{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:10:18Z","timestamp":1790503818472,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":2020,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1038\/labinvest.2017.29","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T08:41:31Z","timestamp":1496652091000},"page":"843-853","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals"],"prefix":"10.1016","volume":"97","author":[{"given":"Nan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quy","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiaohao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Venter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel A","family":"Frampton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"DeMorrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duojia","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanyin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Alpini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.2017.29_bib1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jcmgh.2015.05.005","article-title":"Functional and structural features of cholangiocytes in health and disease","volume":"1","author":"Maroni","year":"2015","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1038\/labinvest.2017.29_bib2","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.dld.2015.05.011","article-title":"Yes-associated protein in the liver: regulation of hepatic development, repair, cell fate determination and tumorigenesis","volume":"47","author":"Nguyen","year":"2015","journal-title":"Dig Liver Dis"},{"key":"10.1038\/labinvest.2017.29_bib3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.biocel.2009.07.020","article-title":"Biliary differentiation and bile duct morphogenesis in development and disease","volume":"43","author":"Raynaud","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1038\/labinvest.2017.29_bib4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/wdev.47","article-title":"Molecular mechanisms of liver and bile duct development","volume":"1","author":"Zong","year":"2012","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"10.1038\/labinvest.2017.29_bib5","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1053\/j.gastro.2011.06.049","article-title":"Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells","volume":"141","author":"Carpentier","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2017.29_bib6","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1242\/dev.129.8.1819","article-title":"The onecut transcription factor HNF6 is required for normal development of the biliary tract","volume":"129","author":"Clotman","year":"2002","journal-title":"Development"},{"key":"10.1038\/labinvest.2017.29_bib7","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1242\/dev.129.8.1829","article-title":"Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta","volume":"129","author":"Coffinier","year":"2002","journal-title":"Development"},{"key":"10.1038\/labinvest.2017.29_bib8","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1053\/j.gastro.2004.09.004","article-title":"The role of notch signaling in the development of intrahepatic bile ducts","volume":"127","author":"Kodama","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2017.29_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.devcel.2010.06.015","article-title":"The Merlin\/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals","volume":"19","author":"Zhang","year":"2010","journal-title":"Dev Cell"},{"key":"10.1038\/labinvest.2017.29_bib10","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1101\/gad.1536007","article-title":"Hippo signaling in organ size control","volume":"21","author":"Pan","year":"2007","journal-title":"Genes Dev"},{"key":"10.1038\/labinvest.2017.29_bib11","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.devcel.2010.09.011","article-title":"The hippo signaling pathway in development and cancer","volume":"19","author":"Pan","year":"2010","journal-title":"Dev Cell"},{"key":"10.1038\/labinvest.2017.29_bib12","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a universal size-control mechanism in Drosophila and mammals","volume":"130","author":"Dong","year":"2007","journal-title":"Cell"},{"key":"10.1038\/labinvest.2017.29_bib13","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.cell.2013.08.025","article-title":"Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin\/NF2","volume":"154","author":"Yin","year":"2013","journal-title":"Cell"},{"key":"10.1038\/labinvest.2017.29_bib14","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/jcp.24872","article-title":"The role of Notch receptors in transcriptional regulation","volume":"230","author":"Wang","year":"2015","journal-title":"J Cell Physiol"},{"key":"10.1038\/labinvest.2017.29_bib15","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/hep.22381","article-title":"Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice","volume":"48","author":"Geisler","year":"2008","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2017.29_bib16","doi-asserted-by":"crossref","first-page":"e1851","DOI":"10.1371\/journal.pone.0001851","article-title":"Notch signaling regulates bile duct morphogenesis in mice","volume":"3","author":"Lozier","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1038\/labinvest.2017.29_bib17","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1002\/hep.26254","article-title":"Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1","volume":"57","author":"Jeliazkova","year":"2013","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2017.29_bib18","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.cell.2014.03.060","article-title":"Hippo pathway activity influences liver cell fate","volume":"157","author":"Yimlamai","year":"2014","journal-title":"Cell"},{"key":"10.1038\/labinvest.2017.29_bib19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF02623304","article-title":"Use of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations","volume":"22","author":"Kreamer","year":"1986","journal-title":"Cell Dev Biol"},{"key":"10.1038\/labinvest.2017.29_bib20","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1177\/17.8.517","article-title":"Histochemical and ultrastructural demonstration of gamma-glutamyl transpeptidase activity","volume":"17","author":"Rutenburg","year":"1969","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/labinvest.2017.29_bib21","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1053\/gast.1996.v110.pm8613073","article-title":"Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver","volume":"110","author":"Alpini","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2017.29_bib22","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/0016-5085(89)91695-8","article-title":"Isolation and morphologic characterization of bile duct epithelial cells from normal rat liver","volume":"97","author":"Ishii","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.2017.29_bib23","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/hep.26105","article-title":"Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes in rats","volume":"57","author":"Renzi","year":"2013","journal-title":"Hepatology"},{"issue":"6 Pt 1","key":"10.1038\/labinvest.2017.29_bib24","doi-asserted-by":"crossref","first-page":"C872","DOI":"10.1152\/ajpcell.1986.251.6.C872","article-title":"Water and nonelectrolyte permeability of isolated rat hepatocytes","volume":"251","author":"Alpini","year":"1986","journal-title":"Am J Physiol"},{"key":"10.1038\/labinvest.2017.29_bib25","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.humpath.2011.12.001","article-title":"Expression of Yes-associated protein modulates Survivin expression in primary liver malignancies","volume":"43","author":"Bai","year":"2012","journal-title":"Hum Pathol"},{"key":"10.1038\/labinvest.2017.29_bib26","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1101\/gad.1664408","article-title":"TEAD mediates YAP-dependent gene induction and growth control","volume":"22","author":"Zhao","year":"2008","journal-title":"Genes Dev"},{"key":"10.1038\/labinvest.2017.29_bib27","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.1128\/MCB.17.12.7353","article-title":"CCAAT\/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice","volume":"17","author":"Timchenko","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1038\/labinvest.2017.29_bib28","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1172\/JCI103450","article-title":"Bile acid content of human serum. I. Serum bile acids in patients with hepatic disease","volume":"36","author":"Rudman","year":"1957","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.2017.29_bib29","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.cub.2007.10.039","article-title":"YAP1 increases organ size and expands undifferentiated progenitor cells","volume":"17","author":"Camargo","year":"2007","journal-title":"Curr Biol"},{"key":"10.1038\/labinvest.2017.29_bib30","doi-asserted-by":"crossref","first-page":"E1312","DOI":"10.1073\/pnas.1110428108","article-title":"Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance","volume":"108","author":"Zhou","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.2017.29_bib31","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.ydbio.2011.07.003","article-title":"The Hippo pathway controls polar cell fate through Notch signaling during Drosophila oogenesis","volume":"357","author":"Chen","year":"2011","journal-title":"Dev Biol"},{"key":"10.1038\/labinvest.2017.29_bib32","doi-asserted-by":"crossref","first-page":"e1761","DOI":"10.1371\/journal.pone.0001761","article-title":"The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity","volume":"3","author":"Yu","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1038\/labinvest.2017.29_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-3476(87)80153-1","article-title":"Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): review of 80 cases","volume":"110","author":"Alagille","year":"1987","journal-title":"J Pediatr"},{"key":"10.1038\/labinvest.2017.29_bib34","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/hep.510290331","article-title":"Features of Alagille syndrome in 92 patients: frequency and relation to prognosis","volume":"29","author":"Emerick","year":"1999","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2017.29_bib35","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/hep.27992","article-title":"YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors","volume":"62","author":"Marti","year":"2015","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.2017.29_bib36","doi-asserted-by":"crossref","first-page":"17206","DOI":"10.18632\/oncotarget.4043","article-title":"YAP is a critical oncogene in human cholangiocarcinoma","volume":"6","author":"Pei","year":"2015","journal-title":"Oncotarget"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/labinvest201729.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201729","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372200438X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372200438X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/labinvest.2017.29","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/labinvest201729.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:28:57Z","timestamp":1758396537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002368372200438X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S002368372200438X"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.2017.29","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.2017.29","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}