{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:47:34Z","timestamp":1792061254451,"version":"4.4.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":6615,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1038\/labinvest.3700180","type":"journal-article","created":{"date-parts":[[2004,10,25]],"date-time":"2004-10-25T05:24:04Z","timestamp":1098681844000},"page":"1619-1630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":204,"title":["Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers"],"prefix":"10.1016","volume":"84","author":[{"given":"Sabine","family":"Colnot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Niwa-Kawakita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislaine","family":"Hamard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Godard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Servane","family":"Le Plenier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Houbron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Romagnolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Berrebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Giovannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Perret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.3700180_bib1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.1651563","article-title":"Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients","volume":"253","author":"Nishisho","year":"1991","journal-title":"Science"},{"key":"10.1038\/labinvest.3700180_bib2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.1651562","article-title":"Identification of FAP locus genes from chromosome 5q21","volume":"253","author":"Kinzler","year":"1991","journal-title":"Science"},{"key":"10.1038\/labinvest.3700180_bib3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)81333-1","article-title":"Lessons from hereditary colorectal cancer","volume":"87","author":"Kinzler","year":"1996","journal-title":"Cell"},{"key":"10.1038\/labinvest.3700180_bib4","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1126\/science.275.5307.1784","article-title":"Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC\u2212\/\u2212 colon carcinoma","volume":"275","author":"Korinek","year":"1997","journal-title":"Science"},{"key":"10.1038\/labinvest.3700180_bib5","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1126\/science.275.5307.1787","article-title":"Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC","volume":"275","author":"Morin","year":"1997","journal-title":"Science"},{"key":"10.1038\/labinvest.3700180_bib6","first-page":"1","article-title":"Caught up in a Wnt storm: Wnt signaling in cancer","volume":"1653","author":"Giles","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/labinvest.3700180_bib7","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1101\/gad.14.15.1837","article-title":"Wnt signaling and cancer","volume":"14","author":"Polakis","year":"2000","journal-title":"Genes Dev"},{"key":"10.1038\/labinvest.3700180_bib8","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1126\/science.281.5382.1509","article-title":"Identification of c-MYC as a target of the APC pathway","volume":"281","author":"He","year":"1998","journal-title":"Science"},{"key":"10.1038\/labinvest.3700180_bib9","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/18884","article-title":"Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells","volume":"398","author":"Tetsu","year":"1999","journal-title":"Nature"},{"key":"10.1038\/labinvest.3700180_bib10","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.1350108","article-title":"Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene","volume":"256","author":"Su","year":"1992","journal-title":"Science"},{"key":"10.1038\/labinvest.3700180_bib11","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1073\/pnas.92.10.4482","article-title":"Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene","volume":"92","author":"Oshima","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3700180_bib12","doi-asserted-by":"crossref","first-page":"8969","DOI":"10.1073\/pnas.91.19.8969","article-title":"A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors","volume":"91","author":"Fodde","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3700180_bib13","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/carcin\/21.5.953","article-title":"Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522","volume":"21","author":"Sasai","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1038\/labinvest.3700180_bib14","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1073\/pnas.89.11.5128","article-title":"Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs","volume":"89","author":"te Riele","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3700180_bib15","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1093\/nar\/gng021","article-title":"Cre-mediated germline mosaicism: a new transgenic mouse for the selective removal of residual markers from tri-lox conditional alleles","volume":"31","author":"Leneuve","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/labinvest.3700180_bib16","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1053\/gast.2003.50094","article-title":"Pathology of mouse models of intestinal cancer: consensus report and recommendations","volume":"124","author":"Boivin","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.3700180_bib17","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/0092-8674(93)80069-Q","article-title":"Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice","volume":"75","author":"Mombaerts","year":"1993","journal-title":"Cell"},{"key":"10.1038\/labinvest.3700180_bib18","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0092-8674(93)80067-O","article-title":"Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene","volume":"75","author":"Sadlack","year":"1993","journal-title":"Cell"},{"key":"10.1038\/labinvest.3700180_bib19","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1172\/JCI118861","article-title":"Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses","volume":"98","author":"Berg","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.3700180_bib20","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.1038\/sj.onc.1206118","article-title":"New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism","volume":"21","author":"Cadoret","year":"2002","journal-title":"Oncogene"},{"key":"10.1038\/labinvest.3700180_bib21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/carcin\/24.1.107","article-title":"Azoxymethane-induced beta-catenin-accumulated crypts in colonic mucosa of rodents as an intermediate biomarker for colon carcinogenesis","volume":"24","author":"Hirose","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1038\/labinvest.3700180_bib22","first-page":"1644","article-title":"Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice","volume":"57","author":"Oshima","year":"1997","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.3700180_bib23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0092-8674(02)01015-2","article-title":"Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB\/ephrinB","volume":"111","author":"Batlle","year":"2002","journal-title":"Cell"},{"key":"10.1038\/labinvest.3700180_bib24","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1136\/gut.51.3.420","article-title":"Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes","volume":"51","author":"Crabtree","year":"2002","journal-title":"Gut"},{"key":"10.1038\/labinvest.3700180_bib25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1023\/A:1023286520725","article-title":"Attenuated familial adenomatous polyposis (AFAP): a review of the literature","volume":"2","author":"Knudsen","year":"2003","journal-title":"Fam Cancer"},{"key":"10.1038\/labinvest.3700180_bib26","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/ncb937","article-title":"Mutated APC and Asef are involved in the migration of colorectal tumour cells","volume":"5","author":"Kawasaki","year":"2003","journal-title":"Nat Cell Biol"},{"key":"10.1038\/labinvest.3700180_bib27","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1126\/science.289.5482.1194","article-title":"Asef, a link between the tumor suppressor APC and G-protein signaling","volume":"289","author":"Kawasaki","year":"2000","journal-title":"Science"},{"key":"10.1038\/labinvest.3700180_bib28","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1126\/science.283.5410.2089","article-title":"Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A","volume":"283","author":"Seeling","year":"1999","journal-title":"Science"},{"key":"10.1038\/labinvest.3700180_bib29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/ncb779","article-title":"Identification of a link between the tumour suppressor APC and the kinesin superfamily","volume":"4","author":"Jimbo","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1038\/labinvest.3700180_bib30","first-page":"1361","article-title":"Action of Min and Mom1 on neoplasia in ectopic intestinal grafts","volume":"7","author":"Gould","year":"1996","journal-title":"Cell Growth Differ"},{"key":"10.1038\/labinvest.3700180_bib31","first-page":"391","article-title":"Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system","volume":"12","author":"Corpet","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1038\/labinvest.3700180_bib32","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1177\/153537020422900702","article-title":"Commensal bacteria, redox stress, and colorectal cancer: mechanisms and models","volume":"229","author":"Huycke","year":"2004","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1038\/labinvest.3700180_bib33","doi-asserted-by":"crossref","first-page":"G7","DOI":"10.1152\/ajpgi.00079.2004","article-title":"Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation","volume":"287","author":"Itzkowitz","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1038\/labinvest.3700180_bib34","first-page":"1070","article-title":"Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min\/+) mice","volume":"60","author":"Hassan","year":"2000","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.3700180_bib35","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)81730-4","article-title":"Smad3 mutant mice develop metastatic colorectal cancer","volume":"94","author":"Zhu","year":"1998","journal-title":"Cell"},{"key":"10.1038\/labinvest.3700180_bib36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/hep.20286","article-title":"Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of beta-catenin in the liver","volume":"40","author":"Ovejero","year":"2004","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.3700180_bib37","first-page":"3245","article-title":"Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin","volume":"61","author":"Cadoret","year":"2001","journal-title":"Cancer Res"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3700180.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700180","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722601624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722601624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700180.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:37:59Z","timestamp":1758397079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722601624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S0023683722601624"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.3700180","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.3700180","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2004 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}