{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:46:00Z","timestamp":1761957960554,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4789,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1038\/labinvest.2009.108","type":"journal-article","created":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T13:16:41Z","timestamp":1254748601000},"page":"1332-1339","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Potentiation of a functional autoantibody in narcolepsy by a cholinesterase inhibitor"],"prefix":"10.1016","volume":"89","author":[{"given":"Michael W","family":"Jackson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas J","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne H","family":"Reed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J F","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom P","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2009.108_bib1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/00004691-200103000-00002","article-title":"Narcolepsy: clinical features, new pathophysiologic insights, and future perspectives","volume":"18","author":"Overeem","year":"2001","journal-title":"J Clin Neurophysiol"},{"key":"10.1038\/labinvest.2009.108_bib2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/ana.10444","article-title":"The neurobiology, diagnosis, and treatment of narcolepsy","volume":"53","author":"Scammell","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1038\/labinvest.2009.108_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0140-6736(99)05582-8","article-title":"Hypocretin (orexin) deficiency in human narcolepsy","volume":"355","author":"Nishino","year":"2000","journal-title":"Lancet"},{"key":"10.1038\/labinvest.2009.108_bib4","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/79690","article-title":"A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains","volume":"6","author":"Peyron","year":"2000","journal-title":"Nat Med"},{"key":"10.1038\/labinvest.2009.108_bib5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0896-6273(00)00058-1","article-title":"Reduced number of hypocretin neurons in human narcolepsy","volume":"27","author":"Thannickal","year":"2000","journal-title":"Neuron"},{"key":"10.1038\/labinvest.2009.108_bib6","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1212\/WNL.48.6.1550","article-title":"HLA DR15 (DR2) and DQB1*0602 typing studies in 188 narcoleptic patients with cataplexy","volume":"48","author":"Rogers","year":"1997","journal-title":"Neurology"},{"key":"10.1038\/labinvest.2009.108_bib7","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1086\/318799","article-title":"Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups","volume":"68","author":"Mignot","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1038\/labinvest.2009.108_bib8","unstructured":"Hallmayer J, Faraco J, Lin L, et al. Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nature Genetics print copy in press May 2009. Available from: URL: www.nature.com\/ng\/journal\/vaop\/ncurrent\/abs\/ng.372.html."},{"key":"10.1038\/labinvest.2009.108_bib9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1080\/02646830500381492","article-title":"Narcolepsy: a review of evidence for autoimmune diathesis","volume":"17","author":"Black","year":"2005","journal-title":"Int Rev Psychiatry"},{"key":"10.1038\/labinvest.2009.108_bib10","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/sleep\/29.5.601","article-title":"The frustrating and mostly fruitless search for an autoimmune cause of narcolepsy","volume":"29","author":"Scammell","year":"2006","journal-title":"Sleep"},{"key":"10.1038\/labinvest.2009.108_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.smrv.2007.07.010","article-title":"Narcolepsy: immunological aspects","volume":"12","author":"Overeem","year":"2008","journal-title":"Sleep Med Rev"},{"key":"10.1038\/labinvest.2009.108_bib12","doi-asserted-by":"crossref","first-page":"e4254","DOI":"10.1371\/journal.pone.0004254","article-title":"IGFBP3 colocalizes with and regulates hypocretin (orexin)","volume":"4","author":"Honda","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1038\/labinvest.2009.108_bib13","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/ng.231","article-title":"Variant between CPT1B and CHKB associated with susceptibility to narcolepsy","volume":"40","author":"Miyagawa","year":"2008","journal-title":"Nat Genet"},{"key":"10.1038\/labinvest.2009.108_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0301-0082(96)00070-6","article-title":"Pharmacological aspects of human and canine narcolepsy","volume":"52","author":"Nishino","year":"1997","journal-title":"Prog Neurobiol"},{"key":"10.1038\/labinvest.2009.108_bib15","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1212\/WNL.50.2_Suppl_1.S8","article-title":"Investigations into the neurologic basis of narcolepsy","volume":"50","author":"Guilleminault","year":"1998","journal-title":"Neurology"},{"key":"10.1038\/labinvest.2009.108_bib16","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1053\/j.gastro.2003.12.015","article-title":"Disruption of intestinal motility by a calcium channel-stimulating autoantibody in type 1 diabetes","volume":"126","author":"Jackson","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2009.108_bib17","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1002\/art.20625","article-title":"Passive transfer of Sjogren\u2019s syndrome IgG produces the pathophysiology of overactive bladder","volume":"50","author":"Wang","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1038\/labinvest.2009.108_bib18","series-title":"The Autoimmune Diseases","first-page":"217","article-title":"Functional effects of autoantibodies","author":"Waterman","year":"2006"},{"key":"10.1038\/labinvest.2009.108_bib19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1365-3083.2006.01877.x","article-title":"Autoantibody-mediated bladder dysfunction in type 1 diabetes","volume":"65","author":"Wan","year":"2007","journal-title":"Scand J Immunol"},{"key":"10.1038\/labinvest.2009.108_bib20","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jaut.2008.03.004","article-title":"Autoantibodies to calcium channels in type 1 diabetes mediate autonomic dysfunction by different mechanisms in colon and bladder and are neutralized by antiidiotypic antibodies","volume":"31","author":"Wan","year":"2008","journal-title":"J Autoimmun"},{"key":"10.1038\/labinvest.2009.108_bib21","doi-asserted-by":"crossref","first-page":"13303","DOI":"10.1523\/JNEUROSCI.4489-08.2008","article-title":"An autoantibody in narcolepsy disrupts colonic migrating motor complexes","volume":"28","author":"Jackson","year":"2008","journal-title":"J Neurosci"},{"key":"10.1038\/labinvest.2009.108_bib22","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0300-9084(00)01174-3","article-title":"Molecular mechanisms of neurotoxin action on voltage-gated sodium channels","volume":"82","author":"Cestele","year":"2000","journal-title":"Biochimie"},{"key":"10.1038\/labinvest.2009.108_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1365-2982.1997.d01-25.x","article-title":"Colonic migrating motor complexes (CMMCs) in the isolated mouse colon","volume":"9","author":"Fida","year":"1997","journal-title":"Neurogastroenterol Motil"},{"key":"10.1038\/labinvest.2009.108_bib24","first-page":"S795","article-title":"Functional autoantibodies in primary Sjogren's syndrome disrupt gastrointestinal tract motility by targeting the muscarinic 3 receptor. American College of Rheumatology","volume":"pp","author":"Park","year":"2008","journal-title":"Arthritis Rheum, San Francisco"},{"key":"10.1038\/labinvest.2009.108_bib25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0003-9861(69)90285-9","article-title":"The isolation of IgG from mammalian sera with the aid of caprylic acid","volume":"134","author":"Steinbuch","year":"1969","journal-title":"Arch Biochem Biophys"},{"key":"10.1038\/labinvest.2009.108_bib26","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1002\/art.11343","article-title":"Antiidiotypic antibodies neutralize autoantibodies that inhibit cholinergic neurotransmission","volume":"48","author":"Cavill","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1038\/labinvest.2009.108_bib27","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1113\/jphysiol.2005.083600","article-title":"Synchronization of enteric neuronal firing during the murine colonic MMC","volume":"564","author":"Spencer","year":"2005","journal-title":"J Physiol"},{"key":"10.1038\/labinvest.2009.108_bib28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/08916930310001604199","article-title":"Thyrotropin receptor autoantibodies (TSHRAbs): epitopes, origins and clinical significance","volume":"36","author":"Kohn","year":"2003","journal-title":"Autoimmunity"},{"key":"10.1038\/labinvest.2009.108_bib29","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1016\/S0140-6736(04)17553-3","article-title":"A functional autoantibody in narcolepsy","volume":"364","author":"Smith","year":"2004","journal-title":"Lancet"},{"key":"10.1038\/labinvest.2009.108_bib30","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/S1471-4892(01)00103-5","article-title":"Control of migrating motor activity in the colon","volume":"1","author":"Spencer","year":"2001","journal-title":"Curr Opin Pharmacol"},{"key":"10.1038\/labinvest.2009.108_bib31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1113\/jphysiol.1984.sp015059","article-title":"Acetylcholine storage, release and leakage at the neuromuscular junction of mature adult and aged rats","volume":"347","author":"Smith","year":"1984","journal-title":"J Physiol"},{"key":"10.1038\/labinvest.2009.108_bib32","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1476-5381.2009.00166.x","article-title":"Spontaneous release of acetylcholine from autonomic nerves in the bladder","volume":"157","author":"Zagorodnyuk","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1038\/labinvest.2009.108_bib33","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/0014-4886(79)90218-8","article-title":"Cholinergic mechanisms and cataplexy in dogs","volume":"66","author":"Delashaw","year":"1979","journal-title":"Exp Neurol"},{"key":"10.1038\/labinvest.2009.108_bib34","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1523\/JNEUROSCI.15-07-04806.1995","article-title":"Muscle atonia is triggered by cholinergic stimulation of the basal forebrain: implication for the pathophysiology of canine narcolepsy","volume":"15","author":"Nishino","year":"1995","journal-title":"J Neurosci"},{"key":"10.1038\/labinvest.2009.108_bib35","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/0306-4522(94)90173-2","article-title":"Cholinergic mechanisms in canine narcolepsy\u2014I. Modulation of cataplexy via local drug administration into the pontine reticular formation","volume":"59","author":"Reid","year":"1994","journal-title":"Neuroscience"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest2009108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2009108","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722025600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722025600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2009108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:49:11Z","timestamp":1758397751000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722025600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0023683722025600"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2009.108","relation":{},"ISSN":["0023-6837"],"issn-type":[{"type":"print","value":"0023-6837"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potentiation of a functional autoantibody in narcolepsy by a cholinesterase inhibitor","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2009.108","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2009.120","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}