{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:43:15Z","timestamp":1791258195883,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":6584,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1038\/labinvest.3700205","type":"journal-article","created":{"date-parts":[[2004,11,15]],"date-time":"2004-11-15T05:33:30Z","timestamp":1100496810000},"page":"34-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Potential role of heme oxygenase-1 in the progression of rat adjuvant arthritis"],"prefix":"10.1016","volume":"85","author":[{"given":"Isabel","family":"Devesa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Ferr\u00e1ndiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Guill\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Miguel","family":"Cerd\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Alcaraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.3700205_bib1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0140-6736(01)06075-5","article-title":"Rheumatoid arthritis","volume":"358","author":"Lee","year":"2001","journal-title":"Lancet"},{"key":"10.1038\/labinvest.3700205_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj2980249","article-title":"Nitric oxide synthases in mammals","volume":"298","author":"Knowles","year":"1994","journal-title":"Biochem J"},{"key":"10.1038\/labinvest.3700205_bib3","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1053\/berh.2001.0196","article-title":"The role of nitric oxide in tissue destruction","volume":"15","author":"Abramson","year":"2001","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1038\/labinvest.3700205_bib4","first-page":"15","article-title":"Role of reactive oxygen and nitrogen species in etiopathogenesis of rheumatoid arthritis","volume":"18","author":"Bauerova","year":"1999","journal-title":"Gen Physiol Biophys"},{"key":"10.1038\/labinvest.3700205_bib5","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1136\/ard.51.11.1219","article-title":"Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases","volume":"51","author":"Farrell","year":"1992","journal-title":"Ann Rheum Dis"},{"key":"10.1038\/labinvest.3700205_bib6","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/art.1780390416","article-title":"Elevated nitric oxide production in rheumatoid arthritis","volume":"39","author":"Grabowski","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1038\/labinvest.3700205_bib7","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1172\/JCI118292","article-title":"Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides","volume":"96","author":"Sakurai","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.3700205_bib8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S1357-4310(99)01528-2","article-title":"Animal models of rheumatoid arthritis","volume":"5","author":"Joe","year":"1999","journal-title":"Mol Med Today"},{"key":"10.1038\/labinvest.3700205_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.berh.2003.09.007","article-title":"The usefulness and the limitations of animal models in identifying targets for therapy in arthritis","volume":"18","author":"Wooley","year":"2004","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1038\/labinvest.3700205_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0014-2999(94)00672-T","article-title":"Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase","volume":"273","author":"Connor","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"10.1038\/labinvest.3700205_bib11","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0022-3565(24)37290-8","article-title":"Therapeutic administration of a selective inhibitor of nitric oxide synthase does not ameliorate the chronic inflammation and tissue damage associated with adjuvant-induced arthritis in rats","volume":"284","author":"Fletcher","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/labinvest.3700205_bib12","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.2174\/1381612033453749","article-title":"Anti-inflammatory actions of the heme oxygenase-1 pathway","volume":"9","author":"Alcaraz","year":"2003","journal-title":"Curr Pharm Des"},{"key":"10.1038\/labinvest.3700205_bib13","first-page":"L268","article-title":"Mechanism of hemoglobin-induced protection against endotoxemia in rats: a ferritin-independent pathway","volume":"272","author":"Otterbein","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1038\/labinvest.3700205_bib14","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1084\/jem.20031003","article-title":"Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1","volume":"198","author":"Zuckerbraun","year":"2003","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3700205_bib15","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1172\/JCI5342","article-title":"Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury","volume":"103","author":"Otterbein","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.3700205_bib16","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1161\/01.RES.88.5.506","article-title":"Heme oxygenase-1 inhibits atherosclerotic lesion formation in ldl-receptor knockout mice","volume":"88","author":"Ishikawa","year":"2001","journal-title":"Circ Res"},{"key":"10.1038\/labinvest.3700205_bib17","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1161\/hh1401.093314","article-title":"Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice","volume":"89","author":"Yet","year":"2001","journal-title":"Circ Res"},{"key":"10.1038\/labinvest.3700205_bib18","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1096\/fj.03-0839fje","article-title":"Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts","volume":"18","author":"Yamashita","year":"2004","journal-title":"FASEB J"},{"key":"10.1038\/labinvest.3700205_bib19","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1021\/tx970041h","article-title":"Vascular endothelial cells generate peroxynitrite in response to carbon monoxide exposure","volume":"10","author":"Thom","year":"1997","journal-title":"Chem Res Toxicol"},{"key":"10.1038\/labinvest.3700205_bib20","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1074\/jbc.M211131200","article-title":"Interaction of nitric oxide with human heme oxygenase-1","volume":"278","author":"Wang","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.3700205_bib21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1161\/01.HYP.0000111721.97169.97","article-title":"Nitric oxide synthesis inhibition promotes renal production of carbon monoxide","volume":"43","author":"Rodriguez","year":"2004","journal-title":"Hypertension"},{"key":"10.1038\/labinvest.3700205_bib22","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1084\/jem.180.3.969","article-title":"Iron regulates nitric oxide synthase activity by controlling nuclear transcription","volume":"180","author":"Weiss","year":"1994","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3700205_bib23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.pa.35.040195.001121","article-title":"Inhibition of constitutive and inducible nitric oxide synthase: potential selective inhibition","volume":"35","author":"Fukuto","year":"1995","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1038\/labinvest.3700205_bib24","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/sj.bjp.0704145","article-title":"Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages","volume":"133","author":"Vicente","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1038\/labinvest.3700205_bib25","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1124\/jpet.103.057992","article-title":"Beneficial effects of heme oxygenase-1 up-regulation in the development of experimental inflammation induced by zymosan","volume":"307","author":"Vicente","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/labinvest.3700205_bib26","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0076-6879(88)62089-1","article-title":"Adjuvant arthritis","volume":"162","author":"Taurog","year":"1988","journal-title":"Methods Enzymol"},{"key":"10.1038\/labinvest.3700205_bib27","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.2042-7158.1988.tb05173.x","article-title":"Selectivity of neutrophil 5-lipoxygenase and cyclo-oxygenase inhibition by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids","volume":"40","author":"Moroney","year":"1988","journal-title":"J Pharm Pharmacol"},{"key":"10.1038\/labinvest.3700205_bib28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/abio.1993.1449","article-title":"A fluorometric assay for the measurement of nitrite in biological samples","volume":"214","author":"Misko","year":"1993","journal-title":"Anal Biochem"},{"key":"10.1038\/labinvest.3700205_bib29","first-page":"R1550","article-title":"Relations between functional, inflammatory, and degenerative parameters during adjuvant arthritits in rats","volume":"273","author":"Philippe","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1038\/labinvest.3700205_bib30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0192-0561(98)00015-0","article-title":"Immunological abnormality associated with the augmented nitric oxide synthesis in adjuvant-induced arthritis","volume":"20","author":"Tanaka","year":"1998","journal-title":"Int J Immunopharmacol"},{"key":"10.1038\/labinvest.3700205_bib31","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1046\/j.1523-1755.2002.00231.x","article-title":"Interactions between inducible nitric oxide synthase and heme oxygenase-1 in glomerulonephritis","volume":"61","author":"Datta","year":"2002","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.3700205_bib32","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1681\/ASN.V10122540","article-title":"Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis","volume":"10","author":"Datta","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/labinvest.3700205_bib33","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1073\/pnas.93.2.795","article-title":"Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation","volume":"93","author":"Zakhary","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3700205_bib34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.18388\/abp.2003_3715","article-title":"Effects of protoporphyrins on production of nitric oxide and expression of vascular endothelial growth factor in vascular smooth muscle cells and macrophages","volume":"50","author":"Jozkowicz","year":"2003","journal-title":"Acta Biochim Pol"},{"key":"10.1038\/labinvest.3700205_bib35","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/1529-0131(200006)43:6<1266::AID-ANR9>3.0.CO;2-P","article-title":"Temporal expression of inflammatory cytokines and chemokines in rat adjuvant-induced arthritis","volume":"43","author":"Szekanecz","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1038\/labinvest.3700205_bib36","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1365-2249.1994.tb06574.x","article-title":"The role of tumour necrosis factor-alpha and IL-1 in polymorphonuclear leucocyte and T lymphocyte recruitment to joint inflammation in adjuvant arthritis","volume":"97","author":"Issekutz","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"10.1038\/labinvest.3700205_bib37","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/00002281-199905000-00009","article-title":"Nitric oxide synthase and cyclooxygenases: distribution, regulation, and intervention in arthritis","volume":"11","author":"Amin","year":"1999","journal-title":"Curr Opin Rheumatol"},{"key":"10.1038\/labinvest.3700205_bib38","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1172\/JCI118717","article-title":"Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis","volume":"97","author":"Anderson","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.3700205_bib39","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/00045391-199509000-00007","article-title":"Nitric oxide activates the cyclooxygenase pathway in inflammation","volume":"2","author":"Salvemini","year":"1995","journal-title":"Am J Ther"},{"key":"10.1038\/labinvest.3700205_bib40","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0006-2952(00)00582-7","article-title":"A functional link between heme oxygenase and cyclooxygenase activities in cortical rat astrocytes","volume":"61","author":"Vairano","year":"2001","journal-title":"Biochem Pharmacol"},{"key":"10.1038\/labinvest.3700205_bib41","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1124\/jpet.300.1.188","article-title":"Regulation of cyclooxygenase by the heme\u2013heme oxygenase system in microvessel endothelial cells","volume":"300","author":"Haider","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/labinvest.3700205_bib42","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1063-4584(03)00150-X","article-title":"The role of reactive oxygen species in homeostasis and degradation of cartilage","volume":"11","author":"Henrotin","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1038\/labinvest.3700205_bib43","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0889-857X(05)70067-3","article-title":"The role of nitric oxide in articular cartilage damage","volume":"25","author":"Lotz","year":"1999","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1038\/labinvest.3700205_bib44","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1002\/1529-0131(200112)44:12<2899::AID-ART478>3.0.CO;2-X","article-title":"Differential expression pattern of the antiapoptotic proteins, Bcl-2 and FLIP, in experimental arthritis","volume":"44","author":"Perlman","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1038\/labinvest.3700205_bib45","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/ar92","article-title":"Apoptosis and p53 expression in rat adjuvant arthritis","volume":"2","author":"Tak","year":"2000","journal-title":"Arthritis Res"},{"key":"10.1038\/labinvest.3700205_bib46","doi-asserted-by":"crossref","first-page":"13613","DOI":"10.1074\/jbc.275.18.13613","article-title":"Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols","volume":"275","author":"Motterlini","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.3700205_bib47","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/1529-0131(200107)44:7<1540::AID-ART277>3.0.CO;2-7","article-title":"Expression of hypoxia-inducible factor 1 alpha by macrophages in the rheumatoid synovium: implications for targeting of therapeutic genes to the inflamed joint","volume":"44","author":"Hollander","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1038\/labinvest.3700205_bib48","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/art.11473","article-title":"The transcription factors hypoxia-inducible factor 1 alpha and Ets-1 colocalize in the hypoxic synovium of inflamed joints in adjuvant-induced arthritis","volume":"50","author":"Peters","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1038\/labinvest.3700205_bib49","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/jsre.1999.5627","article-title":"Fibroblast response to hypoxia: the relationship between angiogenesis and matrix regulation","volume":"84","author":"Steinbrech","year":"1999","journal-title":"J Surg Res"},{"key":"10.1038\/labinvest.3700205_bib50","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1297-319X(03)00088-5","article-title":"Recent data on the role for angiogenesis in rheumatoid arthritis","volume":"70","author":"Clavel","year":"2003","journal-title":"Joint Bone Spine"},{"key":"10.1038\/labinvest.3700205_bib51","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/labinvest.3700053","article-title":"Vascular endothelial growth factor VEGF189 induces human neutrophil chemotaxis in extravascular tissue via an autocrine amplification mechanism","volume":"84","author":"Ancelin","year":"2004","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3700205_bib52","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.4049\/jimmunol.171.9.4853","article-title":"Blockade of vascular endothelial growth factor receptor I (VEGF-RI), but not VEGF-RII, suppresses joint destruction in the K\/BxN model of rheumatoid arthritis","volume":"171","author":"De Bandt","year":"2003","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700205_bib53","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1089\/152308602753666280","article-title":"Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells","volume":"4","author":"Dulak","year":"2002","journal-title":"Antioxid Redox Signal"},{"key":"10.1038\/labinvest.3700205_bib54","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1089\/152308603764816514","article-title":"Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX","volume":"5","author":"Jozkowicz","year":"2003","journal-title":"Antioxid Redox Signal"},{"key":"10.1038\/labinvest.3700205_bib55","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/0008-8749(95)80025-E","article-title":"A novel angiogenesis inhibitor suppresses rat adjuvant arthritis","volume":"160","author":"Peacock","year":"1995","journal-title":"Cell Immunol"},{"key":"10.1038\/labinvest.3700205_bib56","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/bj3440153","article-title":"Haem oxygenase shows pro-oxidant activity in microsomal and cellular systems: implications for the release of low-molecular-mass iron","volume":"344","author":"Lamb","year":"1999","journal-title":"Biochem J"},{"key":"10.1038\/labinvest.3700205_bib57","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1191\/1352458503ms928oa","article-title":"Heme oxygenase-1 in SJL mice with experimental allergic encephalomyelitis","volume":"9","author":"Chakrabarty","year":"2003","journal-title":"Mult Scler"},{"key":"10.1038\/labinvest.3700205_bib58","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1038\/ki.1995.457","article-title":"Iron, heme oxygenase, and glutathione: effects on myohemoglobinuric proximal tubular injury","volume":"48","author":"Zager","year":"1995","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.3700205_bib59","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s005950300005","article-title":"Inhibition of heme oxygenase ameliorates sepsis-induced liver dysfunction in rats","volume":"33","author":"Iwasashi","year":"2003","journal-title":"Surg Today"},{"key":"10.1038\/labinvest.3700205_bib60","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1006\/cyto.1998.0441","article-title":"Induction of haem oxygenase contributes to the synthesis of pro-inflammatory cytokines in re-oxygenated rat macrophages: role of cGMP","volume":"11","author":"Tamion","year":"1999","journal-title":"Cytokine"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3700205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700205","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372201460X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372201460X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:41:24Z","timestamp":1758397284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002368372201460X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S002368372201460X"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.3700205","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential role of heme oxygenase-1 in the progression of rat adjuvant arthritis","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.3700205","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2005 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}