{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:43:53Z","timestamp":1792115033329,"version":"4.4.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":6584,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1038\/labinvest.3700189","type":"journal-article","created":{"date-parts":[[2004,10,18]],"date-time":"2004-10-18T09:58:11Z","timestamp":1098093491000},"page":"137-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response?"],"prefix":"10.1016","volume":"85","author":[{"given":"Motoji","family":"Oki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Ohtani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Kinouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nagura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Yoshie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tooru","family":"Shimosegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.3700189_bib1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0016-5085(98)70381-6","article-title":"Inflammatory bowel disease: etiology and pathogenesis","volume":"115","author":"Fiocchi","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.3700189_bib2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0140-6736(02)07284-7","article-title":"Crohn's disease","volume":"359","author":"Shanahan","year":"2002","journal-title":"Lancet"},{"key":"10.1038\/labinvest.3700189_bib3","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0952-7915(00)00096-0","article-title":"Chemokines in tissue-specific and microenvironment-specific lymphocyte homing","volume":"12","author":"Campbell","year":"2000","journal-title":"Curr Opin Immunol"},{"key":"10.1038\/labinvest.3700189_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1074-7613(00)80165-X","article-title":"Chemokines: a new classification system and their role in immunity","volume":"12","author":"Zlotnik","year":"2000","journal-title":"Immunity"},{"key":"10.1038\/labinvest.3700189_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0065-2776(01)78002-9","article-title":"Chemokines in immunity","volume":"78","author":"Yoshie","year":"2001","journal-title":"Adv Immunol"},{"key":"10.1038\/labinvest.3700189_bib6","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1084\/jem.187.6.875","article-title":"Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes","volume":"187","author":"Sallusto","year":"1998","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3700189_bib7","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/34814","article-title":"CCR5 is characteristic of Th1 lymphocytes","volume":"391","author":"Loetscher","year":"1998","journal-title":"Nature"},{"key":"10.1038\/labinvest.3700189_bib8","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.4049\/jimmunol.161.10.5111","article-title":"Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells","volume":"161","author":"D'Ambrosio","year":"1998","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700189_bib9","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.immunol.18.1.593","article-title":"The role of chemokine receptors in primary, effector and memory immune responses","volume":"18","author":"Sallusto","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1038\/labinvest.3700189_bib10","first-page":"997","article-title":"Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation","volume":"144","author":"Mazzucchelli","year":"1994","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3700189_bib11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1136\/gut.38.1.90","article-title":"Interleukin 8: cells of origin in inflammatory bowel disease","volume":"38","author":"Grimm","year":"1996","journal-title":"Gut"},{"key":"10.1038\/labinvest.3700189_bib12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/(SICI)1096-9896(199602)178:2<201::AID-PATH440>3.0.CO;2-4","article-title":"Differential in situ expression of the genes encoding the chemokines MCP-1 and RANTES in human inflammatory bowel disease","volume":"178","author":"Mazzucchelli","year":"1996","journal-title":"J Pathol"},{"key":"10.1038\/labinvest.3700189_bib13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/path.1245","article-title":"Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease","volume":"199","author":"Banks","year":"2003","journal-title":"J Pathol"},{"key":"10.1038\/labinvest.3700189_bib14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00054725-200111000-00001","article-title":"Chemokine receptor CXCR3 expression in inflammatory bowel disease","volume":"7","author":"Yuan","year":"2001","journal-title":"Inflamm Bowel Dis"},{"key":"10.1038\/labinvest.3700189_bib15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0002-9440(10)64756-6","article-title":"Immunological activation of dermal Langerhans cells in contact with lymphocytes in a model of human inflamed skin","volume":"156","author":"Katou","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3700189_bib16","first-page":"77","article-title":"In situ expression of the cell adhesion molecules in inflammatory bowel disease","volume":"69","author":"Nakamura","year":"1993","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3700189_bib17","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/labinvest.3700039","article-title":"Infiltration of CD8+ T cells containing RANTES\/CCL5+ cytoplasmic granules in actively inflammatory lesions of human chronic gastritis","volume":"84","author":"Ohtani","year":"2004","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3700189_bib18","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/(SICI)1097-0215(19961127)68:5<565::AID-IJC2>3.0.CO;2-X","article-title":"Dual over-expression pattern of membrane-type metalloproteinase-1 in cancer and stromal cells in human gastrointestinal carcinoma revealed by in situ hybridization and immunoelectron microscopy","volume":"27","author":"Ohtani","year":"1996","journal-title":"Int J Cancer"},{"key":"10.1038\/labinvest.3700189_bib19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0002-9440(10)63649-8","article-title":"Infiltrating CD8+ T cells in oral lichen planus predominantly express CCR5 and CXCR3 and carry respective chemokine ligands RANTES\/CCL5 and IP-10\/CXCL10 in their cytolytic granules: a potential self-recruiting mechanism","volume":"163","author":"Iijima","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3700189_bib20","first-page":"175","article-title":"Expression of costimulatory molecules B7-1 and B7-2 in macrophages and granulomas of Crohn's disease: demonstration of cell-to-cell contact with T lymphocytes","volume":"77","author":"Hara","year":"1997","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3700189_bib21","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/36129","article-title":"Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans","volume":"391","author":"Wagner","year":"1998","journal-title":"Nature"},{"key":"10.1038\/labinvest.3700189_bib22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1182\/blood.V99.1.44","article-title":"Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem\/progenitor cells","volume":"99","author":"Sweeney","year":"2002","journal-title":"Blood"},{"key":"10.1038\/labinvest.3700189_bib23","doi-asserted-by":"crossref","first-page":"13570","DOI":"10.1021\/bi971125s","article-title":"Glycosaminoglycans mediate cell surface oligomerization of chemokines","volume":"36","author":"Hoogewerf","year":"1997","journal-title":"Biochemistry"},{"key":"10.1038\/labinvest.3700189_bib24","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S1074-7613(02)00456-9","article-title":"RANTES production by memory phenotype T cells is controlled by a posttranscriptional, TCR-dependent process","volume":"17","author":"Swanson","year":"2002","journal-title":"Immunity"},{"key":"10.1038\/labinvest.3700189_bib25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/jlb.59.1.81","article-title":"Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production","volume":"59","author":"Taub","year":"1996","journal-title":"J Leukoc Biol"},{"key":"10.1038\/labinvest.3700189_bib26","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.4049\/jimmunol.156.6.2095","article-title":"Chemokines and T lymphocyte activation: I. Beta chemokines costimulate human T lymphocyte activation in vitro","volume":"156","author":"Taub","year":"1996","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700189_bib27","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.4049\/jimmunol.165.8.4388","article-title":"Macrophage-derived dendritic cells have strong th1-polarizing potential mediated by beta-chemokines rather than IL-12","volume":"165","author":"Zou","year":"2000","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700189_bib28","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1111\/j.1572-0241.1999.01220.x","article-title":"Type 1 T-helper cell predominance in granulomas of Crohn's disease","volume":"94","author":"Kakazu","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1038\/labinvest.3700189_bib29","doi-asserted-by":"crossref","first-page":"552","DOI":"10.4049\/jimmunol.166.1.552","article-title":"The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat","volume":"166","author":"Ajuebor","year":"2001","journal-title":"J Immunol"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3700189.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700189","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722014684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722014684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700189.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:41:11Z","timestamp":1758397271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722014684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S0023683722014684"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.3700189","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response?","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.3700189","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2005 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}