{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:17:48Z","timestamp":1770772668031,"version":"3.50.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":2720,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1038\/labinvest.2015.72","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T12:26:21Z","timestamp":1432556781000},"page":"886-902","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Bronchial lesions of mouse model of asthma are preceded by immune complex vasculitis and induced bronchial associated lymphoid tissue (iBALT)"],"prefix":"10.1016","volume":"95","author":[{"given":"Ian C","family":"Guest","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stewart","family":"Sell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2015.72_bib1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1164\/ajrccm\/146.2.374","article-title":"CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea","volume":"146","author":"Nakajima","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1038\/labinvest.2015.72_bib2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1165\/ajrcmb.24.5.f207","article-title":"Food for thought: can immunological tolerance be induced to treat asthma?","volume":"24","author":"Cohn","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1038\/labinvest.2015.72_bib3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1365-2222.2007.02740.x","article-title":"Animal models of asthma","volume":"37","author":"Zosky","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1038\/labinvest.2015.72_bib4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1242\/dmm.000323","article-title":"Mouse models of allergic asthma: acute and chronic allergen challenge","volume":"1","author":"Nials","year":"2008","journal-title":"Dis Model Mech"},{"key":"10.1038\/labinvest.2015.72_bib5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3389\/fphys.2012.00312","article-title":"Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?","volume":"3","author":"Kumar","year":"2012","journal-title":"Front Physiol"},{"key":"10.1038\/labinvest.2015.72_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bcp.2013.06.026","article-title":"Animal models of asthma: reprise or reboot?","volume":"87","author":"Mullane","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"10.1038\/labinvest.2015.72_bib7","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2174\/138945008784533561","article-title":"The \u2018classical' ovalbumin challenge model of asthma in mice","volume":"9","author":"Kumar","year":"2008","journal-title":"Curr Drug Targets"},{"key":"10.1038\/labinvest.2015.72_bib8","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1084\/jem.186.3.449","article-title":"Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice","volume":"186","author":"Takeda","year":"1997","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.2015.72_bib9","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1172\/JCI25702","article-title":"Mast cells can promote the development of multiple features of chronic asthma in mice","volume":"116","author":"Yu","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2015.72_bib10","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.4049\/jimmunol.1301538","article-title":"IL-17A promotes the exacerbation of IL-33-induced airway hyperresponsiveness by enhancing neutrophilic inflammation via CXCR2 signaling in mice","volume":"192","author":"Mizutani","year":"2014","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.2015.72_bib11","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1084\/jem.184.6.2353","article-title":"Germinal center formation and local immunoglobulin E (IgE) production in the lung after an airway antigenic challenge","volume":"184","author":"Chvatchko","year":"1996","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.2015.72_bib12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ejphar.2011.12.020","article-title":"Regulatory role of antigen-induced interleukin-10, produced by CD4(+) T cells, in airway neutrophilia in a murine model for asthma","volume":"677","author":"Nabe","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"10.1038\/labinvest.2015.72_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-2222.1994.tb00920.x","article-title":"Attenuation of allergic airway inflammation in IL-4 deficient mice","volume":"24","author":"Brusselle","year":"1994","journal-title":"Clin Exp Allergy"},{"key":"10.1038\/labinvest.2015.72_bib14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1172\/JCI0214097","article-title":"CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation","volume":"109","author":"Ma","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2015.72_bib15","first-page":"101","article-title":"Immediate asthmatic reactions and changes in airway responsiveness after single vs chronic ovalbumin inhalation in sensitized mice","volume":"48","author":"Hessel","year":"1993","journal-title":"Eur J Allergy Clin Immunol"},{"key":"10.1038\/labinvest.2015.72_bib16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1172\/JCI59072","article-title":"Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy","volume":"122","author":"Kashiwakura","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2015.72_bib17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jim.2013.06.007","article-title":"An efficient single prime protocol for the induction of antigen-induced airways inflammation","volume":"395","author":"Shaw","year":"2013","journal-title":"J Immunol Methods"},{"key":"10.1038\/labinvest.2015.72_bib18","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ajpath.2010.11.041","article-title":"Tissue eosinophilia in a mouse model of colitis is highly dependent on TLR2 and independent of mast cells","volume":"178","author":"Albert","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2015.72_bib19","first-page":"1","article-title":"Immunopathology of influenza: Pulmonary viral exanthema, BALT and immune sensitive carcinoma in experimental mouse models","volume":"27","author":"Sell","year":"2014","journal-title":"Viral Immunology"},{"key":"10.1038\/labinvest.2015.72_bib20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1177\/43.4.7897179","article-title":"A novel in situ hybridization signal amplification method based on the deposition of biotinylated tyramine","volume":"43","author":"Kerstens","year":"1995","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/labinvest.2015.72_bib21","first-page":"2.3.1","article-title":"Double-immunodiffusion assay for detecting specific antibodies","volume":"Unit 2.3","author":"Hornbek","year":"2001","journal-title":"Curr Prot Immunol"},{"key":"10.1038\/labinvest.2015.72_bib22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1172\/JCI116162","article-title":"Development and transfer of immediate cutaneous hypersensitivity in mice exposed to aerosolized antigen","volume":"91","author":"Saloga","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2015.72_bib23","doi-asserted-by":"crossref","unstructured":"Sell S, Immunology, Immunopathology and Immunity, 2001, ASM Press: Washington, DC: Washington, DC.","DOI":"10.1128\/9781555818012"},{"key":"10.1038\/labinvest.2015.72_bib24","first-page":"817","article-title":"Injections repetees de serum de cheval chez le lapin","volume":"55","author":"Arthus","year":"1903","journal-title":"C R Soc Biol (Paris)"},{"key":"10.1038\/labinvest.2015.72_bib25","first-page":"405","article-title":"\u00dcber die Beziehunger der Eosinophilie zur Anaphylaxie","volume":"108","author":"Schlecht","year":"1912","journal-title":"Dtsch Arch Klin Med"},{"key":"10.1038\/labinvest.2015.72_bib26","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1084\/jem.39.5.659","article-title":"The fate of antigen (protein) in an animal immunized against it","volume":"39","author":"Opie","year":"1924","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.2015.72_bib27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1084\/jem.57.1.111","article-title":"Allergic lobar pneumonia: experimental study","volume":"57","author":"Fried","year":"1933","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.2015.72_bib28","first-page":"777","article-title":"Acute local anaphylactic inflammation of the lungs","volume":"17","author":"Cannon","year":"1941","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2015.72_bib29","first-page":"258","article-title":"An immunohistochemical study of the occurrence of intravascular antigen-antibody precipitation and its role in anaphylaxis in the rabbit","volume":"101","author":"McKinnon","year":"1957","journal-title":"Bull Johns Hopkins Hosp"},{"key":"10.1038\/labinvest.2015.72_bib30","first-page":"85","article-title":"Immunomorphology of experimental Arthus phenomenon of the lung","volume":"35","author":"Eskensay","year":"1971","journal-title":"Rev Immunol (Paris)"},{"key":"10.1038\/labinvest.2015.72_bib31","first-page":"568","article-title":"Acute experimental hypersensitivity pneumonitis in rabbits","volume":"104","author":"Richerson","year":"1971","journal-title":"Am Rev Respir Dis"},{"key":"10.1038\/labinvest.2015.72_bib32","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/00313027209068946","article-title":"Changes in guinea-pig lungs following the inhalation of powdered egg albumen","volume":"4","author":"Eastham","year":"1972","journal-title":"Pathology"},{"key":"10.1038\/labinvest.2015.72_bib33","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000233441","article-title":"Experimental asthma in guinea pigs revisited","volume":"73","author":"Kallos","year":"1984","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"10.1038\/labinvest.2015.72_bib34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000236807","article-title":"Characterization of a murine model of allergic pulmonary inflammation","volume":"105","author":"Kung","year":"1994","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1038\/labinvest.2015.72_bib35","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1476-5381.1990.tb12989.x","article-title":"Antigen challenge induces pulmonary airway eosinophil accumulation and airway hyperreactivity in sensitized guinea-pigs: the effect of anti-asthma drugs","volume":"99","author":"Sanjar","year":"1990","journal-title":"Br J Pharmacol"},{"key":"10.1038\/labinvest.2015.72_bib36","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1172\/JCI107770","article-title":"Acute immunologic pulmonary alveolitis","volume":"54","author":"Johnson","year":"1974","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2015.72_bib37","first-page":"55","article-title":"Suppression by superoxide dismutase of immune-complex\u2014induced pulmonary alveolitis and dermal inflammation","volume":"102","author":"McCormick","year":"1981","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2015.72_bib38","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1172\/JCI114374","article-title":"Tumor necrosis factor participates in the pathogenesis of acute immune complex alveolitis in the rat","volume":"84","author":"Warren","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2015.72_bib39","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1172\/JCI115446","article-title":"Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats","volume":"88","author":"Mulligan","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2015.72_bib40","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.4049\/jimmunol.148.6.1847","article-title":"Roles of beta 2 integrins of rat neutrophils in complement- and oxygen radical-mediated acute inflammatory injury","volume":"148","author":"Mulligan","year":"1992","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.2015.72_bib41","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4049\/jimmunol.167.2.1022","article-title":"Distinct tissue site-specific requirements of mast cells and complement components C3\/C5a receptor in IgG immune complex-induced injury of skin and lung","volume":"167","author":"Baumann","year":"2001","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.2015.72_bib42","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.4049\/jimmunol.175.6.4060","article-title":"The urokinase\/urokinase receptor system mediates the IgG immune complex-induced inflammation in lung","volume":"175","author":"Shushakova","year":"2005","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.2015.72_bib43","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.4049\/jimmunol.174.5.3041","article-title":"Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation","volume":"174","author":"Skokowa","year":"2005","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.2015.72_bib44","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4049\/jimmunol.1201398","article-title":"Galphai2 is the essential Galphai protein in immune complex-induced lung disease","volume":"190","author":"Wiege","year":"2013","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.2015.72_bib45","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/15287394.2013.752323","article-title":"Recurring BALB\/c mouse lung inflammatory responses to episodic allergen exposure","volume":"76","author":"Wilson","year":"2013","journal-title":"J Toxicol Environ Health A"},{"key":"10.1038\/labinvest.2015.72_bib46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.physbeh.2009.06.003","article-title":"Acute stress affects the physiology and behavior of allergic mice","volume":"98","author":"Sutherland","year":"2009","journal-title":"Physiol Behav"},{"key":"10.1038\/labinvest.2015.72_bib47","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1258\/0007142001903490","article-title":"Eosinophils in asthma and other allergic diseases","volume":"56","author":"Wardlaw","year":"2000","journal-title":"Br Med Bull"},{"key":"10.1038\/labinvest.2015.72_bib48","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1126\/science.1099472","article-title":"Defining a link with asthma in mice congenitally deficient in eosinophils","volume":"305","author":"Lee","year":"2004","journal-title":"Science"},{"key":"10.1038\/labinvest.2015.72_bib49","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1126\/science.1100283","article-title":"A critical role for eosinophils in allergic airways remodeling","volume":"305","author":"Humbles","year":"2004","journal-title":"Science"},{"key":"10.1038\/labinvest.2015.72_bib50","doi-asserted-by":"crossref","first-page":"17406","DOI":"10.1074\/jbc.R113.546218","article-title":"Eosinophil granule proteins: form and function","volume":"289","author":"Acharya","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2015.72_bib51","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.4049\/jimmunol.167.3.1672","article-title":"Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation","volume":"167","author":"Denzler","year":"2001","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.2015.72_bib52","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-2999(02)02364-6","article-title":"Eotaxin protein levels and airway pathology in a mouse model for allergic asthma","volume":"453","author":"Scheerens","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1038\/labinvest.2015.72_bib53","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1067\/mai.2003.1416","article-title":"Inhibition of allergic airways inflammation and airway hyperresponsiveness in mice by dexamethasone: role of eosinophils, IL-5, eotaxin, and IL-13","volume":"111","author":"Eum","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1038\/labinvest.2015.72_bib54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.clim.2013.02.004","article-title":"Hypoxia potentiates allergen induction of HIF-1alpha, chemokines, airway inflammation, TGF-beta1, and airway remodeling in a mouse model","volume":"147","author":"Baek","year":"2013","journal-title":"Clin Immunol"},{"key":"10.1038\/labinvest.2015.72_bib55","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3109\/02770903.2014.917659","article-title":"CCL11 as a potential diagnostic marker for asthma?","volume":"51","author":"Wu","year":"2014","journal-title":"J Asthma"},{"key":"10.1038\/labinvest.2015.72_bib56","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/imr.12183","article-title":"Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense","volume":"260","author":"McAleer","year":"2014","journal-title":"Immunol Rev"},{"key":"10.1038\/labinvest.2015.72_bib57","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/resp.12299","article-title":"Mechanisms of pathogenesis in allergic asthma: role of interleukin-23","volume":"19","author":"Li","year":"2014","journal-title":"Respirology"},{"key":"10.1038\/labinvest.2015.72_bib58","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/cr.2009.128","article-title":"IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation","volume":"20","author":"Peng","year":"2010","journal-title":"Cell Res"},{"key":"10.1038\/labinvest.2015.72_bib59","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1111\/j.1365-2222.2012.04068.x","article-title":"Serum IL-23: a surrogate biomarker for asthma?","volume":"42","author":"Ciprandi","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"10.1038\/labinvest.2015.72_bib60","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1586\/1744666X.4.6.669","article-title":"Resolvin E1: a novel lipid mediator in the resolution of allergic airway inflammation","volume":"4","author":"Ishizuka","year":"2008","journal-title":"Exp Rev Clin Immunol"},{"key":"10.1038\/labinvest.2015.72_bib61","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2332\/allergolint.13-OA-0632","article-title":"Dual role of interleukin-23 in epicutaneously-sensitized asthma in mice","volume":"63","author":"Masaki","year":"2014","journal-title":"Allergol Int"},{"key":"10.1038\/labinvest.2015.72_bib62","doi-asserted-by":"crossref","first-page":"e98915","DOI":"10.1371\/journal.pone.0098915","article-title":"Interleukin-17 A promotes MUC5AC expression and goblet cell hyperplasia in nasal polyps via the Act1-mediated pathway","volume":"9","author":"Xia","year":"2014","journal-title":"PLoS One"},{"key":"10.1038\/labinvest.2015.72_bib63","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/cea.12283","article-title":"IL-33 stimulates CXCL8\/IL-8 secretion in goblet cells but not normally differentiated airway cells","volume":"44","author":"Tanabe","year":"2014","journal-title":"Clin Exp Allergy"},{"key":"10.1038\/labinvest.2015.72_bib64","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1039\/C4FO00384E","article-title":"Inhibition of allergic airway inflammation through the blockage of NF-kappaB activation by ellagic acid in an ovalbumin-induced mouse asthma model","volume":"5","author":"Zhou","year":"2014","journal-title":"Food Funct"},{"key":"10.1038\/labinvest.2015.72_bib65","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.4049\/jimmunol.0803109","article-title":"Development of allergen-induced airway inflammation in the absence of T-bet regulation is dependent on IL-17","volume":"183","author":"Durrant","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.2015.72_bib66","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00418-002-0425-z","article-title":"Mast cells and macrophages in normal C57\/BL\/6 mice","volume":"118","author":"Gersch","year":"2002","journal-title":"Histochem Cell Biol"},{"key":"10.1038\/labinvest.2015.72_bib67","doi-asserted-by":"crossref","first-page":"4860","DOI":"10.4049\/jimmunol.171.9.4860","article-title":"Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences","volume":"171","author":"Ikeda","year":"2003","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.2015.72_bib68","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1165\/ajrcmb.20.5.3446","article-title":"Mucous-cell metaplasia and inflammatory-cell recruitment are dissociated in allergic mice after antibody- and drug-dependent cell depletion in a murine model of asthma","volume":"20","author":"Haile","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1038\/labinvest.2015.72_bib69","doi-asserted-by":"crossref","first-page":"L1027","DOI":"10.1152\/ajplung.00227.2012","article-title":"Mast cell engraftment of the peripheral lung enhances airway hyperresponsiveness in a mouse asthma model","volume":"303","author":"Fuchs","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1038\/labinvest.2015.72_bib70","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/B978-0-12-381300-8.00007-1","article-title":"Bronchus-associated lymphoid tissue (BALT) structure and function","volume":"107","author":"Randall","year":"2010","journal-title":"Adv Immunol"},{"key":"10.1038\/labinvest.2015.72_bib71","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1165\/rcmb.2012-0065OC","article-title":"Autoreactive T and B cells induce the development of bronchus-associated lymphoid tissue in the lung","volume":"48","author":"Shilling","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1038\/labinvest.2015.72_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000028109","article-title":"Bronchus-associated lymphoid tissue (BALT) is not present in the normal adult lung but in different diseases","volume":"68","author":"Tschernig","year":"2000","journal-title":"Pathobiology"},{"key":"10.1038\/labinvest.2015.72_bib73","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/S0002-9440(10)63493-1","article-title":"Specific history of heterologous virus infections determines anti-viral immunity and immunopathology in the lung","volume":"163","author":"Chen","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2015.72_bib74","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1164\/rccm.200308-1167OC","article-title":"Aggregations of lymphoid cells in the airways of nonsmokers, smokers, and subjects with asthma","volume":"169","author":"Elliot","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1038\/labinvest.2015.72_bib75","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nm1091","article-title":"Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity","volume":"10","author":"Moyron-Quiroz","year":"2004","journal-title":"Nat Med"},{"key":"10.1038\/labinvest.2015.72_bib76","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.4049\/jimmunol.181.6.4089","article-title":"TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice","volume":"181","author":"McKinley","year":"2008","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.2015.72_bib77","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000350427","article-title":"Elevated macrophage inflammatory protein 1alpha and interleukin-17 production in an experimental asthma model infected with respiratory syncytial virus","volume":"161","author":"Ishioka","year":"2013","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1038\/labinvest.2015.72_bib78","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4168\/aair.2013.5.4.197","article-title":"Effects of interleukin-9 blockade on chronic airway inflammation in murine asthma models","volume":"5","author":"Kim","year":"2013","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1038\/labinvest.2015.72_bib79","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.2147\/CIA.S50496","article-title":"Effect of aging on airway remodeling and muscarinic receptors in a murine acute asthma model","volume":"8","author":"Kang","year":"2013","journal-title":"Clin Interv Aging"},{"key":"10.1038\/labinvest.2015.72_bib80","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/intimm\/dxp102","article-title":"IL-5- and eosinophil-mediated inflammation: from discovery to therapy","volume":"21","author":"Kouro","year":"2009","journal-title":"Int Immunol"},{"key":"10.1038\/labinvest.2015.72_bib81","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 cells","volume":"27","author":"Korn","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1038\/labinvest.2015.72_bib82","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/ni.2053","article-title":"The development of inducible bronchus-associated lymphoid tissue depends on IL-17","volume":"12","author":"Rangel-Moreno","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1038\/labinvest.2015.72_bib83","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1084\/jem.20131737","article-title":"IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs","volume":"211","author":"Fleige","year":"2014","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.2015.72_bib84","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1056\/NEJM199711203372106","article-title":"Small-vessel vasculitis","volume":"337","author":"Jennette","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1038\/labinvest.2015.72_bib85","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1513\/pats.200511-120JH","article-title":"Pulmonary vasculitis","volume":"3","author":"Brown","year":"2006","journal-title":"Proc Am Thorac Soc"},{"key":"10.1038\/labinvest.2015.72_bib86","first-page":"277","article-title":"Allergic granulomatosis, allergic angiitis, and periarteritis nodosa","volume":"27","author":"Churg","year":"1951","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.2015.72_bib87","first-page":"S69","article-title":"Update on the pathogenesis of Churg-Strauss syndrome","volume":"21","author":"Hellmich","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"10.1038\/labinvest.2015.72_bib88","first-page":"185","article-title":"The role of the polymorphonuclear leukocyte in the pathogenesis of the adult respiratory distress syndrome","volume":"8","author":"Thommasen","year":"1985","journal-title":"Clin Invest Med"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest201572.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201572","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722009886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722009886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201572.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:33:38Z","timestamp":1758396818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722009886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":88,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0023683722009886"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2015.72","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bronchial lesions of mouse model of asthma are preceded by immune complex vasculitis and induced bronchial associated lymphoid tissue (iBALT)","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2015.72","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}