-5","article-title":"OPC-41061, a highly potent human vasopressin V2-receptor antagonist: pharmacological profile and aquaretic effect by single and multiple oral dosing in rats","volume":"287","author":"Yamamura","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/ki.2014.119_bb0155","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/00005072-198707000-00008","article-title":"Protective effect of steroids in electrolyte-induced demyelination","volume":"46","author":"Rojiani","year":"1987","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1038\/ki.2014.119_bb0160","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.tins.2012.11.007","article-title":"Microglia: actively surveying and shaping neuronal circuit structure and function","volume":"36","author":"Wake","year":"2013","journal-title":"Trends Neurosci"},{"key":"10.1038\/ki.2014.119_bb0165","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1038\/ki.1992.239","article-title":"Treatment of chronic hyponatremia in rats by intravenous saline: comparison of rate vs. magnitude of correction","volume":"41","author":"Soupart","year":"1992","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.119_bb0170","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ki.1991.161","article-title":"Neurological and neuropathological sequelae of correction of chronic hyponatremia","volume":"39","author":"Verbalis","year":"1991","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.119_bb0175","first-page":"156","article-title":"Ischemic and hemorrhagic necrosis of the pons with anatomical location similar to that of central pontine myelinolysis in a chronic alcoholic patient","volume":"12","author":"Giannetti","year":"1993","journal-title":"Clin Neuropathol"},{"key":"10.1038\/ki.2014.119_bb0180","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3109\/14767050903265097","article-title":"Late occurrence of severe hyponatremia followed by extrapontine osmotic demyelination syndrome after successful conservative management of postpartum hemorrhage due to placenta accreta by uterine artery embolization","volume":"23","author":"Imoto","year":"2010","journal-title":"J Matern-Fetal Neonatal Med"},{"key":"10.1038\/ki.2014.119_bb0185","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s13760-012-0110-5","article-title":"Atypical forms of the osmotic demyelination syndrome","volume":"113","author":"Ruiz-Sandoval","year":"2013","journal-title":"Acta Neurol Belg"},{"key":"10.1038\/ki.2014.119_bb0190","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1056\/NEJM198606123142402","article-title":"Osmotic demyelination syndrome following correction of hyponatremia","volume":"314","author":"Sterns","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2014.119_bb0195","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrn3468","article-title":"Aquaporin water channels in the nervous system","volume":"14","author":"Papadopoulos","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1038\/ki.2014.119_bb0200","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ygeno.2007.12.003","article-title":"New isoforms of rat Aquaporin-4","volume":"91","author":"Moe","year":"2008","journal-title":"Genomics"},{"key":"10.1038\/ki.2014.119_bb0205","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815304063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815304063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T14:39:14Z","timestamp":1746196754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815304063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0085253815304063"],"URL":"https:\/\/doi.org\/10.1038\/ki.2014.119","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}