{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:03:20Z","timestamp":1791093800428,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5215,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1038\/labinvest.2008.72","type":"journal-article","created":{"date-parts":[[2008,8,18]],"date-time":"2008-08-18T11:42:24Z","timestamp":1219059744000},"page":"1024-1037","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Immunoglobulin derived depositions in the nervous system: novel mass spectrometry application for protein characterization in formalin-fixed tissues"],"prefix":"10.1016","volume":"88","author":[{"given":"Fausto J","family":"Rodriguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D","family":"Gamez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A","family":"Vrana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D","family":"Theis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd W","family":"Scheithauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia F","family":"Lucchinetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W","family":"Pendlebury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"H Robert","family":"Bergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2008.72_bib1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S0090-3019(99)00128-7","article-title":"Amyloidoma in the gasserian ganglion: case report","volume":"52","author":"Matsumoto","year":"1999","journal-title":"Surg Neurol"},{"key":"10.1038\/labinvest.2008.72_bib2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/(SICI)1097-0142(19980115)82:2<375::AID-CNCR18>3.0.CO;2-W","article-title":"Amyloidomas of the nervous system: a monoclonal B-cell disorder with monotypic amyloid light chain lambda amyloid production","volume":"82","author":"Laeng","year":"1998","journal-title":"Cancer"},{"key":"10.1038\/labinvest.2008.72_bib3","doi-asserted-by":"crossref","first-page":"E574","DOI":"10.1227\/01.NEU.0000255361.32689.B3","article-title":"Intracavernous trigeminal ganglion amyloidoma: case report","volume":"60","author":"Bookland","year":"2007","journal-title":"Neurosurgery"},{"key":"10.1038\/labinvest.2008.72_bib4","first-page":"347","article-title":"Intracerebral A lambda amyloidoma diagnosed by stereotactic biopsy","volume":"14","author":"Schroder","year":"1995","journal-title":"Clin Neuropathol"},{"key":"10.1038\/labinvest.2008.72_bib5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3171\/jns.2002.96.2.0368","article-title":"Dural marginal zone lymphoma with massive amyloid deposition: rare low-grade primary central nervous system B-cell lymphoma. Case report","volume":"96","author":"Lehman","year":"2002","journal-title":"J Neurosurg"},{"key":"10.1038\/labinvest.2008.72_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0002-9343(76)90440-X","article-title":"Manifestations of systemic light chain deposition","volume":"60","author":"Randall","year":"1976","journal-title":"Am J Med"},{"key":"10.1038\/labinvest.2008.72_bib7","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1182\/blood.V100.5.1817.h81702001817_1817_1827","article-title":"Generalized crystal-storing histiocytosis associated with monoclonal gammopathy: molecular analysis of a disorder with rapid clinical course and review of the literature","volume":"100","author":"Lebeau","year":"2002","journal-title":"Blood"},{"key":"10.1038\/labinvest.2008.72_bib8","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/S0046-8177(99)90166-1","article-title":"Crystal-storing histiocytosis: a disorder occurring in plasmacytic tumors expressing immunoglobulin kappa light chain","volume":"30","author":"Jones","year":"1999","journal-title":"Hum Pathol"},{"key":"10.1038\/labinvest.2008.72_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00428-006-0323-1","article-title":"Crystal-storing histiocytosis associated with MALT lymphoma of the ocular adnexa: a case report with review of literature","volume":"450","author":"Kusakabe","year":"2007","journal-title":"Virchows Arch"},{"key":"10.1038\/labinvest.2008.72_bib10","series-title":"Proteome Workflow: Workflow Tool for Building Proteomics Workflows, in 55th Annual American Society for Mass Spectrometry","author":"Lentz","year":"2007"},{"key":"10.1038\/labinvest.2008.72_bib11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1479-7364-1-2-134","article-title":"Genomic and proteomic approaches for studying human cancer: prospects for true patient-tailored therapy","volume":"1","author":"Carr","year":"2004","journal-title":"Hum Genomics"},{"key":"10.1038\/labinvest.2008.72_bib12","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1373\/49.4.533","article-title":"Mass spectrometry-based diagnostics: the upcoming revolution in disease detection","volume":"49","author":"Petricoin","year":"2003","journal-title":"Clin Chem"},{"key":"10.1038\/labinvest.2008.72_bib13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5858\/2008-132-14a-UOIFTA","article-title":"Unreliability of immunohistochemistry for typing amyloid deposits","volume":"132","author":"Solomon","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/labinvest.2008.72_bib14","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/labinvest.3700167","article-title":"Proteomics in pathology research","volume":"84","author":"Lim","year":"2004","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.2008.72_bib15","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1021\/ac0352171","article-title":"Serum peptide profiling by magnetic particle-assisted, automated sample processing and MALDI-TOF mass spectrometry","volume":"76","author":"Villanueva","year":"2004","journal-title":"Anal Chem"},{"key":"10.1038\/labinvest.2008.72_bib16","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(02)07746-2","article-title":"Use of proteomic patterns in serum to identify ovarian cancer","volume":"359","author":"Petricoin","year":"2002","journal-title":"Lancet"},{"key":"10.1038\/labinvest.2008.72_bib17","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/(SICI)1522-2683(20000401)21:6<1164::AID-ELPS1164>3.0.CO;2-0","article-title":"Recent advancements in surface-enhanced laser desorption\/ionization-time of flight-mass spectrometry","volume":"21","author":"Merchant","year":"2000","journal-title":"Electrophoresis"},{"key":"10.1038\/labinvest.2008.72_bib18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.brainres.2006.11.082","article-title":"Quantitative proteomic profiling of membrane proteins from the mouse brain cortex, hippocampus, and cerebellum using the HysTag reagent: mapping of neurotransmitter receptors and ion channels","volume":"1134","author":"Olsen","year":"2007","journal-title":"Brain Res"},{"key":"10.1038\/labinvest.2008.72_bib19","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1373\/49.4.552","article-title":"Matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry-based detection of microsatellite instabilities in coding DNA sequences: a novel approach to identify DNA-mismatch repair-deficient cancer cells","volume":"49","author":"Bonk","year":"2003","journal-title":"Clin Chem"},{"key":"10.1038\/labinvest.2008.72_bib20","doi-asserted-by":"crossref","first-page":"7402","DOI":"10.1073\/pnas.0506514103","article-title":"Proteomic identification of oncogenic chromosomal translocation partners encoding chimeric anaplastic lymphoma kinase fusion proteins","volume":"103","author":"Elenitoba-Johnson","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.2008.72_bib21","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1021\/pr050208p","article-title":"Efficient method for the proteomic analysis of fixed and embedded tissues","volume":"4","author":"Palmer-Toy","year":"2005","journal-title":"J Proteome Res"},{"key":"10.1038\/labinvest.2008.72_bib22","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1369\/jhc.7A7177.2007","article-title":"Proteome analysis of microdissected formalin-fixed and paraffin-embedded tissue specimens","volume":"55","author":"Guo","year":"2007","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/labinvest.2008.72_bib23","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/labinvest.3700343","article-title":"Identification of proteins from formalin-fixed paraffin-embedded cells by LC-MS\/MS","volume":"85","author":"Crockett","year":"2005","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.2008.72_bib24","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1021\/pr060549i","article-title":"Direct analysis and MALDI imaging of formalin-fixed, paraffin-embedded tissue sections","volume":"6","author":"Lemaire","year":"2007","journal-title":"J Proteome Res"},{"key":"10.1038\/labinvest.2008.72_bib25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2353\/jmoldx.2007.060031","article-title":"Evaluation of enrichment techniques for mass spectrometry: identification of tyrosine phosphoproteins in cancer cells","volume":"9","author":"Schumacher","year":"2007","journal-title":"J Mol Diagn"},{"key":"10.1038\/labinvest.2008.72_bib26","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1074\/mcp.M500102-MCP200","article-title":"Proteomic analysis of formalin-fixed prostate cancer tissue","volume":"4","author":"Hood","year":"2005","journal-title":"Mol Cell Proteomics"},{"key":"10.1038\/labinvest.2008.72_bib27","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nprot.2006.85","article-title":"Laser-capture microdissection","volume":"1","author":"Espina","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1038\/labinvest.2008.72_bib28","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1002\/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2","article-title":"Probability-based protein identification by searching sequence databases using mass spectrometry data","volume":"20","author":"Perkins","year":"1999","journal-title":"Electrophoresis"},{"key":"10.1038\/labinvest.2008.72_bib29","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1309\/3GECPW2402F6V8EK","article-title":"Amyloid-like pulmonary nodules, including localized light-chain deposition: clinicopathologic analysis of three cases","volume":"121","author":"Khoor","year":"2004","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/labinvest.2008.72_bib30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1046\/j.1365-2141.2002.03781.x","article-title":"Tumoral non-amyloidotic monoclonal immunoglobulin light chain deposits (\u2018aggregoma'): presenting feature of B-cell dyscrasia in three cases with immunohistochemical and biochemical analyses","volume":"119","author":"Rostagno","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1038\/labinvest.2008.72_bib31","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1681\/ASN.V1271482","article-title":"Renal monoclonal immunoglobulin deposition disease: the disease spectrum","volume":"12","author":"Lin","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/labinvest.2008.72_bib32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1750-3639.2006.00003_3.x","article-title":"A 19-year-old male with generalized seizures, unconsciousness and a deviation of gaze","volume":"16","author":"Fischer","year":"2006","journal-title":"Brain Pathol"},{"key":"10.1038\/labinvest.2008.72_bib33","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.humpath.2006.07.010","article-title":"Light chain deposition disease restricted to the brain: the first case report","volume":"38","author":"Popovic","year":"2007","journal-title":"Hum Pathol"},{"key":"10.1038\/labinvest.2008.72_bib34","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/labinvest.3700559","article-title":"Amyloidosis in transgenic mice expressing murine amyloidogenic apolipoprotein A-II (Apoa2c)","volume":"87","author":"Ge","year":"2007","journal-title":"Lab Invest"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest200872.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest200872","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722018402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722018402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest200872.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:43:16Z","timestamp":1758397396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722018402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0023683722018402"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2008.72","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunoglobulin derived depositions in the nervous system: novel mass spectrometry application for protein characterization in formalin-fixed tissues","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2008.72","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}