{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:28:07Z","timestamp":1761895687221,"version":"3.44.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":3450,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1038\/labinvest.2013.81","type":"journal-article","created":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T08:37:49Z","timestamp":1372063069000},"page":"900-910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Dynamics of connective-tissue localization during chronic Borrelia burgdorferi infection"],"prefix":"10.1016","volume":"93","author":[{"given":"Denise M","family":"Imai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunlian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emir","family":"Hodzic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen W","family":"Barthold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2013.81_bib1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1172\/JCI21681","article-title":"The emergence of Lyme disease","volume":"113","author":"Steere","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2013.81_bib2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.tim.2007.06.003","article-title":"Hidden in plain sight: Borrelia burgdorferi and the extracellular matrix","volume":"15","author":"Cabello","year":"2007","journal-title":"Trends Microbiol"},{"key":"10.1038\/labinvest.2013.81_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1749-6632.1988.tb31839.x","article-title":"Clinical pathologic correlations of Lyme disease by stage","volume":"539","author":"Duray","year":"1988","journal-title":"Ann NY Acad Sci"},{"key":"10.1038\/labinvest.2013.81_bib4","first-page":"263","article-title":"Kinetics of Borrelia burgdorferi dissemination and evolution of disease after intradermal inoculation of mice","volume":"139","author":"Barthold","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2013.81_bib5","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/infdis\/166.4.827","article-title":"Delayed dissemination of Lyme disease spirochetes from the site of deposition in the skin of mice","volume":"166","author":"Shih","year":"1992","journal-title":"J Infect Dis"},{"key":"10.1038\/labinvest.2013.81_bib6","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1128\/IAI.00469-06","article-title":"Antibody-mediated disease remission in the mouse model of Lyme borreliosis","volume":"74","author":"Barthold","year":"2006","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib7","first-page":"959","article-title":"Chronic Lyme borreliosis in the laboratory mouse","volume":"143","author":"Barthold","year":"1993","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2013.81_bib8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nrrheum.2010.209","article-title":"A case revealing the natural history of untreated Lyme disease","volume":"7","author":"Schoen","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"10.1038\/labinvest.2013.81_bib9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJM199401273300401","article-title":"Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis","volume":"330","author":"Nocton","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1038\/labinvest.2013.81_bib10","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1002\/art.30384","article-title":"Burden and viability of Borrelia burgdorferi in skin and joints of patients with erythema migrans or Lyme arthritis","volume":"63","author":"Li","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1038\/labinvest.2013.81_bib11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4269\/ajtmh.1992.47.249","article-title":"Carditis in Lyme disease susceptible and resistant strains of laboratory mice infected with Borrelia burgdorferi","volume":"47","author":"Armstrong","year":"1992","journal-title":"Am J Trop Med Hyg"},{"key":"10.1038\/labinvest.2013.81_bib12","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/labinvest.3780109","article-title":"Localization of Borrelia burgdorferi in the nervous system and other organs in the nonhuman primate model of Lyme disease","volume":"80","author":"Cadavid","year":"2000","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.2013.81_bib13","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/labinvest.3700177","article-title":"Cardiac involvement in non-human primates infected with the Lyme disease spirochete Borrelia burgdorferi","volume":"84","author":"Cadavid","year":"2004","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.2013.81_bib14","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1177\/0300985811398246","article-title":"Lyme neuroborreliosis in 2 horses","volume":"48","author":"Imai","year":"2011","journal-title":"Vet Pathol"},{"year":"2002","series-title":"Molecular Biology of the Cell","author":"Alberts","key":"10.1038\/labinvest.2013.81_bib15"},{"key":"10.1038\/labinvest.2013.81_bib16","first-page":"136","article-title":"Common themes in microbial pathogenicity revisited","volume":"61","author":"Finlay","year":"1997","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1038\/labinvest.2013.81_bib17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-94-007-0940-9_3","article-title":"Adhesion mechanisms of Borrelia burgdorferi","volume":"715","author":"Antonara","year":"2011","journal-title":"Adv Exp Med Biol"},{"key":"10.1038\/labinvest.2013.81_bib18","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1128\/iai.63.9.3467-3472.1995","article-title":"Adherence of Borrelia burgdorferi to the proteoglycan decorin","volume":"63","author":"Guo","year":"1995","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib19","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1046\/j.1365-2958.1998.01103.x","article-title":"Decorin-binding adhesins from Borrelia burgdorferi","volume":"30","author":"Guo","year":"1998","journal-title":"Mol Microbiol"},{"key":"10.1038\/labinvest.2013.81_bib20","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1046\/j.1365-2958.2000.01792.x","article-title":"Identification of a candidate glycosaminoglycan-binding adhesin of the Lyme disease spirochete Borrelia burgdorferi","volume":"35","author":"Parveen","year":"2000","journal-title":"Mol Microbiol"},{"key":"10.1038\/labinvest.2013.81_bib21","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1128\/IAI.00227-09","article-title":"Borrelia burgdorferi RevA antigen binds host fibronectin","volume":"77","author":"Brissette","year":"2009","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib22","doi-asserted-by":"crossref","first-page":"4940","DOI":"10.1128\/IAI.01420-08","article-title":"Borrelia burgdorferi BmpA is a laminin-binding protein","volume":"77","author":"Verma","year":"2009","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib23","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1099\/mic.0.024604-0","article-title":"The Borrelia burgdorferi outer-surface protein ErpX binds mammalian laminin","volume":"155","author":"Brissette","year":"2009","journal-title":"Microbiology"},{"key":"10.1038\/labinvest.2013.81_bib24","doi-asserted-by":"crossref","first-page":"9266","DOI":"10.1046\/j.1365-2958.1999.01654.x","article-title":"Characterization of a candidate Borrelia burgdorferi b3-chain integrin ligand identified using phage display library","volume":"34","author":"Coburn","year":"1999","journal-title":"Mol Microbiol"},{"key":"10.1038\/labinvest.2013.81_bib25","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1128\/IAI.72.6.3138-3146.2004","article-title":"Borrelia burgdorferi binds to, invades, and colonizes native type I collagen lattices","volume":"72","author":"Zambrano","year":"2004","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib26","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1365-2958.2007.05924.x","article-title":"Borrelia burgdorferi adhesins identified using in vivo phage display","volume":"66","author":"Antonara","year":"2007","journal-title":"Mol Microbiol"},{"key":"10.1038\/labinvest.2013.81_bib27","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0002-9440(10)63359-7","article-title":"Protective niche for Borrelia burgdorferi to evade humoral immunity","volume":"165","author":"Liang","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2013.81_bib28","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1084\/jem.20011870","article-title":"An immune evasion mechanism for spirochetal persistence in Lyme borreliosis","volume":"195","author":"Liang","year":"2002","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.2013.81_bib29","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1086\/516166","article-title":"Protective and arthritis-resolving activity in sera of mice infected with Borrelia burgdorferi","volume":"25","author":"Barthold","year":"1997","journal-title":"Clin Infect Dis"},{"key":"10.1038\/labinvest.2013.81_bib30","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1046\/j.1365-2958.2000.01698.x","article-title":"A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi","volume":"35","author":"Casjens","year":"2000","journal-title":"Mol Microbiol"},{"key":"10.1038\/labinvest.2013.81_bib31","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/37551","article-title":"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi","volume":"390","author":"Fraser","year":"1997","journal-title":"Nature"},{"key":"10.1038\/labinvest.2013.81_bib32","first-page":"521","article-title":"Isolation and cultivation of Lyme disease spirochetes","volume":"57","author":"Barbour","year":"1984","journal-title":"Yale J Biol Med"},{"key":"10.1038\/labinvest.2013.81_bib33","doi-asserted-by":"crossref","first-page":"5042","DOI":"10.1128\/IAI.71.9.5042-5055.2003","article-title":"Borrelia burgdorferi population dynamics and prototype gene expression during infection of immunocompetent and immunodeficient mice","volume":"71","author":"Hodzic","year":"2003","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib34","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1128\/IAI.66.6.2827-2835.1998","article-title":"Humoral immunity to Borrelia burgdorferi N40 decorin binding proteins during infection in laboratory mice","volume":"66","author":"Feng","year":"1998","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib35","first-page":"57","article-title":"Serum-mediated resolution of Lyme arthritis in mice","volume":"74","author":"Barthold","year":"1996","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.2013.81_bib36","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1128\/IAI.66.11.5275-5285.1998","article-title":"Molecular analysis of sequence heterogeneity among genes encoding decorin binding proteins A and B of Borrelia burgdorferi sensu lato","volume":"66","author":"Roberts","year":"1998","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib37","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1128\/IAI.00163-11","article-title":"Allelic variation of the Lyme disease spirochete adhesin DbpA influences spirochetal binding to decorin, dermatan sulfate, and mammalian cells","volume":"79","author":"Benoit","year":"2011","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib38","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1128\/IAI.66.5.2143-2153.1998","article-title":"Active and passive immunity against Borrelia burgdorferi decorin binding protein A (DbpA) protects against infection","volume":"66","author":"Hanson","year":"1998","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib39","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1083\/jcb.136.3.729","article-title":"Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility","volume":"136","author":"Danielson","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1038\/labinvest.2013.81_bib40","first-page":"962","article-title":"Regional differences in the distribution of the proteoglycans biglycan and decorin in the extracellular matrix of atherosclerotic and restenotic human coronary arteries","volume":"144","author":"Reissen","year":"1994","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2013.81_bib41","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/BF01007492","article-title":"Immunolocalization of collagen types I and III in the arterial wall of the heart","volume":"21","author":"Farquharson","year":"1989","journal-title":"Histochem J"},{"key":"10.1038\/labinvest.2013.81_bib42","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s12265-011-9261-7","article-title":"Changes in expression of proteoglycan core proteins and heparin sulfate enzymes in the developing and adult murine aorta","volume":"4","author":"Adhikari","year":"2011","journal-title":"J Cardiovasc Trans Res"},{"key":"10.1038\/labinvest.2013.81_bib43","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/iub.115","article-title":"Decorin and its galactosaminoglycan chain: Extracellular regulator of cellular function?","volume":"60","author":"Seidler","year":"2008","journal-title":"IUBMB Life"},{"key":"10.1038\/labinvest.2013.81_bib44","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1177\/38.11.2212616","article-title":"Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues","volume":"38","author":"Bianco","year":"1990","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/labinvest.2013.81_bib45","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0966-842X(98)01323-7","article-title":"Pathogenesis of chronic bacterial infections","volume":"6","author":"Godfrey","year":"1998","journal-title":"Trends Microbiol"},{"key":"10.1038\/labinvest.2013.81_bib46","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1128\/IAI.01307-06","article-title":"Infection of mice with Lyme disease spirochetes constituitively produducing outer surface proteins A and B","volume":"75","author":"Strother","year":"2007","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib47","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1128\/IAI.66.11.5379-5387.1998","article-title":"DbpA, but not OspA, is expressed by Borrelia burgdorferi during spirochetemia and is a target for protective antibodies","volume":"66","author":"Cassatt","year":"1998","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib48","doi-asserted-by":"crossref","first-page":"e1002066","DOI":"10.1371\/journal.ppat.1002066","article-title":"Lymphadenopathy during Lyme borreliosis is caused by spirochete migration-induced specific B cell activation","volume":"7","author":"Tunev","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1038\/labinvest.2013.81_bib49","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1128\/IAI.00897-07","article-title":"Both decorin-binding proteins A and B are critical for the overall virulence of Borrelia burgdorferi","volume":"76","author":"Shi","year":"2008","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib50","doi-asserted-by":"crossref","first-page":"e3340","DOI":"10.1371\/journal.pone.0003340","article-title":"Common and unique contributions of decorin-binding proteins A and B to the overall virulence of Borrelia burgdorferi","volume":"3","author":"Shi","year":"2008","journal-title":"Plos One"},{"key":"10.1038\/labinvest.2013.81_bib51","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1128\/IAI.01359-12","article-title":"The early dissemination defect attributed to disruption of decorin-binding proteins is abolished in chronic murine Lyme borreliosis","volume":"81","author":"Imai","year":"2013","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib52","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.1128\/IAI.00690-08","article-title":"Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection","volume":"76","author":"Weening","year":"2008","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib53","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1128\/IAI.00560-07","article-title":"Increasing the interaction of Borrelia burgdorferi with decorin significantly reduces the 50 percent infectious dose and severely impairs dissemination","volume":"75","author":"Xu","year":"2007","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2013.81_bib54","first-page":"63","article-title":"The important and diverse roles of antibodies in the host response to Borrelia infections","volume":"319","author":"LaRocca","year":"2008","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1038\/labinvest.2013.81_bib55","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/ni1102-1026","article-title":"Chronic bacterial infections: living with unwanted guests","volume":"3","author":"Young","year":"2002","journal-title":"Nat Immunol"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest201381.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201381","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722009126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722009126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201381.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:33:26Z","timestamp":1758396806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722009126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0023683722009126"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2013.81","relation":{},"ISSN":["0023-6837"],"issn-type":[{"type":"print","value":"0023-6837"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamics of connective-tissue localization during chronic Borrelia burgdorferi infection","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2013.81","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2013.88","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2013 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}