{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:07:23Z","timestamp":1791086843537,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4515,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1038\/labinvest.2010.121","type":"journal-article","created":{"date-parts":[[2010,6,14]],"date-time":"2010-06-14T10:32:09Z","timestamp":1276511529000},"page":"1357-1364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma"],"prefix":"10.1016","volume":"90","author":[{"given":"Ryuichi","family":"Mashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuho","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumimasa","family":"Arimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nishina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Ema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Nakauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Seed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Yamanashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2010.121_bib1","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","first-page":"356","article-title":"Histiocytic sarcoma","author":"Grogan","year":"2008"},{"key":"10.1038\/labinvest.2010.121_bib2","series-title":"Wintrobe's Clinical Hematology","first-page":"1582","article-title":"Pathology of Langerhans cell histiocytosis and other histiocytic proliferations","author":"Weiss","year":"2009"},{"key":"10.1038\/labinvest.2010.121_bib3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(00)81841-3","article-title":"Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok","volume":"88","author":"Yamanashi","year":"1997","journal-title":"Cell"},{"key":"10.1038\/labinvest.2010.121_bib4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0092-8674(00)81840-1","article-title":"p62dok a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells","volume":"88","author":"Carpino","year":"1997","journal-title":"Cell"},{"key":"10.1038\/labinvest.2010.121_bib5","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1074\/jbc.M005504200","article-title":"Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling","volume":"276","author":"Songyang","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2010.121_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1101\/gad.14.1.11","article-title":"Role of the rasGAP-associated docking protein p62dok in negative regulation of B cell receptor-mediated signaling","volume":"14","author":"Yamanashi","year":"2000","journal-title":"Genes Dev"},{"key":"10.1038\/labinvest.2010.121_bib7","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1084\/jem.20041247","article-title":"Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia","volume":"200","author":"Yasuda","year":"2004","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.2010.121_bib8","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1084\/jem.20041306","article-title":"Role of Dok-1 and Dok-2 in leukemia suppression","volume":"200","author":"Niki","year":"2004","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.2010.121_bib9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-065X.2009.00844.x","article-title":"The roles of Dok family adaptors in immunoreceptor signaling","volume":"232","author":"Mashima","year":"2009","journal-title":"Immunol Rev"},{"key":"10.1038\/labinvest.2010.121_bib10","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1074\/jbc.273.9.4827","article-title":"Molecular cloning and characterization of p56dok\u22122 defines a new family of RasGAP-binding proteins","volume":"273","author":"Di Cristofano","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2010.121_bib11","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1128\/MCB.20.8.2743-2754.2000","article-title":"Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling","volume":"20","author":"Lemay","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1038\/labinvest.2010.121_bib12","doi-asserted-by":"crossref","first-page":"25323","DOI":"10.1074\/jbc.M212430200","article-title":"Two new substrates in insulin signaling, IRS5\/DOK4 and IRS6\/DOK5","volume":"278","author":"Cai","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2010.121_bib13","doi-asserted-by":"crossref","first-page":"42072","DOI":"10.1074\/jbc.M403726200","article-title":"Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth","volume":"279","author":"Crowder","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2010.121_bib14","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1126\/science.1127142","article-title":"The muscle protein Dok-7 is essential for neuromuscular synaptogenesis","volume":"312","author":"Okada","year":"2006","journal-title":"Science"},{"key":"10.1038\/labinvest.2010.121_bib15","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/intimm\/dxm015","article-title":"Dok-1 and Dok-2 are negative regulators of T cell receptor signaling","volume":"19","author":"Yasuda","year":"2007","journal-title":"Int Immunol"},{"key":"10.1038\/labinvest.2010.121_bib16","doi-asserted-by":"crossref","first-page":"8314","DOI":"10.1128\/MCB.19.12.8314","article-title":"Characterization of a novel member of the DOK family that binds and modulates Abl signaling","volume":"19","author":"Cong","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1038\/labinvest.2010.121_bib17","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1128\/MCB.24.6.2332-2343.2004","article-title":"Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3","volume":"24","author":"Robson","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1038\/labinvest.2010.121_bib18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1182\/blood-2006-10-055194","article-title":"Dok-3 plays a nonredundant role in negative regulation of B-cell activation","volume":"110","author":"Ng","year":"2007","journal-title":"Blood"},{"key":"10.1038\/labinvest.2010.121_bib19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2443.2006.00926.x","article-title":"Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases","volume":"11","author":"Honma","year":"2006","journal-title":"Genes Cells"},{"key":"10.1038\/labinvest.2010.121_bib20","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nbt803","article-title":"Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes","volume":"21","author":"Yang","year":"2003","journal-title":"Nat Biotechnol"},{"key":"10.1038\/labinvest.2010.121_bib21","series-title":"International Classification of Rodent tumors: The Mouse","first-page":"417","article-title":"Hematopoietic system","author":"Frith","year":"2001"},{"key":"10.1038\/labinvest.2010.121_bib22","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1182\/blood.V100.1.238","article-title":"Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice","volume":"100","author":"Kogan","year":"2002","journal-title":"Blood"},{"key":"10.1038\/labinvest.2010.121_bib23","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/ng.527","article-title":"Identification of DOK genes as lung tumor suppressors","volume":"42","author":"Berger","year":"2010","journal-title":"Nat Genet"},{"key":"10.1038\/labinvest.2010.121_bib24","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.tcb.2004.09.016","article-title":"CSF-1 regulation of the wandering macrophage: complexity in action","volume":"14","author":"Pixley","year":"2004","journal-title":"Trends Cell Biol"},{"key":"10.1038\/labinvest.2010.121_bib25","first-page":"1004","article-title":"CSF-1 deficiency in the op\/op mouse has differential effects on macrophage populations and differentiation stages","volume":"20","author":"Wiktor-Jedrzejczak","year":"1992","journal-title":"Exp Hematol"},{"key":"10.1038\/labinvest.2010.121_bib26","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0092-8674(87)90136-X","article-title":"Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage","volume":"51","author":"Lang","year":"1987","journal-title":"Cell"},{"key":"10.1038\/labinvest.2010.121_bib27","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/sj.emboj.7601557","article-title":"Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells","volume":"26","author":"Stork","year":"2007","journal-title":"EMBO J"},{"key":"10.1038\/labinvest.2010.121_bib28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1074-7613(01)00208-4","article-title":"Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage","volume":"15","author":"Harder","year":"2001","journal-title":"Immunity"},{"key":"10.1038\/labinvest.2010.121_bib29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(95)90171-X","article-title":"Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease","volume":"83","author":"Hibbs","year":"1995","journal-title":"Cell"},{"key":"10.1038\/labinvest.2010.121_bib30","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ccr.2006.03.028","article-title":"The PTEN and INK4A\/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans","volume":"9","author":"Carrasco","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1038\/labinvest.2010.121_bib31","first-page":"6234","article-title":"Tumor susceptibility of p21Waf1\/Cip1-deficient mice","volume":"61","author":"Martin-Caballero","year":"2001","journal-title":"Cancer Res"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest2010121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2010121","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722028707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722028707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2010121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:53:30Z","timestamp":1758398010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722028707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0023683722028707"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2010.121","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2010.121","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2010 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}