{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:27:10Z","timestamp":1769844430074,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4789,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1038\/labinvest.2009.106","type":"journal-article","created":{"date-parts":[[2009,10,12]],"date-time":"2009-10-12T10:33:26Z","timestamp":1255343606000},"page":"1364-1373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Analysis of Aurora B kinase in non-Hodgkin lymphoma"],"prefix":"10.1016","volume":"89","author":[{"given":"Takayuki","family":"Ikezoe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamotsu","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Nishioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsuo","family":"Furihata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H Phillip","family":"Koeffler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2009.106_bib1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/nrm1245","article-title":"The cellular geography of aurora kinases","volume":"4","author":"Carmena","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1038\/labinvest.2009.106_bib2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nrc1526","article-title":"Aurora A-a guardian of poles","volume":"5","author":"Marumoto","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/labinvest.2009.106_bib3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000015089","article-title":"Identification and characterization of STK12\/Aik2: a human gene related to aurora of Drosphila and yeast IPL1","volume":"82","author":"Kimura","year":"1998","journal-title":"Cytogenet Cell Genet"},{"key":"10.1038\/labinvest.2009.106_bib4","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ydbio.2005.11.036","article-title":"Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis","volume":"290","author":"Tang","year":"2006","journal-title":"Dev Biol"},{"key":"10.1038\/labinvest.2009.106_bib5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/cm.20039","article-title":"Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells","volume":"59","author":"Sasai","year":"2004","journal-title":"Cell Motil Cytoskeleton"},{"key":"10.1038\/labinvest.2009.106_bib6","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1093\/emboj\/17.11.3052","article-title":"A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers","volume":"17","author":"Bischoff","year":"1998","journal-title":"EMBO J"},{"key":"10.1038\/labinvest.2009.106_bib7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/2496","article-title":"Tumour amplified kinase STK15\/BTAK induces centrosome amplification, aneuploidy and transformation","volume":"20","author":"Zhou","year":"1998","journal-title":"Nat Genet"},{"key":"10.1038\/labinvest.2009.106_bib8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/cncr.11879","article-title":"STK15\/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis","volume":"100","author":"Royce","year":"2004","journal-title":"Cancer"},{"key":"10.1038\/labinvest.2009.106_bib9","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1038\/sj.onc.1201065","article-title":"A putative serine\/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines","volume":"14","author":"Sen","year":"1997","journal-title":"Oncogene"},{"key":"10.1038\/labinvest.2009.106_bib10","first-page":"2041","article-title":"Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast","volume":"59","author":"Tanaka","year":"1999","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.2009.106_bib11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/pros.20345","article-title":"Aurora B expression directly correlates with prostate cancer malignancy and influence prostate cell proliferation","volume":"66","author":"Chieffi","year":"2006","journal-title":"Prostate"},{"key":"10.1038\/labinvest.2009.106_bib12","first-page":"991","article-title":"Overexpression of oncogenic STK15\/BTAK\/Aurora A kinase in human pancreatic cancer","volume":"9","author":"Li","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.1038\/labinvest.2009.106_bib13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/ijc.21842","article-title":"Expression of Aurora kinases in human thyroid carcinoma cell lines and tissues","volume":"119","author":"Ulisse","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1038\/labinvest.2009.106_bib14","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1158\/1078-0432.CCR-05-1650","article-title":"Aurora kinase a messenger RNA overexpression is correlated with tumor progression and shortened survival in head and neck squamous cell carcinoma","volume":"12","author":"Reiter","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1038\/labinvest.2009.106_bib15","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1158\/1535-7163.MCT-07-0067","article-title":"A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia","volume":"6","author":"Ikezoe","year":"2007","journal-title":"Mol Cancer Ther"},{"key":"10.1038\/labinvest.2009.106_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1083\/jcb.200208091","article-title":"Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores","volume":"161","author":"Ditchfield","year":"2003","journal-title":"J Cell Biol"},{"key":"10.1038\/labinvest.2009.106_bib17","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1021\/jm061335f","article-title":"Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase","volume":"50","author":"Mortlock","year":"2007","journal-title":"J Med Chem"},{"key":"10.1038\/labinvest.2009.106_bib18","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1182\/blood-2007-02-073700","article-title":"AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitroin vivo","volume":"110","author":"Yang","year":"2007","journal-title":"Blood"},{"key":"10.1038\/labinvest.2009.106_bib19","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1158\/1078-0432.CCR-06-2979","article-title":"AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis","volume":"13","author":"Wilkinson","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1038\/labinvest.2009.106_bib20","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0092-8674(00)00116-1","article-title":"Signal transduction by the JNK group of MAP kinases","volume":"103","author":"Davis","year":"2000","journal-title":"Cell"},{"key":"10.1038\/labinvest.2009.106_bib21","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1038\/sj.bjc.6601834","article-title":"JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA)","volume":"90","author":"Ikezoe","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1038\/labinvest.2009.106_bib22","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0960-9822(06)00380-0","article-title":"A role for JNK\/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells","volume":"7","author":"Smith","year":"1997","journal-title":"Curr Biol"},{"key":"10.1038\/labinvest.2009.106_bib23","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1182\/blood-2004-10-3819","article-title":"c-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells","volume":"106","author":"Gururajan","year":"2005","journal-title":"Blood"},{"key":"10.1038\/labinvest.2009.106_bib24","first-page":"5307","article-title":"Mutational analysis of the peroxisome proliferator-activated receptor gamma gene in human malignancies","volume":"61","author":"Ikezoe","year":"2001","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.2009.106_bib25","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/sj.leu.2404622","article-title":"Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-kappaB signal pathway","volume":"21","author":"Nishioka","year":"2007","journal-title":"Leukemia"},{"key":"10.1038\/labinvest.2009.106_bib26","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1124\/mol.64.6.1521","article-title":"PC-SPES: a potent inhibitor of nuclear factor-kappa B rescues mice from lipopolysaccharide-induced septic shock","volume":"64","author":"Ikezoe","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1038\/labinvest.2009.106_bib27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors","volume":"22","author":"Chou","year":"1984","journal-title":"Adv Enzyme Regul"},{"key":"10.1038\/labinvest.2009.106_bib28","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1046\/j.1365-2141.2003.04311.x","article-title":"Aurora2\/BTAK\/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non-Hodgkin's lymphoma","volume":"121","author":"Hamada","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1038\/labinvest.2009.106_bib29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrc1841","article-title":"Targeting polo-like kinase 1 for cancer therapy","volume":"6","author":"Strebhardt","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/labinvest.2009.106_bib30","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1080\/10428190701615918","article-title":"Expression of PLK1 and survivin in diffuse large B-cell lymphoma","volume":"48","author":"Liu","year":"2007","journal-title":"Leuk Lymphoma"},{"key":"10.1038\/labinvest.2009.106_bib31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/10428190400015709","article-title":"Expression of Polo-Like Kinase (PLK1) in non-Hodgkin\u2019s lymphomas","volume":"46","author":"Mito","year":"2005","journal-title":"Leuk Lymphoma"},{"key":"10.1038\/labinvest.2009.106_bib32","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/leu.2009.94","article-title":"A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies","volume":"23","author":"Ikezoe","year":"2009","journal-title":"Leukemia"},{"key":"10.1038\/labinvest.2009.106_bib33","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1073\/pnas.0608798104","article-title":"Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase","volume":"104","author":"Manfredi","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.2009.106_bib34","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nm1003","article-title":"VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo","volume":"10","author":"Harrington","year":"2004","journal-title":"Nat Med"},{"key":"10.1038\/labinvest.2009.106_bib35","doi-asserted-by":"crossref","first-page":"7247","DOI":"10.1021\/jm060897w","article-title":"1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent aurora kinase inhibitor with a favorable antitumor kinase inhibition profile","volume":"49","author":"Fancelli","year":"2006","journal-title":"J Med Chem"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest2009106.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2009106","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722025648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722025648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2009106.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:49:19Z","timestamp":1758397759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722025648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0023683722025648"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2009.106","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of Aurora B kinase in non-Hodgkin lymphoma","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2009.106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2009.120","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}