{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:56:54Z","timestamp":1791899814876,"version":"4.3.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5885,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1038\/labinvest.3700484","type":"journal-article","created":{"date-parts":[[2006,10,30]],"date-time":"2006-10-30T11:25:50Z","timestamp":1162207550000},"page":"1208-1220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":228,"title":["Characterization of pre- and post-treatment pathology after enzyme replacement therapy for pompe disease"],"prefix":"10.1016","volume":"86","author":[{"given":"Beth L","family":"Thurberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Lynch Maloney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Vaccaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra","family":"Afonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Chun-Hui","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Bossen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya S","family":"Kishnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"O'Callaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.3700484_bib1","first-page":"565","article-title":"Pre- and postnatal pathology, enzyme treatment, and unresolved issues in five lysosomal disorders","volume":"90","author":"Hug","year":"1979","journal-title":"Pharmacol Rev"},{"key":"10.1038\/labinvest.3700484_bib2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00404-004-0620-3","article-title":"Prenatal diagnosis of Pompe disease by electron microscopy","volume":"271","author":"Phupong","year":"2005","journal-title":"Arch Gynecol Obstet"},{"key":"10.1038\/labinvest.3700484_bib3","series-title":"The Metabolic and Molecular Basis of Inherited Disease","first-page":"3389","article-title":"Glycogen storage disease type II: acid \u03b1-glucosidase (acid maltase) deficiency","author":"Hirschhorn","year":"2001"},{"key":"10.1038\/labinvest.3700484_bib4","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1542\/peds.112.2.332","article-title":"The natural course of infantile Pompe's disease: 20 original cases compared with 133 cases from the literature","volume":"112","author":"Van den Hout","year":"2003","journal-title":"Pediatrics"},{"key":"10.1038\/labinvest.3700484_bib5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jpeds.2005.11.033","article-title":"A retrospective, multinational, multicenter study of the natural history of infantile Pompe disease","volume":"148","author":"Kishnani","year":"2006","journal-title":"J Pediatr"},{"key":"10.1038\/labinvest.3700484_bib6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1177\/002215540505300108","article-title":"High resolution light microscopy (HRLM) and digital analysis of Pompe disease pathology","volume":"53","author":"Lynch","year":"2005","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/labinvest.3700484_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF02889849","article-title":"Infantile acid maltase deficiency","volume":"45","author":"Griffin","year":"1984","journal-title":"Virchows Arch"},{"key":"10.1038\/labinvest.3700484_bib8","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1152\/jappl.2001.91.2.534","article-title":"Myogenic satellite cells: physiology to molecular biology","volume":"91","author":"Hawke","year":"2001","journal-title":"J Appl Physiol"},{"key":"10.1038\/labinvest.3700484_bib9","doi-asserted-by":"crossref","first-page":"H241","DOI":"10.1152\/ajpheart.2001.281.1.H241","article-title":"Relationship between capillary angiogenesis, fiber type, and fiber size in chronic systemic hypoxia","volume":"281","author":"Deveci","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1038\/labinvest.3700484_bib10","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1152\/japplphysiol.00744.2001","article-title":"Capillary supply of the tibialis anterior muscle in young, healthy, and moderately active men and women","volume":"92","author":"Porter","year":"2002","journal-title":"J Appl Physiol"},{"key":"10.1038\/labinvest.3700484_bib11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jpeds.2006.02.035","article-title":"Chinese hamster ovary cell-derived recombinant human acid alpha-glucosidase in infantile-onset Pompe disease","volume":"149","author":"Kishnani","year":"2006","journal-title":"J Pediatr"},{"key":"10.1038\/labinvest.3700484_bib12","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1242\/jcs.104.3.751","article-title":"Defining E-cadherin associated complexes in epithelial cells: plakoglobin, beta and gamma catenin are distinct components","volume":"104","author":"Piepenhagen","year":"1993","journal-title":"J Cell Sci"},{"key":"10.1038\/labinvest.3700484_bib13","series-title":"Theory and Practice of Histological Techniques","author":"Bancroft","year":"1990"},{"key":"10.1038\/labinvest.3700484_bib14","series-title":"Theory and Practice of Histotechnology","author":"Sheehan","year":"1980"},{"key":"10.1038\/labinvest.3700484_bib15","first-page":"164","article-title":"Lysosomal dysfunction in muscle with special reference to glycogen storage disease type II","volume":"1637","author":"Hesselink","year":"2003","journal-title":"Biochem Biophys Acta"},{"key":"10.1038\/labinvest.3700484_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1542\/peds.37.2.249","article-title":"A histochemical and electron microscopic study of skeletal muscle in a case of Pompe's disease (glycogenosis II)","volume":"37","author":"Cardiff","year":"1966","journal-title":"Pediatrics"},{"key":"10.1038\/labinvest.3700484_bib17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1001\/archpedi.1966.02090080035001","article-title":"Glycogen storage disease, type II, III, VIII, and IX","volume":"111","author":"Hug","year":"1966","journal-title":"Am J Dis Child"},{"key":"10.1038\/labinvest.3700484_bib18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF00687878","article-title":"Pompe's disease: An inborn lysosomal disorder with storage of glycogen- A study of brain and striated muscle","volume":"23","author":"Martin","year":"1973","journal-title":"Acta Neuropath"},{"key":"10.1038\/labinvest.3700484_bib19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0002-9343(68)90160-5","article-title":"Type II glycogenosis: biochemical and electron microscopic study","volume":"44","author":"Garancis","year":"1968","journal-title":"Am J Med"},{"key":"10.1038\/labinvest.3700484_bib20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/path.1711160303","article-title":"The pathology of type II skeletal muscle glycogenosis: a light and electron-microscopic study","volume":"116","author":"Hudgson","year":"1975","journal-title":"J Path"},{"key":"10.1038\/labinvest.3700484_bib21","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/BF00496413","article-title":"Juvenile acid maltase deficiency presenting as paravertebral pseudotumour","volume":"147","author":"Iancu","year":"1988","journal-title":"Eur J Pediatr"},{"key":"10.1038\/labinvest.3700484_bib22","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/ajmg.1320210322","article-title":"The \u2018muscular variant' of Pompe disease: clinical, biochemical and histologic characteristics","volume":"21","author":"Temple","year":"1985","journal-title":"Am J Med Genet"},{"issue":"Suppl 1","key":"10.1038\/labinvest.3700484_bib23","first-page":"S271","article-title":"Clinical, pathological and electron microscopic findings in two Thai children with Pompe disease","volume":"85","author":"Shotelersuk","year":"2002","journal-title":"J Med Assoc Thai"},{"key":"10.1038\/labinvest.3700484_bib24","first-page":"379","article-title":"Infantile-onset glycogen storage disease type II (Pompe disease): report of a case with genetic diagnosis and pathological findings","volume":"27","author":"Teng","year":"2004","journal-title":"Chang Gung Med J"},{"key":"10.1038\/labinvest.3700484_bib25","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/(SICI)1097-0177(199702)208:2<278::AID-AJA14>3.0.CO;2-#","article-title":"Cellular localization of transforming growth factor-beta2 and -beta3 (TGF-\u03b22, TGF-\u03b23) in damaged and regenerating skeletal muscles","volume":"208","author":"McLennan","year":"1997","journal-title":"Dev Dyn"},{"key":"10.1038\/labinvest.3700484_bib26","first-page":"227","article-title":"Muscle fiber types","volume":"63","author":"Herbison","year":"1982","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1038\/labinvest.3700484_bib27","doi-asserted-by":"crossref","first-page":"S124","DOI":"10.1249\/00005768-198810001-00006","article-title":"Blood flow to different rat skeletal muscle fiber type sections during isometric contractions in situ","volume":"20","author":"Terjung","year":"1988","journal-title":"Med Sci Sports Exerc"},{"key":"10.1038\/labinvest.3700484_bib28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ymgme.2003.08.022","article-title":"Enzyme replacement therapy in the mouse model of Pompe disease","volume":"80","author":"Raben","year":"2003","journal-title":"Mol Genet Metab"},{"key":"10.1038\/labinvest.3700484_bib29","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/ana.20807","article-title":"Dysfunction of endocytic and autophagic pathways in a lysosomal storage disease","volume":"59","author":"Fukada","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1038\/labinvest.3700484_bib30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/ar.1091890204","article-title":"The number of nuclei in adult rat muscles with special reference to satellite cells","volume":"189","author":"Schmalbruch","year":"1977","journal-title":"Anat Record"},{"key":"10.1038\/labinvest.3700484_bib31","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/ar.1092020305","article-title":"The distribution of satellite cells and their relationship to specific fiber types in soleus and extensor digitorum longus muscles","volume":"202","author":"Gibson","year":"1982","journal-title":"Anat Record"},{"key":"10.1038\/labinvest.3700484_bib32","first-page":"132","article-title":"Recombinant human acid alpha-glucosidase enzyme replacement therapy for infantile glycogen storage disease type II: results of a phase I\/II clinical trial","volume":"3","author":"Amalfitano","year":"2001","journal-title":"Genet Med"},{"key":"10.1038\/labinvest.3700484_bib33","doi-asserted-by":"crossref","first-page":"e448","DOI":"10.1542\/peds.113.5.e448","article-title":"Long-term intravenous treatment of Pompe disease with recombinant human \u03b1-glucosidase from milk","volume":"113","author":"Van den Hout","year":"2004","journal-title":"Pediatrics"},{"key":"10.1038\/labinvest.3700484_bib34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF02265613","article-title":"The conduction system in Pompe's disease","volume":"2","author":"Bharati","year":"1982","journal-title":"Pediatr Cardiol"},{"key":"10.1038\/labinvest.3700484_bib35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/01.gim.0000195896.04069.5f","article-title":"Electrocardiographic response to enzyme replacement therapy for Pompe disease","volume":"8","author":"Ansong","year":"2006","journal-title":"Genet Med"},{"key":"10.1038\/labinvest.3700484_bib36","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/ana.410220512","article-title":"Alpha-glucosidase deficiency and basilar artery aneurysm: report of a sibship","volume":"22","author":"Makos","year":"1987","journal-title":"Ann Neurol"},{"key":"10.1038\/labinvest.3700484_bib37","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1212\/WNL.57.5.906","article-title":"Intractable fever and cortical neuronal glycogen storage in glycogenosis type 2","volume":"57","author":"Martini","year":"2001","journal-title":"Neurology"},{"key":"10.1038\/labinvest.3700484_bib38","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/01.gim.0000217786.79173.a8","article-title":"Ambulatory electrocardiogram analysis in infants treated with recombinant human acid \u03b1-glucosidase enzyme replacement therapy for Pompe disease","volume":"8","author":"Cook","year":"2006","journal-title":"Genet Med"},{"key":"10.1038\/labinvest.3700484_bib39","doi-asserted-by":"crossref","first-page":"e532","DOI":"10.1542\/peds.2003-0988-L","article-title":"Nephrotic syndrome complicating alpha-glucosidase replacement therapy for Pompe disease","volume":"144","author":"Hunley","year":"2004","journal-title":"Pediatrics"},{"key":"10.1038\/labinvest.3700484_bib40","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1460-9592.2004.01242.x","article-title":"Anaesthesia management of infants with glycogen storage disease type II: a physiological approach","volume":"14","author":"Ing","year":"2004","journal-title":"Paediatr Anaesth"},{"key":"10.1038\/labinvest.3700484_bib41","article-title":"Recombinant Human Acid \u03b1-glucosidase: major clinical benefits in infantile onset Pompe disease","author":"Kishnani","year":"2006","journal-title":"Neurology"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3700484.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700484","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722017536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722017536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700484.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:41:39Z","timestamp":1758397299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722017536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0023683722017536"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.3700484","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of pre- and post-treatment pathology after enzyme replacement therapy for pompe disease","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.3700484","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2006 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}