{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:11:43Z","timestamp":1761963103781,"version":"build-2065373602"},"reference-count":47,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4485,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1038\/labinvest.2010.130","type":"journal-article","created":{"date-parts":[[2010,7,19]],"date-time":"2010-07-19T11:27:13Z","timestamp":1279538833000},"page":"1468-1481","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Inhibition of capillary repair in proliferative glomerulonephritis results in persistent glomerular inflammation with glomerular sclerosis"],"prefix":"10.1016","volume":"90","author":[{"given":"Yukinari","family":"Masuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitue","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arimi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanyi","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine Kyoko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Aki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Nagasaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Mii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiko","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuh","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2010.130_bib1","series-title":"Immunologic Renal Diseases","first-page":"627","article-title":"Endothelial responses to immune injury","author":"Ballerman","year":"1997"},{"key":"10.1038\/labinvest.2010.130_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000025904","article-title":"Role of glomerular endothelial damage in progressive renal disease","volume":"22","author":"Yamanaka","year":"1999","journal-title":"Kidney Blood Press Res"},{"key":"10.1038\/labinvest.2010.130_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000101796","article-title":"Contribution of the endothelium to the glomerular permselectivity barrier in health and disease","volume":"106","author":"Ballerman","year":"2007","journal-title":"Nephron Physiol"},{"key":"10.1038\/labinvest.2010.130_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00041552-200301000-00008","article-title":"Vascular endothelial growth factor: a new player in the pathogenesis of renal fibrosis","volume":"12","author":"Kang","year":"2003","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1038\/labinvest.2010.130_bib5","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1681\/ASN.2007020255","article-title":"The glomerular injury of preeclampsia","volume":"18","author":"Stillman","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/labinvest.2010.130_bib6","first-page":"195","article-title":"Endothelial regeneration during the repair process following Habu-snake venom induced glomerular injury","volume":"427","author":"Kitamura","year":"1995","journal-title":"Virchows Arch"},{"key":"10.1038\/labinvest.2010.130_bib7","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1172\/JCI6740","article-title":"VEGF(165) mediates glomerular endothelial repair","volume":"104","author":"Ostendorf","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2010.130_bib8","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0002-9440(10)61731-2","article-title":"Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulonephritis","volume":"159","author":"Masuda","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2010.130_bib9","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1097\/01.ASN.0000141038.28733.F2","article-title":"Vascular endothelial growth factor 165 resolves glomerular inflammation and accelerates glomerular capillary repair in rat anti-glomerular basement membrane glomerulonephritis","volume":"15","author":"Shimizu","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/labinvest.2010.130_bib10","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1046\/j.1523-1755.2000.00422.x","article-title":"Vascular endothelial growth factor accelerates renal recovery in experimental thrombotic microangiopathy","volume":"58","author":"Kim","year":"2000","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2010.130_bib11","first-page":"1715","article-title":"Participation of glomerular endothelial cells in the capillary repair of glomerulonephritis","volume":"147","author":"Iruela-Arispe","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2010.130_bib12","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000045026","article-title":"Recovery of damaged glomerular capillary network with endothelial cell apoptosis in experimental proliferative glomerulonephritis","volume":"79","author":"Shimizu","year":"1998","journal-title":"Nephron"},{"key":"10.1038\/labinvest.2010.130_bib13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000045734","article-title":"Complement-mediated killing of mesangial cells in experimental glomerulonephritis: cell death by a combination of apoptosis and necrosis","volume":"86","author":"Shimizu","year":"2000","journal-title":"Nephron"},{"key":"10.1038\/labinvest.2010.130_bib14","first-page":"1","article-title":"Vascular endothelial growth factor: molecular and biological aspects","volume":"237","author":"Ferrara","year":"1999","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1038\/labinvest.2010.130_bib15","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/ndt\/13.4.875","article-title":"Effects of vascular endothelial growth factor (VEGF)\/vascular permeability factor (VPF) on haemodynamics and permselectivity of the isolated perfused rat kidney","volume":"13","author":"Klanke","year":"1998","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/labinvest.2010.130_bib16","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1111\/j.1523-1755.2004.00621.x","article-title":"The role of vascular endothelial growth factor (VEGF) in renal pathophysiology","volume":"65","author":"Schrjvers","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2010.130_bib17","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1093\/ndt\/gfm259","article-title":"Renal side effects of anti-VEGF therapy in man: a new test system","volume":"22","author":"Ostendorf","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/labinvest.2010.130_bib18","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1007\/s00125-008-0989-9","article-title":"Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy","volume":"51","author":"Sim\u00f3","year":"2008","journal-title":"Diabetologia"},{"key":"10.1038\/labinvest.2010.130_bib19","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.bbrc.2005.05.132","article-title":"Bevacizumab (avastin) a humanized anti-VEGF monoclonal antibody for cancer therapy","volume":"333","author":"Ferrara","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/labinvest.2010.130_bib20","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1444-0938.2008.00305.x","article-title":"Inhibitions vascular endothelial growth factor (VEGF) in the management of neovascular age-related macular degeneration: a review of current practice","volume":"91","author":"van Wijingaarden","year":"2008","journal-title":"Clin Exp Optom"},{"key":"10.1038\/labinvest.2010.130_bib21","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1158\/1078-0432.CCR-06-1989","article-title":"Vascular endothelial growth factor-targeted therapy in renal cell carcinoma: current status and future directions","volume":"13","author":"Rini","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1038\/labinvest.2010.130_bib22","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1056\/NEJMoa0707330","article-title":"VEGF inhibition and renal thrombotic microangiopathy","volume":"358","author":"Eremina","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1038\/labinvest.2010.130_bib23","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/annonc\/mdm454","article-title":"Sunitinib induced hypertension, thrombotic microangiopathy and reversible posterior leukencephalopathy syndrome","volume":"18","author":"Kapiteijn","year":"2007","journal-title":"Ann Oncol"},{"key":"10.1038\/labinvest.2010.130_bib24","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/ki.2008.256","article-title":"Glomerular disease related to anti-VEGF therapy","volume":"74","author":"Stokes","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2010.130_bib25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000065591","article-title":"Efficacy of vascular endothelial growth factor in the treatment of experimental gastric injury","volume":"66","author":"Mastui","year":"2002","journal-title":"Digestion"},{"key":"10.1038\/labinvest.2010.130_bib26","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1006\/bbrc.1993.1955","article-title":"Significance of vascular endothelial growth factor\/vascular permeability factor for solid tumor growth and its inhibition by the antibody","volume":"194","author":"Kondo","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/labinvest.2010.130_bib27","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1038\/ki.1996.529","article-title":"Beneficial effects of systemic immunoglobulin in experimental membranous nephropathy","volume":"50","author":"Nangaku","year":"1996","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2010.130_bib28","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1046\/j.1523-1755.2001.0600031018.x","article-title":"Intravenous immunoglobulin protects against experimental thrombotic microangiopathy","volume":"60","author":"Jefferson","year":"2001","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2010.130_bib29","first-page":"299","article-title":"Thrombomodulin and thrombin localization on the vasculature endothelium: their internalization and transcytosis by plasmalemmal vesicles","volume":"61","author":"Horvat","year":"1993","journal-title":"Eur J Cell Biol"},{"key":"10.1038\/labinvest.2010.130_bib30","first-page":"1624","article-title":"Role of vascular endothelial growth factor in angiogenesis of rheumatoid arthritis","volume":"22","author":"Nagashima","year":"1995","journal-title":"J Rheumatol"},{"key":"10.1038\/labinvest.2010.130_bib31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0002-9440(10)65263-7","article-title":"Novel approach to specific growth factor inhibition in vivo: antagonism of platelet-derived growth factor in glomerulonephritis by aptamers","volume":"154","author":"Floege","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2010.130_bib32","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1172\/JCI118697","article-title":"The cytoskeletal linking proteins, moesin and radixin, are upregulated by platelet-derived growth factor, but not basic fibroblast growth factor in experimental mesangial proliferative glomerulonephritis","volume":"97","author":"Hugo","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2010.130_bib33","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1016\/j.transproceed.2009.06.181","article-title":"Role of peritubular capillaries and vascular endothelial growth factor in chronic allograft nephropathy","volume":"41","author":"Modelli de Andrade","year":"2009","journal-title":"Transplant Proc"},{"key":"10.1038\/labinvest.2010.130_bib34","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1053\/hupa.2000.20373","article-title":"Peritubular capillary loss is associated with chronic tubulointerstitial injury in human kidney: altered expression of vascular endothelial growth factor","volume":"31","author":"Choi","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1038\/labinvest.2010.130_bib35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1681\/ASN.V11147","article-title":"Peritubular capillary injury during the progression of experimental glomerulonephritis in rats","volume":"11","author":"Ohashi","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/labinvest.2010.130_bib36","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1681\/ASN.V1271434","article-title":"Impaired angiogenesis in the remnant kidney model: I potential role of vascular endothelial growth factor and thrombospondin-1","volume":"12","author":"Kang","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/labinvest.2010.130_bib37","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1097\/01.ASN.0000018408.51388.57","article-title":"Peritubular capillary regression during the progression of experimental obstructive nephropathy","volume":"13","author":"Ohashi","year":"2002","journal-title":"J Am Soc Nephrl"},{"key":"10.1038\/labinvest.2010.130_bib38","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1681\/ASN.V1271448","article-title":"Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function","volume":"12","author":"Kang","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/labinvest.2010.130_bib39","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/S0002-9440(10)65475-2","article-title":"Expression of platelet-derived endothelial cell growth factor and its potential role in up-regulation of angiogenesis in scarred kidneys secondary to urinary tract diseases","volume":"155","author":"Konda","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2010.130_bib40","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000101798","article-title":"Role of the VEGF-A signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier","volume":"106","author":"Eremina","year":"2007","journal-title":"Nephron Physiol"},{"key":"10.1038\/labinvest.2010.130_bib41","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1(sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2010.130_bib42","doi-asserted-by":"crossref","first-page":"12605","DOI":"10.1074\/jbc.C300012200","article-title":"Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria","volume":"278","author":"Sugimoto","year":"2003","journal-title":"J Bio Chem"},{"key":"10.1038\/labinvest.2010.130_bib43","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1681\/ASN.V125993","article-title":"Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes","volume":"12","author":"De Vriese","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/labinvest.2010.130_bib44","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1681\/ASN.2005080810","article-title":"Vascular endothelial growth factor A signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival","volume":"17","author":"Eremina","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/labinvest.2010.130_bib45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/CAD.0b013e3283161012","article-title":"Hypertension and proteinuria: a class-effect of antiangiogenic therapies","volume":"20","author":"Launay-Vacher","year":"2009","journal-title":"Anticancer Drugs"},{"key":"10.1038\/labinvest.2010.130_bib46","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1053\/j.ajkd.2006.11.039","article-title":"Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis","volume":"49","author":"Zhu","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/labinvest.2010.130_bib47","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1053\/j.ajkd.2007.04.025","article-title":"Angiogenesis inhibitor therapies: focus on kidney toxicity and hypertension","volume":"50","author":"Izzedine","year":"2007","journal-title":"Am J Kidney Dis"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest2010130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2010130","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722028562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722028562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2010130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:52:50Z","timestamp":1758397970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722028562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0023683722028562"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2010.130","relation":{},"ISSN":["0023-6837"],"issn-type":[{"type":"print","value":"0023-6837"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of capillary repair in proliferative glomerulonephritis results in persistent glomerular inflammation with glomerular sclerosis","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2010.130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2010 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}