{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:51:29Z","timestamp":1790175089648,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":2751,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1038\/labinvest.2015.49","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T09:08:32Z","timestamp":1428916112000},"page":"702-717","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition"],"prefix":"10.1016","volume":"95","author":[{"given":"Gargi","family":"Maity","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"De","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amlan","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snigdha","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandipto","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushanta K","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2015.49_bib1","first-page":"10","article-title":"Cancer statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"10.1038\/labinvest.2015.49_bib2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12079-012-0158-2","article-title":"CCN5\/WISP-2: a micromanager of breast cancer progression","volume":"6","author":"Banerjee","year":"2012","journal-title":"J Cell Commun Signal"},{"key":"10.1038\/labinvest.2015.49_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrclinonc.2010.217","article-title":"Breast cancer in 2010: novel targets and therapies for a personalized approach","volume":"8","author":"Higgins","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1038\/labinvest.2015.49_bib4","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1172\/JCI57152","article-title":"Targeted therapies for breast cancer","volume":"121","author":"Higgins","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2015.49_bib5","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1158\/0008-5472.CAN-13-3437","article-title":"Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies","volume":"74","author":"Lin","year":"2014","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.2015.49_bib6","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nrc2256","article-title":"Models, mechanisms and clinical evidence for cancer dormancy","volume":"7","author":"Aguirre-Ghiso","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/labinvest.2015.49_bib7","doi-asserted-by":"crossref","first-page":"13820","DOI":"10.1073\/pnas.0905718106","article-title":"Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features","volume":"106","author":"Creighton","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.2015.49_bib8","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/nm.2795","article-title":"Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance","volume":"18","author":"Balko","year":"2012","journal-title":"Nat Med"},{"key":"10.1038\/labinvest.2015.49_bib9","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1158\/1940-6207.CAPR-11-0106","article-title":"A randomized placebo-controlled prevention trial of aspirin and\/or resistant starch in young people with familial adenomatous polyposis","volume":"4","author":"Burn","year":"2011","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1038\/labinvest.2015.49_bib10","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/S0140-6736(11)61049-0","article-title":"Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial","volume":"378","author":"Burn","year":"2011","journal-title":"Lancet"},{"key":"10.1038\/labinvest.2015.49_bib11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1158\/1940-6207.CAPR-11-0391","article-title":"Aspirin in the chemoprevention of colorectal neoplasia: an overview","volume":"5","author":"Chan","year":"2012","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1038\/labinvest.2015.49_bib12","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s11912-013-0351-3","article-title":"Role of aspirin in cancer prevention","volume":"15","author":"Thorat","year":"2013","journal-title":"Curr Oncol Rep"},{"key":"10.1038\/labinvest.2015.49_bib13","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/jnci\/djs318","article-title":"Daily aspirin use and cancer mortality in a large US cohort","volume":"104","author":"Jacobs","year":"2012","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/labinvest.2015.49_bib14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrclinonc.2011.199","article-title":"The role of aspirin in cancer prevention","volume":"9","author":"Thun","year":"2012","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1038\/labinvest.2015.49_bib15","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1158\/1940-6207.CAPR-11-0146","article-title":"Aspirin, nonsteroidal anti-inflammatory drugs, acetaminophen, and pancreatic cancer risk: a clinic-based case-control study","volume":"4","author":"Tan","year":"2011","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1038\/labinvest.2015.49_bib16","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S1470-2045(12)70112-2","article-title":"Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials","volume":"13","author":"Algra","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1038\/labinvest.2015.49_bib17","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1200\/JCO.2009.22.7918","article-title":"Aspirin intake and survival after breast cancer","volume":"28","author":"Holmes","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1038\/labinvest.2015.49_bib18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1158\/1535-7163.MCT-12-0777","article-title":"A second-generation 2-methoxyestradiol prodrug is effective against Barrett's adenocarcinoma in a mouse xenograft model","volume":"12","author":"Kambhampati","year":"2013","journal-title":"Mol Cancer Ther"},{"key":"10.1038\/labinvest.2015.49_bib19","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1158\/0008-5472.CAN-08-0316","article-title":"Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5\/WISP-2","volume":"68","author":"Dhar","year":"2008","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.2015.49_bib20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/1476-4598-9-209","article-title":"Tumor cell-derived PDGF-B potentiates mouse mesenchymal stem cells-pericytes transition and recruitment through an interaction with NRP-1","volume":"9","author":"Dhar","year":"2010","journal-title":"Mol Cancer"},{"key":"10.1038\/labinvest.2015.49_bib21","doi-asserted-by":"crossref","first-page":"38569","DOI":"10.1074\/jbc.M112.389064","article-title":"The matricellular protein CCN1\/Cyr61 is a critical regulator of Sonic Hedgehog in pancreatic carcinogenesis","volume":"287","author":"Haque","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2015.49_bib22","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1158\/0008-5472.CAN-08-1461","article-title":"CCN5\/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells","volume":"68","author":"Banerjee","year":"2008","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.2015.49_bib23","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1158\/2159-8290.CD-11-0031","article-title":"PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-kappaB-cytokine network","volume":"1","author":"Ying","year":"2011","journal-title":"Cancer Discov"},{"key":"10.1038\/labinvest.2015.49_bib24","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1101\/gad.1061803","article-title":"In vitro propagation and transcriptional profiling of human mammary stem\/progenitor cells","volume":"17","author":"Dontu","year":"2003","journal-title":"Genes Dev"},{"key":"10.1038\/labinvest.2015.49_bib25","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cell.2011.09.048","article-title":"The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells","volume":"147","author":"Cordenonsi","year":"2011","journal-title":"Cell"},{"key":"10.1038\/labinvest.2015.49_bib26","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.stem.2009.08.018","article-title":"Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors","volume":"5","author":"Ikushima","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1038\/labinvest.2015.49_bib27","doi-asserted-by":"crossref","first-page":"43475","DOI":"10.1074\/jbc.M111.284158","article-title":"Cysteine-rich 61-connective tissue growth factor-nephroblastoma-overexpressed 5 (CCN5)\/Wnt-1-induced signaling protein-2 (WISP-2) regulates microRNA-10b via hypoxia-inducible factor-1alpha-TWIST signaling networks in human breast cancer cells","volume":"286","author":"Haque","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2015.49_bib28","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J"},{"key":"10.1038\/labinvest.2015.49_bib29","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1126\/science.270.5244.2017","article-title":"The effect of sodium salicylate and aspirin on NF-kappa B","volume":"270","author":"Frantz","year":"1995","journal-title":"Science"},{"key":"10.1038\/labinvest.2015.49_bib30","unstructured":"Rainsford KD, Aspinin and the Salicylates, 1984, Butterworths: Boston, MA."},{"key":"10.1038\/labinvest.2015.49_bib31","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1096\/fj.06-5987com","article-title":"Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism","volume":"20","author":"Borthwick","year":"2006","journal-title":"FASEB J"},{"key":"10.1038\/labinvest.2015.49_bib32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/23948","article-title":"The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta","volume":"396","author":"Yin","year":"1998","journal-title":"Nature"},{"key":"10.1038\/labinvest.2015.49_bib33","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1038\/emm.2013.91","article-title":"Aspirin-induced Bcl-2 translocation and its phosphorylation in the nucleus trigger apoptosis in breast cancer cells","volume":"45","author":"Choi","year":"2013","journal-title":"Exp Mol Med"},{"key":"10.1038\/labinvest.2015.49_bib34","doi-asserted-by":"crossref","first-page":"e48208","DOI":"10.1371\/journal.pone.0048208","article-title":"Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors","volume":"7","author":"Pathi","year":"2012","journal-title":"PLoS One"},{"key":"10.1038\/labinvest.2015.49_bib35","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.bjc.6601913","article-title":"Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis","volume":"91","author":"Din","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1038\/labinvest.2015.49_bib36","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1002\/jcb.24539","article-title":"Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol","volume":"114","author":"Lin","year":"2013","journal-title":"J Cell Biochem"},{"key":"10.1038\/labinvest.2015.49_bib37","doi-asserted-by":"crossref","first-page":"242ra284","DOI":"10.1126\/scitranslmed.3008455","article-title":"COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models","volume":"6","author":"Xu","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1038\/labinvest.2015.49_bib38","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1053\/jhep.2002.31774","article-title":"COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells","volume":"35","author":"Nzeako","year":"2002","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2015.49_bib39","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1073\/pnas.0530291100","article-title":"Prospective identification of tumorigenic breast cancer cells","volume":"100","author":"Al-Hajj","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.2015.49_bib40","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nrc1235","article-title":"Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice","volume":"3","author":"Rangarajan","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/labinvest.2015.49_bib41","doi-asserted-by":"crossref","first-page":"e77281","DOI":"10.1371\/journal.pone.0077281","article-title":"Mammosphere formation in breast carcinoma cell lines depends upon expression of E-cadherin","volume":"8","author":"Manuel Iglesias","year":"2013","journal-title":"PLoS One"},{"key":"10.1038\/labinvest.2015.49_bib42","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.1203543","article-title":"A perspective on cancer cell metastasis","volume":"331","author":"Chaffer","year":"2011","journal-title":"Science"},{"key":"10.1038\/labinvest.2015.49_bib43","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1038\/sj.onc.1209091","article-title":"Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase\/AKT pathways","volume":"24","author":"Larue","year":"2005","journal-title":"Oncogene"},{"key":"10.1038\/labinvest.2015.49_bib44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/ng1001-117","article-title":"TGF-beta signaling in tumor suppression and cancer progression","volume":"29","author":"Derynck","year":"2001","journal-title":"Nat Genet"},{"key":"10.1038\/labinvest.2015.49_bib45","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1038\/sj.onc.1210272","article-title":"Dissecting the role of TGF-beta type I receptor\/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function","volume":"26","author":"Schniewind","year":"2007","journal-title":"Oncogene"},{"key":"10.1038\/labinvest.2015.49_bib46","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/bcr2224","article-title":"Transforming growth factor-beta in breast cancer: too much, too late","volume":"11","author":"Barcellos-Hoff","year":"2009","journal-title":"Breast Cancer Res"},{"key":"10.1038\/labinvest.2015.49_bib47","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ccr.2009.02.011","article-title":"TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma","volume":"15","author":"Penuelas","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1038\/labinvest.2015.49_bib48","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1158\/0008-5472.CAN-05-3560","article-title":"The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells","volume":"66","author":"Deckers","year":"2006","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.2015.49_bib49","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/labinvest.2009.97","article-title":"Free fatty acids enhance breast cancer cell migration through plasminogen activator inhibitor-1 and SMAD4","volume":"89","author":"Byon","year":"2009","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.2015.49_bib50","doi-asserted-by":"crossref","first-page":"e58183","DOI":"10.1371\/journal.pone.0058183","article-title":"Biomarkers of residual disease, disseminated tumor cells, and metastases in the MMTV-PyMT breast cancer model","volume":"8","author":"Franci","year":"2013","journal-title":"PLoS One"},{"key":"10.1038\/labinvest.2015.49_bib51","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/bcr923","article-title":"Aspirin and breast cancer prevention\u2014a link to ER status","volume":"6","author":"Tait","year":"2004","journal-title":"Breast Cancer Res"},{"key":"10.1038\/labinvest.2015.49_bib52","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s10549-011-1747-0","article-title":"Aspirin use and breast cancer risk: a meta-analysis","volume":"131","author":"Luo","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"10.1038\/labinvest.2015.49_bib53","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/bjc.2014.271","article-title":"Molecular targets of aspirin and cancer prevention","volume":"11","author":"Alfonso","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1038\/labinvest.2015.49_bib54","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1158\/1078-0432.CCR-07-4362","article-title":"Aspirin sensitizes cancer cells to TRAIL-induced apoptosis by reducing survivin levels","volume":"14","author":"Lu","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1038\/labinvest.2015.49_bib55","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1200\/JCO.2012.42.2006","article-title":"Use of aspirin, other nonsteroidal anti-inflammatory drugs, and acetaminophen and postmenopausal breast cancer incidence","volume":"30","author":"Zhang","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1038\/labinvest.2015.49_bib56","first-page":"1012","article-title":"The role of aspirin in colorectal cancer prevention and treatment","volume":"27","author":"Chan","year":"2013","journal-title":"Oncology (Williston Park)"},{"key":"10.1038\/labinvest.2015.49_bib57","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1002\/jcb.21772","article-title":"Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells","volume":"104","author":"Lin","year":"2008","journal-title":"J Cell Biochem"},{"key":"10.1038\/labinvest.2015.49_bib58","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/ijc.28381","article-title":"Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH\/HES1 and activating PPARG in colorectal cancer","volume":"134","author":"Moon","year":"2014","journal-title":"Int J Cancer"},{"key":"10.1038\/labinvest.2015.49_bib59","doi-asserted-by":"crossref","first-page":"29228","DOI":"10.1074\/jbc.M602629200","article-title":"Aspirin induces apoptosis through the inhibition of proteasome function","volume":"281","author":"Dikshit","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2015.49_bib60","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10549-013-2779-4","article-title":"Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties","volume":"143","author":"Kundu","year":"2014","journal-title":"Breast Cancer Res Treat"},{"key":"10.1038\/labinvest.2015.49_bib61","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/cas.12475","article-title":"Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions","volume":"105","author":"Majumder","year":"2014","journal-title":"Cancer Sci"},{"key":"10.1038\/labinvest.2015.49_bib62","doi-asserted-by":"crossref","first-page":"30651","DOI":"10.1074\/jbc.274.43.30651","article-title":"Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45\/inhibitor of caspase-activated DNase inactivation","volume":"274","author":"Wolf","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2015.49_bib63","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/jnci\/djh095","article-title":"Cancer stem cells: are we missing the target?","volume":"96","author":"Jones","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/labinvest.2015.49_bib64","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1158\/0008-5472.CAN-07-2148","article-title":"Direct evidence for epithelial-mesenchymal transitions in breast cancer","volume":"68","author":"Trimboli","year":"2008","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.2015.49_bib65","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/jnci\/djn123","article-title":"Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy","volume":"100","author":"Li","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/labinvest.2015.49_bib66","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/MPA.0b013e318033f9f4","article-title":"Establishment of clonal colony-forming assay for propagation of pancreatic cancer cells with stem cell properties","volume":"34","author":"Gou","year":"2007","journal-title":"Pancreas"},{"key":"10.1038\/labinvest.2015.49_bib67","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/ncb807","article-title":"Metastasis is driven by sequential elevation of H-ras and Smad2 levels","volume":"4","author":"Oft","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1038\/labinvest.2015.49_bib68","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1101\/gad.181700","article-title":"Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells","volume":"14","author":"Lehmann","year":"2000","journal-title":"Genes Dev"},{"key":"10.1038\/labinvest.2015.49_bib69","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1242\/jcs.112.24.4557","article-title":"TGF-(beta) type I receptor\/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells","volume":"112","author":"Piek","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1038\/labinvest.2015.49_bib70","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1091\/mbc.e04-08-0658","article-title":"TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition","volume":"16","author":"Valcourt","year":"2005","journal-title":"Mol Biol Cell"},{"key":"10.1038\/labinvest.2015.49_bib71","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3892\/br.2014.242","article-title":"Aspirin inhibit platelet-induced epithelial-to-mesenchymal transition of circulating tumor cells (Review)","volume":"2","author":"Lou","year":"2014","journal-title":"Biomed Rep"},{"key":"10.1038\/labinvest.2015.49_bib72","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/jnci\/90.6.455","article-title":"Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer","volume":"90","author":"Hwang","year":"1998","journal-title":"J Natl Cancer Inst"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest201549.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201549","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722023157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722023157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201549.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:47:36Z","timestamp":1758397656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722023157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":72,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0023683722023157"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2015.49","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2015.49","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}