{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:59:48Z","timestamp":1791187188345,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4577,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1038\/labinvest.2010.72","type":"journal-article","created":{"date-parts":[[2010,4,5]],"date-time":"2010-04-05T10:33:36Z","timestamp":1270463616000},"page":"1068-1077","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Spectral cytopathology of cervical samples: detecting cellular abnormalities in cytologically normal cells"],"prefix":"10.1016","volume":"90","author":[{"given":"Jennifer M","family":"Schubert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas","family":"Papamarkakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo\u0161","family":"Miljkovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Bedrossian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Laver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Diem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2010.72_bib1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0002-9378(16)40621-6","article-title":"The diagnostic value of vaginal smears in carcinoma of the uterus","volume":"42","author":"Papanicolaou","year":"1941","journal-title":"Am J Obstet Gynecol"},{"key":"10.1038\/labinvest.2010.72_bib2","unstructured":"Papanicolaou GN . New cancer diagnosis. Proc Third Race Betterment Conference, January 2\u20136, 1928. 1928; 528\u2013534."},{"key":"10.1038\/labinvest.2010.72_bib3","unstructured":"Cervical Cancer. June 2009. Available from: www.cancer.org\/docroot\/CRI\/content\/CRI_2_4_IX_what_are_the_key_statistics_for_cervical_cancer_8.asp?rnav=cri."},{"key":"10.1038\/labinvest.2010.72_bib4","unstructured":"Evaluation of Cervical Cytology. Summary, Evidence Report\/Technology Assessment June 2009. Available from: http:\/\/www.ahrq.gov\/clinic\/epcsums\/cervsumm.htm."},{"key":"10.1038\/labinvest.2010.72_bib5","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1001\/jama.287.16.2114","article-title":"The 2001 Bethesda system terminology for reporting results of cervical cytology","volume":"287","author":"Solomon","year":"2002","journal-title":"JAMA"},{"key":"10.1038\/labinvest.2010.72_bib6","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1001\/jama.285.11.1500","article-title":"Interobserver reproducibility of cervical cytologic and histologic interpretations","volume":"285","author":"Stoler","year":"2001","journal-title":"JAMA"},{"key":"10.1038\/labinvest.2010.72_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2303.2004.00227.x","article-title":"Clinical relevance of human papillomavirus testing in cytopathology","volume":"16","author":"Brink","year":"2005","journal-title":"Cytopathology"},{"key":"10.1038\/labinvest.2010.72_bib8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/(SICI)1097-0142(19990625)87:3<118::AID-CNCR4>3.0.CO;2-N","article-title":"The accuracy of urinary cytology in daily practice","volume":"87","author":"Bastacky","year":"1999","journal-title":"Cancer"},{"key":"10.1038\/labinvest.2010.72_bib9","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1378\/chest.116.5.1168","article-title":"The accuracy of the clinical diagnosis of new-onset idiopathic pulmonary fibrosis and other interstitial lung disease","volume":"116","author":"Raghu","year":"1999","journal-title":"Chest"},{"key":"10.1038\/labinvest.2010.72_bib10","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1366\/0003702914335580","article-title":"Phosphodiester stretching bands in the infrared spectra of human tissues and cultured cells","volume":"45","author":"Wong","year":"1991","journal-title":"Appl Spectrosc"},{"key":"10.1038\/labinvest.2010.72_bib11","doi-asserted-by":"crossref","first-page":"10988","DOI":"10.1073\/pnas.88.24.10988","article-title":"Infrared spectroscopy of exfoliated human cervical cells: evidence of extensive structural changes during carcinogenesis","volume":"88","author":"Wong","year":"1991","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1038\/labinvest.2010.72_bib12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/bspy.350010507","article-title":"Characterization of exfoliated cells and tissues from human endocervix and ectocervix by FTIR and ATR\/FTIR spectroscopy","volume":"1","author":"Wong","year":"1995","journal-title":"Biospectroscopy"},{"key":"10.1038\/labinvest.2010.72_bib13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1006\/gyno.1997.4627","article-title":"Infrared spectroscopy of normal and abnormal cervical smears: evaluation by principal component analysis","volume":"66","author":"Cohenford","year":"1997","journal-title":"Gynecol Oncol"},{"key":"10.1038\/labinvest.2010.72_bib14","doi-asserted-by":"crossref","first-page":"15327","DOI":"10.1073\/pnas.95.26.15327","article-title":"Cytologically normal cells from neoplastic cervical samples display extensive structural abnormalities on IR spectroscopy: implications for tumor biology","volume":"95","author":"Cohenford","year":"1998","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1038\/labinvest.2010.72_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/(SICI)1520-6343(1996)2:3<143::AID-BSPY1>3.0.CO;2-9","article-title":"An investigation into FTIR spectroscopy as a biodiagnostic tool for cervical cancer","volume":"2","author":"Wood","year":"1996","journal-title":"Biospectroscopy"},{"key":"10.1038\/labinvest.2010.72_bib16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/(SICI)1520-6343(1998)4:2<75::AID-BSPY1>3.0.CO;2-R","article-title":"A FTIR microspectroscopic study of cell types and potential confounding variables in screening for cervical malignancies","volume":"4","author":"Wood","year":"1998","journal-title":"Biospectroscopy"},{"key":"10.1038\/labinvest.2010.72_bib17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/(SICI)1520-6343(1999)5:4<219::AID-BSPY2>3.0.CO;2-O","article-title":"Infrared spectroscopy of human tissue V. Infraredspectroscopic studies of myeloid leukemia (ML-1) cells at different phases of the cell cycle","volume":"5","author":"Boydston-White","year":"1999","journal-title":"Biospectroscopy"},{"key":"10.1038\/labinvest.2010.72_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/(SICI)1520-6343(1998)4:1<47::AID-BSPY5>3.0.CO;2-P","article-title":"Infrared spectroscopy of human tissue. I. Differentiation and maturation of epithelial cells in the human cervix","volume":"4","author":"Chiriboga","year":"1998","journal-title":"Biospectroscopy"},{"key":"10.1038\/labinvest.2010.72_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/(SICI)1520-6343(1998)4:1<55::AID-BSPY6>3.0.CO;2-R","article-title":"Infrared spectroscopy of human tissue. II. A comparative study of spectra of biopsies of cervical squamous epithelium and of exfoliated cervical cells","volume":"4","author":"Chiriboga","year":"1998","journal-title":"Biospectroscopy"},{"key":"10.1038\/labinvest.2010.72_bib20","first-page":"219","article-title":"Infrared spectroscopy of human tissue IV. Detection of dysplastic and neoplastic changes of human cervical tissue via infrared microspectroscopy","volume":"44","author":"Chiriboga","year":"1998","journal-title":"Cell Mol Biol"},{"key":"10.1038\/labinvest.2010.72_bib21","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.bbamem.2006.05.010","article-title":"Infrared micro-spectroscopic studies of epithelial cells","volume":"1758","author":"Romeo","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/labinvest.2010.72_bib22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.vibspec.2006.04.009","article-title":"Infrared microspectroscopy of human cells: causes for the spectral variance of oral mucosa (buccal) cells","volume":"42","author":"Romeo","year":"2006","journal-title":"Vib Spectrosc"},{"key":"10.1038\/labinvest.2010.72_bib23","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/labinvest.2010.1","article-title":"Cytopathology by optical methods: spectral cytopathology of the oral mucosa","volume":"90","author":"Papamarkakis","year":"2010","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.2010.72_bib24","unstructured":"Diem M, Miljkovic M, Romeo M, et al. Method of reconstituting cellular spectra from spectral mapping data. USA 2009."},{"key":"10.1038\/labinvest.2010.72_bib25","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1039\/b904808a","article-title":"Resonant Mie scattering infrared spectroscopy of biological materials - understanding the \u2032dispersion artefact\u2032","volume":"134","author":"Bassan","year":"2009","journal-title":"Analyst"},{"key":"10.1038\/labinvest.2010.72_bib26","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1039\/b821349f","article-title":"Reflection contributions to the dispersion artefact in FTIR spectra of single biological cells","volume":"134","author":"Bassan","year":"2009","journal-title":"Analyst"},{"key":"10.1038\/labinvest.2010.72_bib27","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1039\/B921056C","article-title":"Resonant Mie scattering (RMieS) correction of infrared spectra from highly scattering biological samples","volume":"135","author":"Bassan","year":"2010","journal-title":"Analyst"},{"key":"10.1038\/labinvest.2010.72_bib28","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1021\/ac60214a047","article-title":"Smoothing and differentiation of data by simplified least squares procedures","volume":"36","author":"Savitzky","year":"1964","journal-title":"Anal Chem"},{"key":"10.1038\/labinvest.2010.72_bib29","series-title":"The Cervix","first-page":"128","article-title":"The effects of oral contraceptive steroids, menopause and hormone replacement therapy on the cervical epithelium","author":"Tay","year":"2006"},{"key":"10.1038\/labinvest.2010.72_bib30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0924-2031(01)00155-2","article-title":"Observing the cyclical changes in cervical epithelium using infrared microspectroscopy","volume":"28","author":"Romeo","year":"2002","journal-title":"Vib Spectrosc"},{"key":"10.1038\/labinvest.2010.72_bib31","series-title":"Chemometrics in Analytical Spectroscopy","author":"Adams","year":"2004"},{"key":"10.1038\/labinvest.2010.72_bib32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillmoavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"Walboomers","year":"1999","journal-title":"J Pathol"},{"key":"10.1038\/labinvest.2010.72_bib33","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1136\/jcp.55.4.244","article-title":"The causal relation between human papillomavirus and cervical cancer","volume":"55","author":"Bosch","year":"2002","journal-title":"J Clin Pathol"},{"key":"10.1038\/labinvest.2010.72_bib34","doi-asserted-by":"crossref","unstructured":"Woodman CBJ, Collins S, Winter H, et al. Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study. Lancet 2001; 1931\u20131936.","DOI":"10.1016\/S0140-6736(00)04956-4"},{"key":"10.1038\/labinvest.2010.72_bib35","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1086\/427557","article-title":"Development and duration of human papillomavirus lesions, after initial infection","volume":"191","author":"Winer","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1038\/labinvest.2010.72_bib36","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1054\/bjoc.2001.1926","article-title":"HPV presence precedes abnormal cytology in women developing cervical cancer and signals false negative smears","volume":"85","author":"Zielinski","year":"2001","journal-title":"Br J Cancer"},{"key":"10.1038\/labinvest.2010.72_bib37","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/infdis\/169.2.235","article-title":"Persistence of type-specific human papillomavirus infection among cytologically normal women","volume":"169","author":"Hildesheim","year":"1994","journal-title":"J Infect Dis"},{"key":"10.1038\/labinvest.2010.72_bib38","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1056\/NEJM199911253412201","article-title":"Type specific persistence of human papillomavirus DNA before the development of invasive cervical cancer","volume":"341","author":"Wallin","year":"1999","journal-title":"New Engl J Med"},{"key":"10.1038\/labinvest.2010.72_bib39","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/jcp.2006.045948","article-title":"High-risk human papillomavirus is present in cytologically false-negative smears: an analysis of \u2018normal\u2019 smears preceeding CIN2\/3","volume":"61","author":"Bulk","year":"2008","journal-title":"J Clin Pathol"},{"key":"10.1038\/labinvest.2010.72_bib40","series-title":"The Pap Test","author":"DeMay","year":"2005"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest201072.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201072","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722013095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722013095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201072.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:39:51Z","timestamp":1758397191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722013095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0023683722013095"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2010.72","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spectral cytopathology of cervical samples: detecting cellular abnormalities in cytologically normal cells","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2010.72","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2010.114","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2010 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}