{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:53:25Z","timestamp":1792634005669,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":8320,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2000,4]]},"DOI":"10.1038\/labinvest.3780061","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T07:30:40Z","timestamp":1353051040000},"page":"557-573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Development of Intermediate-Grade (Mantle Cell) and Low-Grade (Small Lymphocytic and Marginal Zone) Human Non-Hodgkin's Lymphomas Xenotransplanted in Severe Combined Immunodeficiency Mouse Models"],"prefix":"10.1016","volume":"80","author":[{"given":"Jerry","family":"Bryant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archito","family":"Tamayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Ordonez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.3780061_bib1","doi-asserted-by":"crossref","unstructured":"Anonymous (1982). Non-Hodgkin's lymphoma pathologic classification project: National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: Summary and description of a Working Formulation for clinical usage. Cancer49:2112\u20132135.","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"10.1038\/labinvest.3780061_bib2","first-page":"135","article-title":"Growth of sensitive and drug-resistant human myeloid leukemia cells in SCID mice","volume":"8","author":"Beran","year":"1994","journal-title":"Hematol Pathol"},{"key":"10.1038\/labinvest.3780061_bib3","first-page":"3603","article-title":"Biological properties and growth in SCID mice of a new myelogenous leukemia cell line (KBM-5) derived from chronic myelogenous leukemia cells in the blastic phase","volume":"53","author":"Beran","year":"1993","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.3780061_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/301527a0","article-title":"A severe combined immunodeficiency mutation in the mouse","volume":"301","author":"Bosma","year":"1983","journal-title":"Nature"},{"key":"10.1038\/labinvest.3780061_bib5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.iy.09.040191.001543","article-title":"The SCID mouse mutant: Definition, characterization, and potential uses","volume":"9","author":"Bosma","year":"1991","journal-title":"Annu Rev Immunol"},{"key":"10.1038\/labinvest.3780061_bib6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0065-2776(08)60022-X","article-title":"Lymphocyte trafficking and regional immunity","volume":"72","author":"Butcher","year":"1999","journal-title":"Adv Immunol"},{"key":"10.1038\/labinvest.3780061_bib7","first-page":"827","article-title":"The severe combined immunodeficient (SCID) mouse as a model for human myeloid leukemias","volume":"7","author":"Cesano","year":"1992","journal-title":"Oncogene"},{"key":"10.1038\/labinvest.3780061_bib8","first-page":"20","article-title":"Childhood acute myeloid leukemia in mice pretreated with radiation and anti-asialo GM1","volume":"84","author":"Chelstrom","year":"1994","journal-title":"Anticancer Res"},{"key":"10.1038\/labinvest.3780061_bib9","first-page":"464","article-title":"Severe combined immunodeficiency (SCID) in the mouse: Pathology, reconstitution, neoplasms","volume":"120","author":"Custer","year":"1985","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3780061_bib10","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1002\/eji.1830201009","article-title":"Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B-lineage leukemias","volume":"20","author":"Deane","year":"1990","journal-title":"Eur J Immunol"},{"key":"10.1038\/labinvest.3780061_bib11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0090-1229(88)90126-2","article-title":"Lymphocyte immunophenotyping of B-cell lymphomas: A flow cytometric analysis of neoplastic and non-neoplastic cells in 271 cases","volume":"49","author":"DeMartini","year":"1988","journal-title":"Clin Immunol Immunopath"},{"key":"10.1038\/labinvest.3780061_bib12","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.4049\/jimmunol.134.6.3798","article-title":"Natural killer cells are present in mice with severe combined immunodeficiency","volume":"134","author":"Dorshkind","year":"1985","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3780061_bib13","first-page":"919","article-title":"Preferential expression of the mucosal homing receptor integrin \u03b14\u03b27 in gastrointestinal non-Hodgkin's lymphomas","volume":"150","author":"Drillenburg","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3780061_bib14","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/0008-8749(92)90086-5","article-title":"The hu-PBL-SCID mouse model: Long-term human serologic evolution associated with the xenogeneic transfer of human peripheral blood leukocytes into SCID mice","volume":"139","author":"Duchosal","year":"1992","journal-title":"Cell Immunol"},{"key":"10.1038\/labinvest.3780061_bib15","first-page":"7050","article-title":"A murine model for B-cell lymphomagenesis in immunocompromised hosts\u2014Natural killer cells are an important component of host resistance to premalignant B-cell lines","volume":"50","author":"Felsher","year":"1990","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.3780061_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF00049529","article-title":"Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis","volume":"5","author":"Fidler","year":"1986","journal-title":"Cancer Metastasis Rev"},{"key":"10.1038\/labinvest.3780061_bib17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/(SICI)1099-1069(199606)14:2<67::AID-HON567>3.0.CO;2-U","article-title":"Modeling human leukemia and lymphoma in severe combined immunodeficient (SCID) mice: Practical applications","volume":"14","author":"Flavell","year":"1996","journal-title":"Hematol Oncol"},{"key":"10.1038\/labinvest.3780061_bib18","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1182\/blood.V86.1.283.bloodjournal861283","article-title":"Identification of B-Cell growth factors (interleukin-14; high molecular weight-B-cell growth factors) in effusion fluids from patients with aggressive B-cell lymphomas","volume":"86","author":"Ford","year":"1995","journal-title":"Blood"},{"issue":"Suppl 1","key":"10.1038\/labinvest.3780061_bib19","first-page":"386a","article-title":"Human lymphoma models in SCID mice: Non-Hodgkin and Hodgkin's","volume":"88","author":"Ford","year":"1996","journal-title":"Blood"},{"key":"10.1038\/labinvest.3780061_bib20","first-page":"1288a","article-title":"In vitroin vivo models for mantle cell lymphoma","volume":"92","author":"Ford","year":"1998","journal-title":"Blood"},{"key":"10.1038\/labinvest.3780061_bib21","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European-American Classification of lymphoid neoplasms: A proposal from the international lymphoma study group","volume":"84","author":"Harris","year":"1994","journal-title":"Blood"},{"key":"10.1038\/labinvest.3780061_bib22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1600-065X.1979.tb00267.x","article-title":"Natural killer cells: Characteristics and regulation of activity","volume":"44","author":"Herberman","year":"1979","journal-title":"Immunol Rev"},{"key":"10.1038\/labinvest.3780061_bib23","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/ijc.2910160204","article-title":"Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity","volume":"16","author":"Herberman","year":"1975","journal-title":"Int J Cancer"},{"key":"10.1038\/labinvest.3780061_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0092-8674(87)90615-5","article-title":"Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals","volume":"49","author":"Hesse","year":"1987","journal-title":"Cell"},{"key":"10.1038\/labinvest.3780061_bib25","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1023\/A:1008396618983","article-title":"Gastric MALT lymphoma: From concept to cure","volume":"10","author":"Isaacson","year":"1999","journal-title":"Ann Oncol"},{"key":"10.1038\/labinvest.3780061_bib26","first-page":"151","article-title":"Gastrointestinal lymphomas of T- and B- cell types","volume":"12","author":"Isaacson","year":"1999","journal-title":"Mod Pathol"},{"key":"10.1038\/labinvest.3780061_bib27","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1126\/science.2904703","article-title":"Engraftment of immune-deficient mice with human hematopoietic stem cells","volume":"242","author":"Kamel-Reid","year":"1988","journal-title":"Science"},{"key":"10.1038\/labinvest.3780061_bib28","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/eji.1830050208","article-title":"Natural killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype","volume":"5","author":"Kiessling","year":"1975","journal-title":"Eur J Immunol"},{"key":"10.1038\/labinvest.3780061_bib29","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1600-065X.1979.tb00270.x","article-title":"An analysis of the murine NK cell as to structure, function and biological relevance","volume":"44","author":"Kiessling","year":"1979","journal-title":"Immunol Rev"},{"key":"10.1038\/labinvest.3780061_bib30","first-page":"1385","article-title":"Homing and antigenic characterization of a human Non-Hodgkin's lymphoma B cell line in severe combined immunodeficient (SCID) mice","volume":"8","author":"Kroon","year":"1994","journal-title":"Leukemia"},{"key":"10.1038\/labinvest.3780061_bib31","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1084\/jem.164.5.1797","article-title":"An expanded population of natural killer cells in mice severe combined immunodeficiency (SCID) lack rearrangement and expression of T cell receptor genes","volume":"164","author":"Lauzon","year":"1986","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3780061_bib32","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0167-5699(95)80046-8","article-title":"The human immune system in hu-PBL-SCID mice","volume":"16","author":"Lehmann","year":"1995","journal-title":"Immunol Today"},{"key":"10.1038\/labinvest.3780061_bib33","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0092-8674(88)90004-9","article-title":"The defect in murine severe combined immune deficiency. Joining of signal sequences but not coding segments in V(D) J recombination","volume":"55","author":"Lieber","year":"1988","journal-title":"Cell"},{"key":"10.1038\/labinvest.3780061_bib34","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0092-8674(88)90066-9","article-title":"The SCID affects the final step of the immunoglobulin VDJ recombinase mechanism","volume":"54","author":"Malynn","year":"1988","journal-title":"Cell"},{"key":"10.1038\/labinvest.3780061_bib35","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/eji.1830230506","article-title":"The fate of human peripheral blood lymphocytes after transplantation into SCID mice","volume":"23","author":"Martino","year":"1993","journal-title":"Eur J Immunol"},{"key":"10.1038\/labinvest.3780061_bib36","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1006\/mcpr.1996.0062","article-title":"Analysis of Epstein-Barr Virus (EBV) type and variant in spontaneous lymphoblastoid cells and Hu-SCID mouse tumors","volume":"10","author":"Menin","year":"1996","journal-title":"Mol and Cellul Probes"},{"key":"10.1038\/labinvest.3780061_bib37","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/335256a0","article-title":"Transfer of a functional human immune system to mice with severe combined immunodeficiency","volume":"335","author":"Mosier","year":"1988","journal-title":"Nature"},{"key":"10.1038\/labinvest.3780061_bib38","first-page":"5552s","article-title":"Epstein-Barr virus-induced human B-cell lymphomas in SCID mice reconstituted with human peripheral blood leukocytes","volume":"52","author":"Mosier","year":"1992","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.3780061_bib39","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/350512a0","article-title":"A novel cyclin encoded by a bcl-1 linked candidate oncogene","volume":"50","author":"Motokura","year":"1991","journal-title":"Nature"},{"key":"10.1038\/labinvest.3780061_bib40","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/00000478-199604000-00007","article-title":"Lymphomatous polyposis: A neoplasm of either follicular mantle or germinal center cell origin","volume":"20","author":"Moynihan","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/labinvest.3780061_bib41","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1182\/blood.V82.8.2526.2526","article-title":"Growth of human myeloid leukemias in the human marrow environment of SCID-hu mice","volume":"82","author":"Namikawa","year":"1993","journal-title":"Blood"},{"key":"10.1038\/labinvest.3780061_bib42","first-page":"496","article-title":"Expression of lymphocyte homing receptor antigen in non-Hodgkin's lymphoma","volume":"30","author":"Picker","year":"1988","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3780061_bib43","doi-asserted-by":"crossref","first-page":"9638","DOI":"10.1073\/pnas.88.21.9638","article-title":"Prad1, a candidate BCL1 oncogene: Mapping and expression in centrocytic lymphoma","volume":"88","author":"Rosenberg","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3780061_bib44","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.4049\/jimmunol.152.8.3806","article-title":"Human primary immune response in SCID mice engrafted with human peripheral blood lymphocytes","volume":"152","author":"Sandhu","year":"1994","journal-title":"J Immunol"},{"key":"10.1038\/labinvest.3780061_bib45","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1182\/blood.V79.8.2089.2089","article-title":"Propagation of human blastic myeloid leukemias in the SCID mouse","volume":"79","author":"Sawyers","year":"1992","journal-title":"Blood"},{"key":"10.1038\/labinvest.3780061_bib46","first-page":"1071","article-title":"Retinoid-mediated inhibition of cell growth with stimulation of apoptosis in aggressive B-cell lymphomas","volume":"8","author":"Sundaresan","year":"1997","journal-title":"Cell Growth Differ"},{"key":"10.1038\/labinvest.3780061_bib47","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1182\/blood.V78.10.2650.2650","article-title":"Growth of primary T-cell non-Hodgkin's lymphomata in SCID-hu mice: Requirement for a human lymphoid microenvironment","volume":"78","author":"Waller","year":"1991","journal-title":"Blood"},{"key":"10.1038\/labinvest.3780061_bib48","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/ajcp\/103.6.756","article-title":"Cyclin D1 expression in non-Hodgkin's lymphomas","volume":"103","author":"Zukerberg","year":"1995","journal-title":"Am J Clin Pathol"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3780061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3780061","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722021912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722021912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3780061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:46:22Z","timestamp":1758397582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722021912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["S0023683722021912"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.3780061","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2000,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of Intermediate-Grade (Mantle Cell) and Low-Grade (Small Lymphocytic and Marginal Zone) Human Non-Hodgkin's Lymphomas Xenotransplanted in Severe Combined Immunodeficiency Mouse Models","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.3780061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2000 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}