{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:50:43Z","timestamp":1792205443938,"version":"4.4.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1038\/ki.2015.192","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T15:42:05Z","timestamp":1436370125000},"page":"1126-1134","source":"Crossref","is-referenced-by-count":92,"title":["Urinary uromodulin, kidney function, and cardiovascular disease in elderly adults"],"prefix":"10.1016","volume":"88","author":[{"given":"Pranav S.","family":"Garimella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L.","family":"Biggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim H.","family":"Ix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Devarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan R.","family":"Kestenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Siscovick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majken K.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Shlipak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo H.M.","family":"Chaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Sarnak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2015.192_bb0005","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1053\/j.ajkd.2009.09.035","article-title":"Prevalence of CKD and comorbid illness in elderly patients in the United States: results from the Kidney Early Evaluation Program (KEEP)","volume":"55","author":"Stevens","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2015.192_bb0010","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/j.1532-5415.2012.04046.x","article-title":"Kidney function and mortality in octogenarians: Cardiovascular Health Study All Stars","volume":"60","author":"Shastri","year":"2012","journal-title":"J Am Geriatr Soc"},{"key":"10.1038\/ki.2015.192_bb0015","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/sj.ki.5000047","article-title":"Arterial stiffness and enlargement in mild-to-moderate chronic kidney disease","volume":"69","author":"Briet","year":"2006","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2015.192_bb0020","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1681\/ASN.2005030226","article-title":"Anemia as a risk factor for cardiovascular disease and all-cause mortality in diabetes: the impact of chronic kidney disease","volume":"16","author":"Vlagopoulos","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2015.192_bb0025","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1159\/000320681","article-title":"Uromodulin and chronic kidney disease","volume":"33","author":"Lhotta","year":"2010","journal-title":"Kidney Blood Press Res"},{"key":"10.1038\/ki.2015.192_bb0030","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1097\/01.ASN.0000092147.83480.B5","article-title":"A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin","volume":"14","author":"Dahan","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2015.192_bb0035","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1136\/jmg.39.12.882","article-title":"Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy","volume":"39","author":"Hart","year":"2002","journal-title":"J Med Genet"},{"key":"10.1038\/ki.2015.192_bb0040","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1681\/ASN.2009070725","article-title":"Uromodulin levels associate with a common UMOD variant and risk for incident CKD","volume":"21","author":"Kottgen","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2015.192_bb0045","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ng.377","article-title":"Multiple loci associated with indices of renal function and chronic kidney disease","volume":"41","author":"Kottgen","year":"2009","journal-title":"Nat Genet"},{"key":"10.1038\/ki.2015.192_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/8e7ba8d6-a174-4a3a-93b4-510d5ca7ed1e","article-title":"Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases","volume":"6","author":"Gudbjartsson","year":"2010","journal-title":"PLoS Genet"},{"key":"10.1038\/ki.2015.192_bb0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00240-003-0374-6","article-title":"Tamm-Horsfall protein in patients with kidney damage and diabetes","volume":"32","author":"Chakraborty","year":"2004","journal-title":"Urol Res"},{"key":"10.1038\/ki.2015.192_bb0060","first-page":"253","article-title":"Excretion of Tamm\u2013Horsfall glycoprotein in renal disease","volume":"22","author":"Lynn","year":"1984","journal-title":"Clin Nephrol"},{"key":"10.1038\/ki.2015.192_bb0065","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ng.568","article-title":"New loci associated with kidney function and chronic kidney disease","volume":"42","author":"Kottgen","year":"2010","journal-title":"Nat Genet"},{"key":"10.1038\/ki.2015.192_bb0070","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2369-12-2","article-title":"Uromodulin concentrations are not associated with incident CKD among persons with coronary artery disease","volume":"12","author":"Shlipak","year":"2011","journal-title":"BMC Nephrol"},{"key":"10.1038\/ki.2015.192_bb0075","first-page":"1","article-title":"2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease","volume":"3","author":"KDIGO","year":"2013","journal-title":"Kidney Int Suppl"},{"key":"10.1038\/ki.2015.192_bb0080","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1159\/000321013","article-title":"Uromodulin biology and pathophysiology\u2013an update","volume":"33","author":"Vyletal","year":"2010","journal-title":"Kidney Blood Press Res"},{"key":"10.1038\/ki.2015.192_bb0085","doi-asserted-by":"crossref","first-page":"9924","DOI":"10.1074\/jbc.M008610200","article-title":"Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors","volume":"276","author":"Pak","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2015.192_bb0090","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1093\/ndt\/15.10.1580","article-title":"Determinants of urinary excretion of Tamm-Horsfall protein in non-selected kidney stone formers and healthy subjects","volume":"15","author":"Glauser","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2015.192_bb0095","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00508-005-0353-8","article-title":"The multiple functions of Tamm\u2013Horsfall protein in human health and disease: a mystery clears up","volume":"117","author":"Weichhart","year":"2005","journal-title":"Wien Klin Wochenschr"},{"key":"10.1038\/ki.2015.192_bb0100","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1053\/j.ajkd.2004.08.021","article-title":"Uromodulin storage diseases: clinical aspects and mechanisms","volume":"44","author":"Scolari","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2015.192_bb0105","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/j.1523-1755.2004.00845.x","article-title":"Mutations in the uromodulin gene decrease urinary excretion of Tamm-Horsfall protein","volume":"66","author":"Bleyer","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2015.192_bb0110","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000183300","article-title":"Variations of urinary Tamm\u2013Horsfall protein in humans during the first thirty years of life","volume":"38","author":"Ollier-Hartmann","year":"1984","journal-title":"Nephron"},{"key":"10.1038\/ki.2015.192_bb0115","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/sj.jhh.1000680","article-title":"Urinary excretion of Tamm-Horsfall protein in normotensive and hypertensive elderly patients","volume":"12","author":"Dulawa","year":"1998","journal-title":"J Hum Hypertens"},{"key":"10.1038\/ki.2015.192_bb0120","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000187479","article-title":"Tubular secretion of Tamm-Horsfall protein is decreased in type 1 (insulin-dependent) diabetic patients with diabetic nephropathy","volume":"65","author":"Torffvit","year":"1993","journal-title":"Nephron"},{"key":"10.1038\/ki.2015.192_bb0125","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1471-2350-13-78","article-title":"UMOD as a susceptibility gene for end-stage renal disease","volume":"13","author":"Reznichenko","year":"2012","journal-title":"BMC Med Genet"},{"key":"10.1038\/ki.2015.192_bb0130","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1159\/000332231","article-title":"Uromodulin in renal transplant recipients: elevated urinary levels and bimodal association with graft failure","volume":"34","author":"Reznichenko","year":"2011","journal-title":"Am J Nephrol"},{"key":"10.1038\/ki.2015.192_bb0135","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2337\/dc11-1491","article-title":"Novel urinary protein biomarkers predicting the development of microalbuminuria and renal function decline in type 1 diabetes","volume":"35","author":"Schlatzer","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1038\/ki.2015.192_bb0140","doi-asserted-by":"crossref","first-page":"e71023","DOI":"10.1371\/journal.pone.0071023","article-title":"Urinary uromodulin excretion predicts progression of chronic kidney disease resulting from IgA nephropathy","volume":"8","author":"Zhou","year":"2013","journal-title":"PLoS One"},{"key":"10.1038\/ki.2015.192_bb0145","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1093\/ndt\/gfp748","article-title":"Evidence for a role of uromodulin in chronic kidney disease progression","volume":"25","author":"Prajczer","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2015.192_bb0150","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/ki.1980.34","article-title":"Tubulointerstitial immune complex nephritis in rats immunized with Tamm-Horsfall protein","volume":"17","author":"Hoyer","year":"1980","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2015.192_bb0155","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1046\/j.1523-1755.1999.00439.x","article-title":"Binding of human neutrophils to cell-surface anchored Tamm-Horsfall glycoprotein in tubulointerstitial nephritis","volume":"55","author":"Cavallone","year":"1999","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2015.192_bb0160","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1126\/science.2409603","article-title":"Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women","volume":"229","author":"Muchmore","year":"1985","journal-title":"Science"},{"key":"10.1038\/ki.2015.192_bb0165","doi-asserted-by":"crossref","first-page":"F534","DOI":"10.1152\/ajprenal.00083.2008","article-title":"Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression","volume":"295","author":"El-Achkar","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2015.192_bb0170","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1053\/j.ajkd.2011.10.054","article-title":"Uromodulin in kidney injury: an instigator, bystander, or protector?","volume":"59","author":"El-Achkar","year":"2012","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2015.192_bb0175","first-page":"1755","article-title":"The serum uromodulin level is associated with kidney function","volume":"52","author":"Risch","year":"2014","journal-title":"Clin Chem Lab Med"},{"key":"10.1038\/ki.2015.192_bb0180","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1053\/j.ajkd.2014.07.030","article-title":"GFR decline as an end point for clinical trials in CKD: a scientific workshop sponsored by the National Kidney Foundation and the US Food and Drug Administration","volume":"64","author":"Levey","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2015.192_bb0185","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/ndt\/gft345","article-title":"Determination of uromodulin in human urine: influence of storage and processing","volume":"29","author":"Youhanna","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2015.192_bb0190","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/1047-2797(91)90005-W","article-title":"The Cardiovascular Health Study: design and rationale","volume":"1","author":"Fried","year":"1991","journal-title":"Ann Epidemiol"},{"key":"10.1038\/ki.2015.192_bb0195","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1001\/jama.2014.6634","article-title":"Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality","volume":"311","author":"Coresh","year":"2014","journal-title":"JAMA"},{"key":"10.1038\/ki.2015.192_bb0200","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1053\/j.ajkd.2007.11.018","article-title":"Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD","volume":"51","author":"Stevens","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2015.192_bb0205","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1056\/NEJMoa043161","article-title":"Cystatin C and the risk of death and cardiovascular events among elderly persons","volume":"352","author":"Shlipak","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2015.192_bb0210","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11606-010-1511-x","article-title":"Chronic kidney disease and the risk of end-stage renal disease versus death","volume":"26","author":"Dalrymple","year":"2011","journal-title":"J Gen Intern Med"},{"key":"10.1038\/ki.2015.192_bb0215","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/S0735-1097(00)00582-9","article-title":"Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study","volume":"35","author":"Gottdiener","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1038\/ki.2015.192_bb0220","doi-asserted-by":"crossref","first-page":"497","DOI":"10.7326\/0003-4819-142-7-200504050-00008","article-title":"Cystatin C concentration as a risk factor for heart failure in older adults","volume":"142","author":"Sarnak","year":"2005","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.2015.192_bb0225","first-page":"278","article-title":"Surveillance and ascertainment of cardiovascular events","volume":"5","author":"Ives","year":"1995","journal-title":"The Cardiovascular Health Study. Ann Epidemiol"},{"key":"10.1038\/ki.2015.192_bb0230","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/1047-2797(93)90105-D","article-title":"Assessment of cerebrovascular disease in the Cardiovascular Health Study","volume":"3","author":"Price","year":"1993","journal-title":"Ann Epidemiol"},{"key":"10.1038\/ki.2015.192_bb0235","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/1047-2797(94)00092-8","article-title":"Methods of assessing prevalent cardiovascular disease in the Cardiovascular Health Study","volume":"5","author":"Psaty","year":"1995","journal-title":"Ann Epidemiol"},{"key":"10.1038\/ki.2015.192_bb0240","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0895-4356(99)00102-X","article-title":"Analysis of case-cohort designs","volume":"52","author":"Barlow","year":"1999","journal-title":"J Clin Epidemiol"},{"key":"10.1038\/ki.2015.192_bb0245","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1023\/A:1009691327335","article-title":"Computing the Cox model for case cohort designs","volume":"5","author":"Therneau","year":"1999","journal-title":"Lifetime Data Anal"},{"key":"10.1038\/ki.2015.192_bb0250","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/003655999750015970","article-title":"A study of Tamm-Horsfall protein excretion in hypertensive patients and type 1 diabetic patients","volume":"33","author":"Torffvit","year":"1999","journal-title":"Scand J Urol Nephrol"},{"key":"10.1038\/ki.2015.192_bb0255","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0891-6632(91)90037-P","article-title":"Tamm-Horsfall-Protein excretion as a marker of ascending limb transport indicates early renal tubular damage in diabetes mellitus type I","volume":"5","author":"Zimmerhackl","year":"1991","journal-title":"J Diabet Complications"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815609905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815609905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T01:00:49Z","timestamp":1572656449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815609905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0085253815609905"],"URL":"https:\/\/doi.org\/10.1038\/ki.2015.192","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}