{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:20:36Z","timestamp":1782483636256,"version":"3.54.5"},"reference-count":50,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":2262,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1038\/labinvest.2016.95","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T08:43:10Z","timestamp":1474879390000},"page":"1165-1177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["MiR-139-5p is associated with inflammatory regulation through c-FOS suppression, and contributes to the progression of primary biliary cholangitis"],"prefix":"10.1016","volume":"96","author":[{"given":"Tomohiro","family":"Katsumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Ninomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketo","family":"Nishina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Haga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Okumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tooru","family":"Shimosegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5623-4250","authenticated-orcid":false,"given":"Yoshiyuki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2016.95_bib1","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/0016-5085(79)90396-2","article-title":"Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis","volume":"76","author":"Nakanuma","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2016.95_bib2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1053\/j.gastro.2004.05.005","article-title":"Primary biliary cirrhosis in monozygotic and dizygotic twins: genetics, epigenetics, and environment","volume":"127","author":"Selmi","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2016.95_bib3","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.jhep.2011.10.025","article-title":"Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: a systematic review","volume":"56","author":"Boonstra","year":"2012","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.2016.95_bib4","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.4049\/jimmunol.138.10.3525","article-title":"Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis","volume":"138","author":"Gershwin","year":"1987","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.2016.95_bib5","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1073\/pnas.85.19.7317","article-title":"Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase","volume":"85","author":"Coppel","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.2016.95_bib6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jaut.2011.11.005","article-title":"Primary biliary cirrhosis and Sjogren's syndrome: autoimmune epithelitis","volume":"39","author":"Selmi","year":"2012","journal-title":"J Autoimmun"},{"key":"10.1038\/labinvest.2016.95_bib7","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/MCG.0b013e3181c74e0d","article-title":"Concurrent autoimmune diseases in patients with autoimmune hepatitis","volume":"44","author":"Teufel","year":"2010","journal-title":"J Clin Gastroenterol"},{"key":"10.1038\/labinvest.2016.95_bib8","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1046\/j.1440-1746.2002.02672.x","article-title":"Tumor necrosis factor-alpha and transforming growth factor-beta reflect severity of liver damage in primary biliary cirrhosis","volume":"17","author":"Neuman","year":"2002","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1038\/labinvest.2016.95_bib9","first-page":"8","article-title":"Cytokines in primary biliary cirrhosis (diagnostic and prognostic value)","volume":"76","author":"Golovanova","year":"2004","journal-title":"Ter Arkh"},{"key":"10.1038\/labinvest.2016.95_bib10","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ajhg.2012.08.010","article-title":"Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population","volume":"91","author":"Nakamura","year":"2012","journal-title":"Am J Hum Genet"},{"key":"10.1038\/labinvest.2016.95_bib11","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1056\/NEJMoa0810440","article-title":"Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants","volume":"360","author":"Hirschfield","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1038\/labinvest.2016.95_bib12","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/ng.627","article-title":"Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis","volume":"42","author":"Liu","year":"2010","journal-title":"Nat Genet"},{"key":"10.1038\/labinvest.2016.95_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/ng.789","article-title":"Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis","volume":"43","author":"Mells","year":"2011","journal-title":"Nat Genet"},{"key":"10.1038\/labinvest.2016.95_bib14","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s12016-015-8482-y","article-title":"Animal models of primary biliary cirrhosis","volume":"48","author":"Katsumi","year":"2015","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1038\/labinvest.2016.95_bib15","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.gastro.2005.12.029","article-title":"Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic Acid","volume":"130","author":"Pares","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2016.95_bib16","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1053\/gast.2002.36027","article-title":"Survival and symptom progression in a geographically based cohort of patients with primary biliary cirrhosis: follow-up for up to 28 years","volume":"123","author":"Prince","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2016.95_bib17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1572-0241.1999.00770.x","article-title":"Asymptomatic primary biliary cirrhosis: a study of its natural history and prognosis","volume":"94","author":"Springer","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1038\/labinvest.2016.95_bib18","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/0016-5085(86)90972-8","article-title":"Azathioprine and prognosis in primary biliary cirrhosis","volume":"90","author":"Christensen","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2016.95_bib19","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/0016-5085(89)90526-X","article-title":"Prospective evaluation of esophageal varices in primary biliary cirrhosis: development, natural history, and influence on survival","volume":"96","author":"Gores","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2016.95_bib20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1053\/j.gastro.2004.11.009","article-title":"The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis","volume":"128","author":"Corpechot","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2016.95_bib21","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/hep.21871","article-title":"Geotherapeutics of primary biliary cirrhosis: bright and sunny around the Mediterranean but still cloudy and foggy in the United Kingdom","volume":"46","author":"Corpechot","year":"2007","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2016.95_bib22","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/S0140-6736(96)04410-8","article-title":"Natural history of early primary biliary cirrhosis","volume":"348","author":"Metcalf","year":"1996","journal-title":"Lancet"},{"key":"10.1038\/labinvest.2016.95_bib23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/hep.22906","article-title":"Primary biliary cirrhosis","volume":"50","author":"Lindor","year":"2009","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2016.95_bib24","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.1065062","article-title":"An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans","volume":"294","author":"Lau","year":"2001","journal-title":"Science"},{"key":"10.1038\/labinvest.2016.95_bib25","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1064921","article-title":"Identification of novel genes coding for small expressed RNAs","volume":"294","author":"Lagos-Quintana","year":"2001","journal-title":"Science"},{"key":"10.1038\/labinvest.2016.95_bib26","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1126\/science.1065329","article-title":"An extensive class of small RNAs in Caenorhabditis elegans","volume":"294","author":"Lee","year":"2001","journal-title":"Science"},{"key":"10.1038\/labinvest.2016.95_bib27","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1038\/labinvest.2016.95_bib28","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","article-title":"Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases","volume":"18","author":"Chen","year":"2008","journal-title":"Cell Res"},{"key":"10.1038\/labinvest.2016.95_bib29","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"10.1038\/labinvest.2016.95_bib30","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/hep.25691","article-title":"Up-regulation of microRNA 506 leads to decreased Cl-\/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis","volume":"56","author":"Banales","year":"2012","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2016.95_bib31","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jaut.2009.02.022","article-title":"Primary biliary cirrhosis is associated with altered hepatic microRNA expression","volume":"32","author":"Padgett","year":"2009","journal-title":"J Autoimmun"},{"key":"10.1038\/labinvest.2016.95_bib32","first-page":"E189","article-title":"Expression of micro-RNAs in peripheral blood mononuclear cells from primary biliary cirrhosis patients","volume":"44","author":"Katsushima","year":"2013","journal-title":"Hepatol Res"},{"key":"10.1038\/labinvest.2016.95_bib33","doi-asserted-by":"crossref","first-page":"e66086","DOI":"10.1371\/journal.pone.0066086","article-title":"Distinct microRNAs expression profile in primary biliary cirrhosis and evaluation of miR 505-3p and miR197-3p as novel biomarkers","volume":"8","author":"Ninomiya","year":"2013","journal-title":"PloS One"},{"key":"10.1038\/labinvest.2016.95_bib34","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/hep.22428","article-title":"Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis","volume":"48","author":"Corpechot","year":"2008","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2016.95_bib35","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/hepr.12214","article-title":"Application of deep sequence technology in hepatology","volume":"44","author":"Ninomiya","year":"2014","journal-title":"Hepatol Res"},{"key":"10.1038\/labinvest.2016.95_bib36","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J"},{"key":"10.1038\/labinvest.2016.95_bib37","doi-asserted-by":"crossref","first-page":"D52","DOI":"10.1093\/nar\/gkq1237","article-title":"Entrez Gene: gene-centered information at NCBI","volume":"39","author":"Maglott","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/labinvest.2016.95_bib38","doi-asserted-by":"crossref","first-page":"D152","DOI":"10.1093\/nar\/gkq1027","article-title":"miRBase: integrating microRNA annotation and deep-sequencing data","volume":"39","author":"Kozomara","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/labinvest.2016.95_bib39","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol"},{"key":"10.1038\/labinvest.2016.95_bib40","series-title":"A language and environment for statistical computing","author":"Team RDC","year":"2011"},{"key":"10.1038\/labinvest.2016.95_bib41","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.2016.95_bib42","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ymeth.2012.08.001","article-title":"Digital PCR strategies in the development and analysis of molecular biomarkers for personalized medicine","volume":"59","author":"Day","year":"2013","journal-title":"Methods"},{"key":"10.1038\/labinvest.2016.95_bib43","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.immuni.2008.12.021","article-title":"Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein","volume":"30","author":"Koga","year":"2009","journal-title":"Immunity"},{"key":"10.1038\/labinvest.2016.95_bib44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbrc.2009.11.005","article-title":"Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction","volume":"391","author":"Ai","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/labinvest.2016.95_bib45","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1373\/clinchem.2007.097972","article-title":"Detection and characterization of placental microRNAs in maternal plasma","volume":"54","author":"Chim","year":"2008","journal-title":"Clin Chem"},{"key":"10.1038\/labinvest.2016.95_bib46","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1002\/hep.24538","article-title":"Circulating microRNAs as potential markers of human drug-induced liver injury","volume":"54","author":"Starkey Lewis","year":"2011","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2016.95_bib47","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1038\/sj.onc.1204385","article-title":"Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity","volume":"20","author":"Chinenov","year":"2001","journal-title":"Oncogene"},{"key":"10.1038\/labinvest.2016.95_bib48","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ncb0502-e131","article-title":"AP-1 as a regulator of cell life and death","volume":"4","author":"Shaulian","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1038\/labinvest.2016.95_bib49","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/intimm\/dxl004","article-title":"c-Fos suppresses systemic inflammatory response to endotoxin","volume":"18","author":"Ray","year":"2006","journal-title":"Int Immunol"},{"key":"10.1038\/labinvest.2016.95_bib50","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0928-4346(94)90035-3","article-title":"Reduced expression of cellular fos gene in peripheral blood mononuclear cells of patients with primary biliary cirrhosis","volume":"2","author":"Ogino","year":"1994","journal-title":"Int Hepatol Commun"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest201695.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201695","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722012247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722012247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201695.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:38:29Z","timestamp":1758397109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722012247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0023683722012247"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2016.95","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726778314.793537265","asserted-by":"object"}]},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiR-139-5p is associated with inflammatory regulation through c-FOS suppression, and contributes to the progression of primary biliary cholangitis","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2016.95","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1038\/modpathol.2016.183","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}