{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:01:49Z","timestamp":1791414109090,"version":"4.3.3"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1038\/ki.2015.165","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T19:05:32Z","timestamp":1433963132000},"page":"833-842","source":"Crossref","is-referenced-by-count":70,"title":["Magnesium modifies the association between serum phosphate and the risk of progression to end-stage kidney disease in patients with non-diabetic chronic kidney disease"],"prefix":"10.1016","volume":"88","author":[{"given":"Yusuke","family":"Sakaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotsugu","family":"Iwatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Hamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kodo","family":"Tomida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Kusunoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Shimomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terumasa","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Tsubakihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Isaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Rakugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2015.165_bb0010","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1001\/jama.2011.308","article-title":"Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis","volume":"305","author":"Palmer","year":"2011","journal-title":"JAMA"},{"key":"10.1038\/ki.2015.165_bb0015","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2215\/CJN.02101205","article-title":"Association of disorders in mineral metabolism with progression of chronic kidney disease","volume":"1","author":"Schwarz","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2015.165_bb0020","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1681\/ASN.2005101101","article-title":"Baseline predictors of renal disease progression in the African American Study of Hypertension and Kidney Disease","volume":"17","author":"Norris","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2015.165_bb0025","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1093\/ndt\/gfm286","article-title":"High plasma phosphate as a risk factor for decline in renal function and mortality in pre-dialysis patients","volume":"22","author":"Voormolen","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2015.165_bb0030","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/ndt\/gfq787","article-title":"Serum phosphate but not pulse wave velocity predicts decline in renal function in patients with early chronic kidney disease","volume":"26","author":"Chue","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2015.165_bb0035","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1093\/ndt\/gfq808","article-title":"Serum phosphorus predicts incident chronic kidney disease and end-stage renal disease","volume":"26","author":"O'Seaghdha","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2015.165_bb0040","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1681\/ASN.2011020175","article-title":"Phosphate may promote CKD progression and attenuate renoprotective effect of ACE inhibition","volume":"22","author":"Zoccali","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2015.165_bb0045","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2215\/CJN.07810910","article-title":"Chronic kidney disease progression and outcome according to serum phosphorus in mild-to-moderate kidney dysfunction","volume":"6","author":"Bellasi","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2015.165_bb0050","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.amjmed.2012.08.018","article-title":"Phosphorus and risk of renal failure in subjects with normal renal function","volume":"126","author":"Sim","year":"2013","journal-title":"Am J Med"},{"key":"10.1038\/ki.2015.165_bb0055","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2369-14-14","article-title":"Mineral metabolism and outcomes in chronic kidney disease stage 2\u20134 patients","volume":"14","author":"Chartsrisak","year":"2013","journal-title":"BMC Nephrol"},{"key":"10.1038\/ki.2015.165_bb0060","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/ki.2013.145","article-title":"No independent association of serum phosphorus with risk for death or progression to end-stage renal disease in a large screen for chronic kidney disease","volume":"84","author":"Mehrotra","year":"2013","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2015.165_bb0065","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1056\/NEJM197801192980302","article-title":"Preservation of function in experimental renal disease by dietary restriction of phosphate","volume":"298","author":"Ibels","year":"1978","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2015.165_bb0070","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1111\/j.1523-1755.2004.66013.x","article-title":"Adverse effects of hyperphosphatemia on myocardial hypertrophy, renal function, and bone in rats with renal failure","volume":"66","author":"Neves","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2015.165_bb0075","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1097\/01.ASN.0000025782.24383.0D","article-title":"The effects of sevelamer hydrochloride and calcium carbonate on kidney calcification in uremic rats","volume":"13","author":"Cozzolino","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2015.165_bb0080","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1093\/ndt\/gfg309","article-title":"Sevelamer hydrochloride, a phosphate binder, protects against deterioration of renal function in rats with progressive chronic renal insufficiency","volume":"18","author":"Nagano","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2015.165_bb0085","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1096\/fj.09-152488","article-title":"Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging","volume":"24","author":"Ohnishi","year":"2010","journal-title":"FASEB J"},{"key":"10.1038\/ki.2015.165_bb0090","doi-asserted-by":"crossref","first-page":"e57720","DOI":"10.1371\/journal.pone.0057720","article-title":"Magnesium and the risk of cardiovascular events: a meta-analysis of prospective cohort studies","volume":"8","author":"Qu","year":"2013","journal-title":"PLoS One"},{"key":"10.1038\/ki.2015.165_bb0095","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3945\/ajcn.111.022376","article-title":"Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies","volume":"95","author":"Larsson","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"10.1038\/ki.2015.165_bb0100","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3945\/ajcn.112.053132","article-title":"Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies","volume":"98","author":"Del Gobbo","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"10.1038\/ki.2015.165_bb0105","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000341868","article-title":"Relationship between serum magnesium levels and cardiovascular events in chronic kidney disease patients","volume":"36","author":"Kanbay","year":"2012","journal-title":"Am J Nephrol"},{"key":"10.1038\/ki.2015.165_bb0110","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/ki.2013.327","article-title":"Hypomagnesemia is a significant predictor of cardiovascular and non-cardiovascular mortality in patients undergoing hemodialysis","volume":"85","author":"Sakaguchi","year":"2014","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2015.165_bb0115","doi-asserted-by":"crossref","first-page":"222","DOI":"10.5414\/CNP68222","article-title":"Significant association between the presence of peripheral vascular calcification and lower serum magnesium in hemodialysis patients","volume":"68","author":"Ishimura","year":"2007","journal-title":"Clin Nephrol"},{"key":"10.1038\/ki.2015.165_bb0120","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jcmg.2013.10.006","article-title":"Magnesium intake is inversely associated with coronary artery calcification: the Framingham Heart Study","volume":"7","author":"Hruby","year":"2014","journal-title":"JACC Cardiovasc Imag"},{"key":"10.1038\/ki.2015.165_bb0125","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/ndt\/gfr321","article-title":"Magnesium reduces calcification in bovine vascular smooth muscle cells in a dose-dependent manner","volume":"27","author":"Kircelli","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2015.165_bb0130","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1681\/ASN.2010080793","article-title":"Mechanisms of tubulointerstitial fibrosis","volume":"21","author":"Zeisberg","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2015.165_bb0135","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fphys.2013.00095","article-title":"The mitochondrial permeability transition pore: a mystery solved?","volume":"4","author":"Bernardi","year":"2013","journal-title":"Front Physiol"},{"key":"10.1038\/ki.2015.165_bb0140","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1161\/CIRCRESAHA.112.265942","article-title":"Physiological roles of the permeability transition pore","volume":"111","author":"Brenner","year":"2012","journal-title":"Circ Res"},{"key":"10.1038\/ki.2015.165_bb0145","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-5793(98)00318-4","article-title":"Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition","volume":"426","author":"Petit","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1038\/ki.2015.165_bb0150","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/ki.1987.14","article-title":"Relation between renal calcium content and renal impairment in 246 human renal biopsies","volume":"31","author":"Gimenez","year":"1987","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2015.165_bb0155","first-page":"255","article-title":"Onset of nephrocalcinosis depends on dietary phosphorus concentration in male rats fed a magnesium-deficient diet","volume":"19","author":"Matsuzaki","year":"2006","journal-title":"Magnes Res"},{"key":"10.1038\/ki.2015.165_bb0160","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.2215\/CJN.03730410","article-title":"Prevalence and prognostic significance of renal artery calcification in patients with diabetes and proteinuria","volume":"5","author":"Chiu","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2015.165_bb0165","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1046\/j.1523-1755.2003.00226.x","article-title":"Calcium phosphate-induced renal epithelial injury and stone formation: involvement of reactive oxygen species","volume":"64","author":"Aihara","year":"2003","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2015.165_bb0170","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1016\/S0142-9612(03)00089-9","article-title":"Importance of hydroxyapatite particles characteristics on cytokines production by human monocytes in vitro","volume":"24","author":"Laquerriere","year":"2003","journal-title":"Biomaterials"},{"key":"10.1038\/ki.2015.165_bb0175","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3945\/ajcn.114.085167","article-title":"Serum magnesium, phosphorus, and calcium are associated with risk of incident heart failure: the Atherosclerosis Risk in Communities (ARIC) Study","volume":"100","author":"Lutsey","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"10.1038\/ki.2015.165_bb0180","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.2337\/dc12-0226","article-title":"Hypomagnesemia in type 2 diabetic nephropathy: a novel predictor of end-stage renal disease","volume":"35","author":"Sakaguchi","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1038\/ki.2015.165_bb0185","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1023\/A:1006836001489","article-title":"Effect of cations on the tyrosine kinase activity of the insulin receptor: inhibition by fluoride is magnesium dependent","volume":"171","author":"Vi\u00f1als","year":"1997","journal-title":"Mol Cell Biochem"},{"key":"10.1038\/ki.2015.165_bb0190","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2337\/diacare.26.4.1147","article-title":"Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial","volume":"26","author":"Rodr\u00edguez-Mor\u00e1n","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1038\/ki.2015.165_bb0195","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2337\/diab.41.1.35","article-title":"Effect of Mg2+ on Na(+)-dependent inositol transport. Role for Mg2+ in etiology of diabetic complications","volume":"41","author":"Grafton","year":"1992","journal-title":"Diabetes"},{"key":"10.1038\/ki.2015.165_bb0200","doi-asserted-by":"crossref","first-page":"366","DOI":"10.2215\/CJN.02960906","article-title":"Hypomagnesemia in patients with type 2 diabetes","volume":"2","author":"Pham","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2015.165_bb0205","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1053\/j.ajkd.2008.12.034","article-title":"Collaborators developing the Japanese equation for estimated GFR Revised equations for estimated GFR from serum creatinine in Japan","volume":"53","author":"Matsuo","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2015.165_bb0210","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1681\/ASN.2013090986","article-title":"Autophagic clearance of mitochondria in the kidney copes with metabolic acidosis","volume":"25","author":"Namba","year":"2014","journal-title":"J Am Soc Nephrol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2157171615322516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2157171615322516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T15:19:22Z","timestamp":1636125562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2157171615322516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S2157171615322516"],"URL":"https:\/\/doi.org\/10.1038\/ki.2015.165","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725547412.793508088","asserted-by":"object"}]},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}