{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:56:10Z","timestamp":1789012570983,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4850,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1038\/labinvest.2009.81","type":"journal-article","created":{"date-parts":[[2009,8,10]],"date-time":"2009-08-10T10:28:29Z","timestamp":1249900109000},"page":"1182-1186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["IGH and IGK gene rearrangements as PCR targets for pediatric Burkitt's lymphoma and mature B-ALL MRD analysis"],"prefix":"10.1016","volume":"89","author":[{"given":"Federica","family":"Lovisa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Mussolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia","family":"Corral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cazzaniga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Biondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Rosolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2009.81_bib1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0145-2126(80)90045-4","article-title":"Bone marrow involvement in Burkitt's lymphoma and its relationship to acute B-cell leukemia","volume":"4","author":"Magrath","year":"1980","journal-title":"Leuk Res"},{"key":"10.1038\/labinvest.2009.81_bib2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2141.1976.tb03563.x","article-title":"Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group","volume":"33","author":"Bennett","year":"1976","journal-title":"Br J Haematol"},{"key":"10.1038\/labinvest.2009.81_bib3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2141.1979.tb03723.x","article-title":"t(8;14) translocation in a Burkitt's type of lymphoblastic leukaemia (L3)","volume":"43","author":"Berger","year":"1979","journal-title":"Br J Haematol"},{"key":"10.1038\/labinvest.2009.81_bib4","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1073\/pnas.79.18.5611","article-title":"Translocation of immunoglobulin VH genes in Burkitt lymphoma","volume":"79","author":"Erikson","year":"1982","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.2009.81_bib5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/sj.leu.2402828","article-title":"Prospective analysis of minimal bone marrow infiltration in pediatric Burkitt's lymphomas by long-distance polymerase chain reaction for t(8;14)(q24;q32)","volume":"17","author":"Mussolin","year":"2003","journal-title":"Leukemia"},{"key":"10.1038\/labinvest.2009.81_bib6","doi-asserted-by":"crossref","first-page":"5254","DOI":"10.1200\/JCO.2007.11.3159","article-title":"Prognostic role of minimal residual disease in mature B-cell acute lymphoblastic leukemia of childhood","volume":"25","author":"Mussolin","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1038\/labinvest.2009.81_bib7","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/S0140-6736(98)04058-6","article-title":"Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood","volume":"352","author":"van Dongen","year":"1998","journal-title":"Lancet"},{"key":"10.1038\/labinvest.2009.81_bib8","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/sj.leu.2402206","article-title":"Precursor-B-ALL with D(H)-J(H) gene rearrangements have an immature immunogenotype with a high frequency of oligoclonality and hyperdiploidy of chromosome 14","volume":"15","author":"Szczepanski","year":"2001","journal-title":"Leukemia"},{"key":"10.1038\/labinvest.2009.81_bib9","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936","volume":"17","author":"van Dongen","year":"2003","journal-title":"Leukemia"},{"key":"10.1038\/labinvest.2009.81_bib10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/sj.leu.2401245","volume":"13","author":"Pongers-Willemse","year":"1999","journal-title":"Leukemia"},{"key":"10.1038\/labinvest.2009.81_bib11","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1038\/sj.leu.2400887","article-title":"Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations","volume":"11","author":"Langerak","year":"1997","journal-title":"Leukemia"},{"key":"10.1038\/labinvest.2009.81_bib12","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/leu.2008.5","article-title":"Minimal residual disease-directed risk stratification using real-time quantitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements in the international multicenter trial AIEOP-BFM ALL 2000 for childhood acute lymphoblastic leukemia","volume":"22","author":"Flohr","year":"2008","journal-title":"Leukemia"},{"key":"10.1038\/labinvest.2009.81_bib13","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1038\/sj.leu.2401246","article-title":"Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes","volume":"12","author":"Pongers-Willemse","year":"1998","journal-title":"Leukemia"},{"key":"10.1038\/labinvest.2009.81_bib14","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/sj.leu.2404586","article-title":"Analysis of minimal residual disease by Ig\/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data","volume":"21","author":"van der Velden","year":"2007","journal-title":"Leukemia"},{"key":"10.1038\/labinvest.2009.81_bib15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4049\/jimmunol.155.1.190","article-title":"Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction","volume":"155","author":"Brezinschek","year":"1995","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.2009.81_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1745-7580-4-3","article-title":"Large-scale analysis of human heavy chain V(D)J recombination patterns","volume":"4","author":"Volpe","year":"2008","journal-title":"Immunome Res"},{"key":"10.1038\/labinvest.2009.81_bib17","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1084\/jem.173.2.395","article-title":"Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes","volume":"173","author":"Yamada","year":"1991","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.2009.81_bib18","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1172\/JCI119324","article-title":"Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells","volume":"99","author":"Foster","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2009.81_bib19","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1002\/eji.1830231231","article-title":"Expressed human immunoglobulin kappa genes and their hypermutation","volume":"23","author":"Klein","year":"1993","journal-title":"Eur J Immunol"},{"key":"10.1038\/labinvest.2009.81_bib20","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1038\/sj.leu.2400904","article-title":"Heterogeneity in junctional regions of immunoglobulin kappa deleting element rearrangements in B cell leukemias: a new molecular target for detection of minimal residual disease","volume":"11","author":"Beishuizen","year":"1997","journal-title":"Leukemia"},{"key":"10.1038\/labinvest.2009.81_bib21","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.biocel.2004.09.007","article-title":"B cells","volume":"37","author":"Ollila","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1038\/labinvest.2009.81_bib22","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.4049\/jimmunol.152.7.3467","article-title":"Limited junctional diversity in kappa light chains. Junctional sequences from CD43+B220+ early B cell progenitors resemble those from peripheral B cells","volume":"152","author":"Victor","year":"1994","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.2009.81_bib23","first-page":"382","article-title":"Molecular monitoring of childhood acute lymphoblastic leukemia using antigen receptor gene rearrangements and quantitative polymerase chain reaction technology","volume":"90","author":"Cazzaniga","year":"2005","journal-title":"Haematologica"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest200981.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest200981","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722029592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722029592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest200981.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:53:48Z","timestamp":1758398028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722029592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0023683722029592"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2009.81","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IGH and IGK gene rearrangements as PCR targets for pediatric Burkitt's lymphoma and mature B-ALL MRD analysis","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2009.81","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2009.100","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}