{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:57:38Z","timestamp":1789095458675,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":6706,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1038\/labinvest.3700142","type":"journal-article","created":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T05:29:26Z","timestamp":1087795766000},"page":"1185-1192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["A novel FISH assay for SS18\u2013SSX fusion type in synovial sarcoma"],"prefix":"10.1016","volume":"84","author":[{"given":"Cecilia","family":"Surace","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Panagopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"P\u00e5lsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Rocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Mandahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Mertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.3700142_bib1","series-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone","author":"Fletcher","year":"2002"},{"key":"10.1038\/labinvest.3700142_bib2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1053\/hupa.2001.21130","article-title":"Detection of the synovial sarcoma translocation t(X;18) (SYT;SSX) in paraffin-embedded tissue using reverse transcriptase-polymerase chain reaction: a reliable and powerful diagnostic tool for pathologists","volume":"32","author":"Guillou","year":"2001","journal-title":"Hum Pathol"},{"key":"10.1038\/labinvest.3700142_bib3","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1073\/pnas.84.7.1981","article-title":"Involvement of chromosome X in primary cytogenetic change in human neoplasia: nonrandom translocation in synovial sarcoma","volume":"84","author":"Turc-Carel","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3700142_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-4608(01)00626-4","article-title":"Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Synovial sarcoma","volume":"133","author":"Sandberg","year":"2002","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/labinvest.3700142_bib5","author":"Mitelman","year":"2004","journal-title":"Mitelman Database of Chromosome Aberrations in Cancer"},{"key":"10.1038\/labinvest.3700142_bib6","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/ng0894-502","article-title":"Identification of novel genes, SYT SSXinvolved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma","volume":"7","author":"Clark","year":"1994","journal-title":"Nat Genet"},{"key":"10.1038\/labinvest.3700142_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1056>3.0.CO;2-G","article-title":"Molecular mechanisms underlying human synovial sarcoma development","volume":"30","author":"dos Santos","year":"2001","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/labinvest.3700142_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00019606-200003000-00001","article-title":"Strong association of SYT\u2013SSX fusion type and morphologic epithelial differentiation in synovial sarcoma","volume":"9","author":"Antonescu","year":"2000","journal-title":"Diagn Mol Pathol"},{"key":"10.1038\/labinvest.3700142_bib9","first-page":"135","article-title":"Impact of SYT\u2013SSX fusion type on the clinical behaviour of synovial sarcoma: a multi-institutional retrospective study of 243 patients","volume":"62","author":"Ladanyi","year":"2002","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.3700142_bib10","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/jnci\/91.11.974","article-title":"A novel fusion gene, SYT\u2013SSX4in synovial sarcoma","volume":"91","author":"Skytting","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/labinvest.3700142_bib11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/gcc.10210","article-title":"A novel fusion gene, SS18L1\u2013SSX1in synovial sarcoma","volume":"37","author":"Storlazzi","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/labinvest.3700142_bib12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00366238","article-title":"Three major cytogenetic subgroups can be identified among chromosomally abnormal solitary lipomas","volume":"79","author":"Mandahl","year":"1998","journal-title":"Hum Genet"},{"key":"10.1038\/labinvest.3700142_bib13","series-title":"An International System for Human Cytogenetic Nomenclature","author":"Mitelman","year":"1995"},{"key":"10.1038\/labinvest.3700142_bib14","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/gcc.1155","article-title":"Clinical impact of molecular and cytogenetic findings in synovial sarcoma","volume":"31","author":"Panagopoulos","year":"2001","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/labinvest.3700142_bib15","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1182\/blood.V87.1.324.324","article-title":"Molecular characterization of 12p abnormalities in hematologic malignancies: deletion of KIP1rearrangement of TELand amplification of CCND2","volume":"87","author":"H\u00f6glund","year":"1996","journal-title":"Blood"},{"key":"10.1038\/labinvest.3700142_bib16","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1002\/j.1460-2075.1995.tb07228.x","article-title":"Fusion of SYT to two genes, SSX1 SSX2encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma","volume":"14","author":"Crew","year":"1995","journal-title":"EMBO J"},{"key":"10.1038\/labinvest.3700142_bib17","first-page":"1447","article-title":"The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome","volume":"9","author":"Shipley","year":"1994","journal-title":"Oncogene"},{"key":"10.1038\/labinvest.3700142_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0165-4608(94)90191-0","article-title":"Distinct Xp11.2 breakpoint regions in synovial sarcoma revealed by metaphase and interphase FISH: relationship to histologic subtypes","volume":"73","author":"de Leeuw","year":"1994","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/labinvest.3700142_bib19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/path.1711750405","article-title":"Interphase cytogenetic analysis of distinct X-chromosomal translocation breakpoints in synovial sarcoma","volume":"175","author":"Janz","year":"1995","journal-title":"J Pathol"},{"key":"10.1038\/labinvest.3700142_bib20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0165-4608(95)00090-9","article-title":"Detection of chromosome 18 rearrangement in synovial sarcoma by fluorescence in situ hybridization","volume":"84","author":"Poteat","year":"1995","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/labinvest.3700142_bib21","first-page":"601","article-title":"Chromosomal translocation t(X;18) in human synovial sarcomas analyzed by fluorescence in situ hybridization using paraffin-embedded tissue","volume":"148","author":"Nagao","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3700142_bib22","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/S0046-8177(96)90284-1","article-title":"Overexpression of bcl-2 protein in synovial sarcoma: a comparative study of other soft tissue spindle cell sarcomas and an additional analysis by fluorescence in situ hybridization","volume":"27","author":"Hirakawa","year":"1996","journal-title":"Hum Pathol"},{"key":"10.1038\/labinvest.3700142_bib23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0046-8177(97)90096-4","article-title":"Relevance of cytogenetic and fluorescent in situ hybridization analyses in the clinical assessment of soft tissue sarcoma","volume":"28","author":"Sozzi","year":"1997","journal-title":"Hum Pathol"},{"key":"10.1038\/labinvest.3700142_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/(SICI)1096-9896(199801)184:1<7::AID-PATH978>3.0.CO;2-X","article-title":"Dual-colour fluorescence in situ hybridization analysis of synovial sarcoma","volume":"184","author":"Yang","year":"1998","journal-title":"J Pathol"},{"key":"10.1038\/labinvest.3700142_bib25","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/(SICI)1098-2264(199810)23:2<198::AID-GCC15>3.0.CO;2-K","article-title":"Masked t(X;18)(p11;q11) in a biphasic synovial sarcoma revealed by FISH and RT-PCR","volume":"23","author":"Geurts van Kessel","year":"1998","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/labinvest.3700142_bib26","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00000478-199902000-00012","article-title":"Synovial sarcoma of the prostate with t(X;18)(p11.2;q11.2)","volume":"23","author":"Iwasaki","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/labinvest.3700142_bib27","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/(SICI)1097-0215(19990812)82:4<605::AID-IJC22>3.0.CO;2-H","article-title":"Synovial sarcoma specific translocation associated with both epithelial and spindle cell components","volume":"82","author":"Birdsall","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1038\/labinvest.3700142_bib28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0165-4608(00)00320-4","article-title":"Common chromosome aberrations in the proximal type of epithelioid sarcoma","volume":"123","author":"Debiec-Rychter","year":"2000","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/labinvest.3700142_bib29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0165-4608(02)00583-6","article-title":"Cryptic t(X;18), ins(6;18), and SYT\u2013SSX2 fusion gene in a case of intraneural monophasic synovial sarcoma","volume":"138","author":"Lestou","year":"2002","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/labinvest.3700142_bib30","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1038\/sj.onc.1205569","article-title":"Co-existence of SYT\u2013SSX1 SYT\u2013SSX2 fusions in synovial sarcomas","volume":"21","author":"Yang","year":"2002","journal-title":"Oncogene"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3700142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700142","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722602095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722602095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:38:20Z","timestamp":1758397100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722602095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0023683722602095"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.3700142","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel FISH assay for SS18\u2013SSX fusion type in synovial sarcoma","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.3700142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2004 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}