{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:08:02Z","timestamp":1791774482472,"version":"4.3.4"},"reference-count":84,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":1461,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1038\/ki.2014.244","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T12:38:09Z","timestamp":1406119089000},"page":"685-692","source":"Crossref","is-referenced-by-count":59,"title":["The role of adenosine receptors A2A and A2B signaling in renal fibrosis"],"prefix":"10.1016","volume":"86","author":[{"given":"Veena S.","family":"Roberts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen I.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Robson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Dwyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2014.244_bb0010","doi-asserted-by":"crossref","first-page":"F1078","DOI":"10.1152\/ajprenal.00017.2010","article-title":"Acute kidney injury: a springboard for progression in chronic kidney disease","volume":"298","author":"Venkatachalam","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.244_bb0015","doi-asserted-by":"crossref","first-page":"F338","DOI":"10.1152\/ajprenal.00169.2002","article-title":"Chronic renal hypoxia after acute ischemic injury: effects of l-arginine on hypoxia and secondary damage","volume":"284","author":"Basile","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.244_bb0020","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1681\/ASN.2005070757","article-title":"Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure","volume":"17","author":"Nangaku","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.244_bb0025","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/ki.2008.350","article-title":"Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics","volume":"74","author":"Fine","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.244_bb0030","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMra0910283","article-title":"Hypoxia and inflammation","volume":"364","author":"Eltzschig","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2014.244_bb0035","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1681\/ASN.2009121217","article-title":"Adenosine generation and signaling during acute kidney injury","volume":"22","author":"Bauerle","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.244_bb0040","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1097\/ALN.0b013e3181b060f2","article-title":"Adenosine: an old drug newly discovered","volume":"111","author":"Eltzschig","year":"2009","journal-title":"Anesthesiology"},{"key":"10.1038\/ki.2014.244_bb0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3410\/B3-21","article-title":"Adenosine receptors and fibrosis: a translational review","volume":"3","author":"Cronstein","year":"2011","journal-title":"F1000 Biol Rep"},{"key":"10.1038\/ki.2014.244_bb0050","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/sj.cdd.4402132","article-title":"Adenosine, an endogenous distress signal, modulates tissue damage and repair","volume":"14","author":"Fredholm","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1038\/ki.2014.244_bb0055","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1002\/art.21974","article-title":"Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma","volume":"54","author":"Chan","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1038\/ki.2014.244_bb0060","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1096\/fj.09-140772","article-title":"Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease","volume":"24","author":"Schneider","year":"2010","journal-title":"FASEB J"},{"key":"10.1038\/ki.2014.244_bb0065","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/sj.bjp.0706812","article-title":"Adenosine A2A receptors play a role in the pathogenesis of hepatic cirrhosis","volume":"148","author":"Chan","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1038\/ki.2014.244_bb0070","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1053\/j.gastro.2007.10.030","article-title":"Disordered pancreatic inflammatory responses and inhibition of fibrosis in CD39-null mice","volume":"134","author":"K\u00fcnzli","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1038\/ki.2014.244_bb0075","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1161\/CIRCULATIONAHA.106.630087","article-title":"Long-term stimulation of adenosine A2b receptors begun after myocardial infarction prevents cardiac remodeling in rats","volume":"114","author":"Wakeno","year":"2006","journal-title":"Circulation"},{"issue":"2 Pt 2","key":"10.1038\/ki.2014.244_bb0080","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/01.HYP.37.2.716","article-title":"A(2b) receptors mediate the antimitogenic effects of adenosine in cardiac fibroblasts","volume":"37","author":"Dubey","year":"2001","journal-title":"Hypertension"},{"key":"10.1038\/ki.2014.244_bb0085","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1152\/physrev.00031.2005","article-title":"Adenosine and kidney function","volume":"86","author":"Vallon","year":"2006","journal-title":"Physiol Rev"},{"key":"10.1038\/ki.2014.244_bb0090","doi-asserted-by":"crossref","first-page":"F62","DOI":"10.1152\/ajprenal.00473.2010","article-title":"P2X7 receptors mediate deleterious renal epithelial-fibroblast cross talk","volume":"300","author":"Ponnusamy","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.244_bb0095","doi-asserted-by":"crossref","first-page":"F60","DOI":"10.1152\/ajprenal.00593.2010","article-title":"ATP as a death factor: purinergic signaling in renal epithelial-fibroblast cross talk","volume":"300","author":"Zarjou","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.244_bb0100","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0031-6997(24)01511-4","article-title":"International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors","volume":"53","author":"Fredholm","year":"2001","journal-title":"Pharmacol Rev"},{"key":"10.1038\/ki.2014.244_bb0105","first-page":"215","article-title":"Adenosine receptors and inflammation","volume":"193","author":"Blackburn","year":"2009"},{"key":"10.1038\/ki.2014.244_bb0110","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11302-006-9003-5","article-title":"The E-NTPDase family of ectonucleotidases: structure function relationships and pathophysiological significance","volume":"2","author":"Robson","year":"2006","journal-title":"Purinergic Signal"},{"key":"10.1038\/ki.2014.244_bb0115","doi-asserted-by":"crossref","first-page":"F1032","DOI":"10.1152\/ajprenal.00108.2004","article-title":"Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling","volume":"288","author":"Kishore","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.244_bb0120","doi-asserted-by":"crossref","first-page":"F550","DOI":"10.1152\/ajprenal.00151.2005","article-title":"Immunolocalization of ectonucleotidases along the rat nephron","volume":"290","author":"Vekaria","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.244_bb0125","doi-asserted-by":"crossref","first-page":"F377","DOI":"10.1152\/ajprenal.1993.264.3.F377","article-title":"Distribution and regulation of renal ecto-5'-nucleotidase: implications for physiological functions of adenosine","volume":"264","author":"Le Hir","year":"1993","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.244_bb0130","doi-asserted-by":"crossref","first-page":"F844","DOI":"10.1152\/ajprenal.00195.2001","article-title":"Adenosine attenuates oxidant injury in human proximal tubular cells via A1 and A2a adenosine receptors","volume":"282","author":"Lee","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.244_bb0135","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1161\/CIRCRESAHA.111.300166","article-title":"Elevated CD73-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension","volume":"112","author":"Zhang","year":"2013","journal-title":"Circ Res"},{"key":"10.1038\/ki.2014.244_bb0140","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrneph.2010.120","article-title":"Renal fibrosis: novel insights into mechanisms and therapeutic targets","volume":"6","author":"Boor","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"10.1038\/ki.2014.244_bb0145","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat Med"},{"key":"10.1038\/ki.2014.244_bb0150","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s00424-006-0045-x","article-title":"Adenosine produced via the CD73\/ecto-5\u2032-nucleotidase pathway has no impact on erythropoietin production but is associated with reduced kidney weight","volume":"452","author":"\u00d6z\u00fcyaman","year":"2006","journal-title":"Pflugers Arch"},{"key":"10.1038\/ki.2014.244_bb0155","doi-asserted-by":"crossref","first-page":"e37100","DOI":"10.1371\/journal.pone.0037100","article-title":"Autoimmunity in CD73\/Ecto-59-nucleotidase deficient mice induces renal injury","volume":"7","author":"Blume","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1038\/ki.2014.244_bb0160","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/ki.2011.217","article-title":"Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis","volume":"80","author":"Anders","year":"2011","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.244_bb0165","doi-asserted-by":"crossref","first-page":"F3","DOI":"10.1152\/ajprenal.00122.2013","article-title":"Pathogenic and protective role of macrophages in kidney disease","volume":"305","author":"Cao","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.244_bb0170","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1681\/ASN.2009060615","article-title":"Distinct macrophage phenotypes contribute to kidney injury and repair","volume":"22","author":"Lee","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.244_bb0175","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.pharmthera.2005.04.013","article-title":"Adenosine 5\u2032-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation","volume":"112","author":"Bours","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1038\/ki.2014.244_bb0180","doi-asserted-by":"crossref","first-page":"e59778","DOI":"10.1371\/journal.pone.0059778","article-title":"Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor","volume":"8","author":"Sakaki","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1038\/ki.2014.244_bb0185","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/eji.200939741","article-title":"NTPDase1 governs P2X7-dependent functions in murine macrophages","volume":"40","author":"L\u00e9vesque","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1038\/ki.2014.244_bb0190","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1124\/jpet.105.096016","article-title":"Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor","volume":"317","author":"Kreckler","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/ki.2014.244_bb0195","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1161\/ATVBAHA.111.226852","article-title":"Regulation of macrophage function by adenosine","volume":"32","author":"Hask\u00f3","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1038\/ki.2014.244_bb0200","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.pharmthera.2006.08.003","article-title":"Shaping of monocyte and macrophage function by adenosine receptors","volume":"113","author":"Hasko","year":"2007","journal-title":"Pharmacol Ther"},{"key":"10.1038\/ki.2014.244_bb0205","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1096\/fj.11-190934","article-title":"Adenosine promotes alternative macrophage activation via A2A and A2B receptors","volume":"26","author":"Cs\u00f3ka","year":"2012","journal-title":"FASEB J"},{"key":"10.1038\/ki.2014.244_bb0210","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1182\/blood-2013-04-496216","article-title":"TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses","volume":"122","author":"Cohen","year":"2013","journal-title":"Blood"},{"key":"10.1038\/ki.2014.244_bb0215","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s10753-013-9621-3","article-title":"The adenosine-dependent angiogenic switch of macrophages to an M2-like phenotype is independent of interleukin-4 receptor alpha (IL-4R\u03b1) signaling","volume":"36","author":"Ferrante","year":"2013","journal-title":"Inflammation"},{"key":"10.1038\/ki.2014.244_bb0220","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ki.2008.183","article-title":"The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease","volume":"74","author":"Eardley","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.244_bb0225","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/ki.2011.101","article-title":"Adenosine A2A receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation","volume":"80","author":"Garcia","year":"2011","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.244_bb0230","doi-asserted-by":"crossref","first-page":"F828","DOI":"10.1152\/ajprenal.00310.2005","article-title":"Adenosine A2A receptor activation attenuates inflammation and injury in diabetic nephropathy","volume":"290","author":"Awad","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2014.244_bb0235","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/ki.2010.177","article-title":"Pivotal role of CD4\u00fe T cells in renal fibrosis following ureteric obstruction","volume":"78","author":"Tapmeier","year":"2010","journal-title":"Kidney Int."},{"key":"10.1038\/ki.2014.244_bb0240","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1084\/jem.20062512","article-title":"Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression","volume":"204","author":"Deaglio","year":"2007","journal-title":"J Exp Med"},{"key":"10.1038\/ki.2014.244_bb0245","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.acthis.2012.09.002","article-title":"The effects of adenosine A2A receptor knockout on renal interstitial fibrosis in a mouse model of unilateral ureteral obstruction","volume":"115","author":"Xiao","year":"2013","journal-title":"Acta Histochem"},{"key":"10.1038\/ki.2014.244_bb0250","doi-asserted-by":"crossref","first-page":"e60173","DOI":"10.1371\/journal.pone.0060173","article-title":"Adenosine A2A receptor: a target for regulating renal interstitial fibrosis in obstructive nephropathy","volume":"8","author":"Xiao","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1038\/ki.2014.244_bb0255","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1681\/ASN.2005080842","article-title":"CD4+CD25+ regulatory T cells protect against injury in an innate murine model of chronic kidney disease","volume":"17","author":"Mahajan","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.244_bb0260","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1002\/eji.201242434","article-title":"Regulatory T cells participate in CD39-mediated protection from renal injury","volume":"42","author":"Wang","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1038\/ki.2014.244_bb0265","first-page":"115","article-title":"Chapter 5 - Role of adenosine A2B receptors in inflammation","volume":"Vol 61","author":"Feoktistov","year":"2011"},{"key":"10.1038\/ki.2014.244_bb0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.110.003285","article-title":"International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors\u2014an update","volume":"63","author":"Fredholm","year":"2011","journal-title":"Pharmacol Rev"},{"key":"10.1038\/ki.2014.244_bb0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0272-6386(12)80312-X","article-title":"Tubulointerstitial changes as a major determinant in the progression of renal damage","volume":"20","author":"Nath","year":"1992","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2014.244_bb0280","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.2353\/ajpath.2008.080433","article-title":"Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney","volume":"173","author":"Lin","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.2014.244_bb0285","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nm.1985","article-title":"Biomechanical regulation of blood vessel growth during tissue vascularization","volume":"15","author":"Kilarski","year":"2009","journal-title":"Nat Med"},{"key":"10.1038\/ki.2014.244_bb0290","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1093\/ndt\/gfs296","article-title":"The renal (myo-)fibroblast: a heterogeneous group of cells","volume":"27","author":"Boor","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2014.244_bb0295","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1681\/ASN.2008050549","article-title":"The mesangial cell revisited: no cell is an island","volume":"20","author":"Schl\u00f6ndorff","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.244_bb0300","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.semnephrol.2007.10.010","article-title":"The glomerular response to IgA deposition in IgA nephropathy","volume":"28","author":"Moura","year":"2008","journal-title":"Semin Nephrol"},{"key":"10.1038\/ki.2014.244_bb0305","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1083\/jcb.44.3.645","article-title":"Wound healing and collagen formation: VI. The origin of the wound fibroblast studied in parabiosis","volume":"44","author":"Ross","year":"1970","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2014.244_bb0310","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/ki.1991.51","article-title":"Ontogeny of tubulointerstitial cells","volume":"39","author":"Ekblom","year":"1991","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.244_bb0315","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1172\/JCI0215518","article-title":"Evidence that fibroblasts derive from epithelium during tissue fibrosis","volume":"110","author":"Iwano","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2014.244_bb0320","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1172\/JCI44595","article-title":"Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?","volume":"121","author":"Kriz","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2014.244_bb0325","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00467-011-1772-6","article-title":"The origin of interstitial myofibroblasts in chronic kidney disease","volume":"27","author":"Grgic","year":"2012","journal-title":"Pediatr Nephrol"},{"key":"10.1038\/ki.2014.244_bb0330","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1681\/ASN.2011080851","article-title":"Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury","volume":"23","author":"Schrimpf","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.244_bb0335","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1681\/ASN.2010080890","article-title":"A2B adenosine receptor\u2013mediated induction of IL-6 promotes CKD","volume":"22","author":"Dai","year":"2011","journal-title":"JAm Soc Nephrol"},{"key":"10.1038\/ki.2014.244_bb0340","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1165\/rcmb.2004-0103OC","article-title":"Synergy between A2B adenosine receptors and hypoxia in activating human lung fibroblasts","volume":"32","author":"Zhong","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1038\/ki.2014.244_bb0345","doi-asserted-by":"crossref","first-page":"e52415","DOI":"10.1371\/journal.pone.0052415","article-title":"Effect of interleukin 6 deficiency on renal interstitial fibrosis","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1038\/ki.2014.244_bb0350","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/ki.2013.43","article-title":"The volatile anesthetic isoflurane induces ecto-5-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury","volume":"84","author":"Kim","year":"2013","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.244_bb0355","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/ki.2013.157","article-title":"Progressive endothelin-1 gene activation initiates chronic\/end-stage renal disease following experimental ischemic\/reperfusion injury","volume":"84","author":"Zager","year":"2013","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.244_bb0360","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1056\/NEJM199811123392007","article-title":"Pathophysiology of progressive nephropathies","volume":"339","author":"Remuzzi","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2014.244_bb0365","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.bbrc.2010.12.051","article-title":"Purinergic modulation of glucose uptake into cultured rat podocytes: effect of diabetic milieu","volume":"404","author":"Karczewska","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/ki.2014.244_bb0370","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1016\/j.febslet.2009.09.003","article-title":"Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats","volume":"583","author":"Roa","year":"2009","journal-title":"FEBS Lett"},{"key":"10.1038\/ki.2014.244_bb0375","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1681\/ASN.2012101014","article-title":"CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathy","volume":"25","author":"Tak","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.244_bb0380","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1124\/mol.63.1.81","article-title":"The effect of insulin on expression level of nucleoside transporters in diabetic rats","volume":"63","author":"Pawelczyk","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1038\/ki.2014.244_bb0385","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.2337\/db05-1683","article-title":"Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db\/db mice and its restoration by pioglitazone","volume":"55","author":"Makino","year":"2006","journal-title":"Diabetes"},{"key":"10.1038\/ki.2014.244_bb0390","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1096\/fj.06-6419com","article-title":"HIF-dependent induction of adenosine A2B receptor in hypoxia","volume":"20","author":"Kong","year":"2006","journal-title":"FASEB J"},{"key":"10.1038\/ki.2014.244_bb0395","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bbrc.2007.11.113","article-title":"Adenosine A2B receptor mediates an increase on VEGF-A production in rat kidney glomeruli","volume":"366","author":"Valladares","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/ki.2014.244_bb0400","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/ki.2010.516","article-title":"Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases","volume":"79","author":"Barnes","year":"2011","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.244_bb0405","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/labinvest.2012.143","article-title":"Adenosine A2B receptor-mediated VEGF induction promotes diabetic glomerulopathy","volume":"93","author":"Cardenas","year":"2013","journal-title":"Lab Invest"},{"key":"10.1038\/ki.2014.244_bb0410","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1124\/jpet.113.210849","article-title":"BAY60-6583 acts as a partial agonist at adenosine A2B receptors","volume":"349","author":"Hinz","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/ki.2014.244_bb0415","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.clinbiochem.2008.10.009","article-title":"Correlations of six related purine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients","volume":"42","author":"Xia","year":"2009","journal-title":"Clin Biochem"},{"key":"10.1038\/ki.2014.244_bb0420","doi-asserted-by":"crossref","first-page":"999","DOI":"10.2337\/db08-1214","article-title":"Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease","volume":"58","author":"Friedman","year":"2009","journal-title":"Diabetes"},{"key":"10.1038\/ki.2014.244_bb0425","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.2337\/db06-1593","article-title":"The vascular ectonucleotidase ENTPD1 is a novel renoprotective factor in diabetic nephropathy","volume":"56","author":"Friedman","year":"2007","journal-title":"Diabetes"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381530394X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381530394X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T22:30:15Z","timestamp":1746311415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S008525381530394X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":84,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S008525381530394X"],"URL":"https:\/\/doi.org\/10.1038\/ki.2014.244","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}