{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:52:42Z","timestamp":1787503962267,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4880,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1038\/labinvest.2009.58","type":"journal-article","created":{"date-parts":[[2009,6,22]],"date-time":"2009-06-22T10:30:12Z","timestamp":1245666612000},"page":"1007-1017","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Osteopetrosis with micro-lacunar resorption because of defective integrin organization"],"prefix":"10.1016","volume":"89","author":[{"given":"Harry C","family":"Blair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice B","family":"Yaroslavskiy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus Y","family":"Mapara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Pangrazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lida","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Vezzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Tolar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"Orchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2009.58_bib1","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1056\/NEJMra040952","article-title":"Osteopetrosis","volume":"351","author":"Tolar","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1038\/labinvest.2009.58_bib2","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1126\/science.2528207","article-title":"Osteoclastic bone resorption by a polarized vacuolar proton pump","volume":"245","author":"Blair","year":"1989","journal-title":"Science"},{"key":"10.1038\/labinvest.2009.58_bib3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/70563","article-title":"Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification","volume":"23","author":"Li","year":"1999","journal-title":"Nat Genet"},{"key":"10.1038\/labinvest.2009.58_bib4","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1359\/JBMR.040403","article-title":"In vitro differentiation of CD14 cells from osteopetrotic subjects: contrasting phenotypes with TCIRG1, CLCN7, and attachment defects","volume":"19","author":"Blair","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1038\/labinvest.2009.58_bib5","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nature03860","article-title":"Voltage-dependent electrogenic chloride\/proton exchange by endosomal CLC proteins","volume":"436","author":"Scheel","year":"2005","journal-title":"Nature"},{"key":"10.1038\/labinvest.2009.58_bib6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(01)00206-9","article-title":"Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man","volume":"104","author":"Kornak","year":"2001","journal-title":"Cell"},{"key":"10.1038\/labinvest.2009.58_bib7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature04535","article-title":"ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function","volume":"440","author":"Lange","year":"2006","journal-title":"Nature"},{"key":"10.1038\/labinvest.2009.58_bib8","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1172\/JCI30328","article-title":"Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans","volume":"117","author":"Van Wesenbeeck","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2009.58_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11154-006-9010-4","article-title":"Osteoclastic differentiation and function regulated by old and new pathways","volume":"7","author":"Blair","year":"2006","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1038\/labinvest.2009.58_bib10","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/ng2076","article-title":"Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL","volume":"39","author":"Sobacchi","year":"2007","journal-title":"Nat Genet"},{"key":"10.1038\/labinvest.2009.58_bib11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nm1194","article-title":"Vav3 regulates osteoclast function and bone mass","volume":"11","author":"Faccio","year":"2005","journal-title":"Nat Med"},{"key":"10.1038\/labinvest.2009.58_bib12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ajhg.2008.06.015","article-title":"Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations","volume":"83","author":"Guerrini","year":"2008","journal-title":"Am J Hum Genet"},{"key":"10.1038\/labinvest.2009.58_bib13","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1046\/j.1365-2141.2003.04530.x","article-title":"Upregulation of osteoclast \u03b12\u03b21 integrin compensates for lack of \u03b1v\u03b23 vitronectin receptor in Iraqi-Jewish-type Glanzmann thrombasthenia","volume":"122","author":"Horton","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1038\/labinvest.2009.58_bib14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/77131","article-title":"Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis","volume":"25","author":"Frattini","year":"2000","journal-title":"Nat Genet"},{"key":"10.1038\/labinvest.2009.58_bib15","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.yexcr.2009.01.014","article-title":"Estrogen inhibits RANKL-stimulated osteoclastic differentiation of human monocytes through estrogen and RANKL-regulated interaction of ER-\u03b1 with BCAR1 and Traf6","volume":"315","author":"Robinson","year":"2009","journal-title":"Exp Cell Res"},{"key":"10.1038\/labinvest.2009.58_bib16","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/jcb.20009","article-title":"Autocrine and paracrine nitric oxide regulate attachment of human osteoclasts","volume":"91","author":"Yaroslavskiy","year":"2004","journal-title":"J Cell Biochem"},{"key":"10.1038\/labinvest.2009.58_bib17","doi-asserted-by":"crossref","first-page":"C694","DOI":"10.1152\/ajpcell.1993.264.3.C694","article-title":"Acid and base effects on avian osteoclast activity","volume":"264","author":"Carano","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1038\/labinvest.2009.58_bib18","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/path.1190","article-title":"Proinflammatory cytokine (TNF\u03b1\/IL-1a) induction of human osteoclast formation","volume":"198","author":"Kudo","year":"2002","journal-title":"J Pathol"},{"key":"10.1038\/labinvest.2009.58_bib19","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.4161\/cc.6.24.5105","article-title":"The dissection of human autosomal recessive osteopetrosis identifies an osteoclast-poor form due to RANKL deficiency","volume":"6","author":"Frattini","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1038\/labinvest.2009.58_bib20","first-page":"189","article-title":"Recent advances in osteoclast biology and pathological bone resorption","volume":"19","author":"Blair","year":"2004","journal-title":"Histol Histopathol"},{"key":"10.1038\/labinvest.2009.58_bib21","doi-asserted-by":"crossref","first-page":"9901","DOI":"10.1016\/S0021-9258(18)98430-9","article-title":"Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin \u03b1v\u03b23 potentiate bone resorption","volume":"268","author":"Ross","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2009.58_bib22","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1210\/endo.138.4.5070","article-title":"Effects of prostaglandins on human hematopoietic osteoclast precursors","volume":"138","author":"Roux","year":"1997","journal-title":"Endocrinology"},{"key":"10.1038\/labinvest.2009.58_bib23","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0092-8674(00)81618-9","article-title":"Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all \u03b1v integrins","volume":"95","author":"Bader","year":"1998","journal-title":"Cell"},{"key":"10.1038\/labinvest.2009.58_bib24","doi-asserted-by":"crossref","first-page":"45368","DOI":"10.1074\/jbc.M308786200","article-title":"\u03b21 integrin\/focal adhesion kinase-mediated signaling induces intercellular adhesion molecule 1 and receptor activator of nuclear factor \u03baB ligand on osteoblasts and osteoclast maturation","volume":"278","author":"Nakayamada","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2009.58_bib25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1359\/jbmr.1999.14.1.32","article-title":"The integrin \u03b1v\u03b25 is expressed on avian osteoclast precursors and regulated by retinoic acid","volume":"14","author":"Sago","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1038\/labinvest.2009.58_bib26","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/12021","article-title":"Selective regulation of integrin\u2014cytoskeleton interactions by the tyrosine kinase Src","volume":"1","author":"Felsenfeld","year":"1999","journal-title":"Nat Cell Biol"},{"key":"10.1038\/labinvest.2009.58_bib27","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1242\/jcs.02655","article-title":"NO-dependent osteoclast motility: reliance on cGMP-dependent protein kinase I and VASP","volume":"118","author":"Yaroslavskiy","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1038\/labinvest.2009.58_bib28","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1242\/jcs.004184","article-title":"Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility","volume":"120","author":"Yaroslavskiy","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1038\/labinvest.2009.58_bib29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3109\/s10165-006-0460-z","article-title":"The role of c-Src kinase in the regulation of osteoclast function","volume":"16","author":"Miyazaki","year":"2006","journal-title":"Mod Rheumatol"},{"key":"10.1038\/labinvest.2009.58_bib30","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1359\/jbmr.070109","article-title":"Are nonresorbing osteoclasts sources of bone anabolic activity?","volume":"22","author":"Karsdal","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1038\/labinvest.2009.58_bib31","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s00277-002-0571-3","article-title":"Osteopetrosis and Glanzmann's thrombasthenia in a child","volume":"82","author":"Yarali","year":"2003","journal-title":"Ann Hematol"},{"key":"10.1038\/labinvest.2009.58_bib32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ejcb.2005.09.002","article-title":"Integrin-linked kinase and its partners: a modular platform regulating cell-matrix adhesion dynamics and cytoskeletal organization","volume":"85","author":"Boulter","year":"2006","journal-title":"Eur J Cell Biol"},{"key":"10.1038\/labinvest.2009.58_bib33","first-page":"2033","article-title":"Increased expression of a novel osteoclast-stimulating factor, ADAM8, in interface tissue around loosened hip prostheses","volume":"30","author":"Mandelin","year":"2003","journal-title":"J Rheumatol"},{"key":"10.1038\/labinvest.2009.58_bib34","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1136\/ard.2008.088260","article-title":"Involvement of ADAM8 in osteoclastogenesis and pathological bone destruction","volume":"68","author":"Ainola","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1038\/labinvest.2009.58_bib35","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1242\/jcs.01331","article-title":"ILK is required for the assembly of matrix-forming adhesions and capillary morphogenesis in endothelial cells","volume":"117","author":"Vouret-Craviari","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1038\/labinvest.2009.58_bib36","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1074\/jbc.M108673200","article-title":"Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-\u03baB-dependent manner","volume":"277","author":"Tan","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2009.58_bib37","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1074\/jbc.M805777200","article-title":"Impaired micro-RNA pathways diminish osteoclast differentiation and function","volume":"284","author":"Sugatani","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2009.58_bib38","doi-asserted-by":"crossref","first-page":"6698","DOI":"10.1038\/onc.2008.282","article-title":"Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma","volume":"27","author":"M\u00fcller","year":"2008","journal-title":"Oncogene"},{"key":"10.1038\/labinvest.2009.58_bib39","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/carcin\/bgn126","article-title":"Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer","volume":"29","author":"Brendle","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1038\/labinvest.2009.58_bib40","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/S0960-9822(07)00559-3","article-title":"Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1","volume":"8","author":"Miranti","year":"1998","journal-title":"Curr Biol"},{"key":"10.1038\/labinvest.2009.58_bib41","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/eji.200323858","article-title":"Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse","volume":"33","author":"Ardouin","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1038\/labinvest.2009.58_bib42","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1172\/JCI32729","article-title":"Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice","volume":"117","author":"Graham","year":"2007","journal-title":"J Clin Invest"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest200958.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest200958","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372202966X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372202966X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest200958.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:53:33Z","timestamp":1758398013000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002368372202966X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S002368372202966X"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2009.58","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Osteopetrosis with micro-lacunar resorption because of defective integrin organization","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2009.58","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}