{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:56:14Z","timestamp":1785174974686,"version":"3.55.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":4212,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1038\/labinvest.2011.69","type":"journal-article","created":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T10:27:38Z","timestamp":1303727258000},"page":"1092-1106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Transient ischemia\/hypoxia enhances gentamicin ototoxicity via caspase-dependent cell death pathway"],"prefix":"10.1016","volume":"91","author":[{"given":"Chia-Der","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Ching","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hsui","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Ho","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Hua","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mang-Hung","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Wen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Jen","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Yuang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2011.69_bib1","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1126\/science.1061861","article-title":"Public health. Responding to market failures in tuberculosis control","volume":"293","author":"Gupta","year":"2001","journal-title":"Science"},{"key":"10.1038\/labinvest.2011.69_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000013861","article-title":"Aminoglycoside antibiotics","volume":"5","author":"Forge","year":"2000","journal-title":"Audiol Neurootol"},{"key":"10.1038\/labinvest.2011.69_bib3","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1542\/peds.114.1.e111","article-title":"Extended-interval aminoglycoside administration for children: a meta-analysis","volume":"114","author":"Contopoulos-Ioannidis","year":"2004","journal-title":"Pediatrics"},{"key":"10.1038\/labinvest.2011.69_bib4","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1288\/00005537-198112000-00001","article-title":"Freedom from ototoxicity in aminoglycoside treated neonates: a mistaken notion","volume":"91","author":"Bernard","year":"1981","journal-title":"Laryngoscope"},{"key":"10.1038\/labinvest.2011.69_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1365-2273.1998.00089.x","article-title":"Mitochondrial inherited hearing loss","volume":"23","author":"Ensink","year":"1998","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"10.1038\/labinvest.2011.69_bib6","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/hmg\/9.12.1787","article-title":"A biochemical basis for the inherited susceptibility to aminoglycoside ototoxicity","volume":"9","author":"Guan","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1038\/labinvest.2011.69_bib7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/(SICI)1098-1004(1999)13:4<261::AID-HUMU1>3.0.CO;2-W","article-title":"Mitochondrial deafness mutations reviewed","volume":"13","author":"Fischel-Ghodsian","year":"1999","journal-title":"Hum Mutat"},{"key":"10.1038\/labinvest.2011.69_bib8","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.otohns.2010.01.030","article-title":"Genetic mutations and aminoglycoside-induced ototoxicity in neonates","volume":"142","author":"Johnson","year":"2010","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1038\/labinvest.2011.69_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0378-5955(83)90078-3","article-title":"Ethacrynic acid facilitates gentamicin entry into endolymph of the rat","volume":"11","author":"Tran Ba Huy","year":"1983","journal-title":"Hear Res"},{"key":"10.1038\/labinvest.2011.69_bib10","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1345\/aph.1A216","article-title":"Ototoxicity induced by gentamicin and furosemide","volume":"36","author":"Bates","year":"2002","journal-title":"Ann Pharmacother"},{"key":"10.1038\/labinvest.2011.69_bib11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tox.2008.04.015","article-title":"Aminoglycoside induced ototoxicity","volume":"249","author":"Guthrie","year":"2008","journal-title":"Toxicology"},{"key":"10.1038\/labinvest.2011.69_bib12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4103\/1463-1741.45310","article-title":"Synergistic ototoxicity due to noise exposure and aminoglycoside antibiotics","volume":"11","author":"Li","year":"2009","journal-title":"Noise Health"},{"key":"10.1038\/labinvest.2011.69_bib13","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0022-3476(89)80151-9","article-title":"Neonatal status and hearing loss in high-risk infants","volume":"114","author":"Salamy","year":"1989","journal-title":"J Pediatr"},{"key":"10.1038\/labinvest.2011.69_bib14","first-page":"27","article-title":"Vestibulotoxicity and ototoxicity of gentamicin in newborns at risk","volume":"7","author":"Aust","year":"2001","journal-title":"Int Tinnitus J"},{"key":"10.1038\/labinvest.2011.69_bib15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0887-8994(96)00054-9","article-title":"Recording of brainstem evoked potentials and their association with gentamicin in neonates","volume":"14","author":"Chayasirisobhon","year":"1996","journal-title":"Pediatr Neurol"},{"key":"10.1038\/labinvest.2011.69_bib16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/00016489009107442","article-title":"Observations of cochlear microcirculation using intravital microscopy","volume":"109","author":"Axelsson","year":"1990","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"10.1038\/labinvest.2011.69_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0306-9877(97)90304-2","article-title":"Can hypotension episodes cause cochlear damage in young subjects?","volume":"48","author":"Pirodda","year":"1997","journal-title":"Med Hypotheses"},{"key":"10.1038\/labinvest.2011.69_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/000348940411300116","article-title":"Sudden sensorineural hearing loss after rapid reduction of blood pressure in malignant hypertension","volume":"113","author":"Chao","year":"2004","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1038\/labinvest.2011.69_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1568-1637(02)00004-1","article-title":"Molecular mechanisms of age-related hearing loss","volume":"1","author":"Seidman","year":"2002","journal-title":"Ageing Res Rev"},{"key":"10.1038\/labinvest.2011.69_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.aud.0000191942.36672.f3","article-title":"The role of oxidative stress in noise-induced hearing loss","volume":"27","author":"Henderson","year":"2006","journal-title":"Ear Hear"},{"key":"10.1038\/labinvest.2011.69_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5955(87)90021-9","article-title":"Laser Doppler measurements of cochlear blood flow during loud sound exposure in the guinea pig","volume":"27","author":"Thorne","year":"1987","journal-title":"Hear Res"},{"key":"10.1038\/labinvest.2011.69_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0378-5955(01)00303-3","article-title":"Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat","volume":"158","author":"Wu","year":"2001","journal-title":"Hear Res"},{"key":"10.1038\/labinvest.2011.69_bib23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/00003446-198708000-00003","article-title":"Synergistic interactions of noise and other ototraumatic agents","volume":"8","author":"Boettcher","year":"1987","journal-title":"Ear Hear"},{"key":"10.1038\/labinvest.2011.69_bib24","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/WNR.0b013e32833da3c3","article-title":"Changes in guinea pig cochlea after transient cochlear ischemia","volume":"21","author":"Lin","year":"2010","journal-title":"NeuroReport"},{"key":"10.1038\/labinvest.2011.69_bib25","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1288\/00005537-195906000-00001","article-title":"Experiments on temporary obstruction of the internal auditory artery","volume":"69","author":"Perlman","year":"1959","journal-title":"Laryngoscope"},{"key":"10.1038\/labinvest.2011.69_bib26","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s10162-003-4002-5","article-title":"Uptake of gentamicin by bullfrog saccular hair cells in vitro","volume":"4","author":"Steyger","year":"2003","journal-title":"J Assoc Res Otolaryngol"},{"key":"10.1038\/labinvest.2011.69_bib27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10162-009-0160-4","article-title":"Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells","volume":"10","author":"Wang","year":"2009","journal-title":"J Assoc Res Otolaryngol"},{"key":"10.1038\/labinvest.2011.69_bib28","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.taap.2009.08.011","article-title":"Arsenic induces cell apoptosis in cultured osteoblasts through endoplasmic reticulum stress","volume":"241","author":"Tang","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1038\/labinvest.2011.69_bib29","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/000164801300102752","article-title":"Methylcobalamin as antagonist to transient ototoxic action of gentamicin","volume":"121","author":"Jin","year":"2001","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"10.1038\/labinvest.2011.69_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0378-5955(88)90018-4","article-title":"Cochlear pathology of long term neomycin induced deafness in cats","volume":"33","author":"Leake","year":"1988","journal-title":"Hear Res"},{"key":"10.1038\/labinvest.2011.69_bib31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00453548","article-title":"Distribution of gentamicin by immunofluorescence in the guinea pig inner ear","volume":"242","author":"Hayashida","year":"1985","journal-title":"Arch Otorhinolaryngol"},{"key":"10.1038\/labinvest.2011.69_bib32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3109\/00016486709139091","article-title":"Oxygen consumption in normal and kanamycin damaged cochleae","volume":"64","author":"Mizukoshi","year":"1967","journal-title":"Acta Otolaryngol"},{"key":"10.1038\/labinvest.2011.69_bib33","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1288\/00005537-197212000-00013","article-title":"The influence of ischemia upon the energy reserves of inner ear tissues","volume":"82","author":"Thalmann","year":"1972","journal-title":"Laryngoscope"},{"key":"10.1038\/labinvest.2011.69_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(01)00224-6","article-title":"Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals","volume":"155","author":"Sha","year":"2001","journal-title":"Hear Res"},{"key":"10.1038\/labinvest.2011.69_bib35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/sj.cdd.4401706","article-title":"Caspase-independent pathways of hair cell death induced by kanamycin in vivo","volume":"13","author":"Jiang","year":"2006","journal-title":"Cell Death Differ"},{"key":"10.1038\/labinvest.2011.69_bib36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/03005368209081457","article-title":"Patterns of cochlear degeneration following gentamicin administration in both old and young guinea pigs","volume":"16","author":"McDowell","year":"1982","journal-title":"Br J Audiol"},{"key":"10.1038\/labinvest.2011.69_bib37","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/sj.gt.3301180","article-title":"Effect of transgenic GDNF expression on gentamicin-induced cochlear and vestibular toxicity","volume":"7","author":"Suzuki","year":"2000","journal-title":"Gene Ther"},{"key":"10.1038\/labinvest.2011.69_bib38","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0378-5955(02)00349-0","article-title":"Outer hair cells functionally and structurally deteriorate during reperfusion","volume":"173","author":"Tabuchi","year":"2002","journal-title":"Hear Res"},{"key":"10.1038\/labinvest.2011.69_bib39","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1080\/00016480701714244","article-title":"Time course of apoptotic cell death in guinea pig cochlea following intratympanic gentamicin application","volume":"128","author":"Suzuki","year":"2008","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"10.1038\/labinvest.2011.69_bib40","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1097\/MLG.0b013e31817c1303","article-title":"Secondary apoptosis of spiral ganglion cells induced by aminoglycoside: Fas-Fas ligand signaling pathway","volume":"118","author":"Bae","year":"2008","journal-title":"Laryngoscope"},{"key":"10.1038\/labinvest.2011.69_bib41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbrc.2007.03.098","article-title":"Glutamate induces apoptosis in cultured spiral ganglion explants","volume":"357","author":"Steinbach","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/labinvest.2011.69_bib42","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1177\/147323000203000407","article-title":"Comparative cochlear toxicities of streptomycin, gentamicin, amikacin and netilmicin in guinea-pigs","volume":"30","author":"Kalkandelen","year":"2002","journal-title":"J Int Med Res"},{"key":"10.1038\/labinvest.2011.69_bib43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0006-8993(95)01198-6","article-title":"Endocytosis of aminoglycoside antibiotics in sensory hair cells","volume":"704","author":"Hashino","year":"1995","journal-title":"Brain Res"},{"key":"10.1038\/labinvest.2011.69_bib44","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1113\/jphysiol.2005.085951","article-title":"The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels","volume":"567","author":"Marcotti","year":"2005","journal-title":"J Physiol (Lond)"},{"key":"10.1038\/labinvest.2011.69_bib45","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.heares.2007.10.010","article-title":"A systemic gentamicin pathway across the stria vascularis","volume":"235","author":"Dai","year":"2008","journal-title":"Hear Res"},{"key":"10.1038\/labinvest.2011.69_bib46","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1080\/000164800750061624","article-title":"Blood-perilymph barrier and ototoxicity: an in vivo study in the rat","volume":"120","author":"Laurell","year":"2000","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"10.1038\/labinvest.2011.69_bib47","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-211-98811-4_3","article-title":"Past and recent BBB studies with particular emphasis on changes in ischemic brain edema","volume":"106","author":"Spatz","year":"2010","journal-title":"Acta Neurochir Suppl"},{"key":"10.1038\/labinvest.2011.69_bib48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF00455891","article-title":"The blood-perilymph barrier","volume":"228","author":"Jahnke","year":"1980","journal-title":"Arch Otorhinolaryngol"},{"key":"10.1038\/labinvest.2011.69_bib49","first-page":"339","article-title":"Effects of microcirculatory disorders of inner ear on blood-labyrinth barrier permeability in guinea pigs","volume":"35","author":"Zhang","year":"2000","journal-title":"Chin J Otorhinolaryngol"},{"key":"10.1038\/labinvest.2011.69_bib50","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0006-8993(01)02164-3","article-title":"Reactive nitrogen species contribute to blood-labyrinth barrier disruption in suppurative labyrinthitis complicating experimental pneumococcal meningitis in the rat","volume":"904","author":"Kastenbauer","year":"2001","journal-title":"Brain Res"},{"key":"10.1038\/labinvest.2011.69_bib51","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/tx0496946","article-title":"Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species","volume":"18","author":"Lesniak","year":"2005","journal-title":"Chem Res Toxicol"},{"key":"10.1038\/labinvest.2011.69_bib52","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0378-5955(01)00315-X","article-title":"Ischemia-reperfusion injury of the cochlea: effects of an iron chelator and nitric oxide synthase inhibitors","volume":"160","author":"Tabuchi","year":"2001","journal-title":"Hear Res"},{"key":"10.1038\/labinvest.2011.69_bib53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0378-5955(01)00388-4","article-title":"Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death","volume":"166","author":"Ylikoski","year":"2002","journal-title":"Hear Res"},{"key":"10.1038\/labinvest.2011.69_bib54","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/00020840-200310000-00004","article-title":"Ototoxicity: bioprotective mechanisms","volume":"11","author":"Rybak","year":"2003","journal-title":"Curr Opin Otolaryngol HN Surg"},{"key":"10.1038\/labinvest.2011.69_bib55","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/00005537-200303000-00012","article-title":"Gentamicin-induced hair cell death is not dependent on the apoptosis receptor Fas","volume":"113","author":"Bodmer","year":"2003","journal-title":"Laryngoscope"},{"key":"10.1038\/labinvest.2011.69_bib56","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1196\/annals.1293.025","article-title":"Molecular pathogenetic mechanism of maternally inherited deafness","volume":"1011","author":"Guan","year":"2004","journal-title":"Ann NY Acad Sci"},{"key":"10.1038\/labinvest.2011.69_bib57","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/08860229909085109","article-title":"Oxidant mechanisms in gentamicin nephrotoxicity","volume":"21","author":"Walker","year":"1999","journal-title":"Ren Fail"},{"key":"10.1038\/labinvest.2011.69_bib58","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1080\/00016480801935541","article-title":"Ototoxic interaction of kanamycin and 3-nitropropionic acid","volume":"128","author":"Lin","year":"2008","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"10.1038\/labinvest.2011.69_bib59","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1749-6632.1999.tb08657.x","article-title":"Dynamic studies of ototoxicity in mature avian auditory epithelium","volume":"884","author":"Hirose","year":"1999","journal-title":"Ann NY Acad Sci"},{"key":"10.1038\/labinvest.2011.69_bib60","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0378-5955(01)00417-8","article-title":"Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity","volume":"164","author":"Ding","year":"2002","journal-title":"Hear Res"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest201169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201169","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372202760X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372202760X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:51:24Z","timestamp":1758397884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002368372202760X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":60,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S002368372202760X"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2011.69","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transient ischemia\/hypoxia enhances gentamicin ototoxicity via caspase-dependent cell death pathway","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2011.69","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}