{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T04:49:49Z","timestamp":1775105389926,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1038\/ki.2014.212","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T12:47:29Z","timestamp":1402490849000},"page":"427-433","source":"Crossref","is-referenced-by-count":27,"title":["Markers of endothelial dysfunction and inflammation predict progression of diabetic nephropathy in African Americans with type 1 diabetes"],"prefix":"10.1016","volume":"87","author":[{"given":"Monique S.","family":"Roy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malvin N.","family":"Janal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Crosby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2014.212_bb0010","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1056-8727(02)00279-9","article-title":"Proteinuria in African Americans with type 1 diabetes","volume":"18","author":"Roy","year":"2004","journal-title":"J Diabetes Complications"},{"key":"10.1038\/ki.2014.212_bb0015","series-title":"US Renal Data System: USRDS 2002 Annual Data Report","year":"2002"},{"key":"10.1038\/ki.2014.212_bb0020","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2337\/dc06-2534","article-title":"Six-year incidence of proteinuria in type 1 diabetic African Americans","volume":"30","author":"Roy","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1038\/ki.2014.212_bb0025","series-title":"Diabetic Nephropathy Theory and Practice","first-page":"55","article-title":"Microalbuminuria in type 1 diabetes","author":"Reddi","year":"2004"},{"key":"10.1038\/ki.2014.212_bb0030","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/ki.2009.399","article-title":"In patients with type 1 diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria","volume":"77","author":"Perkins","year":"2010","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.212_bb0035","series-title":"Diabetic Nephropathy Theory and Practice","first-page":"109","article-title":"Pathology of the kidney in type 1 diabetes","author":"Reddi","year":"2004"},{"key":"10.1038\/ki.2014.212_bb0040","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1210\/jc.2008-2534","article-title":"Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications","volume":"94","author":"Goldberg","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1038\/ki.2014.212_bb0045","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s101570070001","article-title":"Chemokines: new target molecules in renal diseases","volume":"4","author":"Wada","year":"2000","journal-title":"Clin Exp Nephrol"},{"key":"10.1038\/ki.2014.212_bb0050","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1681\/ASN.2007091048","article-title":"The role of inflammatory cytokines in diabetic nephropathy","volume":"19","author":"Navarro-Gonzalez","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.212_bb0055","series-title":"Inflammation in diabetic nephropathy","author":"Lim","year":"2012"},{"key":"10.1038\/ki.2014.212_bb0060","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0344-0338(11)80780-6","article-title":"The pathogenesis of chronic renal failure in diabetic nephropathy. Investigation of 488 cases of diabetic glomerulosclerosis","volume":"187","author":"Bohle","year":"1991","journal-title":"Pathol Res Pract"},{"key":"10.1038\/ki.2014.212_bb0065","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.2337\/diab.46.12.2075","article-title":"Increased expression of intercellular adhesion molecule-1(ICAM-1) in diabetic rat glomeruli: glomerular hyperfiltration is a potential mechanism of ICAM-1 upregulation","volume":"46","author":"Sugimoto","year":"1997","journal-title":"Diabetes"},{"key":"10.1038\/ki.2014.212_bb0070","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.2337\/diabetes.52.10.2586","article-title":"Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes","volume":"52","author":"Okada","year":"2003","journal-title":"Diabetes"},{"key":"10.1038\/ki.2014.212_bb0075","first-page":"4313","article-title":"Elevated concentrations of circulating adhesion molecules and their association with microvascular complications in insulin-dependent diabetes mellitus","volume":"81","author":"Fasching","year":"1996","journal-title":"J Clin Endocronol Metab"},{"key":"10.1038\/ki.2014.212_bb0080","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1046\/j.1464-5491.2000.00347.x","article-title":"Plasma concentrations of VCAM-1 and ICAM-1 are elevated in patients with type 1 diabetes mellitus with microalbuminuria and overt nephropathy","volume":"17","author":"Clausen","year":"2000","journal-title":"Diabet Med"},{"key":"10.1038\/ki.2014.212_bb0085","unstructured":"Saraheimo M, Teppo A-M, Forsblom C et al. The FinnDiane Study Group. Diabetic nephropathy is associated with low-grade inflammation in type 1 diabetic patients. Available from http:\/\/link.springer.com\/article\/10.1007\/s00125-003-1194-5. Accessed 20 August 2013. http:\/\/link.springer.com\/article\/10.1007\/s00125-003-1194-5"},{"key":"10.1038\/ki.2014.212_bb0090","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1262-3636(07)70051-4","article-title":"Acute-phase proteins among patients with type 1 diabetes","volume":"29","author":"Gomes","year":"2003","journal-title":"Diabetes Metab"},{"key":"10.1038\/ki.2014.212_bb0095","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.2337\/diacare.26.7.2165","article-title":"Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes. The EURODIAB Prospective Complications Study","volume":"26","author":"Schram","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1038\/ki.2014.212_bb0100","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/j.1464-5491.2005.01562.x","article-title":"Increase plasma markers of inflammation and endothelial dysfunction and their association with microvascular complications in type 1 diabetic patients without clinically manifest macroangiopathy","volume":"22","author":"Targher","year":"2005","journal-title":"Diabet Med"},{"key":"10.1038\/ki.2014.212_bb0105","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1093\/ndt\/gfi067","article-title":"Systemic and vascular inflammation is elevated in early IgA and type 1 diabetic nephropathies and relates to vascular disease risk factors and renal function","volume":"20","author":"Nelson","year":"2005","journal-title":"Nephrol Dial Tranplant"},{"key":"10.1038\/ki.2014.212_bb0110","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jdiacomp.2005.06.005","article-title":"Soluble vascular cell adhesion molecule-1 and soluble E-selectin are associated with micro- and macrovascular complications in type 1 diabetic patients","volume":"20","author":"Soedamah-Muthu","year":"2006","journal-title":"J Diabetes Complications"},{"key":"10.1038\/ki.2014.212_bb0115","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.2337\/dc08-0659","article-title":"The DCCT\/EDIC Cohort Study Group. Risk factors related to inflammation and endothelial dysfunction in the DCCT\/EDIC cohort and their relationship with nephropathy and macrovascular complications","volume":"31","author":"Lopes-Virella","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1038\/ki.2014.212_bb0120","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1111\/j.1464-5491.2012.03651.x","article-title":"Urinary markers of renal inflammation in adolescents with type 1 diabetes mellitus and normoalbuminuria","volume":"29","author":"Cherney","year":"2012","journal-title":"Diabet Med"},{"key":"10.1038\/ki.2014.212_bb0125","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1399-5448.2006.00204.x","article-title":"Low risk of overt nephropathy after 24 yr of childhood-onset type 1 diabetes mellitus (T1DM) in Norway","volume":"7","author":"Skrivarhaug","year":"2006","journal-title":"Pediatr Diabetes"},{"key":"10.1038\/ki.2014.212_bb0130","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.2337\/dc07-1960","article-title":"Markers of endothelial dysfunction and inflammation in type 1 diabetic patients with or without diabetic nephropathy followed for 10 years","volume":"31","author":"Astrup","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1038\/ki.2014.212_bb0135","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1681\/ASN.2011060628","article-title":"Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes","volume":"23","author":"Gohda","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.212_bb0140","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.2337\/dc12-2521","article-title":"The DCCT\/EDIC Research Group. Baseline markers of inflammation are associated with progression to macroalbuminuria in type 1 diabetic subjects","volume":"8","author":"Lopes-Virella","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1038\/ki.2014.212_bb0145","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1080\/00365510802187226","article-title":"Endothelial dysfunction and inflammation predict development of diabetic nephropathy in the Irbesartan in patients with type 2 diabetes and microalbuminuria (IRMA 2) study","volume":"68","author":"Persson","year":"2008","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1038\/ki.2014.212_bb0150","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.bioeng.7.060804.100423","article-title":"Molecular mechanics and dynamics of leukocyte recruitment during inflammation","volume":"7","author":"Simon","year":"2005","journal-title":"Annu Rev Biomed Eng"},{"key":"10.1038\/ki.2014.212_bb0155","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1046\/j.1523-1755.2003.00750.x","article-title":"Chemokines and chemokine receptors are involved in the resolution or progression of renal disease","volume":"63","author":"Anders","year":"2003","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.212_bb0160","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/15321819.2010.524860","article-title":"Multiplex bead analysis of urinary cytokines of type 2 diabetic patients with normo- and microalbuminuria","volume":"31","author":"Liu","year":"2010","journal-title":"J Immunoassay Immunochem"},{"key":"10.1038\/ki.2014.212_bb0165","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2337\/dc10-1219","article-title":"The acute effect of clamped hyperglycemia on the urinary excretion of inflammatory cytokines\/chemokines in uncomplicated type 1 diabetes. A pilot study","volume":"34","author":"Cherney","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1038\/ki.2014.212_bb0170","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/ndt\/14.1.76","article-title":"Eotaxin contributes to renal interstitial eosinophilia","volume":"14","author":"Wada","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2014.212_bb0175","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1567-5769(01)00004-2","article-title":"Chemokines in renal diseases","volume":"1","author":"Wada","year":"2001","journal-title":"Intern Immunopharmacol"},{"key":"10.1038\/ki.2014.212_bb0180","doi-asserted-by":"crossref","first-page":"7571","DOI":"10.4049\/jimmunol.166.12.7571","article-title":"Eotaxin (CCL11) induces in vivo angiogenic responses by human CCR3+ endothelial cells","volume":"166","author":"Salcedo","year":"2001","journal-title":"J Immunol"},{"key":"10.1038\/ki.2014.212_bb0185","doi-asserted-by":"crossref","first-page":"27348","DOI":"10.1074\/jbc.270.45.27348","article-title":"The functional role of the ELR motif in CXC chemokine-mediated angiogenesis","volume":"270","author":"Strieter","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2014.212_bb0190","first-page":"697","article-title":"MCP1\/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy","volume":"294","author":"Tesch","year":"2008","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.2014.212_bb0195","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1681\/ASN.2005080859","article-title":"Leukocyte recruitment and vascular injury in diabetic nephropathy","volume":"17","author":"Galkina","year":"2006","journal-title":"J Am Soc Nephrol"},{"issue":"Suppl.71","key":"10.1038\/ki.2014.212_bb0200","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1046\/j.1523-1755.1999.07112.x","article-title":"Mechanisms of glomerular macrophage infiltration in lipid-induced renal injury","volume":"55","author":"Hattori","year":"1999","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.212_bb0205","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0002-9440(10)63938-7","article-title":"Cyclic stretching of mesangial cells up-regulates intercellular adhesion molecule-1 and leukocyte adherence. A possible new mechanism for glomerulosclerosis","volume":"158","author":"Riser","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.2014.212_bb0210","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1006\/cyto.2000.0764","article-title":"Effects of sample handling on the stability of interleukin 6, tumour necrosis factor-alpha and leptin","volume":"12","author":"Flower","year":"2000","journal-title":"Cytokine"},{"key":"10.1038\/ki.2014.212_bb0215","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.2014.212_bb0220","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/archopht.118.1.97","article-title":"Diabetic retinopathy in African Americans with type 1 diabetes: The New Jersey 725. I. Methodology, population, frequency of retinopathy, and visual impairment","volume":"118","author":"Roy","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"10.1038\/ki.2014.212_bb0225","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.2337\/diacare.20.7.1183","article-title":"Report of the Expert Committee on the Diagnosis and Classification of diabetes mellitus","volume":"20","year":"1997","journal-title":"Diabetes Care"},{"key":"10.1038\/ki.2014.212_bb0230","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1001\/archopht.124.9.1297","article-title":"Six-year progression of retinopathy and associated risk factors in African American patients with type 1 diabetes mellitus. The New Jersey 725","volume":"124","author":"Roy","year":"2006","journal-title":"Arch Ophthalmol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815300454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815300454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T07:36:16Z","timestamp":1549006576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815300454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0085253815300454"],"URL":"https:\/\/doi.org\/10.1038\/ki.2014.212","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}