{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:58:48Z","timestamp":1787162328752,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5215,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1038\/labinvest.2008.71","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T10:07:02Z","timestamp":1217239622000},"page":"1090-1100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"title":["Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury"],"prefix":"10.1016","volume":"88","author":[{"given":"Erawan","family":"Borkham-Kamphorst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenia","family":"Kovalenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia R C","family":"van Roeyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Gassler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bomble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammo","family":"Ostendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Floege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel M","family":"Gressner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Weiskirchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2008.71_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cytogfr.2004.03.007","article-title":"The PDGF family: four gene products form five dimeric isoforms","volume":"15","author":"Fredriksson","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1038\/labinvest.2008.71_bib2","doi-asserted-by":"crossref","first-page":"C485","DOI":"10.1152\/ajpcell.1991.260.3.C485","article-title":"Mitogenic signals for platelet-derived growth factor isoforms in liver fat-storing cells","volume":"260","author":"Pinzani","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1038\/labinvest.2008.71_bib3","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.jhep.2007.01.029","article-title":"Pro-fibrogenic potential of PDGF-D in liver fibrosis","volume":"46","author":"Borkham-Kamphorst","year":"2007","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2008.71_bib4","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1172\/JCI117497","article-title":"Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture","volume":"94","author":"Wong","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2008.71_bib5","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/hep.1840190323","article-title":"Expression of platelet-derived growth factor in a model of acute liver injury","volume":"19","author":"Pinzani","year":"1994","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2008.71_bib6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit Rev Toxicol"},{"key":"10.1038\/labinvest.2008.71_bib7","first-page":"2350","article-title":"Modeling liver fibrosis in rodents","volume":"117","author":"Constandinou","year":"2005","journal-title":"Methods Mol Med"},{"key":"10.1038\/labinvest.2008.71_bib8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bbrc.2004.06.153","article-title":"Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrogenesis","volume":"32","author":"Borkham-Kamphorst","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/labinvest.2008.71_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0091-679X(08)61797-5","article-title":"Preparation of isolated rat liver cells","volume":"13","author":"Seglen","year":"1976","journal-title":"Methods Cell Biol"},{"key":"10.1038\/labinvest.2008.71_bib10","first-page":"229","article-title":"Isolation of rat hepatocytes","volume":"320","author":"Papeleu","year":"2006","journal-title":"Methods Mol Biol"},{"key":"10.1038\/labinvest.2008.71_bib11","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jhep.2007.05.015","article-title":"Differential effects of TGF-\u03b2 on connective tissue growth factor (CTGF\/CCN2) expression in hepatic stellate cells and hepatocytes","volume":"47","author":"Gressner","year":"2007","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2008.71_bib12","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2008.71_bib13","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jhep.2007.07.006","article-title":"Grading and staging systems for inflammation and fibrosis in chronic liver diseases","volume":"47","author":"Goodman","year":"2007","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2008.71_bib14","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1083\/jcb.127.6.2037","article-title":"Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis","volume":"127","author":"Jarnagin","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1038\/labinvest.2008.71_bib15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0300-483X(97)03617-2","article-title":"Tissue injury and repair as parallel and opposing responses to CCl4 hepatotoxicity: a novel dose-response","volume":"118","author":"Rao","year":"1997","journal-title":"Toxicology"},{"key":"10.1038\/labinvest.2008.71_bib16","first-page":"1333","article-title":"Reversibility of hepatic fibrosis in experimentally induced cholestasis in rat","volume":"137","author":"Abdel-Aziz","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2008.71_bib17","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0016-5085(95)90403-4","article-title":"Neutrophil adhesion is impaired in rat model of cholestasis","volume":"109","author":"Swain","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2008.71_bib18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1096\/fasebj.4.2.2298342","article-title":"Regulation of TGF\u03b2 gene expression in rat liver intoxicated with carbon tetrachloride","volume":"4","author":"Armendariz-Borunda","year":"1990","journal-title":"FASEB J"},{"key":"10.1038\/labinvest.2008.71_bib19","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/exmp.2001.2399","article-title":"Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats","volume":"71","author":"Luckey","year":"2001","journal-title":"Exp Mol Pathol"},{"key":"10.1038\/labinvest.2008.71_bib20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0168-8278(88)80461-6","article-title":"Cell population kinetics of Kupffer cells during the onset of fibrosis in rat liver by chronic carbon tetrachloride administration","volume":"6","author":"Geerts","year":"1988","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2008.71_bib21","first-page":"785","article-title":"Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis","volume":"148","author":"Pinzani","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2008.71_bib22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0092-8674(85)90033-9","article-title":"A significant part of macrophage-derived growth factor consists of at least two forms of PDGF","volume":"43","author":"Shimokado","year":"1985","journal-title":"Cell"},{"key":"10.1038\/labinvest.2008.71_bib23","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1172\/JCI114362","article-title":"Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors","volume":"84","author":"Friedman","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2008.71_bib24","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/35074588","article-title":"PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor","volume":"3","author":"Bergsten","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1038\/labinvest.2008.71_bib25","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/35074593","article-title":"PDGF-D, a new protease-activated growth factor","volume":"3","author":"LaRochelle","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1038\/labinvest.2008.71_bib26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cyto.2005.06.005","article-title":"Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors \u03b1 \u03b2 in activated rat hepatic stellate cells (HSC)","volume":"31","author":"Breitkopf","year":"2005","journal-title":"Cytokine"},{"key":"10.1038\/labinvest.2008.71_bib27","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0168-8278(98)80348-6","article-title":"Translocation of platelets into Disse spaces and their entry into hepatocytes in response to lipopolysaccharides, interleukin-1 and tumour necrosis factor: the role of Kupffer cells","volume":"28","author":"Nakamura","year":"1998","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2008.71_bib28","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/01.ATV.0000120785.82268.8b","article-title":"PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle","volume":"24","author":"Fang","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1038\/labinvest.2008.71_bib29","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1073\/pnas.0409722102","article-title":"Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma","volume":"102","author":"Campbell","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.2008.71_bib30","first-page":"367","article-title":"CCl4-induced liver cirrhosis and hepatocellular carcinoma in rats: relationship to plasma zinc, copper and estradiol levels","volume":"41","author":"Frezza","year":"1994","journal-title":"Hepatogastroenterology"},{"key":"10.1038\/labinvest.2008.71_bib31","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1158\/1535-7163.MCT-06-0720","article-title":"Platelet-derived growth factor receptor-\u03b1: a novel therapeutic target in human hepatocellular cancer","volume":"6","author":"Stock","year":"2007","journal-title":"Mol Cancer Ther"},{"key":"10.1038\/labinvest.2008.71_bib32","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/labinvest.3700094","article-title":"Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis","volume":"84","author":"Borkham-Kamphorst","year":"2004","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.2008.71_bib33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jhep.2005.06.015","article-title":"Oral imatinib treatment reduces early fibrogenesis but does not prevent progression in the long term","volume":"44","author":"Neef","year":"2006","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2008.71_bib34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/01926230590881808","article-title":"Tissue repair: an important determinant of final outcome of toxicant-induced injury","volume":"33","author":"Mehendale","year":"2005","journal-title":"Toxicol Pathol"},{"key":"10.1038\/labinvest.2008.71_bib35","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1177\/019262339802600505","article-title":"Zonal location of compensatory hepatocyte proliferation following chemically induced hepatotoxicity in rats and humans","volume":"26","author":"Lee","year":"1998","journal-title":"Toxicol Pathol"},{"key":"10.1038\/labinvest.2008.71_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0168-8278(00)80412-2","article-title":"Liver regeneration","volume":"32","author":"Fausto","year":"2000","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2008.71_bib37","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jss.2003.10.026","article-title":"Molecular and cellular features of hepatic regeneration","volume":"117","author":"Black","year":"2004","journal-title":"J Surg Res"},{"key":"10.1038\/labinvest.2008.71_bib38","first-page":"101","article-title":"Liver regeneration","volume":"93","author":"Michalopoulos","year":"2005","journal-title":"Adv Biochem Eng Biotechnol"},{"key":"10.1038\/labinvest.2008.71_bib39","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1002\/hep.20969","article-title":"Liver regeneration","volume":"43","author":"Fausto","year":"2006","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2008.71_bib40","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jss.2007.02.035","article-title":"Platelets strongly induce hepatocyte proliferation with IGF-1 and HGF in vitro","volume":"145","author":"Matsuo","year":"2008","journal-title":"J Surg Res"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest200871.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest200871","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722018463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722018463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest200871.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:43:05Z","timestamp":1758397385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722018463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0023683722018463"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2008.71","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2008.71","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}