{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T23:09:28Z","timestamp":1758409768901,"version":"3.44.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":8229,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1038\/labinvest.3780113","type":"journal-article","created":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T08:26:42Z","timestamp":1294388802000},"page":"1079-1087","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Down-Regulation of Renal Endothelial Nitric Oxide Synthase Expression in Experimental Glomerular Thrombotic Microangiopathy"],"prefix":"10.1016","volume":"80","author":[{"given":"Xin J","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Laszik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenmin","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu Q","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J","family":"Brackett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan R","family":"Lerner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred G","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nosratola D","family":"Vaziri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.3780113_bib1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0272-6386(12)80170-3","article-title":"Nitric oxide in the kidney: Synthesis, localization and function","volume":"24","author":"Bachmann","year":"1994","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/labinvest.3780113_bib2","first-page":"419","article-title":"Tumor necrosis factor induces glomerular damage in the rabbits","volume":"134","author":"Bertani","year":"1989","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3780113_bib3","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1073\/pnas.83.12.4533","article-title":"Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: Characterization and comparison with the actions of interleukin-1","volume":"83","author":"Bevilacqua","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3780113_bib4","first-page":"365","article-title":"Biology of disease. Acute inflammation and microthrombosis induced by endotoxin, interleukin-1, and tumor necrosis factor and their implications in gram negative infection","volume":"58","author":"Cybulsky","year":"1988","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3780113_bib5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0006-291X(05)80832-0","article-title":"Nitric oxide mediates tumor necrosis factor-\u03b1 cytotoxicity in endothelial cells","volume":"186","author":"Estrada","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/labinvest.3780113_bib6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3109\/00365599709030646","article-title":"The arginine-nitric oxide pathway in thrombotic microangiopathy","volume":"31","author":"Herlitz","year":"1997","journal-title":"Scand J Urol Nephrol"},{"key":"10.1038\/labinvest.3780113_bib7","doi-asserted-by":"crossref","first-page":"C634","DOI":"10.1152\/ajpcell.1991.261.4.C634","article-title":"Nitric oxide synthesis in endothelial cells: Evidence of a pathway inducible by TNF\u03b1","volume":"261","author":"Lamas","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1038\/labinvest.3780113_bib8","first-page":"862","article-title":"Lack of suppressed renal thrombomodulin expression in a septic rat model with glomerular thrombotic microangiopathy","volume":"70","author":"Laszik","year":"1994","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3780113_bib9","first-page":"115","article-title":"Renal interleukin-1 expression during endotoxemia and gram-negative septicemia in conscious rats","volume":"43","author":"Laszik","year":"1994","journal-title":"Circulat Shock"},{"key":"10.1038\/labinvest.3780113_bib10","first-page":"1003","article-title":"Thrombotic microangiopathy","author":"Laszik","year":"1998","journal-title":"Heptinstall's Pathology of the Kidney"},{"key":"10.1038\/labinvest.3780113_bib11","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/0968-0004(89)90181-3","article-title":"Nitric oxide: Biosynthesis and biological significance","volume":"14","author":"Marletta","year":"1989","journal-title":"Trends Biochem Sci"},{"issue":"3","key":"10.1038\/labinvest.3780113_bib12","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/ki.1994.318","article-title":"Differential expression and induction of mRNAs encoding two inducible nitric oxide synthases in rat kidney","volume":"46","author":"Mohaupt","year":"1994","journal-title":"Kidney International"},{"key":"10.1038\/labinvest.3780113_bib13","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1096\/fasebj.9.13.7557022","article-title":"Molecular mechanism and therapeutic strategies related to nitric oxide","volume":"9","author":"Moncada","year":"1995","journal-title":"FASEB J"},{"key":"10.1038\/labinvest.3780113_bib14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: Physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol Rev"},{"key":"10.1038\/labinvest.3780113_bib15","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/ki.1994.135","article-title":"Location of an inducible nitric oxide synthase mRNA in the normal kidney","volume":"45","author":"Morrissey","year":"1994","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.3780113_bib16","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1073\/pnas.83.10.3460","article-title":"Interleukin 1 induces endothelial cell procoagulant while suppressing cell surface anticoagulant activity","volume":"83","author":"Nawroth","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3780113_bib17","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1084\/jem.163.3.740","article-title":"Modulation of endothelial cell hemostatic properties by tumor necrosis factor","volume":"163","author":"Nawroth","year":"1986","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3780113_bib18","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0272-6386(96)90515-6","article-title":"Increased nitric oxide formation in recurrent thrombotic microangiopathies: A possible mediator of microvascular injury","volume":"27","author":"Noris","year":"1996","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/labinvest.3780113_bib19","first-page":"556","article-title":"Effect of low density lipoprotein on cytosolic [Ca2+] in cultured rat mesangial cells","volume":"44","author":"Pahl","year":"1996","journal-title":"J Invest Med"},{"key":"10.1038\/labinvest.3780113_bib20","first-page":"301","article-title":"What can be learned from the expression of endothelial adhesion molecules in tissues","volume":"64","author":"Pober","year":"1991","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3780113_bib21","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0140-6736(87)91481-4","article-title":"Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium","volume":"2","author":"Radomski","year":"1987","journal-title":"Lancet"},{"key":"10.1038\/labinvest.3780113_bib22","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1093\/cvr\/27.7.1380","article-title":"Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide","volume":"27","author":"Radomski","year":"1993","journal-title":"Cardiovasc Res"},{"key":"10.1038\/labinvest.3780113_bib23","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/ki.1994.102","article-title":"Glomerular thrombosis in pregnancy: Role of the L-arginine-nitric oxide pathway","volume":"45","author":"Raij","year":"1994","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.3780113_bib24","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1172\/JCI119551","article-title":"Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats","volume":"100","author":"Schwartz","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.3780113_bib25","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1172\/JCI116045","article-title":"Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis","volume":"90","author":"Shultz","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1038\/labinvest.3780113_bib26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1440-1681.1997.tb02100.x","article-title":"Intrarenal localization of nitric oxide synthase isoforms and soluble guanylyl cyclase","volume":"24","author":"Star","year":"1997","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1038\/labinvest.3780113_bib27","doi-asserted-by":"crossref","first-page":"7738","DOI":"10.1073\/pnas.82.22.7738","article-title":"Mammalian biosynthesis: Mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide","volume":"82","author":"Stuehr","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3780113_bib28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0306-3623(96)00410-7","article-title":"Nitric oxide and septic shock","volume":"29","author":"Thiemermann","year":"1997","journal-title":"Gen Pharmacol"},{"key":"10.1038\/labinvest.3780113_bib29","first-page":"F642","article-title":"Downregulation of nitric oxide synthase in chronic renal insufficiency: Role of excess PTH","volume":"274","author":"Vaziri","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1038\/labinvest.3780113_bib30","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1161\/01.HYP.34.6.1237","article-title":"cGMP-mediated negative feedback regulation of endothelial nitric oxide synthase by nitric oxide","volume":"34","author":"Vaziri","year":"1999","journal-title":"Hypertension"},{"key":"10.1038\/labinvest.3780113_bib31","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1096\/fasebj.5.3.1825816","article-title":"A specific receptor antagonist for interleukin 1 prevents Escherichia coli-induced shock in rabbits","volume":"5","author":"Wakabayashi","year":"1991","journal-title":"FASEB J"},{"key":"10.1038\/labinvest.3780113_bib32","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/ki.1994.325","article-title":"Exogenous nitric oxide prevents endotoxin-induced glomerular thrombosis in rats","volume":"46","author":"Westberg","year":"1994","journal-title":"Kidney Int"},{"key":"10.1038\/labinvest.3780113_bib33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1161\/01.RES.73.1.205","article-title":"Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life","volume":"73","author":"Yoshizumi","year":"1993","journal-title":"Cir Res"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3780113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3780113","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372202133X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372202133X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3780113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:45:54Z","timestamp":1758397554000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002368372202133X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["S002368372202133X"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.3780113","relation":{},"ISSN":["0023-6837"],"issn-type":[{"type":"print","value":"0023-6837"}],"subject":[],"published":{"date-parts":[[2000,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Down-Regulation of Renal Endothelial Nitric Oxide Synthase Expression in Experimental Glomerular Thrombotic Microangiopathy","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.3780113","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2000 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}