{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:34:16Z","timestamp":1787002456898,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":3876,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1038\/labinvest.2012.64","type":"journal-article","created":{"date-parts":[[2012,4,2]],"date-time":"2012-04-02T08:41:06Z","timestamp":1333356066000},"page":"926-936","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Human monocyte-derived cells with individual hepatocyte characteristics: a novel tool for personalized in vitro studies"],"prefix":"10.1016","volume":"92","author":[{"given":"Andreas","family":"Benesic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora L","family":"Rahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Ernst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L","family":"Gerbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2012.64_bib1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00204-008-0332-8","article-title":"Inhibition and induction of human cytochrome P450 enzymes: current status","volume":"82","author":"Pelkonen","year":"2008","journal-title":"Arch Toxicol"},{"key":"10.1038\/labinvest.2012.64_bib2","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1126\/science.1060762","article-title":"The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity","volume":"292","author":"Watkins","year":"2001","journal-title":"Science"},{"key":"10.1038\/labinvest.2012.64_bib3","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(02)11203-7","article-title":"Clinical importance of the cytochromes P450","volume":"360","author":"Nebert","year":"2002","journal-title":"Lancet"},{"key":"10.1038\/labinvest.2012.64_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/15376520590918847","article-title":"Impact of genetic polymorphism in relation to other factors on expression and function of human drug-metabolizing p450s","volume":"15","author":"Zanger","year":"2005","journal-title":"Toxicol Mech Methods"},{"key":"10.1038\/labinvest.2012.64_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fphar.2010.00129","article-title":"Pathway-targeted pharmacogenomics of CYP1A2 in human liver.","volume":"1","author":"Klein","year":"2010","journal-title":"Front Pharmacol"},{"key":"10.1038\/labinvest.2012.64_bib6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2217\/14622416.8.5.443","article-title":"Sex-dependent genetic markers of CYP3A4 expression and activity in human liver microsomes","volume":"8","author":"Schirmer","year":"2007","journal-title":"Pharmacogenomics"},{"key":"10.1038\/labinvest.2012.64_bib7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1517\/17425255.4.4.413","article-title":"Sex-specific differences in CYP450 isoforms in humans","volume":"4","author":"Scandlyn","year":"2008","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1038\/labinvest.2012.64_bib8","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s00216-008-2291-6","article-title":"Functional pharmacogenetics\/genomics of human cytochromes P450 involved in drug biotransformation","volume":"392","author":"Zanger","year":"2008","journal-title":"Anal Bioanal Chem"},{"key":"10.1038\/labinvest.2012.64_bib9","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00228-007-0393-2","article-title":"The limited impact of CYP3A5 genotype for the pharmacokinetics of CYP3A substrates","volume":"63","author":"Burk","year":"2007","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1038\/labinvest.2012.64_bib10","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1056\/NEJMoa1008410","article-title":"Effects of CYP2C19 genotype on outcomes of clopidogrel treatment","volume":"363","author":"Par\u00e9","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1038\/labinvest.2012.64_bib11","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1101\/gr.103341.109","article-title":"Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver","volume":"20","author":"Yang","year":"2010","journal-title":"Genome Res"},{"key":"10.1038\/labinvest.2012.64_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.taap.2004.01.010","article-title":"The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes","volume":"199","author":"Parkinson","year":"2004","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1038\/labinvest.2012.64_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-60761-688-7_1","article-title":"General review on in vitro hepatocyte models and their applications","volume":"640","author":"Guguen-Guillouzo","year":"2010","journal-title":"Methods Mol Biol"},{"key":"10.1038\/labinvest.2012.64_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/00498250310001657568","article-title":"Phase I and II enzyme characterization of two sources of HepG2 cell lines","volume":"34","author":"Hewitt","year":"2004","journal-title":"Xenobiotica"},{"key":"10.1038\/labinvest.2012.64_bib15","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.biocel.2006.10.007","article-title":"Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2","volume":"39","author":"Mavri-Damelin","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1038\/labinvest.2012.64_bib16","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nature10263","article-title":"Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors","volume":"475","author":"Sekiya","year":"2011","journal-title":"Nature"},{"key":"10.1038\/labinvest.2012.64_bib17","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nature10116","article-title":"Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors","volume":"475","author":"Huang","year":"2011","journal-title":"Nature"},{"key":"10.1038\/labinvest.2012.64_bib18","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/ajh.21030","article-title":"Peripheral blood monocytes from patients with HBV related decompensated liver cirrhosis can differentiate into functional hepatocytes","volume":"82","author":"Yan","year":"2007","journal-title":"Am J Hematol"},{"key":"10.1038\/labinvest.2012.64_bib19","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1053\/jhep.2002.33162","article-title":"Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse","volume":"35","author":"Dambach","year":"2002","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2012.64_bib20","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.immuni.2007.06.005","article-title":"Negotiation of the T lineage fate decision by transcription-factor interplay and microenvironmental signals","volume":"26","author":"Rothenberg","year":"2007","journal-title":"Immunity"},{"key":"10.1038\/labinvest.2012.64_bib21","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1053\/j.gastro.2005.03.029","article-title":"Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells","volume":"128","author":"uhnke","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2012.64_bib22","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.diff.2008.10.008","article-title":"A refined characterisation of the NeoHepatocyte phenotype necessitates a reappraisal of the transdifferentiation hypothesis","volume":"77","author":"Riquelme","year":"2009","journal-title":"Differentiation"},{"key":"10.1038\/labinvest.2012.64_bib23","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3727\/096368910X550224","article-title":"Autologous serum improves yield and metabolic capacity of monocyte-derived hepatocyte-like cells: possible implication for cell transplantation","volume":"20","author":"Ehnert","year":"2011","journal-title":"Cell Transplant"},{"key":"10.1038\/labinvest.2012.64_bib24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/A:1026392429112","article-title":"Charitable state-controlled foundation human tissue and cell research: ethic and legal aspects in the supply of surgically removed human tissue for research in the academic and commercial sector in Germany","volume":"4","author":"Thasler","year":"2003","journal-title":"Cell Tissue Banking"},{"key":"10.1038\/labinvest.2012.64_bib25","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jhep.2006.10.010","article-title":"P60-c-src suppresses apoptosis through inhibition of caspase 8 activation in hepatoma cells, but not in primary hepatocytes","volume":"46","author":"De Toni","year":"2007","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2012.64_bib26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0009-8981(02)00341-8","article-title":"New IFCC reference procedures for the determination of catalytic activity concentrations of five enzymes in serum: preliminary upper reference limits obtained in hospitalized subjects","volume":"327","author":"Schumann","year":"2003","journal-title":"Clin Chim Acta"},{"key":"10.1038\/labinvest.2012.64_bib27","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1159\/000096177","article-title":"Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy","volume":"29","author":"Benesic","year":"2006","journal-title":"Kidney Blood Press Res"},{"key":"10.1038\/labinvest.2012.64_bib28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1517\/17425255.2.4.629","article-title":"Luminogenic cytochrome P450 assays","volume":"2","author":"Cali","year":"2006","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1038\/labinvest.2012.64_bib29","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1124\/dmd.108.020677","article-title":"Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction","volume":"36","author":"Hariparsad","year":"2008","journal-title":"Drug Metab Dispos"},{"key":"10.1038\/labinvest.2012.64_bib30","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/978-3-642-00663-0_12","article-title":"Mechanisms of acetaminophen-induced liver necrosis","volume":"196","author":"Hinson","year":"2010","journal-title":"Handb Exp Pharmacol"},{"key":"10.1038\/labinvest.2012.64_bib31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2174\/1389200033489398","article-title":"The metabolism of diclofenac--enzymology and toxicology perspectives","volume":"4","author":"Tang","year":"2003","journal-title":"Curr Drug Metab"},{"key":"10.1038\/labinvest.2012.64_bib32","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1124\/dmd.104.003095","article-title":"Detection of a novel reactive metabolite of diclofenac: evidence for CYP2C9-mediated bioactivation via arene oxides","volume":"33","author":"Yan","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"10.1038\/labinvest.2012.64_bib33","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1053\/j.gastro.2006.12.036","article-title":"Hepatic expression of candidate genes in patients with alcoholic hepatitis: correlation with disease severity","volume":"132","author":"Colmenero","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2012.64_bib34","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/toxsci\/65.2.166","article-title":"Mechanisms of hepatotoxicity","volume":"65","author":"Jaeschke","year":"2002","journal-title":"Toxicol Sci"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest201264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201264","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722026915?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722026915?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:51:03Z","timestamp":1758397863000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722026915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0023683722026915"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2012.64","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human monocyte-derived cells with individual hepatocyte characteristics: a novel tool for personalized in vitro studies","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2012.64","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2012 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}