{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:38:57Z","timestamp":1769600337453,"version":"3.49.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":6038,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1038\/labinvest.3700430","type":"journal-article","created":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T15:05:30Z","timestamp":1146495930000},"page":"633-644","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development"],"prefix":"10.1016","volume":"86","author":[{"given":"Xinli","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine M","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinquan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia","family":"Soo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun'ichi","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Ting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.3700430_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00429-001-0223-8","article-title":"Sequential observations of exencephaly and subsequent morphological changes by mouse exo utero development system: analysis of the mechanism of transformation from exencephaly to anencephaly","volume":"205","author":"Matsumoto","year":"2002","journal-title":"Anat Embryol (Berlin)"},{"key":"10.1038\/labinvest.3700430_bib2","unstructured":"Laurence KM . Principles and practice of medical genetics. In: Emery AEH, Rimoin DL (eds). Churchill, Livingston, Edenburgh, 1990, pp 323\u2013346."},{"key":"10.1038\/labinvest.3700430_bib3","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1001\/jama.1988.03720040050026","article-title":"Neural tube defects","volume":"259","author":"Lemire","year":"1988","journal-title":"JAMA"},{"key":"10.1038\/labinvest.3700430_bib4","doi-asserted-by":"crossref","first-page":"7384","DOI":"10.1523\/JNEUROSCI.20-19-07384.2000","article-title":"Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS","volume":"20","author":"Lomaga","year":"2000","journal-title":"J Neurosci"},{"key":"10.1038\/labinvest.3700430_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/ajmg.c.30051","article-title":"Mouse models of neural tube defects: investigating preventive mechanisms","volume":"135","author":"Greene","year":"2005","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1038\/labinvest.3700430_bib6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/(SICI)1096-9926(199911)60:5<292::AID-TERA10>3.0.CO;2-6","article-title":"Mini-review: toward understanding mechanisms of genetic neural tube defects in mice","volume":"60","author":"Harris","year":"1999","journal-title":"Teratology"},{"key":"10.1038\/labinvest.3700430_bib7","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/ajmg.1320460620","article-title":"Acalvaria: a unique congenital anomaly","volume":"46","author":"Harris","year":"1993","journal-title":"Am J Med Genet"},{"key":"10.1038\/labinvest.3700430_bib8","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/jcu.1870190608","article-title":"Sonographic diagnosis of fetal acrania","volume":"19","author":"Ekici","year":"1991","journal-title":"J Clin Ultrasound"},{"key":"10.1038\/labinvest.3700430_bib9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.7863\/jum.1987.6.12.715","article-title":"Antenatal diagnosis of fetal acrania","volume":"6","author":"Vergani","year":"1987","journal-title":"J Ultrasound Med"},{"key":"10.1038\/labinvest.3700430_bib10","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1242\/dev.117.2.409","article-title":"The triple origin of skull in higher vertebrates: a study in quail-chick chimeras","volume":"117","author":"Couly","year":"1993","journal-title":"Development"},{"key":"10.1038\/labinvest.3700430_bib11","doi-asserted-by":"crossref","first-page":"F11","DOI":"10.1136\/fn.82.1.F11","article-title":"Fetal acalvaria with amniotic band syndrome","volume":"82","author":"Chandran","year":"2000","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1038\/labinvest.3700430_bib12","first-page":"381","article-title":"The mechanics of sea urchin development","volume":"26","author":"Horstadius","year":"1950","journal-title":"Annee Biol"},{"key":"10.1038\/labinvest.3700430_bib13","first-page":"33","article-title":"Differential mitosis and degeneration patterns in relation to the alterations in the shape of the embryonic ectoderm of early post-implantation mouse embryos","volume":"55","author":"Poelmann","year":"1980","journal-title":"J Embryol Exp Morphol"},{"key":"10.1038\/labinvest.3700430_bib14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1242\/dev.116.2.297","article-title":"Vital dye analysis of cranial neural crest cell migration in the mouse embryo","volume":"116","author":"Serbedzija","year":"1992","journal-title":"Development"},{"key":"10.1038\/labinvest.3700430_bib15","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0012-1606(75)90318-8","article-title":"An analysis of migratory behavior of avian cephalic neural crest cells","volume":"42","author":"Noden","year":"1975","journal-title":"Dev Biol"},{"key":"10.1038\/labinvest.3700430_bib16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0012-1606(82)90289-5","article-title":"The segregation and early migration of cranial neural crest cells in the avian embryo","volume":"89","author":"Tosney","year":"1982","journal-title":"Dev Biol"},{"key":"10.1038\/labinvest.3700430_bib17","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","article-title":"Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis","volume":"127","author":"Chai","year":"2000","journal-title":"Development"},{"key":"10.1038\/labinvest.3700430_bib18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/ajmg.a.30038","article-title":"Treacher Collins syndrome with craniosynostosis, choanal atresia, and esophageal regurgitation caused by a novel nonsense mutation in TCOF1","volume":"128A","author":"Horiuchi","year":"2004","journal-title":"Am J Med Genet"},{"key":"10.1038\/labinvest.3700430_bib19","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1093\/hmg\/9.10.1473","article-title":"Increased levels of apoptosis in the prefusion neural folds underlie the craniofacial disorder, Treacher Collins syndrome","volume":"9","author":"Dixon","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1038\/labinvest.3700430_bib20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0022-2143(99)90201-9","article-title":"Tumor necrosis factor-alpha and interleukin-1beta increase the Fas-mediated apoptosis of human osteoblasts","volume":"134","author":"Tsuboi","year":"1999","journal-title":"J Lab Clin Med"},{"key":"10.1038\/labinvest.3700430_bib21","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1359\/jbmr.1997.12.10.1637","article-title":"Fas and Fas ligand interaction is necessary for human osteoblast apoptosis","volume":"12","author":"Kawakami","year":"1997","journal-title":"J Bone Miner Res"},{"key":"10.1038\/labinvest.3700430_bib22","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1359\/jbmr.2003.18.12.2126","article-title":"Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development","volume":"18","author":"Zhang","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.1038\/labinvest.3700430_bib23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1359\/jbmr.1999.14.1.80","article-title":"Human NELL-1 expressed in unilateral coronal synostosis","volume":"14","author":"Ting","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1038\/labinvest.3700430_bib24","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/geno.1996.0628","article-title":"Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats","volume":"38","author":"Watanabe","year":"1996","journal-title":"Genomics"},{"key":"10.1038\/labinvest.3700430_bib25","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1006\/bbrc.1999.1753","article-title":"Involvement of epidermal growth factor-like domain of NELL proteins in the novel protein-protein interaction with protein kinase C","volume":"265","author":"Kuroda","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/labinvest.3700430_bib26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/bbrc.1999.1638","article-title":"Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2","volume":"265","author":"Kuroda","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/labinvest.3700430_bib27","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1073\/pnas.92.10.4547","article-title":"Metaxin, a gene contiguous to both thrombospondin 3 and glucocerebrosidase, is required for embryonic development in the mouse: implications for Gaucher disease","volume":"92","author":"Bornstein","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3700430_bib28","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1172\/JCI15375","article-title":"Craniosynostosis in transgenic mice overexpressing Nell-1","volume":"110","author":"Zhang","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.3700430_bib29","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1053\/joca.1998.0220","article-title":"Mechanisms of chondrocyte apoptosis","volume":"7","author":"Lotz","year":"1999","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1038\/labinvest.3700430_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2202-5-11","article-title":"The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas\/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins","volume":"5","author":"Cheema","year":"2004","journal-title":"BMC Neurosci"},{"key":"10.1038\/labinvest.3700430_bib31","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1523\/JNEUROSCI.19-05-01754.1999","article-title":"Fas\/Apo [apoptosis]-1 and associated proteins in the differentiating cerebral cortex: induction of caspase-dependent cell death and activation of NF-kappaB","volume":"19","author":"Cheema","year":"1999","journal-title":"J Neurosci"},{"key":"10.1038\/labinvest.3700430_bib32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/jsre.1999.5761","article-title":"Downregulation of apoptosis-related genes in keloid tissues","volume":"87","author":"Sayah","year":"1999","journal-title":"J Surg Res"},{"key":"10.1038\/labinvest.3700430_bib33","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/00001665-200011040-00015","article-title":"Internal craniofacial distraction with biodegradable devices: early stabilization and protected bone regeneration","volume":"11","author":"Cohen","year":"2000","journal-title":"J Craniofac Surg"},{"key":"10.1038\/labinvest.3700430_bib34","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ydbio.2004.02.017","article-title":"Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives","volume":"270","author":"Inoue","year":"2004","journal-title":"Dev Biol"},{"key":"10.1038\/labinvest.3700430_bib35","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/01.PRS.0000070971.95846.9C","article-title":"Common craniofacial anomalies: facial clefts and encephaloceles","volume":"112","author":"Hunt","year":"2003","journal-title":"Plast Reconstr Surg"},{"key":"10.1038\/labinvest.3700430_bib36","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/hmg\/9.6.993","article-title":"Mouse models for neural tube closure defects","volume":"9","author":"Juriloff","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1038\/labinvest.3700430_bib37","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0955-0674(95)80066-2","article-title":"Apoptosis and the cell cycle","volume":"7","author":"Evan","year":"1995","journal-title":"Curr Opin Cell Biol"},{"key":"10.1038\/labinvest.3700430_bib38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0092-8674(00)81873-5","article-title":"Programmed cell death in animal development","volume":"88","author":"Jacobson","year":"1997","journal-title":"Cell"},{"key":"10.1038\/labinvest.3700430_bib39","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1523\/JNEUROSCI.4444-03.2004","article-title":"Barhl1 regulates migration and survival of cerebellar granule cells by controlling expression of the neurotrophin-3 gene","volume":"24","author":"Li","year":"2004","journal-title":"J Neurosci"},{"key":"10.1038\/labinvest.3700430_bib40","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1242\/dev.126.21.4827","article-title":"FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate","volume":"126","author":"Liu","year":"1999","journal-title":"Development"},{"key":"10.1038\/labinvest.3700430_bib41","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/hmg\/6.3.369","article-title":"Perinatal lethality and multiple craniofacial malformations in MSX2 transgenic mice","volume":"6","author":"Winograd","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1038\/labinvest.3700430_bib42","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/hmg\/10.12.1325","article-title":"Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice","volume":"10","author":"Ikeda","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1038\/labinvest.3700430_bib43","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.1242\/dev.127.24.5285","article-title":"The WNT antagonist cSFRP2 modulates programmed cell death in the developing hindbrain","volume":"127","author":"Ellies","year":"2000","journal-title":"Development"},{"key":"10.1038\/labinvest.3700430_bib44","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1006\/dbio.1998.9114","article-title":"Msx2 gene dosage influences the number of proliferative osteogenic cells in growth centers of the developing murine skull: a possible mechanism for MSX2-mediated craniosynostosis in humans","volume":"205","author":"Liu","year":"1999","journal-title":"Dev Biol"},{"key":"10.1038\/labinvest.3700430_bib45","doi-asserted-by":"crossref","first-page":"29028","DOI":"10.1074\/jbc.M011265200","article-title":"Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway","volume":"276","author":"Hay","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.3700430_bib46","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/intimm\/dxg141","article-title":"Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression","volume":"15","author":"Pardo","year":"2003","journal-title":"Int Immunol"},{"key":"10.1038\/labinvest.3700430_bib47","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0003-9969(02)00035-3","article-title":"Differential expression of the Fas-Fas ligand system on cytokine-induced apoptotic cell death in mouse osteoblastic cells","volume":"47","author":"Ozeki","year":"2002","journal-title":"Arch Oral Biol"},{"key":"10.1038\/labinvest.3700430_bib48","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/S0002-9440(10)64139-9","article-title":"Increased osteoblast apoptosis in apert craniosynostosis: role of protein kinase C and interleukin-1","volume":"158","author":"Lemonnier","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3700430_bib49","first-page":"156","article-title":"Constitutive Fas ligand expression in several non-lymphoid mouse tissues: implications for immune-protection and cell turnover","volume":"97","author":"French","year":"1996","journal-title":"Behring Inst Mitt"},{"key":"10.1038\/labinvest.3700430_bib50","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0006-8993(95)00699-Q","article-title":"Fas antigen expression in brains of patients with Alzheimer-type dementia","volume":"695","author":"Nishimura","year":"1995","journal-title":"Brain Res"},{"key":"10.1038\/labinvest.3700430_bib51","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1582-4934.2000.tb00128.x","article-title":"Apoptosis in human embryo development: 1. Cerebral cortex","volume":"4","author":"Voiculescu","year":"2000","journal-title":"J Cell Mol Med"},{"key":"10.1038\/labinvest.3700430_bib52","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/0092-8674(93)90326-L","article-title":"Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family","volume":"75","author":"Suda","year":"1993","journal-title":"Cell"},{"key":"10.1038\/labinvest.3700430_bib53","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/nm0596-574","article-title":"Involvement of the CD95 (APO-1\/FAS) receptor\/ligand system in drug-induced apoptosis in leukemia cells","volume":"2","author":"Friesen","year":"1996","journal-title":"Nat Med"},{"key":"10.1038\/labinvest.3700430_bib54","doi-asserted-by":"crossref","first-page":"7795","DOI":"10.1074\/jbc.270.14.7795","article-title":"A novel protein that interacts with the death domain of Fas\/APO1 contains a sequence motif related to the death domain","volume":"270","author":"Boldin","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.3700430_bib55","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0092-8674(95)90071-3","article-title":"FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis","volume":"81","author":"Chinnaiyan","year":"1995","journal-title":"Cell"},{"key":"10.1038\/labinvest.3700430_bib56","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1074\/jbc.271.9.4961","article-title":"FADD\/MORT1 is a common mediator of CD95 (Fas\/APO-1) and tumor necrosis factor receptor-induced apoptosis","volume":"271","author":"Chinnaiyan","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.3700430_bib57","series-title":"Craniosynostosis: Diagnosis, Evaluation, and Management","first-page":"24","article-title":"Embryology of the skull","author":"Lemire","year":"2000"},{"key":"10.1038\/labinvest.3700430_bib58","series-title":"Understanding Craniofacial Anomalies, The Etiopathogenesis of Craniosynostoses and Facial Clefting","first-page":"275","article-title":"Evolutionary changes in the cranial vault and base: establishing the primate form","author":"Mooney","year":"2002"},{"key":"10.1038\/labinvest.3700430_bib59","series-title":"Craniosynostosis, Diagnosis, Evaluation, and Management","first-page":"316","article-title":"Apert syndrome","author":"Cohen","year":"2000"},{"key":"10.1038\/labinvest.3700430_bib60","first-page":"230","article-title":"Ueber den Cretinismus, namentlich in Franken, und ueber pathologische Schaedelforamen","volume":"2","author":"Virchow","year":"1852","journal-title":"Verh Phys Med Ges Wuerzburg"},{"key":"10.1038\/labinvest.3700430_bib61","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00001665-199601000-00008","article-title":"Apert's syndrome: cephalometric evaluation and considerations on pathogenesis","volume":"7","author":"Avantaggiato","year":"1996","journal-title":"J Craniofac Surg"},{"key":"10.1038\/labinvest.3700430_bib62","first-page":"105","article-title":"Neural crest formation in the head of the mouse embryo as observed using a new histological technique","volume":"64","author":"Nichols","year":"1981","journal-title":"J Embryol Exp Morphol"},{"key":"10.1038\/labinvest.3700430_bib63","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/381238a0","article-title":"Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2","volume":"381","author":"Zhang","year":"1996","journal-title":"Nature"},{"key":"10.1038\/labinvest.3700430_bib64","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s002230010069","article-title":"The immunohistochemical localization of Fas and Fas ligand in jaw bone and tooth germ of human fetuses","volume":"66","author":"Hatakeyama","year":"2000","journal-title":"Calcif Tissue Int"},{"key":"10.1038\/labinvest.3700430_bib65","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00429-003-0343-4","article-title":"Prenatal development of the human mandible. 3D reconstructions, morphometry and bone remodelling pattern, sizes 12\u2013117 mm CRL","volume":"207","author":"Radlanski","year":"2003","journal-title":"Anat Embryol (Berlin)"},{"key":"10.1038\/labinvest.3700430_bib66","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1126\/science.1077827","article-title":"The cellular and molecular origins of beak morphology","volume":"299","author":"Schneider","year":"2003","journal-title":"Science"},{"key":"10.1038\/labinvest.3700430_bib67","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1177\/00220345710500052801","article-title":"Contribution of Meckel's cartilage to ossification of the mandible in mice","volume":"50","author":"Frommer","year":"1971","journal-title":"J Dent Res"},{"key":"10.1038\/labinvest.3700430_bib68","series-title":"Craniofacial Development","author":"Sperber","year":"2001"},{"key":"10.1038\/labinvest.3700430_bib69","first-page":"331","article-title":"The development of the first branchial arch in man and the fate of Meckel's cartilage","volume":"30","author":"Richany","year":"1956","journal-title":"Q Bull Northwest Univ Med Sch"},{"key":"10.1038\/labinvest.3700430_bib70","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1006\/dbio.1995.1224","article-title":"Modulated expression of type X collagen in Meckel's cartilage with different developmental fates","volume":"170","author":"Chung","year":"1995","journal-title":"Dev Biol"},{"key":"10.1038\/labinvest.3700430_bib71","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1177\/00220345530320031401","article-title":"Role of Meckel's cartilage in the development and growth of the rat mandible","volume":"32","author":"Bhaskar","year":"1953","journal-title":"J Dent Res"},{"key":"10.1038\/labinvest.3700430_bib72","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/tera.1031","article-title":"A screen for mutations in human homologues of mice exencephaly genes Tfap2alpha and Msx2 in patients with neural tube defects","volume":"63","author":"Stegmann","year":"2001","journal-title":"Teratology"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3700430.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700430","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722032585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722032585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700430.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:55:42Z","timestamp":1758398142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722032585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":72,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S0023683722032585"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.3700430","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.3700430","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2006 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}