{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:44:25Z","timestamp":1790721865078,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5123,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1038\/labinvest.2008.104","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T15:02:43Z","timestamp":1226329363000},"page":"47-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":182,"title":["PPAR-\u03b3 agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-\u03b2"],"prefix":"10.1016","volume":"89","author":[{"given":"Toru","family":"Kawai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigehiro","family":"Doi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Doi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuoki","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Yorioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2008.104_bib1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s004670000461","article-title":"Molecular basis of renal fibrosis","volume":"15","author":"Eddy","year":"2000","journal-title":"Pediatr Nephrol"},{"key":"10.1038\/labinvest.2008.104_bib2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.ki.5000054","article-title":"Renal fibrosis: new insights into the pathogenesis and therapeutics","volume":"69","author":"Liu","year":"2006","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2008.104_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/01.mop.0000193287.56528.a4","article-title":"Pathogenesis of renal injury in obstructive uropathy","volume":"18","author":"Chevalier","year":"2006","journal-title":"Curr Opin Pediatr"},{"key":"10.1038\/labinvest.2008.104_bib4","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/sj.ki.5001815","article-title":"Specific molecular targeting of renal injury in obstructive nephropathy","volume":"70","author":"Chevalier","year":"2006","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2008.104_bib5","first-page":"384","article-title":"The nuclear receptor ligand-binding domain: structure and function","volume":"10","author":"Moras","year":"1998","journal-title":"Cell Biol"},{"key":"10.1038\/labinvest.2008.104_bib6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1046\/j.1523-1755.2001.00766.x","article-title":"Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease","volume":"60","author":"Guan","year":"2001","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2008.104_bib7","doi-asserted-by":"crossref","first-page":"F528","DOI":"10.1152\/ajprenal.00445.2003","article-title":"The effect of high glucose and PPAR-gamma agonists on PPAR-gamma expression and function in HK-2 cells","volume":"287","author":"Panchapakesan","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/labinvest.2008.104_bib8","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1111\/j.1523-1755.2004.00574.x","article-title":"Pioglitazone increases renal tubular cell albumin uptake but limits proinflammatory and fibrotic responses","volume":"65","author":"Zafiriou","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2008.104_bib9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1358\/dnp.2002.15.3.840011","article-title":"The role of PPARs in the transcriptional control of cellular processes","volume":"15","author":"Guan","year":"2002","journal-title":"Drug News Perspect"},{"key":"10.1038\/labinvest.2008.104_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta8130","article-title":"Clinical effectiveness and cost-effectiveness of pioglitazone and rosiglitazone in the treatment of type 2 diabetes: a systematic review and economic evaluation","volume":"8","author":"Czoski-Murray","year":"2004","journal-title":"Health Technol Assess"},{"key":"10.1038\/labinvest.2008.104_bib11","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1001\/archinte.164.19.2097","article-title":"A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors","volume":"19","author":"Chiquette","year":"2004","journal-title":"Arch Intern Med"},{"key":"10.1038\/labinvest.2008.104_bib12","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.2337\/diacare.21.12.2135","article-title":"Effect of troglitazone on microalbuminuria in patients with incipient diabetic nephropathy","volume":"21","author":"Imano","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1038\/labinvest.2008.104_bib13","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1097\/01.hjh.0000244955.39491.88","article-title":"Rosiglitazone reduces microalbuminuria and blood pressure independently of glycemia in type 2 diabetes patients with microalbuminuria","volume":"24","author":"Bakris","year":"2006","journal-title":"J Hypertens"},{"key":"10.1038\/labinvest.2008.104_bib14","first-page":"1326","article-title":"Peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats","volume":"47","author":"Buckingham","year":"1998","journal-title":"Diabetes"},{"key":"10.1038\/labinvest.2008.104_bib15","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1053\/meta.2000.9509","article-title":"Renal protective effect of troglitazone in Wistar fatty rats","volume":"49","author":"Fujiwara","year":"2000","journal-title":"Metabolism"},{"key":"10.1038\/labinvest.2008.104_bib16","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1046\/j.1523-1755.2001.0590051899.x","article-title":"Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats","volume":"59","author":"Ma","year":"2001","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2008.104_bib17","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1681\/ASN.2005090983","article-title":"Transcriptional regulation of nephrin gene by peroxisome proliferator-activated receptor-gamma agonist: molecular mechanism of the antiproteinuric effect of pioglitazone","volume":"17","author":"Benigni","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/labinvest.2008.104_bib18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s101570300003","article-title":"Suppression of experimental crescentic glomerulonephritis by peroxisome proliferator-activated receptor (PPAR)gamma activators","volume":"7","author":"Haraguchi","year":"2003","journal-title":"Clin Exp Nephrol"},{"key":"10.1038\/labinvest.2008.104_bib19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1152\/ajprenal.00019.2007","article-title":"Amelioration of anti-Thy1-glomerulonephritis by PPAR-gamma agonism without increase of endothelial progenitor cell homing","volume":"294","author":"Westerweel","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/labinvest.2008.104_bib20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000072088","article-title":"Agonists of peroxisome-proliferator activated receptor-gamma reduce renal ischemia\/reperfusion injury","volume":"23","author":"Sivarajah","year":"2003","journal-title":"Am J Nephrol"},{"key":"10.1038\/labinvest.2008.104_bib21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/01.tp.0000269614.21367.3f","article-title":"Protective effects of peroxisome proliferator-activated receptor gamma ligand on apoptosis and hepatocyte growth factor induction in renal ischemia-reperfusion injury","volume":"84","author":"Doi","year":"2007","journal-title":"Transplantation"},{"key":"10.1038\/labinvest.2008.104_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.1523-1755.2003.00054.x","article-title":"PPAR-\u03b3 ligand attenuates PDGF-induced mesangial cell proliferation: role of MAP kinase","volume":"64","author":"Ghosh","year":"2003","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2008.104_bib23","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1046\/j.1523-1755.2002.00277.x","article-title":"Troglitazone suppresses the secretion of type I collagen by mesangial cells in vitro","volume":"61","author":"Routh","year":"2002","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2008.104_bib24","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0006-291X(03)00599-0","article-title":"c-Fos-driven transcriptional activation of transforming growth factor \u03b2-1: inhibition of high glucose-induced promoter activity by thiazolidinediones","volume":"304","author":"Weigert","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/labinvest.2008.104_bib25","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1440-1797.2007.00881.x","article-title":"Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction","volume":"12","author":"Kuratsune","year":"2007","journal-title":"Nephrology"},{"key":"10.1038\/labinvest.2008.104_bib26","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1046\/j.1523-1755.2003.00874.x","article-title":"Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney","volume":"63","author":"Masaki","year":"2003","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2008.104_bib27","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1523-1755.2005.00179.x","article-title":"Angiotensin II induces fibronectin expression in human peritoneal mesothelial cells via ERK1\/2 and p38 MAPK","volume":"67","author":"Kiribayashi","year":"2005","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2008.104_bib28","doi-asserted-by":"crossref","first-page":"F278","DOI":"10.1152\/ajprenal.00139.2003","article-title":"Angiotensin II induced thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: a mechanism for activation of latent TGF-\u03b2","volume":"286","author":"Naito","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/labinvest.2008.104_bib29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1365-2249.2006.03073.x","article-title":"PDGF receptor tyrosine kinase inhibitor suppresses mesangial cell proliferation involving STAT3 activation","volume":"144","author":"Hirai","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"10.1038\/labinvest.2008.104_bib30","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/S0022-3565(24)36525-5","article-title":"Pharmacokinetics of troglitazone, an anti-diabetic agent: prediction of in vivo stereoselective sulfation and glucuronidation from in vitro data","volume":"280","author":"Izumi","year":"1997","journal-title":"J Pharmacol Exp Ter"},{"key":"10.1038\/labinvest.2008.104_bib31","first-page":"356","article-title":"Disposition and metabolism of the new oral anti-diabetic drug troglitazone in rats, mice and dogs","volume":"47","author":"Kawai","year":"1997","journal-title":"Arzneim-Forsch\/Drug Res"},{"key":"10.1038\/labinvest.2008.104_bib32","first-page":"3344","article-title":"Ligand for peroxisome proliferator-activated receptor (troglitazone) has potent antitumor effect against human prostate cancer both in vitro in vivo","volume":"58","author":"Kubota","year":"1998","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.2008.104_bib33","doi-asserted-by":"crossref","first-page":"8806","DOI":"10.1073\/pnas.95.15.8806","article-title":"Ligands for peroxisome proliferator-activated receptor and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice","volume":"95","author":"Elstner","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.2008.104_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASN.0000106015.29070.E7","article-title":"Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention","volume":"15","author":"Liu","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/labinvest.2008.104_bib35","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/sj.ki.5001775","article-title":"IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy","volume":"70","author":"Moon","year":"2006","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2008.104_bib36","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1093\/ndt\/gfh705","article-title":"Agonist of peroxisome proliferator-activated receptor-gamma, rosiglitazone, reduces renal injury and dysfunction in a murine sepsis model","volume":"20","author":"Lee","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/labinvest.2008.104_bib37","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1046\/j.1523-1755.2002.00476.x","article-title":"Effects of different PPARgamma-agonists on MCP-1 expression and monocyte recruitment in experimental glomerulonephritis","volume":"62","author":"Panzer","year":"2002","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2008.104_bib38","doi-asserted-by":"crossref","first-page":"F861","DOI":"10.1152\/ajprenal.00362.2001","article-title":"Obstructive nephropathy and renal fibrosis","volume":"283","author":"Klahr","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/labinvest.2008.104_bib39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/ncpneph0098","article-title":"Obstructive nephropathy: towards biomarker discovery and gene therapy","volume":"2","author":"Chevalier","year":"2006","journal-title":"Nat Clin Pract Nephrol"},{"key":"10.1038\/labinvest.2008.104_bib40","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1046\/j.1523-1755.2000.00414.x","article-title":"Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction","volume":"58","author":"Miyajima","year":"2000","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2008.104_bib41","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1053\/gast.2002.33666","article-title":"Anti-diabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo in vitro","volume":"122","author":"Galli","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2008.104_bib42","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1152\/ajplung.00383.2004","article-title":"PPAR-gamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis","volume":"288","author":"Burgess","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1038\/labinvest.2008.104_bib43","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.2337\/diabetes.49.6.1022","article-title":"Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats","volume":"49","author":"Isshiki","year":"2000","journal-title":"Diabetes"},{"key":"10.1038\/labinvest.2008.104_bib44","doi-asserted-by":"crossref","first-page":"22910","DOI":"10.1074\/jbc.M703597200","article-title":"Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma","volume":"282","author":"Hong","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2008.104_bib45","doi-asserted-by":"crossref","first-page":"F513","DOI":"10.1152\/ajprenal.2001.281.3.F513","article-title":"Quantification of TGF-beta1 mRNA along rat nephron in obstructive nephropathy","volume":"281","author":"Fukuda","year":"2001","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/labinvest.2008.104_bib46","doi-asserted-by":"crossref","first-page":"F1257","DOI":"10.1152\/ajprenal.00205.2004","article-title":"Troglitazone's rapid and sustained activation of ERK1\/2 induces cellular acidosis in LLC-PK1-F+ cells: physiological responses","volume":"288","author":"Oliver","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/labinvest.2008.104_bib47","doi-asserted-by":"crossref","first-page":"48950","DOI":"10.1074\/jbc.M108722200","article-title":"15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK\/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells","volume":"276","author":"Takeda","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2008.104_bib48","doi-asserted-by":"crossref","first-page":"C1137","DOI":"10.1152\/ajpcell.00396.2006","article-title":"Troglitazone and pioglitazone interactions via PPAR-gamma-independent and-dependent pathways in regulating physiological responses in renal tubule-derived cell lines","volume":"292","author":"Turturro","year":"2007","journal-title":"Am J Physiol Cell Physiol"}],"updated-by":[{"DOI":"10.1038\/labinvest.2008.156","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000}}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest2008104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2008104","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722014908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722014908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2008104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T16:26:10Z","timestamp":1738513570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722014908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0023683722014908"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2008.104","relation":{"erratum":[{"id-type":"doi","id":"10.1038\/labinvest.2008.156","asserted-by":"object"}]},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PPAR-\u03b3 agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-\u03b2","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2008.104","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2008.156","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}