{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:26:43Z","timestamp":1790843203860,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5154,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1038\/labinvest.2008.101","type":"journal-article","created":{"date-parts":[[2008,10,27]],"date-time":"2008-10-27T10:12:42Z","timestamp":1225102362000},"page":"1278-1290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":195,"title":["Deep dermal fibroblasts contribute to hypertrophic scarring"],"prefix":"10.1016","volume":"88","author":[{"given":"JianFei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Dodd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A","family":"Shankowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward E","family":"Tredget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2008.101_bib1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0749-0712(21)00203-1","article-title":"Molecular and cellular aspects of fibrosis following thermal injury","volume":"16","author":"Scott","year":"2000","journal-title":"Hand Clin"},{"key":"10.1038\/labinvest.2008.101_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1749-6632.1999.tb07955.x","article-title":"Pathophysiology and treatment of fibroproliferative disorders following thermal injury","volume":"888","author":"Tredget","year":"1999","journal-title":"Ann NY Acad Sci"},{"key":"10.1038\/labinvest.2008.101_bib3","series-title":"Molecular and Cellular Hypertrophic Scarring","first-page":"596","author":"Scott","year":"2007"},{"key":"10.1038\/labinvest.2008.101_bib4","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1242\/jcs.01005","article-title":"Fibroblast heterogeneity: more than skin deep","volume":"117","author":"Sorrell","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1038\/labinvest.2008.101_bib5","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/jcp.10474","article-title":"Site-matched papillary and reticular human dermal fibroblasts differ in their release of specific growth factors\/cytokines and in their interaction with keratinocytes","volume":"200","author":"Sorrell","year":"2004","journal-title":"J Cell Physiol"},{"key":"10.1038\/labinvest.2008.101_bib6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0891-8422(23)00321-X","article-title":"Functional anatomy of the skin","volume":"6","author":"Bressler","year":"1989","journal-title":"Clin Podiatr Med Surg"},{"key":"10.1038\/labinvest.2008.101_bib7","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1749-6632.1991.tb24390.x","article-title":"Inductive properties of hair follicle cells","volume":"642","author":"Reynolds","year":"1991","journal-title":"Ann NY Acad Sci"},{"key":"10.1038\/labinvest.2008.101_bib8","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1126\/science.432659","article-title":"Human skin fibroblasts derived from papillary and reticular dermis: differences in growth potential in vitro","volume":"204","author":"Harper","year":"1979","journal-title":"Science"},{"key":"10.1038\/labinvest.2008.101_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1242\/jcs.57.1.177","article-title":"Heterogeneity of the kinetics of proliferation within human skin fibroblastic cell populations","volume":"57","author":"Azzarone","year":"1982","journal-title":"J Cell Sci"},{"key":"10.1038\/labinvest.2008.101_bib10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0047-6374(85)90095-8","article-title":"Comparative observation of fibroblasts derived from the papillary and reticular dermis of infants and adults: growth kinetics, packing density at confluence and surface morphology","volume":"31","author":"Schafer","year":"1985","journal-title":"Mech Ageing Dev"},{"key":"10.1038\/labinvest.2008.101_bib11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0733-8635(05)70385-5","article-title":"Dermal-epidermal interactions. Adult follicle-derived cell populations and hair growth","volume":"14","author":"Jahoda","year":"1996","journal-title":"Dermatol Clin"},{"key":"10.1038\/labinvest.2008.101_bib12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1067-1927.2004.012110.x","article-title":"Dermal fibroblasts from different layers of human skin are heterogeneous in expression of collagenase and types I and III procollagen mRNA","volume":"12","author":"Ali-Bahar","year":"2004","journal-title":"Wound Repair Regen"},{"key":"10.1038\/labinvest.2008.101_bib13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00441-006-0317-y","article-title":"Clonal characterization of fibroblasts in the superficial layer of the adult human dermis","volume":"327","author":"Sorrell","year":"2007","journal-title":"Cell Tissue Res"},{"key":"10.1038\/labinvest.2008.101_bib14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0190-9622(00)90016-1","article-title":"Comparison of carbon dioxide laser, erbium:YAG laser, dermabrasion, and dermatome: a study of thermal damage, wound contraction, and wound healing in a live pig model: implications for skin resurfacing","volume":"42","author":"Ross","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/labinvest.2008.101_bib15","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1046\/j.1365-2133.1997.6631648.x","article-title":"Adverse reactions following pulsed tunable dye laser treatment of port wine stains in 701 patients","volume":"136","author":"Seukeran","year":"1997","journal-title":"Br J Dermatol"},{"key":"10.1038\/labinvest.2008.101_bib16","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.burns.2006.02.023","article-title":"A porcine deep dermal partial thickness burn model with hypertrophic scarring","volume":"32","author":"Cuttle","year":"2006","journal-title":"Burns"},{"key":"10.1038\/labinvest.2008.101_bib17","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1097\/01.prs.0000258829.07399.f0","article-title":"Scarring occurs at a critical depth of skin injury: precise measurement in a graduated dermal scratch in human volunteers","volume":"119","author":"Dunkin","year":"2007","journal-title":"Plast Reconstr Surg"},{"key":"10.1038\/labinvest.2008.101_bib18","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/(SICI)1097-4652(199803)174:3<301::AID-JCP4>3.0.CO;2-S","article-title":"Induction of transforming growth factor beta 1 by insulin-like growth factor-1 in dermal fibroblasts","volume":"174","author":"Ghahary","year":"1998","journal-title":"J Cell Physiol"},{"key":"10.1038\/labinvest.2008.101_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00929499","article-title":"Enhanced expression of mRNA for insulin-like growth factor-1 in post-burn hypertrophic scar tissue and its fibrogenic role by dermal fibroblasts","volume":"148","author":"Ghahary","year":"1995","journal-title":"Mol Cell Biochem"},{"key":"10.1038\/labinvest.2008.101_bib20","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1524-475X.2007.00261.x","article-title":"Increased TGF-beta-producing CD4+ T lymphocytes in postburn patients and their potential interaction with dermal fibroblasts in hypertrophic scarring","volume":"15","author":"Wang","year":"2007","journal-title":"Wound Repair Regen"},{"key":"10.1038\/labinvest.2008.101_bib21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0174-173X(83)80011-9","article-title":"Cleavage of the carboxy-terminal cross-linking region of type I collagen by proteolytic activity from cultured porcine gingival explants","volume":"3","author":"Scott","year":"1983","journal-title":"Coll Relat Res"},{"key":"10.1038\/labinvest.2008.101_bib22","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.0022-202X.2004.23521.x","article-title":"Differentiated keratinocyte-releasable stratifin (14-3-3 sigma) stimulates MMP-1 expression in dermal fibroblasts","volume":"124","author":"Ghahary","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1038\/labinvest.2008.101_bib23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1524-475X.2003.11505.x","article-title":"Proliferation of peripheral blood mononuclear cells is suppressed by the indoleamine 2,3-dioxygenase expression of interferon-gamma-treated skin cells in a co-culture system","volume":"11","author":"Sarkhosh","year":"2003","journal-title":"Wound Repair Regen"},{"key":"10.1038\/labinvest.2008.101_bib24","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1189\/jlb.0507306","article-title":"Accelerated wound healing in leukocyte-specific, protein 1-deficient mouse is associated with increased infiltration of leukocytes and fibrocytes","volume":"82","author":"Wang","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1038\/labinvest.2008.101_bib25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1524-475X.2006.00192.x","article-title":"Fibrocytes from burn patients regulate the activities of fibroblasts","volume":"15","author":"Wang","year":"2007","journal-title":"Wound Repair Regen"},{"key":"10.1038\/labinvest.2008.101_bib26","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/S0002-9440(10)63066-0","article-title":"Healing of burn wounds in transgenic mice overexpressing transforming growth factor-beta 1 in the epidermis","volume":"159","author":"Yang","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2008.101_bib27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1677\/joe.0.1780169","article-title":"The CCN family: a new stimulus package","volume":"178","author":"Brigstock","year":"2003","journal-title":"J Endocrinol"},{"key":"10.1038\/labinvest.2008.101_bib28","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/1523-1747.ep12343658","article-title":"Collagenase production is lower in post-burn hypertrophic scar fibroblasts than in normal fibroblasts and is reduced by insulin-like growth factor-1","volume":"106","author":"Ghahary","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1038\/labinvest.2008.101_bib29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0968-0004(06)80023-X","article-title":"Hsp47: a collagen-specific molecular chaperone","volume":"21","author":"Nagata","year":"1996","journal-title":"Trends Biochem Sci"},{"key":"10.1038\/labinvest.2008.101_bib30","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1091\/mbc.e05-11-1065","article-title":"Type I collagen in Hsp47-null cells is aggregated in endoplasmic reticulum and deficient in N-propeptide processing and fibrillogenesis","volume":"17","author":"Ishida","year":"2006","journal-title":"Mol Biol Cell"},{"key":"10.1038\/labinvest.2008.101_bib31","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2353\/ajpath.2007.070112","article-title":"The myofibroblast: one function, multiple origins","volume":"170","author":"Hinz","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2008.101_bib32","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/sj.jid.5700613","article-title":"Formation and function of the myofibroblast during tissue repair","volume":"127","author":"Hinz","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1038\/labinvest.2008.101_bib33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0074-7696(07)57004-X","article-title":"Fibroblast differentiation in wound healing and fibrosis","volume":"257","author":"Darby","year":"2007","journal-title":"Int Rev Cytol"},{"key":"10.1038\/labinvest.2008.101_bib34","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1042\/cs0940541","article-title":"Fibroblasts from post-burn hypertrophic scar tissue synthesize less decorin than normal dermal fibroblasts","volume":"94","author":"Scott","year":"1998","journal-title":"Clin Sci (Lond)"},{"key":"10.1038\/labinvest.2008.101_bib35","first-page":"261","article-title":"Versican","volume":"3","author":"Lebaron","year":"1996","journal-title":"Perspect Dev Neurobiol"},{"issue":"Part 1","key":"10.1038\/labinvest.2008.101_bib36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1042\/bj3020049","article-title":"Glomerular mesangial cells in vitro synthesize an aggregating proteoglycan immunologically related to versican","volume":"302","author":"Thomas","year":"1994","journal-title":"Biochem J"},{"key":"10.1038\/labinvest.2008.101_bib37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/03008200009005290","article-title":"Molecular and cell biology of skin wound healing in a pig model","volume":"41","author":"Wang","year":"2000","journal-title":"Connect Tissue Res"},{"key":"10.1038\/labinvest.2008.101_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1737","article-title":"Epidermis promotes dermal fibrosis: role in the pathogenesis of hypertrophic scars","volume":"206","author":"Bellemare","year":"2005","journal-title":"J Pathol"},{"key":"10.1038\/labinvest.2008.101_bib39","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1097\/01.LAB.0000027841.50269.61","article-title":"Peripheral blood fibrocytes from burn patients: identification and quantification of fibrocytes in adherent cells cultured from peripheral blood mononuclear cells","volume":"82","author":"Yang","year":"2002","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.2008.101_bib40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1089\/jir.2006.26.179","article-title":"Polarized Th2 cytokine production in patients with hypertrophic scar following thermal injury","volume":"26","author":"Tredget","year":"2006","journal-title":"J Interferon Cytokine Res"},{"key":"10.1038\/labinvest.2008.101_bib41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/jaut.1999.0339","article-title":"The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases","volume":"14","author":"Prud'homme","year":"2000","journal-title":"J Autoimmun"},{"key":"10.1038\/labinvest.2008.101_bib42","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/1523-1747.ep12398532","article-title":"Expression of mRNA for transforming growth factor-beta 1 is reduced in hypertrophic scar and normal dermal fibroblasts following serial passage in vitro","volume":"103","author":"Ghahary","year":"1994","journal-title":"J Invest Dermatol"},{"key":"10.1038\/labinvest.2008.101_bib43","doi-asserted-by":"crossref","first-page":"7741","DOI":"10.1016\/S0021-9258(18)68561-8","article-title":"Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells","volume":"263","author":"Van Obberghen-Schilling","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2008.101_bib44","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1046\/j.1524-475x.2000.00128.x","article-title":"Hypertrophic scar tissues and fibroblasts produce more transforming growth factor-beta1 mRNA and protein than normal skin and cells","volume":"8","author":"Wang","year":"2000","journal-title":"Wound Repair Regen"},{"key":"10.1038\/labinvest.2008.101_bib45","first-page":"341","article-title":"The pig as a model for excisional skin wound healing: characterization of the molecular and cellular biology, and bacteriology of the healing process","volume":"51","author":"Wang","year":"2001","journal-title":"Comp Med"},{"key":"10.1038\/labinvest.2008.101_bib46","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1139\/o03-069","article-title":"The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology","volume":"81","author":"Leask","year":"2003","journal-title":"Biochem Cell Biol"},{"key":"10.1038\/labinvest.2008.101_bib47","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1046\/j.1524-475X.2003.11311.x","article-title":"Recombinant connective tissue growth factor modulates porcine skin fibroblast gene expression","volume":"11","author":"Wang","year":"2003","journal-title":"Wound Repair Regen"},{"key":"10.1038\/labinvest.2008.101_bib48","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1097\/01.prs.0000182343.99694.28","article-title":"Hypertrophic scar fibroblasts have increased connective tissue growth factor expression after transforming growth factor-beta stimulation","volume":"116","author":"Colwell","year":"2005","journal-title":"Plast Reconstr Surg"},{"key":"10.1038\/labinvest.2008.101_bib49","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1067-1927.2005.130102.x","article-title":"Tissue repair, contraction, and the myofibroblast","volume":"13","author":"Desmouliere","year":"2005","journal-title":"Wound Repair Regen"},{"issue":"Suppl 1","key":"10.1038\/labinvest.2008.101_bib50","doi-asserted-by":"crossref","first-page":"73s","DOI":"10.1111\/1523-1747.ep12545835","article-title":"Regulation of collagen synthesis","volume":"79","author":"Pinnell","year":"1982","journal-title":"J Invest Dermatol"},{"key":"10.1038\/labinvest.2008.101_bib51","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0094-1298(20)30598-8","article-title":"Wide spread scars, hypertrophic scars, and keloids","volume":"14","author":"Rudolph","year":"1987","journal-title":"Clin Plast Surg"},{"key":"10.1038\/labinvest.2008.101_bib52","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/00005373-198505000-00006","article-title":"Can collagen metabolism be controlled: theoretical considerations","volume":"25","author":"Cohen","year":"1985","journal-title":"J Trauma"},{"key":"10.1038\/labinvest.2008.101_bib53","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jcp.1040980210","article-title":"Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro","volume":"98","author":"Diegelmann","year":"1979","journal-title":"J Cell Physiol"},{"key":"10.1038\/labinvest.2008.101_bib54","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/cs0900417","article-title":"Chemical characterization and quantification of proteoglycans in human post-burn hypertrophic and mature scars","volume":"90","author":"Scott","year":"1996","journal-title":"Clin Sci (Lond)"},{"key":"10.1038\/labinvest.2008.101_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-4827(77)80002-5","article-title":"Tissue-specific differences in cultured human diploid fibroblasts","volume":"108","author":"Schneider","year":"1977","journal-title":"Exp Cell Res"},{"key":"10.1038\/labinvest.2008.101_bib56","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0014-5793(77)80444-4","article-title":"Serum modulates collagen types in human gingiva fibroblasts","volume":"80","author":"Narayanan","year":"1977","journal-title":"FEBS Lett"},{"key":"10.1038\/labinvest.2008.101_bib57","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/art.1780250212","article-title":"Fibroblast selection in scleroderma. An alternative model of fibrosis","volume":"25","author":"Botstein","year":"1982","journal-title":"Arthritis Rheum"},{"key":"10.1038\/labinvest.2008.101_bib58","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1006\/cimm.1996.0268","article-title":"Differential Thy-1 expression by splenic fibroblasts defines functionally distinct subsets","volume":"173","author":"Borrello","year":"1996","journal-title":"Cell Immunol"},{"key":"10.1038\/labinvest.2008.101_bib59","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/jir.1995.15.63","article-title":"Synthesis of interleukin-1 receptor antagonist by Thy-1+ and Thy-1\u2212 murine lung fibroblast subsets","volume":"15","author":"Silvera","year":"1995","journal-title":"J Interferon Cytokine Res"},{"key":"10.1038\/labinvest.2008.101_bib60","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1165\/ajrcmb\/1.1.65","article-title":"Characterization of two major populations of lung fibroblasts: distinguishing morphology and discordant display of Thy 1 and class II MHC","volume":"1","author":"Phipps","year":"1989","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1038\/labinvest.2008.101_bib61","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0014-4827(76)90336-0","article-title":"Increased nuclear sizes in senescent human diploid fibroblast cultures","volume":"100","author":"Mitsui","year":"1976","journal-title":"Exp Cell Res"},{"key":"10.1038\/labinvest.2008.101_bib62","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0014-4827(76)90236-6","article-title":"Characterization of fractionated human diploid fibroblast cell populations","volume":"103","author":"Mitsui","year":"1976","journal-title":"Exp Cell Res"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest2008101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2008101","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722018190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722018190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2008101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:42:44Z","timestamp":1758397364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722018190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":62,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0023683722018190"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2008.101","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deep dermal fibroblasts contribute to hypertrophic scarring","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2008.101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}