{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:45:48Z","timestamp":1778820348040,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":2111,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1038\/labinvest.2016.156","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T10:54:42Z","timestamp":1485773682000},"page":"395-408","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Rescue of retinal morphology and function in a humanized mouse at the mouse retinol-binding protein locus"],"prefix":"10.1016","volume":"97","author":[{"given":"Li","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingling","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeharu","family":"Wakana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimi","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichi","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenghua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2016.156_bib1","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1002\/j.1460-2075.1985.tb03881.x","article-title":"Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5'-flanking region contains hepatoma specific transcriptional signals","volume":"4","author":"D'Onofrio","year":"1985","journal-title":"EMBO J"},{"key":"10.1038\/labinvest.2016.156_bib2","doi-asserted-by":"crossref","first-page":"11476","DOI":"10.1016\/S0021-9258(17)39053-1","article-title":"Characterization of the rat retinol-binding protein gene and its comparison to the three-dimensional structure of the protein","volume":"260","author":"Laurent","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2016.156_bib3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0022-2275(20)38843-X","article-title":"Retinol-binding protein messenger RNA levels in the liver and in extrahepatic tissues of the rat","volume":"27","author":"Soprano","year":"1986","journal-title":"J Lipid Res"},{"key":"10.1038\/labinvest.2016.156_bib4","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1095\/biolreprod47.4.528","article-title":"Synthesis and secretion of retinol-binding protein by cultured rat Sertoli cells","volume":"47","author":"Davis","year":"1992","journal-title":"Biol Reprod"},{"key":"10.1038\/labinvest.2016.156_bib5","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1095\/biolreprod52.2.356","article-title":"Retinol processing by the peritubular cell from rat testis","volume":"52","author":"Davis","year":"1995","journal-title":"Biol Reprod"},{"key":"10.1038\/labinvest.2016.156_bib6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0304-4165(95)00079-Q","article-title":"Protein synthesis and secretion by cultured retinal pigment epithelia","volume":"1245","author":"Jaworowski","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/labinvest.2016.156_bib7","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1021\/bi00173a029","article-title":"Synthesis and secretion of retinol-binding protein and transthyretin by cultured retinal pigment epithelium","volume":"33","author":"Ong","year":"1994","journal-title":"Biochemistry"},{"key":"10.1038\/labinvest.2016.156_bib8","series-title":"The Retinoids: Biology, Chemistry, and Medicine","first-page":"257","article-title":"Plasma retinol-binding protein","author":"Soprano","year":"1994"},{"key":"10.1038\/labinvest.2016.156_bib9","series-title":"Plasma Retinol-Binding Protein","author":"Goodman","year":"1984"},{"key":"10.1038\/labinvest.2016.156_bib10","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/jn\/131.6.1647","article-title":"The discovery of the visual function of vitamin A","volume":"131","author":"Wolf","year":"2001","journal-title":"J Nutr"},{"key":"10.1038\/labinvest.2016.156_bib11","doi-asserted-by":"crossref","first-page":"e50205","DOI":"10.1371\/journal.pone.0050205","article-title":"Exome analysis identified a novel mutation in the RBP4 gene in a consanguineous pedigree with retinal dystrophy and developmental abnormalities","volume":"7","author":"Cukras","year":"2012","journal-title":"PLoS One"},{"key":"10.1038\/labinvest.2016.156_bib12","first-page":"3","article-title":"Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis","volume":"40","author":"Seeliger","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/labinvest.2016.156_bib13","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1093\/emboj\/18.17.4633","article-title":"Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein","volume":"18","author":"Quadro","year":"1999","journal-title":"EMBO J"},{"key":"10.1038\/labinvest.2016.156_bib14","doi-asserted-by":"crossref","first-page":"30191","DOI":"10.1074\/jbc.M205046200","article-title":"Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice","volume":"277","author":"Quadro","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2016.156_bib15","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/labinvest.2016.39","article-title":"Severe ocular phenotypes in Rbp4-deficient mice in the C57BL\/6 genetic background","volume":"96","author":"Shen","year":"2016","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.2016.156_bib16","doi-asserted-by":"crossref","first-page":"23395","DOI":"10.1016\/S0021-9258(17)31527-2","article-title":"The Ile-84\u2014>Ser amino acid substitution in transthyretin interferes with the interaction with plasma retinol-binding protein","volume":"269","author":"Berni","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2016.156_bib17","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1073\/pnas.90.6.2375","article-title":"Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone","volume":"90","author":"Episkopou","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.2016.156_bib18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0014-4827(91)90488-G","article-title":"Retinol-binding protein and transthyretin expressed in HeLa cells form a complex in the endoplasmic reticulum in both the absence and the presence of retinol","volume":"197","author":"Melhus","year":"1991","journal-title":"Exp Cell Res"},{"key":"10.1038\/labinvest.2016.156_bib19","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1074\/jbc.270.2.866","article-title":"Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombination","volume":"270","author":"Wei","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2016.156_bib20","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/j.1365-2443.2008.01242.x","article-title":"Inconsistency between hepatic expression and serum concentration of transthyretin in mice humanized at the transthyretin locus","volume":"13","author":"Zhao","year":"2008","journal-title":"Genes Cells"},{"key":"10.1038\/labinvest.2016.156_bib21","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1993.1458","article-title":"A novel ES cell line, TT2, with high germline-differentiating potency","volume":"214","author":"Yagi","year":"1993","journal-title":"Anal Biochem"},{"key":"10.1038\/labinvest.2016.156_bib22","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/oxfordjournals.jbchem.a021860","article-title":"Efficiency of recombination by Cre transient expression in embryonic stem cells: comparison of various promoters","volume":"122","author":"Araki","year":"1997","journal-title":"J Biochem"},{"key":"10.1038\/labinvest.2016.156_bib23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11248-010-9389-2","article-title":"Enhanced expression of human cDNA by phosphoglycerate kinase promoter-puromycin cassette in the mouse transthyretin locus","volume":"20","author":"Li","year":"2011","journal-title":"Transgenic Res"},{"key":"10.1038\/labinvest.2016.156_bib24","first-page":"378","article-title":"A monogenic dominant mutation in Rom1 generated by N-ethyl-N-nitrosourea mutagenesis causes retinal degeneration in mice","volume":"16","author":"Sato","year":"2010","journal-title":"Mol Vis"},{"key":"10.1038\/labinvest.2016.156_bib25","first-page":"190","article-title":"Determination of retinol in serum by high-performance liquid chromatograpgy with fluorometric detection using a column-switching system","volume":"22","author":"Notsumoto","year":"1993","journal-title":"Clin Chem"},{"key":"10.1038\/labinvest.2016.156_bib26","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1093\/jaoac\/93.5.1523","article-title":"Determination of vitamin A (retinol) in infant and medical nutritional formulas with AOAC method 992.06 using a modified extraction procedure: single-laboratory validation","volume":"93","author":"Thompson","year":"2010","journal-title":"J AOAC Int"},{"key":"10.1038\/labinvest.2016.156_bib27","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1167\/iovs.12-9662","article-title":"The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL\/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes","volume":"53","author":"Mattapallil","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/labinvest.2016.156_bib28","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1093\/hmg\/ddg232","article-title":"CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina","volume":"12","author":"Mehalow","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1038\/labinvest.2016.156_bib29","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1074\/jbc.M708028200","article-title":"Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic: a lesson in the generation of transgenic models of diseases involving oligomeric proteins","volume":"283","author":"Reixach","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.2016.156_bib30","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0098-2997(03)00038-4","article-title":"Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models","volume":"24","author":"Quadro","year":"2003","journal-title":"Mol Aspects Med"},{"key":"10.1038\/labinvest.2016.156_bib31","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1523\/JNEUROSCI.23-07-02769.2003","article-title":"Partial rescue of the p35\u2212\/\u2212 brain phenotype by low expression of a neuronal-specific enolase p25 transgene","volume":"23","author":"Patzke","year":"2003","journal-title":"J Neurosci"},{"key":"10.1038\/labinvest.2016.156_bib32","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/ki.1995.270","article-title":"Functional rescue of the glomerulosclerosis phenotype in Mpv17 mice by transgenesis with the human Mpv17 homologue","volume":"48","author":"Schenkel","year":"1995","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.2016.156_bib33","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1182\/blood.V99.11.3931","article-title":"Rescue of the lethal scl(\u2212\/\u2212) phenotype by the human SCL locus","volume":"99","author":"Sinclair","year":"2002","journal-title":"Blood"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest2016156.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2016156","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722011655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722011655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest2016156.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:35:16Z","timestamp":1758396916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722011655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0023683722011655"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2016.156","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rescue of retinal morphology and function in a humanized mouse at the mouse retinol-binding protein locus","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2016.156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}