{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:49:42Z","timestamp":1791154182212,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"vor","delay-in-days":1461,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1038\/ki.2014.84","type":"journal-article","created":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T14:00:12Z","timestamp":1395842412000},"page":"538-547","source":"Crossref","is-referenced-by-count":28,"title":["Deletion of ErbB4 accelerates polycystic kidney disease progression in cpk mice"],"prefix":"10.1016","volume":"86","author":[{"given":"Fenghua","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Miyazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance A.","family":"Kloepfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond C.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2014.84_bb0010","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.pathol.2.010506.091850","article-title":"Cystic disease of the kidney","volume":"2","author":"Wilson","year":"2007","journal-title":"Annu Rev Pathol"},{"key":"10.1038\/ki.2014.84_bb0015","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/ki.1995.62","article-title":"Epidermal growth factor receptor expression is abnormal in murine polycystic kidney","volume":"47","author":"Orellana","year":"1995","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.84_bb0020","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1111\/j.1523-1755.2004.00952.x","article-title":"Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats","volume":"66","author":"Torres","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.84_bb0025","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1093\/emboj\/19.13.3159","article-title":"The ErbB signaling network: receptor heterodimerization in development and cancer","volume":"19","author":"Olayioye","year":"2000","journal-title":"EMBO J"},{"key":"10.1038\/ki.2014.84_bb0030","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1096\/fj.08-121947","article-title":"Nedd4 mediates ErbB4 JM-a\/CYT-1 ICD ubiquitination and degradation in MDCK II cells","volume":"23","author":"Zeng","year":"2009","journal-title":"FASEB J"},{"key":"10.1038\/ki.2014.84_bb0035","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1126\/science.1065412","article-title":"gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase","volume":"294","author":"Ni","year":"2001","journal-title":"Science"},{"key":"10.1038\/ki.2014.84_bb0040","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1083\/jcb.139.4.995","article-title":"Constitutive proteolysis of the ErbB-4 receptor tyrosine kinase by a unique, sequential mechanism","volume":"139","author":"Vecchi","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2014.84_bb0045","doi-asserted-by":"crossref","first-page":"33334","DOI":"10.1074\/jbc.M305597200","article-title":"WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus","volume":"278","author":"Komuro","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2014.84_bb0050","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0014-4827(02)00100-3","article-title":"ErbB-4: mechanism of action and biology","volume":"284","author":"Carpenter","year":"2003","journal-title":"Exp Cell Res"},{"key":"10.1038\/ki.2014.84_bb0055","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1158\/0008-5472.CAN-04-3150","article-title":"Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells","volume":"65","author":"Junttila","year":"2005","journal-title":"Cancer Res"},{"key":"10.1038\/ki.2014.84_bb0060","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1242\/dev.124.24.4999","article-title":"ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice","volume":"124","author":"Erickson","year":"1997","journal-title":"Development"},{"key":"10.1038\/ki.2014.84_bb0065","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/376337a0","article-title":"Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor","volume":"376","author":"Miettinen","year":"1995","journal-title":"Nature"},{"key":"10.1038\/ki.2014.84_bb0070","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/378390a0","article-title":"Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor","volume":"378","author":"Gassmann","year":"1995","journal-title":"Nature"},{"key":"10.1038\/ki.2014.84_bb0075","doi-asserted-by":"crossref","first-page":"8281","DOI":"10.1073\/pnas.1436402100","article-title":"Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality","volume":"100","author":"Tidcombe","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2014.84_bb0080","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1681\/ASN.2011020160","article-title":"ErbB4 modulates tubular cell polarity and lumen diameter during kidney development","volume":"23","author":"Veikkolainen","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.84_bb0085","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1203\/01.PDR.0000159513.51898.60","article-title":"Transforming growth factor alpha (TGF-alpha) and other targets of tumor necrosis factor-alpha converting enzyme (TACE) in murine polycystic kidney disease","volume":"57","author":"Nemo","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1038\/ki.2014.84_bb0090","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1091\/mbc.e07-03-0223","article-title":"ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis","volume":"18","author":"Zeng","year":"2007","journal-title":"Mol Biol Cell"},{"key":"10.1038\/ki.2014.84_bb0095","doi-asserted-by":"crossref","first-page":"34737","DOI":"10.1074\/jbc.M003756200","article-title":"Heregulin-dependent trafficking and cleavage of ErbB-4","volume":"275","author":"Zhou","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2014.84_bb0100","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.1128\/MCB.16.12.6917","article-title":"Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint","volume":"16","author":"Lukas","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1038\/ki.2014.84_bb0105","doi-asserted-by":"crossref","first-page":"31308","DOI":"10.1074\/jbc.273.47.31308","article-title":"Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways","volume":"273","author":"Lange","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2014.84_bb0110","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1083\/jcb.200403155","article-title":"The ERBB4\/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone","volume":"167","author":"Williams","year":"2004","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2014.84_bb0115","doi-asserted-by":"crossref","first-page":"L516","DOI":"10.1152\/ajplung.00423.2007","article-title":"ErbB4 deletion leads to changes in lung function and structure similar to bronchopulmonary dysplasia","volume":"294","author":"Purevdorj","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1038\/ki.2014.84_bb0120","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1126\/science.7618084","article-title":"Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype","volume":"269","author":"Threadgill","year":"1995","journal-title":"Science"},{"key":"10.1038\/ki.2014.84_bb0125","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1046\/j.1523-1755.2003.00058.x","article-title":"Model of robust induction of glomerulosclerosis in mice: importance of genetic background","volume":"64","author":"Ma","year":"2003","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.84_bb0130","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000045411","article-title":"Abnormal tenascin expression in murine autosomal recessive polycystic kidneys","volume":"82","author":"Ojeda","year":"1999","journal-title":"Nephron"},{"key":"10.1038\/ki.2014.84_bb0135","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.bbadis.2011.01.006","article-title":"Apoptosis in polycystic kidney disease","volume":"1812","author":"Goilav","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/ki.2014.84_bb0140","doi-asserted-by":"crossref","first-page":"6905","DOI":"10.1038\/sj.onc.1210501","article-title":"Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains","volume":"26","author":"Sundvall","year":"2007","journal-title":"Oncogene"},{"key":"10.1038\/ki.2014.84_bb0145","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.1128\/MCB.01705-08","article-title":"ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo","volume":"29","author":"Muraoka-Cook","year":"2009","journal-title":"Mol Cell Biol"},{"key":"10.1038\/ki.2014.84_bb0150","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/ki.2012.239","article-title":"Specific deletion of glycogen synthase kinase-3beta in the renal proximal tubule protects against acute nephrotoxic injury in mice","volume":"82","author":"Howard","year":"2012","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2014.84_bb0155","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2215\/CJN.04140510","article-title":"Inflammation, oxidative stress, and insulin resistance in polycystic kidney disease","volume":"6","author":"Menon","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2014.84_bb0160","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/nm1675","article-title":"A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1","volume":"13","author":"Piontek","year":"2007","journal-title":"Nat Med"},{"key":"10.1038\/ki.2014.84_bb0165","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1006\/dbio.1995.1164","article-title":"Epidermal growth factor ameliorates autosomal recessive polycystic kidney disease in mice","volume":"169","author":"Gattone","year":"1995","journal-title":"Dev Biol"},{"key":"10.1038\/ki.2014.84_bb0170","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0272-6386(12)80330-1","article-title":"Murine infantile polycystic kidney disease: a role for reduced renal epidermal growth factor","volume":"17","author":"Gattone","year":"1991","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2014.84_bb0175","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0002-9440(10)64239-3","article-title":"A new method for large scale isolation of kidney glomeruli from mice","volume":"161","author":"Takemoto","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.2014.84_bb0180","doi-asserted-by":"crossref","first-page":"21819","DOI":"10.1073\/pnas.0911987106","article-title":"Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models","volume":"106","author":"Cao","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2014.84_bb0185","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381530329X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381530329X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T01:19:47Z","timestamp":1648689587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S008525381530329X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S008525381530329X"],"URL":"https:\/\/doi.org\/10.1038\/ki.2014.84","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]}}}