{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:40:24Z","timestamp":1790394024308,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4819,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1038\/labinvest.2009.90","type":"journal-article","created":{"date-parts":[[2009,9,7]],"date-time":"2009-09-07T10:26:45Z","timestamp":1252319205000},"page":"1291-1303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Helicobacter pylori promotes hepatic fibrosis in the animal model"],"prefix":"10.1016","volume":"89","author":[{"given":"Moon-Jung","family":"Goo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Ran","family":"Ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Rim","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Wei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Hwa","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Kyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Sook","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Youn","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ok-Kyung","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Hee","family":"Do","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald D","family":"Cohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Shik","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2009.90_bib1","first-page":"32","article-title":"Helicobacter infection, chronic inflammation, and the development of malignancy","volume":"21","author":"Crowe","year":"2005","journal-title":"Curr Opin Gastroenterol"},{"issue":"Suppl","key":"10.1038\/labinvest.2009.90_bib2","first-page":"271","article-title":"Correlation between liver damage and degree of gastric mucosae colonisation by Helicobacter pylori in subjects with parenchymatous liver damage","volume":"7","author":"Stalke","year":"2001","journal-title":"Med Sci Monit"},{"key":"10.1038\/labinvest.2009.90_bib3","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0168-8278(00)80018-5","article-title":"Helicobacter pylori seroprevalance in hepatitis C virus positive patients with cirrhosis","volume":"33","author":"Pellicano","year":"2000","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2009.90_bib4","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1128\/jcm.34.10.2479-2482.1996","article-title":"Helicobacter canis isolated from a dog liver with multifocal necrotizing hepatitis","volume":"34","author":"Fox","year":"1996","journal-title":"J Clin Microbiol"},{"key":"10.1038\/labinvest.2009.90_bib5","first-page":"321","article-title":"Helicobacter pylori infection in patients with hepatitis C virus positive chronic liver diseases","volume":"26","author":"Ponzetto","year":"2003","journal-title":"New Microbiol"},{"key":"10.1038\/labinvest.2009.90_bib6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0300-2977(00)00033-4","article-title":"Helicobacter pylori seroprevalence in cirrhotic patients with hepatitis B virus infection","volume":"56","author":"Ponzetto","year":"2000","journal-title":"Neth J Med"},{"key":"10.1038\/labinvest.2009.90_bib7","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/S0168-8278(97)80459-X","article-title":"Seroprevalence and epidemiology of Helicobacter pylori infections in patients with cirrhosis","volume":"26","author":"Calvet","year":"1997","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2009.90_bib8","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1128\/JCM.38.3.1072-1076.2000","article-title":"Identification of Helicobacter pylori and other Helicobacter species by PCR, hybridization, and partial DNA sequencing in human liver samples from patients with primary sclerosing cholangitis or primary biliary cirrhosis","volume":"38","author":"Nilsson","year":"2000","journal-title":"Clin Microbiol"},{"key":"10.1038\/labinvest.2009.90_bib9","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1002\/1097-0142(20001001)89:7<1431::AID-CNCR4>3.0.CO;2-5","article-title":"Detection of Helicobacter species in the liver of patients with and without primary liver carcinoma","volume":"89","author":"Avenaud","year":"2000","journal-title":"Cancer"},{"key":"10.1038\/labinvest.2009.90_bib10","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jhep.2004.03.007","article-title":"Cirrhosis reversal: a duel between dogma and myth","volume":"40","author":"Desmet","year":"2004","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2009.90_bib11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1357-2725(03)00253-X","article-title":"Expression of hyaluronic acid in N-nitrosodimethylamine induced hepatic fibrosis in rats","volume":"36","author":"George","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1038\/labinvest.2009.90_bib12","first-page":"780","article-title":"Experimental study on the pathological effect of Helicobacter pylori on liver tissues","volume":"13","author":"Tian","year":"2005","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"10.1038\/labinvest.2009.90_bib13","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1034\/j.1600-0463.2003.1110410.x","article-title":"Two-year follow-up of Helicobacter pylori infection in C57BL\/6 and Balb\/cA mice","volume":"111","author":"Wang","year":"2003","journal-title":"APMIS"},{"key":"10.1038\/labinvest.2009.90_bib14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1099\/00222615-42-1-48","article-title":"In-vitro hepatotoxic factor in Helicobacter hepaticusH. pylori and other Helicobacter species","volume":"42","author":"Taylor","year":"1995","journal-title":"J Med Microbiol"},{"key":"10.1038\/labinvest.2009.90_bib15","first-page":"44","article-title":"In vitro cytotoxicity of Helicobacter pylori on hepatocarcinoma HepG2 cells","volume":"23","author":"Chen","year":"2004","journal-title":"Ai Zheng"},{"key":"10.1038\/labinvest.2009.90_bib16","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/S0016-5085(97)70155-0","article-title":"A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain","volume":"112","author":"Lee","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2009.90_bib17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1124\/mol.107.039818","article-title":"Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation","volume":"73","author":"Fu","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1038\/labinvest.2009.90_bib18","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2613.2008.00607.x","article-title":"Embryonic stem cells reduce liver fibrosis in CCl4-treated mice","volume":"89","author":"Oriya","year":"2008","journal-title":"Int J Exp Pathol"},{"key":"10.1038\/labinvest.2009.90_bib19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/BF00790046","article-title":"Functional state of the hematopoietic system in different stages of CCL4-induced liver fibrosis in mice","volume":"114","author":"Zubakhin","year":"1992","journal-title":"Biull Eksp Biol Med"},{"key":"10.1038\/labinvest.2009.90_bib20","first-page":"407A","article-title":"A novel semi-quantitative histological scoring system for nonalcoholic fatty liver disease: evaluation and clinical correlations","volume":"36","author":"Mendler","year":"2002","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2009.90_bib21","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.3748\/wjg.v11.i8.1141","article-title":"Alterations of mast cells and TGF-beta1 on the silymarin treatment for CCl(4)-induced hepatic fibrosis","volume":"11","author":"Jeong","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1038\/labinvest.2009.90_bib22","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1097\/MEG.0b013e3282f5e9db","article-title":"Primary biliary cirrhosis, similar to that in human beings, in a male C57BL\/6 mouse infected with Helicobacter pylori","volume":"20","author":"Goo","year":"2008","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1038\/labinvest.2009.90_bib23","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1096\/fj.04-2291fje","article-title":"A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats","volume":"19","author":"Carmiel-Haggai","year":"2005","journal-title":"FASEB J"},{"key":"10.1038\/labinvest.2009.90_bib24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/hep.20750","article-title":"Steatosis: co-factor in other liver diseases","volume":"42","author":"Powell","year":"2005","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2009.90_bib25","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1269\/jrr.0629","article-title":"Acute effects of fast neutron irradiation on mouse liver","volume":"48","author":"Jeong","year":"2007","journal-title":"J Radiat Res (Tokyo)"},{"key":"10.1038\/labinvest.2009.90_bib26","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/j.1872-034X.2007.00146.x","article-title":"Helicobacter pylori infection in hepatic encephalopathy: relationship to plasma endotoxins and blood ammonia","volume":"37","author":"Abdel-Hady","year":"2007","journal-title":"Hepatol Res"},{"key":"10.1038\/labinvest.2009.90_bib27","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1445-2197.2006.03763.x","article-title":"Effect of nitric oxide on the hypoglycaemic phase of endotoxaemia","volume":"76","author":"Engin","year":"2006","journal-title":"ANZ J Surg"},{"key":"10.1038\/labinvest.2009.90_bib28","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1084\/jem.110.3.389","article-title":"Effects of bacterial endotoxin on metabolism. I. Carbohydrate depletion and the protective role of cortisone","volume":"110","author":"Berry","year":"1959","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.2009.90_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1053\/jhep.2002.30083","article-title":"Differential regulation of TGF-beta signal in hepatic stellate cells between acute and chronic rat liver injury","volume":"35","author":"Tahashi","year":"2002","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2009.90_bib30","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0016-5085(03)00666-8","article-title":"Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats","volume":"125","author":"Dooley","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2009.90_bib31","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1042\/bj1230805","article-title":"The stimulatory effects of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver fractions in vitro. General features of the systems used","volume":"123","author":"Slater","year":"1971","journal-title":"Biochem J"},{"key":"10.1038\/labinvest.2009.90_bib32","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/hep.510270313","article-title":"Fibrogenic effect of oxidative stress on rat hepatic stellate cells","volume":"27","author":"Svegliati Baroni","year":"1998","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2009.90_bib33","first-page":"758","article-title":"Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism","volume":"13","author":"Casini","year":"1991","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2009.90_bib34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11010-007-9462-1","article-title":"Alterations in expression of senescence marker protein-30 gene by 3,3\u2032,5-triiodo-L: -thyronine (T(3))","volume":"303","author":"Sar","year":"2007","journal-title":"Mol Cell Biochem"},{"key":"10.1038\/labinvest.2009.90_bib35","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S0002-9440(10)64404-5","article-title":"Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-alpha- and Fas-mediated apoptosis","volume":"161","author":"Ishigami","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2009.90_bib36","first-page":"454","article-title":"Primary biliary cirrhosis and primary sclerosing cholangitis are of infectious origin!","volume":"49","author":"Wadstr\u00f6m","year":"2001","journal-title":"Gut"},{"key":"10.1038\/labinvest.2009.90_bib37","first-page":"675","article-title":"Immunohistochemical detection of Helicobacter pylori vacuolating cytotoxin in the hepatocytes of patients with isolated hypertransaminasaemia","volume":"3","author":"Francavilla","year":"1999","journal-title":"Ital J Gastroenterol Hepatol"},{"key":"10.1038\/labinvest.2009.90_bib38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1523-5378.1996.tb00037.x","article-title":"Hypothesis: Helicobacter toxins and liver","volume":"1","author":"Figura","year":"1996","journal-title":"Helicobacter"},{"key":"10.1038\/labinvest.2009.90_bib39","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1023\/A:1010691216207","article-title":"Characterization of virulence factors of mouse-adapted Helicobacter pylori strain SS1 and effects on gastric hydrophobicity","volume":"46","author":"Day","year":"2001","journal-title":"Dig Dis Sci"},{"key":"10.1038\/labinvest.2009.90_bib40","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.exger.2004.04.005","article-title":"Modulation of gene expression of SMP-30 by LPS and calorie restriction during aging process","volume":"39","author":"Jung","year":"2004","journal-title":"Exp Gerontol"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest200990.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest200990","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722029464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722029464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest200990.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:54:49Z","timestamp":1758398089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722029464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0023683722029464"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2009.90","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Helicobacter pylori promotes hepatic fibrosis in the animal model","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2009.90","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}