{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:39:33Z","timestamp":1791250773440,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":6859,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1038\/labinvest.3700056","type":"journal-article","created":{"date-parts":[[2004,2,16]],"date-time":"2004-02-16T05:59:27Z","timestamp":1076911167000},"page":"485-492","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Immunogenetic analysis of gastric MALT lymphoma-like lesions induced by Helicobacter pylori infection in neonatally thymectomized mice"],"prefix":"10.1016","volume":"84","author":[{"given":"Toshiro","family":"Fukui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuichi","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimio","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Asada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushige","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Iwano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Ohana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Hiai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.3700056_bib1","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0140-6736(95)91084-0","article-title":"Long-term sequelae of Helicobacter pylori gastritis","volume":"345","author":"Kuipers","year":"1995","journal-title":"Lancet"},{"key":"10.1038\/labinvest.3700056_bib2","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1056\/NEJM199110173251603","article-title":"Helicobacter pylori infection and the risk of gastric carcinoma","volume":"325","author":"Parsonnet","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1038\/labinvest.3700056_bib3","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1056\/NEJM199510123331508","article-title":"The treatment of Helicobacter pylori infection in the management of peptic ulcer disease","volume":"333","author":"Walsh","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1038\/labinvest.3700056_bib4","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/0140-6736(91)92035-Z","article-title":"Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma","volume":"338","author":"Wotherspoon","year":"1991","journal-title":"Lancet"},{"key":"10.1038\/labinvest.3700056_bib5","doi-asserted-by":"crossref","first-page":"6749","DOI":"10.1128\/IAI.69.11.6749-6754.2001","article-title":"Analysis of cytokines in the early development of gastric secondary lymphoid follicles in Helicobacter pylori-infected BALB\/c mice with neonatal thymectomy","volume":"69","author":"Uchida","year":"2001","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.3700056_bib6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1349-7006.2002.tb01306.x","article-title":"Clinicopathologic comparison between the API2-MALT1 chimeric transcript-positive and -negative gastric low-grade B-cell lymphoma of mucosa- associated lymphoid tissue type","volume":"93","author":"Nakamura","year":"2002","journal-title":"Jpn J Cancer Res"},{"key":"10.1038\/labinvest.3700056_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1470-2045(02)00651-4","article-title":"Gastric MALT lymphoma: from aetiology to treatment","volume":"3","author":"Du","year":"2002","journal-title":"Lancet Oncol"},{"key":"10.1038\/labinvest.3700056_bib8","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/0016-5085(94)90543-6","article-title":"A conserved epitope on H+,K(+)-adenosine triphosphatase of parietal cells discerned by a murine gastritogenic T-cell clone","volume":"107","author":"Nishio","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.3700056_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0016-5085(91)90002-3","article-title":"The parietal cell autoantigens recognized in neonatal thymectomy-induced murine gastritis are the alpha and beta subunits of the gastric proton pump [corrected]","volume":"101","author":"Jones","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.3700056_bib10","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/intimm\/10.9.1325","article-title":"Differential localization of Th1 and Th2 cells in autoimmune gastritis","volume":"10","author":"Katakai","year":"1998","journal-title":"Int Immunol"},{"key":"10.1038\/labinvest.3700056_bib11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1084\/jem.161.1.72","article-title":"Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease","volume":"161","author":"Sakaguchi","year":"1985","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3700056_bib12","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1128\/IAI.68.1.100-106.2000","article-title":"Induction of follicular gastritis following postthymectomy autoimmune gastritis in Helicobacter pylori-infected BALB\/c mice","volume":"68","author":"Oshima","year":"2000","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.3700056_bib13","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0016-5085(98)70143-X","article-title":"Helicobacter pylori infection induces gastric cancer in mongolian gerbils","volume":"115","author":"Watanabe","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.3700056_bib14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000228215","article-title":"Une micro-methode de l'immuno-electrophorese","volume":"7","author":"Scheidegger","year":"1955","journal-title":"Int Arch Allergy"},{"key":"10.1038\/labinvest.3700056_bib15","first-page":"273","article-title":"Helicobacter mustelae-associated gastric MALT lymphoma in ferrets","volume":"151","author":"Erdman","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3700056_bib16","first-page":"217","article-title":"MALToma-like lesions in the murine gastric mucosa after long-term infection with Helicobacter felis. A mouse model of Helicobacter pylori-induced gastric lymphoma","volume":"147","author":"Enno","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3700056_bib17","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/1097-0215(20010601)92:5<634::AID-IJC1241>3.0.CO;2-V","article-title":"Helicobacter-induced expression of Bcl-X(L) in B lymphocytes in the mouse model: a possible step in the development of gastric mucosa- associated lymphoid tissue (MALT) lymphoma","volume":"92","author":"Morgner","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1038\/labinvest.3700056_bib18","doi-asserted-by":"crossref","unstructured":"Cavalli F, Isaacson PG, Gascoyne RD, et al. MALT Lymphomas. Hematology (Am Soc Hematol Educ Program) 2001; 241\u2013258.","DOI":"10.1182\/asheducation-2001.1.241"},{"key":"10.1038\/labinvest.3700056_bib19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1365-2559.2002.01360.x","article-title":"Marginal zone cell lymphoma\u2014an update on recent advances","volume":"40","author":"Maes","year":"2002","journal-title":"Histopathology"},{"key":"10.1038\/labinvest.3700056_bib20","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/(SICI)1097-0029(20000315)48:6<349::AID-JEMT5>3.0.CO;2-7","article-title":"Gastric MALT lymphoma and its relationship to Helicobacter pylori infection: management and pathogenesis of the disease","volume":"48","author":"Morgner","year":"2000","journal-title":"Microsc Res Technol"},{"key":"10.1038\/labinvest.3700056_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1084\/jem.169.1.59","article-title":"Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets","volume":"169","author":"Heinzel","year":"1989","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3700056_bib22","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.4049\/jimmunol.168.12.5979","article-title":"Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease","volume":"168","author":"McHugh","year":"2002","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700056_bib23","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.4049\/jimmunol.160.3.1212","article-title":"CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells","volume":"160","author":"Suri-Payer","year":"1998","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700056_bib24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1053\/gast.1996.v110.pm8536852","article-title":"Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL\/6 mice and p53 hemizygous transgenic mice","volume":"110","author":"Fox","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.3700056_bib25","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1128\/iai.64.1.238-245.1996","article-title":"Role of the host in pathogenesis of Helicobacter-associated gastritis: H. felis infection of inbred and congenic mouse strains","volume":"64","author":"Mohammadi","year":"1996","journal-title":"Infect Immun"},{"key":"10.1038\/labinvest.3700056_bib26","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1136\/gut.39.5.639","article-title":"Atrophic gastric changes in both Helicobacter felisHelicobacter pylori infected mice are host dependent and separate from antral gastritis","volume":"39","author":"Sakagami","year":"1996","journal-title":"Gut"},{"key":"10.1038\/labinvest.3700056_bib27","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1126\/science.3874430","article-title":"Involvement of the bcl-2 gene in human follicular lymphoma","volume":"228","author":"Tsujimoto","year":"1985","journal-title":"Science"},{"key":"10.1038\/labinvest.3700056_bib28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-2559.1995.tb00624.x","article-title":"Heterogeneity of bcl-2 expression in MALT lymphoma","volume":"26","author":"Ashton-Key","year":"1995","journal-title":"Histopathology"},{"key":"10.1038\/labinvest.3700056_bib29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/jcp.48.1.18","article-title":"Expression of the bcl-2 protein in B cell lymphomas arising from mucosa associated lymphoid tissue","volume":"48","author":"Navratil","year":"1995","journal-title":"J Clin Pathol"},{"key":"10.1038\/labinvest.3700056_bib30","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/eji.1830260325","article-title":"Expression of blc-x during mouse B cell differentiation and following activation by various stimuli","volume":"26","author":"Choi","year":"1996","journal-title":"Eur J Immunol"},{"key":"10.1038\/labinvest.3700056_bib31","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/j.1460-2075.1994.tb06307.x","article-title":"Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes","volume":"13","author":"Merino","year":"1994","journal-title":"EMBO J"},{"key":"10.1038\/labinvest.3700056_bib32","first-page":"173","article-title":"B cell development in the bone marrow","volume":"2","author":"Osmond","year":"1990","journal-title":"Semin Immunol"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3700056.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700056","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722022371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722022371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700056.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:46:03Z","timestamp":1758397563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722022371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0023683722022371"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.3700056","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunogenetic analysis of gastric MALT lymphoma-like lesions induced by Helicobacter pylori infection in neonatally thymectomized mice","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.3700056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2004 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}