{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:03:58Z","timestamp":1791903838192,"version":"4.3.4"},"reference-count":56,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4485,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1038\/labinvest.2010.109","type":"journal-article","created":{"date-parts":[[2010,6,7]],"date-time":"2010-06-07T11:46:50Z","timestamp":1275911210000},"page":"1507-1516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Helicobacter pylori accelerates hepatic fibrosis by sensitizing transforming growth factor-\u03b21-induced inflammatory signaling"],"prefix":"10.1016","volume":"90","author":[{"given":"Mi-Ran","family":"Ki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon-Jung","family":"Goo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Kyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Hwa","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ae-Ri","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon-Young","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Young","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Mi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Joon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Joo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Yoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Shik","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11 Suppl","key":"10.1038\/labinvest.2010.109_bib1","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/S0002-9270(99)00657-7","article-title":"Helicobacter pylori: from the benign to the malignant","volume":"94","author":"Williams","year":"1999","journal-title":"Am J Gastroenterol"},{"issue":"5A","key":"10.1038\/labinvest.2010.109_bib2","doi-asserted-by":"crossref","first-page":"12S","DOI":"10.1016\/S0002-9343(96)80224-5","article-title":"Transmission and epidemiology of Helicobacter pylori","volume":"100","author":"Cave","year":"1996","journal-title":"Am J Med"},{"key":"10.1038\/labinvest.2010.109_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.1994.03520010077036","article-title":"NIH consensus development panel on Helicobacter pylori in peptic ulcer disease","volume":"272","author":"Yamada","year":"1994","journal-title":"J Am Med Assoc"},{"key":"10.1038\/labinvest.2010.109_bib4","first-page":"177","article-title":"Evaluation of carcinogenic risks to humans, schistosomes, liver flukes and Helicobacter pylori","volume":"61","author":"International Agency for research on Cancer","year":"1994","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"10.1038\/labinvest.2010.109_bib5","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"Uemura","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1038\/labinvest.2010.109_bib6","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1053\/j.gastro.2005.03.037","article-title":"Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers","volume":"128","author":"Houghton","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2010.109_bib7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.med.49.1.289","article-title":"Gastric lymphoma of mucosa-associated lymphoid tissue and Helicobacter pylori","volume":"49","author":"Wotherspoon","year":"1998","journal-title":"Annu Rev Med"},{"key":"10.1038\/labinvest.2010.109_bib8","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1182\/blood-2008-07-167155","article-title":"Effects of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura: a systematic review","volume":"113","author":"Stasi","year":"2009","journal-title":"Blood"},{"key":"10.1038\/labinvest.2010.109_bib9","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/01.CIR.0000023894.10871.2F","article-title":"Cytotoxin-associated gene-A\u2212-positive Helicobacter pylori strains are associated with atherosclerotic stroke","volume":"106","author":"Pietroiusti","year":"2002","journal-title":"Circulation"},{"key":"10.1038\/labinvest.2010.109_bib10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1001\/jama.286.3.327","article-title":"C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus","volume":"286","author":"Pradhan","year":"2001","journal-title":"JAMA"},{"key":"10.1038\/labinvest.2010.109_bib11","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.jacc.2005.01.019","article-title":"Association of Helicobacter pylori infection with systemic inflammation and endothelial dysfunction in healthy male subjects","volume":"45","author":"Oshima","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1038\/labinvest.2010.109_bib12","article-title":"Frequency of vacuolating cytotoxin A (VacA)-positive Helicobacter pylori seropositivity and TGF-beta(1) decrease in atrial fibrillation","author":"Ki","year":"2009","journal-title":"Int J Cardiol"},{"key":"10.1038\/labinvest.2010.109_bib13","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0140-6736(09)60872-2","article-title":"Eradication of insulin resistance","volume":"374","author":"Imai","year":"2009","journal-title":"Lancet"},{"key":"10.1038\/labinvest.2010.109_bib14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1054\/mehy.1999.0987","article-title":"Helicobacter infection and cirrhosis in hepatitis C virus carriage: is it an innocent bystander or a troublemaker?","volume":"54","author":"Ponzetto","year":"2000","journal-title":"Med Hypoth"},{"key":"10.1038\/labinvest.2010.109_bib15","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/gut.2004.042168","article-title":"Association of Helicobacter species with hepatitis C cirrhosis with or without hepatocellular carcinoma","volume":"54","author":"Rocha","year":"2005","journal-title":"Gut"},{"key":"10.1038\/labinvest.2010.109_bib16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0300-2977(00)00033-4","article-title":"Helicobacter pylori seroprevalence in cirrhotic patients with hepatitis B virus infection","volume":"56","author":"Ponzetto","year":"2000","journal-title":"Neth J Med"},{"key":"10.1038\/labinvest.2010.109_bib17","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.cdp.2003.07.004","article-title":"Helicobacter pylori seroprevalence in patients with cirrhosis of the liver and hepatocellular carcinoma","volume":"27","author":"Leone","year":"2003","journal-title":"Cancer Detect Prev"},{"key":"10.1038\/labinvest.2010.109_bib18","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1128\/JCM.38.3.1072-1076.2000","article-title":"Identification of Helicobacterpylori and other Helicobacter species by PCR, hybridization, and partial DNA sequencing in human liver samples from patients with primary sclerosing cholangitis or primary biliary cirrhosis","volume":"38","author":"Nilsson","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1038\/labinvest.2010.109_bib19","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1136\/jcp.2004.018556","article-title":"Identification of helicobacter species in human liver samples from patients with primary hepatocellular carcinoma","volume":"57","author":"Huang","year":"2004","journal-title":"J Clin Pathol"},{"key":"10.1038\/labinvest.2010.109_bib20","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1093\/jnci\/86.16.1222","article-title":"Chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel Helicobacter species","volume":"86","author":"Ward","year":"1994","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/labinvest.2010.109_bib21","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S1473-3099(08)70066-5","article-title":"Helicobacter species and liver diseases: association or causation?","volume":"8","author":"Pellicano","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"10.1038\/labinvest.2010.109_bib22","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/labinvest.2009.90","article-title":"Helicobacter pylori Promotes Hepatic Fibrosis in the Animal Model","volume":"89","author":"Goo","year":"2009","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.2010.109_bib23","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat Med"},{"key":"10.1038\/labinvest.2010.109_bib24","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0022-2275(20)32030-7","article-title":"An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro","volume":"41","author":"Vogel","year":"2000","journal-title":"J Lipid Res"},{"key":"10.1038\/labinvest.2010.109_bib25","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","article-title":"Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis","volume":"270","author":"Xia","year":"1995","journal-title":"Science"},{"key":"10.1038\/labinvest.2010.109_bib26","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1053\/gast.2000.9365","article-title":"Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells","volume":"119","author":"Marra","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2010.109_bib27","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1084\/jem.188.7.1277","article-title":"Coordinate activation of activator protein 1 and inflammatory cytokines in response to Neisseria gonorrhoeae epithelial cell contact involves stress response kinases","volume":"188","author":"Naumann","year":"1998","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.2010.109_bib28","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.2353\/ajpath.2006.050921","article-title":"ERK, p38, and Smad signaling pathway differentially regulate transforming growth factor-1 autoinduction in proximal tubular epithelial cells","volume":"169","author":"Zhang","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2010.109_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semi Immunol"},{"key":"10.1038\/labinvest.2010.109_bib30","doi-asserted-by":"crossref","first-page":"G635","DOI":"10.1152\/ajpgi.00281.2007","article-title":"Differential regulation of ERK1\/2 and p38 MAP kinases in VacA-induced apoptosis of gastric epithelial cells","volume":"294","author":"Ki","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1038\/labinvest.2010.109_bib31","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(94)90133-3","article-title":"Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells","volume":"77","author":"Cowley","year":"1994","journal-title":"Cell"},{"key":"10.1038\/labinvest.2010.109_bib32","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/jcp.10146","article-title":"Growth arrest in G1 protects against oxygen-induced DNA damage and cell death","volume":"193","author":"Rancourt","year":"2002","journal-title":"J Cell Physiol"},{"key":"10.1038\/labinvest.2010.109_bib33","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0168-8278(00)80398-0","article-title":"Stress-activated protein kinases in the activation of rat hepatic stellate cells in culture","volume":"32","author":"Reeves","year":"2000","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2010.109_bib34","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1074\/jbc.M109358200","article-title":"The IKK-2\/I\u03baB\u03b1\/NF\u03baB pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts. A critical link to dermatitis in I\u03baB\u03b1-deficient mice","volume":"277","author":"Huber","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2010.109_bib35","doi-asserted-by":"crossref","first-page":"18842","DOI":"10.1074\/jbc.M500620200","article-title":"Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light","volume":"280","author":"Tanos","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2010.109_bib36","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1096\/fj.04-2291fje","article-title":"A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats","volume":"19","author":"Carmiel-Haggai","year":"2005","journal-title":"FASEB J"},{"key":"10.1038\/labinvest.2010.109_bib37","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/j.1872-034X.2007.00146.x","article-title":"Helicobacter pylori infection in hepatic encephalopathy: relationship to plasma endotoxins and blood ammonia","volume":"37","author":"Abdel-Hady","year":"2007","journal-title":"Hepatol Res"},{"key":"10.1038\/labinvest.2010.109_bib38","doi-asserted-by":"crossref","first-page":"G256","DOI":"10.1152\/ajpgi.00550.2001","article-title":"Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation","volume":"283","author":"Su","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1038\/labinvest.2010.109_bib39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2010.109_bib40","first-page":"1029","article-title":"Transforming growth factor-beta and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2\/3 phosphorylation in rat hepatic stellate cells after acute liver injury","volume":"164","author":"Yoshida","year":"2005","journal-title":"Am J Pahtol"},{"key":"10.1038\/labinvest.2010.109_bib41","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1474-9726.2009.00517.x","article-title":"Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses","volume":"8","author":"Carlson","year":"2009","journal-title":"Aging Cell"},{"key":"10.1038\/labinvest.2010.109_bib42","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1053\/j.gastro.2008.07.006","article-title":"Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation","volume":"135","author":"Nakagawa","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2010.109_bib43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0955-0674(98)80143-9","article-title":"Signal transduction by c-Jun N-terminal kinase (JNK)-from inflammation to development","volume":"10","author":"Ip","year":"1998","journal-title":"Curr Opin Cell Biol"},{"key":"10.1038\/labinvest.2010.109_bib44","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1074\/jbc.273.7.4027","article-title":"Correlation between sustained c-Jun N-terminal protein kinase activation and apoptosis induced by tumor necrosis factor-alpha in rat mesangial cells","volume":"273","author":"Guo","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2010.109_bib45","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1053\/jhep.2003.50135","article-title":"c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration","volume":"37","author":"Schwabe","year":"2003","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2010.109_bib46","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1053\/j.gastro.2009.09.015","article-title":"Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition","volume":"138","author":"Kluwe","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2010.109_bib47","doi-asserted-by":"crossref","first-page":"22173","DOI":"10.1074\/jbc.M109.005355","article-title":"Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis","volume":"284","author":"Sommerfeld","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2010.109_bib48","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/S0891-5849(01)00748-1","article-title":"The role of Kupffer cell oxidant production in early ethanol-induced liver disease","volume":"31","author":"Wheeler","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1038\/labinvest.2010.109_bib49","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/hep.510290346","article-title":"Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C\/EBPbeta-dependent mechanism in rat hepatic stellate cells","volume":"29","author":"Garc\u00eda-Trevijano","year":"1999","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2010.109_bib50","doi-asserted-by":"crossref","first-page":"G660","DOI":"10.1152\/ajpgi.1996.270.4.G660","article-title":"Endotoxin stimulates gene expression of ROS-eliminating pathways in rat hepatic endothelial and Kupffer cells","volume":"270","author":"Spolarics","year":"1996","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1038\/labinvest.2010.109_bib51","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1093\/emboj\/cdf366","article-title":"TGF-\u03b2 receptor-activated p38 MAP kinase mediates Smad-independent TGF-\u03b2 responses","volume":"21","author":"Yu","year":"2002","journal-title":"EMBO J"},{"key":"10.1038\/labinvest.2010.109_bib52","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ceb.2009.01.021","article-title":"Mechanism of TGF-\u03b2 signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition","volume":"21","author":"Heldin","year":"2009","journal-title":"Curr Opin Cell Biol"},{"key":"10.1038\/labinvest.2010.109_bib53","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1096\/fj.06-7764com","article-title":"Homogeneous differentiation of hepatocytes-like cells from embryonic stem cells: applications for the treatment of liver failure","volume":"22","author":"Cho","year":"2008","journal-title":"FASEB J"},{"key":"10.1038\/labinvest.2010.109_bib54","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.bbrc.2006.11.029","article-title":"CD133+ hepatic stellate cells are progenitor cells","volume":"352","author":"Kordes","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/labinvest.2010.109_bib55","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0034-5288(95)90045-4","article-title":"Immunohistochemical evaluation of canine primary liver carcinomas: distribution of alpha-fetoprotein, carcinoembryonic antigen, keratins and vimentin","volume":"59","author":"Martin de las Mulas","year":"1995","journal-title":"Res Vet Sci"},{"key":"10.1038\/labinvest.2010.109_bib56","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3181\/0901-MR-12","article-title":"The epidermal growth factor receptor: a link between inflammation and liver cancer","volume":"234","author":"Berasain","year":"2009","journal-title":"Exp Biol Med"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest2010109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2010109","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722028598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722028598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2010109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:53:37Z","timestamp":1758398017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722028598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0023683722028598"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2010.109","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.3788956.3519054","asserted-by":"object"}]},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Helicobacter pylori accelerates hepatic fibrosis by sensitizing transforming growth factor-\u03b21-induced inflammatory signaling","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2010.109","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2010 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}