{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T19:18:30Z","timestamp":1770146310385,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":5854,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1038\/labinvest.3700497","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T21:51:19Z","timestamp":1166133079000},"page":"14-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Lupus resistance is associated with marginal zone abnormalities in an NZM murine model"],"prefix":"10.1016","volume":"87","author":[{"given":"Biyan","family":"Duan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron P","family":"Croker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Morel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.3700497_bib1","first-page":"419","article-title":"Differences in expression of lupus nephritis in New Zealand mixed H-2z homozygous inbred strains of mice derived from New Zealand black and New Zealand white mice. Origins and initial characterization","volume":"68","author":"Rudofsky","year":"1993","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3700497_bib2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/1074-7613(94)90100-7","article-title":"Polygenic control of susceptibility to murine systemic lupus erythematosus","volume":"1","author":"Morel","year":"1994","journal-title":"Immunity"},{"key":"10.1038\/labinvest.3700497_bib3","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.4049\/jimmunol.158.12.6019","article-title":"Functional dissection of systemic lupus erythematosus using congenic mouse strains","volume":"158","author":"Morel","year":"1997","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700497_bib4","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1006\/clim.2001.5079","article-title":"NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci","volume":"100","author":"Waters","year":"2001","journal-title":"Clin Immunol"},{"key":"10.1038\/labinvest.3700497_bib5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1084\/jem.20031519","article-title":"Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis","volume":"199","author":"Waters","year":"2004","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3700497_bib6","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1073\/pnas.97.12.6670","article-title":"Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains","volume":"97","author":"Morel","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3700497_bib7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1074-7613(00)80088-6","article-title":"Epistatic modifers of autoimmunity in a murine model of lupus nephritis","volume":"11","author":"Morel","year":"1999","journal-title":"Immunity"},{"key":"10.1038\/labinvest.3700497_bib8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1074-7613(01)00201-1","article-title":"Delineating the genetic basis of systemic lupus erythematosus","volume":"15","author":"Wakeland","year":"2001","journal-title":"Immunity"},{"key":"10.1038\/labinvest.3700497_bib9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1600-065X.2000.imr017515.x","article-title":"B-cell subsets and the mature preimmune repertoire. Marginal zone and B1B cells as part of a \u2018natural immune memory'","volume":"175","author":"Martin","year":"2000","journal-title":"Immunol Rev"},{"key":"10.1038\/labinvest.3700497_bib10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.immunol.20.100301.064833","article-title":"Origins and functions of B-1 cells with notes on the role of CD5","volume":"20","author":"Berland","year":"2002","journal-title":"Ann Rev Immunol"},{"key":"10.1038\/labinvest.3700497_bib11","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/1529-0131(199809)41:9<1652::AID-ART17>3.0.CO;2-W","article-title":"Accumulation of splenic B1a cells with potent antigen-presenting capability in NZM2410 lupus-prone mice","volume":"41","author":"Mohan","year":"1998","journal-title":"Arthr Rheumat"},{"key":"10.1038\/labinvest.3700497_bib12","doi-asserted-by":"crossref","first-page":"936","DOI":"10.4049\/jimmunol.175.2.936","article-title":"Genetic dissection of the murine lupus susceptibility locus Sle2: contributions to increased peritoneal B-1a cells and lupus nephritis map to different loci","volume":"175","author":"Xu","year":"2005","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700497_bib13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/clim.1999.4806","article-title":"Activated B cells express increased levels of costimulatory molecules in young autoimmune NZB and (NZB \u00d7 NZW)F-1 mice","volume":"94","author":"Wither","year":"2000","journal-title":"Clin Immunol"},{"key":"10.1038\/labinvest.3700497_bib14","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.4049\/jimmunol.167.4.1886","article-title":"Cutting edge: expansion and activation of a population of autoreactive marginal zone B cells in a model of estrogen-induced lupus","volume":"167","author":"Grimaldi","year":"2001","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700497_bib15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1084\/jem.20011453","article-title":"Autoreactive B cells in the marginal zone that express dual receptors","volume":"195","author":"Li","year":"2002","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3700497_bib16","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.4049\/jimmunol.175.7.4309","article-title":"Colocalization of expansion of the splenic marginal zone population with abnormal B cell activation and autoantibody production in B6 mice with an introgressed New Zealand black chromosome 13 interval","volume":"175","author":"Wither","year":"2005","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700497_bib17","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1002\/(SICI)1521-4141(199910)29:10<3319::AID-IMMU3319>3.0.CO;2-9","article-title":"Negative regulation of antigen receptor-mediated signaling by constitutive association of CD5 with the SHP-1 protein tyrosine phosphatase in B-1B cells","volume":"29","author":"Sen","year":"1999","journal-title":"Eur J Immunol"},{"key":"10.1038\/labinvest.3700497_bib18","first-page":"323","article-title":"Marginal-zone B cells","volume":"2","author":"Martin","year":"2002","journal-title":"Nat Rev"},{"key":"10.1038\/labinvest.3700497_bib19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s003359900098","article-title":"Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain","volume":"7","author":"Morel","year":"1996","journal-title":"Mammal Genome"},{"key":"10.1038\/labinvest.3700497_bib20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/01.ASN.0000108969.21691.5D","article-title":"The classification of glomerulonephritis in systemic lupus erythematosus revisited","volume":"15","author":"Weening","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/labinvest.3700497_bib21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.clim.2006.03.009","article-title":"STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus","volume":"120","author":"Xu","year":"2006","journal-title":"Clin Immunol"},{"key":"10.1038\/labinvest.3700497_bib22","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S1074-7613(01)00228-X","article-title":"Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein","volume":"15","author":"Boackle","year":"2001","journal-title":"Immunity"},{"key":"10.1038\/labinvest.3700497_bib23","first-page":"1072","article-title":"Adoptive transfer of NZM-derived lupus susceptibility locus SLE1 on murine chromosome 1 by bone marrow","volume":"40","author":"Sobel","year":"1997","journal-title":"Arthr Rheumat"},{"key":"10.1038\/labinvest.3700497_bib24","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s003359900964","article-title":"Multiplex inheritance of component phenotypes in a murine model of lupus","volume":"10","author":"Morel","year":"1999","journal-title":"Mammal Genome"},{"key":"10.1038\/labinvest.3700497_bib25","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/jid.1968.79","article-title":"Study of autoimmune disease in New Zealand mice. I. genetic features and natural history of NZB, NZY and NZW strains and NZB-NZW hybrids","volume":"50","author":"Braverman","year":"1968","journal-title":"J Invest Dermatol"},{"key":"10.1038\/labinvest.3700497_bib26","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0090-1229(80)90198-1","article-title":"Age- and sex-related glomerulonephritis in New Zealand white mice","volume":"16","author":"Kelley","year":"1980","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1038\/labinvest.3700497_bib27","doi-asserted-by":"crossref","first-page":"7692","DOI":"10.4049\/jimmunol.174.12.7692","article-title":"Genetic determination of T cell help in loss of tolerance to nuclear antigens","volume":"174","author":"Chen","year":"2005","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700497_bib28","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.4049\/jimmunol.168.11.5605","article-title":"CD9 is a unique marker for marginal zone B cells, B1 cells, and plasma cells in mice","volume":"168","author":"Won","year":"2002","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700497_bib29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev.immunol.23.021704.115628","article-title":"Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs","volume":"23","author":"Cyster","year":"2005","journal-title":"Ann Rev Immunol"},{"key":"10.1038\/labinvest.3700497_bib30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1084\/jem.20030684","article-title":"Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone","volume":"198","author":"Karlsson","year":"2003","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3700497_bib31","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.4049\/jimmunol.172.6.3620","article-title":"B cells are crucial for both development and maintenance of the splenic marginal zone","volume":"172","author":"Nolte","year":"2004","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700497_bib32","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1084\/jem.20051038","article-title":"Characterization of marginal zone B cell precursors","volume":"202","author":"Srivastava","year":"2005","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3700497_bib33","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0171-2985(85)80064-4","article-title":"In vivo effects of LPS on lymphocyte-B subpopulations\u2014migration of marginal zone-lymphocytes and IgD-blast formation in the mouse spleen","volume":"170","author":"Groeneveld","year":"1985","journal-title":"Immunobiol"},{"key":"10.1038\/labinvest.3700497_bib34","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/0090-1229(76)90085-4","article-title":"Age and genetic influence on immunity in NZB and autoimmune-resistant mice","volume":"6","author":"Fernandes","year":"1976","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1038\/labinvest.3700497_bib35","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/5941","article-title":"QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2","volume":"21","author":"Encinas","year":"1999","journal-title":"Nat Genet"},{"key":"10.1038\/labinvest.3700497_bib36","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1126\/science.7542801","article-title":"A role for Cd5 in TCR-mediated signal-transduction and thymocyte selection","volume":"269","author":"Tarakhovsky","year":"1995","journal-title":"Science"},{"key":"10.1038\/labinvest.3700497_bib37","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1126\/science.1086907","article-title":"Predominant autoantibody production by early human B cell precursors","volume":"301","author":"Wardemann","year":"2003","journal-title":"Science"},{"key":"10.1038\/labinvest.3700497_bib38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.smim.2005.02.008","article-title":"Models for peripheral B cell development and homeostasis","volume":"17","author":"Srivastava","year":"2005","journal-title":"Semin Immunol"},{"key":"10.1038\/labinvest.3700497_bib39","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.4049\/jimmunol.171.4.1758","article-title":"Incomplete activation of CD4T cells by antigen-presenting transitional immature B cells: implications for peripheral B and T cell responsiveness","volume":"171","author":"Chung","year":"2003","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700497_bib40","doi-asserted-by":"crossref","first-page":"6492","DOI":"10.4049\/jimmunol.162.11.6492","article-title":"Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death","volume":"162","author":"Mohan","year":"1999","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700497_bib41","doi-asserted-by":"crossref","first-page":"803","DOI":"10.4049\/jimmunol.172.2.803","article-title":"Marginal zone, but not follicular B cells, are potent activators of naive CD4T cells","volume":"172","author":"Attanavanich","year":"2004","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3700497_bib42","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1084\/jem.20060701","article-title":"Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help","volume":"203","author":"Mandik-Nayak","year":"2006","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3700497_bib43","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1084\/jem.191.5.883","article-title":"CD5 maintains tolerance in anergic B cells","volume":"191","author":"Hippen","year":"2000","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3700497_bib44","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.4049\/jimmunol.175.5.2925","article-title":"The CD9 tetraspanin is not required for the development of peripheral B cells or for humoral immunity","volume":"175","author":"Cariappa","year":"2005","journal-title":"J Immunol"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3700497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700497","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722017433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722017433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3700497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:42:29Z","timestamp":1758397349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722017433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0023683722017433"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.3700497","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lupus resistance is associated with marginal zone abnormalities in an NZM murine model","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.3700497","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}