{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:49:27Z","timestamp":1770151767956,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":2901,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1038\/labinvest.2014.148","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T08:37:24Z","timestamp":1419237444000},"page":"180-192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Low doses of CMV induce autoimmune-mediated and inflammatory responses in bile duct epithelia of regulatory T cell-depleted neonatal mice"],"prefix":"10.1016","volume":"95","author":[{"given":"Jie","family":"Wen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongtao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bisheng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenghong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2014.148_bib1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/hep.21366","article-title":"Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia","volume":"44","author":"Mack","year":"2006","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2014.148_bib2","first-page":"4","article-title":"Pathogenesis and outcome of biliary atresia: current concepts","volume":"37","author":"Sokol","year":"2003","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1038\/labinvest.2014.148_bib3","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/hep.22229","article-title":"Temporal-spatial activation of apoptosis and epithelial injury in murine experimental biliary atresia","volume":"47","author":"Erickson","year":"2008","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2014.148_bib4","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1172\/JCI38879","article-title":"Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia","volume":"119","author":"Shivakumar","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2014.148_bib5","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/hep.20547","article-title":"Outcome in adulthood of biliary atresia: a study of 63 patients who survived for over 20 years with their native liver","volume":"41","author":"Lykavieris","year":"2005","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2014.148_bib6","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/lt.21711","article-title":"Prognostic value of computerized quantification of liver fibrosis in children with biliary atresia","volume":"15","author":"Pape","year":"2009","journal-title":"Liver Transplant"},{"key":"10.1038\/labinvest.2014.148_bib7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jpeds.2003.09.042","article-title":"Hepatic fibrosis and survival in biliary atresia","volume":"144","author":"Weerasooriya","year":"2004","journal-title":"J Pediatr"},{"key":"10.1038\/labinvest.2014.148_bib8","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.jhep.2009.12.027","article-title":"Post-natal paucity of regulatory T cells and control of NK cell activation in experimental biliary atresia","volume":"52","author":"Miethke","year":"2010","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2014.148_bib9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1053\/j.gastro.2007.04.032","article-title":"Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia","volume":"133","author":"Mack","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2014.148_bib10","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1053\/j.gastro.2010.09.020","article-title":"Viruses and autoantibodies in biliary atresia","volume":"139","author":"Selmi","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2014.148_bib11","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1053\/j.gastro.2007.04.031","article-title":"Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia","volume":"133","author":"Shivakumar","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2014.148_bib12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1203\/01.PDR.0000130480.51066.FB","article-title":"Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation","volume":"56","author":"Mack","year":"2004","journal-title":"Pediatr Res"},{"key":"10.1038\/labinvest.2014.148_bib13","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.clim.2005.01.012","article-title":"Armed CD4+ Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia","volume":"115","author":"Mack","year":"2005","journal-title":"Clin Immunol"},{"key":"10.1038\/labinvest.2014.148_bib14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.virol.2011.05.015","article-title":"Osteopontin upregulation in rotavirus-induced murine biliary atresia requires replicating virus but is not necessary for development of biliary atresia","volume":"417","author":"Hertel","year":"2011","journal-title":"Virology"},{"key":"10.1038\/labinvest.2014.148_bib15","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s00535-005-1683-z","article-title":"Cytomegalovirus cholangitis and pancreatitis in an immunocompetent patient","volume":"40","author":"Oku","year":"2005","journal-title":"J Gastroenterol"},{"key":"10.1038\/labinvest.2014.148_bib16","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0168-8278(99)80294-3","article-title":"Cytomegalovirus infection of bile duct epithelial cells, hepatic artery and portal venous endothelium in relation to chronic rejection of liver grafts","volume":"31","author":"Evans","year":"1999","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2014.148_bib17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3109\/15513815.2011.572959","article-title":"Development of a guinea pig model of perinatal cytomegalovirus-induced hepatobiliary injury","volume":"30","author":"Wang","year":"2011","journal-title":"Fetal Pediatr Pathol"},{"key":"10.1038\/labinvest.2014.148_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/0009922811406264","article-title":"The perinatal infection of cytomegalovirus is an important etiology for biliary atresia in China","volume":"51","author":"Xu","year":"2012","journal-title":"Clin Pediatr (Phila)"},{"key":"10.1038\/labinvest.2014.148_bib19","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/hep.24807","article-title":"Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells","volume":"55","author":"Brindley","year":"2012","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2014.148_bib20","first-page":"281","article-title":"Is there any association of extra hepatic biliary atresia with cytomegalovirus or other infections?","volume":"61","author":"Soomro","year":"2011","journal-title":"J Pak Med Assoc"},{"key":"10.1038\/labinvest.2014.148_bib21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12519-008-0024-8","article-title":"Relationship between prognosis of biliary atresia and infection of cytomegalovirus","volume":"4","author":"Shen","year":"2008","journal-title":"World J Pediatr"},{"key":"10.1038\/labinvest.2014.148_bib22","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1038\/labinvest.2014.148_bib23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ni1428","article-title":"Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice","volume":"8","author":"Kim","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1038\/labinvest.2014.148_bib24","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jhep.2013.05.010","article-title":"Regulatory T cells inhibit Th1 cell-mediated bile duct injury in murine biliary atresia","volume":"59","author":"Tucker","year":"2013","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2014.148_bib25","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/hep.25662","article-title":"Regulatory T cells control the CD8 adaptive immune response at the time of ductal obstruction in experimental biliary atresia","volume":"56","author":"Lages","year":"2012","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2014.148_bib26","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.4049\/jimmunol.168.12.5979","article-title":"Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease","volume":"168","author":"McHugh","year":"2002","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.2014.148_bib27","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1016\/j.transproceed.2007.06.077","article-title":"An animal model of human cytomegalovirus infection","volume":"39","author":"Gao","year":"2007","journal-title":"Transplant Proc"},{"key":"10.1038\/labinvest.2014.148_bib28","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/infdis\/168.2.336","article-title":"A rabbit model for human cytomegalovirus-induced chorioretinal disease","volume":"168","author":"Dunkel","year":"1993","journal-title":"J Infect Dis"},{"key":"10.1038\/labinvest.2014.148_bib29","first-page":"271","article-title":"[An experimental study of rat infected with human cytomegalovirus AD169 strain]","volume":"14","author":"Meng","year":"2000","journal-title":"Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi"},{"key":"10.1038\/labinvest.2014.148_bib30","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1053\/j.gastro.2010.07.042","article-title":"alpha-enolase autoantibodies cross-reactive to viral proteins in a mouse model of biliary atresia","volume":"139","author":"Lu","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2014.148_bib31","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.autrev.2006.10.004","article-title":"Alpha-enolase: a target of antibodies in infectious and autoimmune diseases","volume":"6","author":"Terrier","year":"2007","journal-title":"Autoimmun Rev"},{"key":"10.1038\/labinvest.2014.148_bib32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/j.1536-4801.1993.tb10818.x","article-title":"Genetics, immunology, and biliary atresia: an opening or a diversion?","volume":"16","author":"Schreiber","year":"1993","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1038\/labinvest.2014.148_bib33","first-page":"57","article-title":"The viral association of neonatal cholestasis in Sweden: a possible link between cytomegalovirus infection and extrahepatic biliary atresia","volume":"27","author":"Fischler","year":"1998","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1038\/labinvest.2014.148_bib34","first-page":"87","article-title":"Biliary atresia\u2013an autoimmune disorder?","volume":"22","author":"Vasiliauskas","year":"1995","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2014.148_bib35","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0168-8278(97)80251-6","article-title":"Identification of an autoantibody against alpha-enolase in primary biliary cirrhosis","volume":"26","author":"Akisawa","year":"1997","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2014.148_bib36","doi-asserted-by":"crossref","first-page":"6178","DOI":"10.1128\/IAI.71.11.6178-6183.2003","article-title":"Differential production of macrophage inflammatory protein 1gamma (MIP-1gamma), lymphotactin, and MIP-2 by CD4(+) Th subsets polarized in vitroin vivo","volume":"71","author":"Muller","year":"2003","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.2014.148_bib37","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1016\/j.biocel.2003.10.019","article-title":"Macrophage inflammatory protein-1","volume":"36","author":"Maurer","year":"2004","journal-title":"Int J Biochem Cell Biol"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest2014148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2014148","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722023443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722023443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2014148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:48:04Z","timestamp":1758397684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722023443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0023683722023443"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2014.148","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low doses of CMV induce autoimmune-mediated and inflammatory responses in bile duct epithelia of regulatory T cell-depleted neonatal mice","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2014.148","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}