{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:06:04Z","timestamp":1761645964752,"version":"3.44.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":7802,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2001,9]]},"DOI":"10.1038\/labinvest.3780333","type":"journal-article","created":{"date-parts":[[2006,11,10]],"date-time":"2006-11-10T04:20:35Z","timestamp":1163132435000},"page":"1191-1198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["MNU Induction of Neoplasia in a Platyfish Model"],"prefix":"10.1016","volume":"81","author":[{"given":"Steven","family":"Kazianis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irma","family":"Gimenez-Conti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard B","family":"Setlow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avril D","family":"Woodhead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C","family":"Harshbarger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Trono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Ledesma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney S","family":"Nairn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald B","family":"Walter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.3780333_bib1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/oxfordjournals.jhered.a109395","article-title":"Linkage between a regulatory locus for melanoma cell differentiation and an esterase locus in Xiphophorus","volume":"71","author":"Ahuja","year":"1980","journal-title":"J Hered"},{"key":"10.1038\/labinvest.3780333_bib2","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1101\/gad.12.22.3467","article-title":"Malignant melanoma: Modern black plague and genetic black box","volume":"12","author":"Chin","year":"1998","journal-title":"Genes Dev"},{"key":"10.1038\/labinvest.3780333_bib3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/PL00020694","article-title":"Analysis of an esterase linked to a locus involved in the regulation of the melanoma oncogene and isolation of polymorphic marker sequences in Xiphophorus","volume":"29","author":"Fornzler","year":"1991","journal-title":"Biochem Genet"},{"key":"10.1038\/labinvest.3780333_bib4","first-page":"845","article-title":"Thymomas induced by simple alkylating agents in C57BL\/Cbi mice: Kinetics of the dose response","volume":"64","author":"Frei","year":"1980","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/labinvest.3780333_bib5","first-page":"59","author":"Friedberg","year":"1995","journal-title":"DNA repair and mutagenesis"},{"key":"10.1038\/labinvest.3780333_bib6","first-page":"1495","article-title":"Hereditary basis of melanosis in hybrid fishes","volume":"15","author":"Gordon","year":"1931","journal-title":"Am J Cancer"},{"key":"10.1038\/labinvest.3780333_bib7","first-page":"732","article-title":"Morphology of the heritable color patterns in the Mexican killifish, Platypoecilus","volume":"15","author":"Gordon","year":"1931","journal-title":"Am J Cancer"},{"key":"10.1038\/labinvest.3780333_bib8","first-page":"335","article-title":"Effects of dose and schedule of methylnitrosourea on incidence of malignant lymphoma in adult female mice","volume":"45","author":"Joshi","year":"1970","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/labinvest.3780333_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-4613-4470-4_6","article-title":"The platyfish, Xiphophorus maculatus","author":"Kallman","year":"1975","journal-title":"Handbook of genetics"},{"key":"10.1038\/labinvest.3780333_bib10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/jez.1401760204","article-title":"The origin and possible genetic control of new, stable pigment patterns in the poeciliid fish Xiphophorus maculatus","volume":"176","author":"Kallman","year":"1971","journal-title":"J Exp Zool"},{"key":"10.1038\/labinvest.3780333_bib11","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/carcin\/21.4.599","article-title":"Overexpression of a fish CDKN2 gene in a hereditary melanoma model","volume":"21","author":"Kazianis","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1038\/labinvest.3780333_bib12","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/(SICI)1098-2264(199807)22:3<210::AID-GCC6>3.0.CO;2-Z","article-title":"Localization of a CDKN2 gene in linkage group V of Xiphophorus fishes defines it as a candidate for the DIFF tumor suppressor","volume":"22","author":"Kazianis","year":"1998","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1038\/labinvest.3780333_bib13","doi-asserted-by":"crossref","first-page":"5088","DOI":"10.1038\/sj.onc.1202884","article-title":"Comparative structure and characterization of a CDKN2 gene in a Xiphophorus fish melanoma model","volume":"18","author":"Kazianis","year":"1999","journal-title":"Oncogene"},{"key":"10.1038\/labinvest.3780333_bib14","first-page":"253","article-title":"Uber bastarde der teleostier Platypoecilus und Xiphophorus","volume":"44","author":"Kosswig","year":"1927","journal-title":"Z Indukt Abstamm Ver"},{"key":"10.1038\/labinvest.3780333_bib15","first-page":"809","article-title":"Linkage group V of platyfishes and Swordtails of the genus Xiphophorus (Poeciliidae): Linkage of loci for malate dehydrogenase-2 and esterase-1 and esterase-4 with a gene controlling the severity of hybrid melanomas","volume":"71","author":"Morizot","year":"1983","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/labinvest.3780333_bib16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1101\/SQB.1986.051.01.032","article-title":"Specific enzymatic amplification of DNA in vitro: The polymerase chain reaction","volume":"51","author":"Mullis","year":"1986","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"10.1038\/labinvest.3780333_bib17","doi-asserted-by":"crossref","first-page":"13042","DOI":"10.1073\/pnas.93.23.13042","article-title":"A CDKN2-like polymorphism in Xiphophorus LG V is associated with UV-B-induced melanoma formation in platyfish-swordtail hybrids","volume":"93","author":"Nairn","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3780333_bib18","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1751-1097.1996.tb03089.x","article-title":"Nonmammalian models for sunlight carcinogenesis: Genetic analysis of melanoma formation in Xiphophorus hybrid fish","volume":"64","author":"Nairn","year":"1996","journal-title":"Photochem Photobiol"},{"key":"10.1038\/labinvest.3780333_bib19","first-page":"289","article-title":"Promotion of N-methyl-N-nitrosourea-induced thyroid tumors by iodine deficiency in F344\/NCr rats","volume":"73","author":"Ohshima","year":"1984","journal-title":"J Natl Cancer Inst"},{"key":"10.1038\/labinvest.3780333_bib20","first-page":"1524","article-title":"The morphology of melanotic over-growths in hybrids of Mexican killifishes","volume":"15","author":"Reed","year":"1931","journal-title":"Am J Cancer"},{"key":"10.1038\/labinvest.3780333_bib21","first-page":"23","article-title":"Tlag1, a novel murine tumor susceptibility gene that regulates MNU-induced thymic lymphoma development","volume":"395","author":"Richie","year":"1996","journal-title":"Prog Clin Biol Res"},{"key":"10.1038\/labinvest.3780333_bib22","first-page":"F115","article-title":"The p16INK4a\/CDKN2A tumor suppressor and its relatives","volume":"1378","author":"Ruas","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/labinvest.3780333_bib23","first-page":"159","article-title":"Spontaneous melanoma formation in nonhybrid Xiphophorus","volume":"55","author":"Schartl","year":"1995","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.3780333_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0168-9525(00)89041-1","article-title":"Platyfish and swordtails: A genetic system for the analysis of molecular mechanisms in tumor formation","volume":"11","author":"Schartl","year":"1995","journal-title":"Trends Genet"},{"key":"10.1038\/labinvest.3780333_bib25","first-page":"301","article-title":"Genetics of susceptibility in the platyfish\/swordtail tumor system to develop fibrosarcoma and rhabdomyosarcoma following treatment with N-methyl-N-nitrosourea (MNU)","volume":"91","author":"Schwab","year":"1978","journal-title":"Cancer Res Clin Oncol"},{"key":"10.1038\/labinvest.3780333_bib26","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1007\/BF01947324","article-title":"Genetic basis of susceptibility for development of neoplasms following treatment with N-methyl-N-nitrosourea (MNU) or x-rays in the platyfish\/swordtail system","volume":"34","author":"Schwab","year":"1978","journal-title":"Experientia"},{"key":"10.1038\/labinvest.3780333_bib27","first-page":"519","article-title":"Genetic basis of susceptibility for neuroblastoma following treatment with N-methyl-N-nitrosourea and X-rays in Xiphophorus","volume":"39","author":"Schwab","year":"1979","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.3780333_bib28","doi-asserted-by":"crossref","first-page":"6666","DOI":"10.1073\/pnas.90.14.6666","article-title":"Wavelengths effective in induction of malignant melanoma","volume":"90","author":"Setlow","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3780333_bib29","doi-asserted-by":"crossref","first-page":"8922","DOI":"10.1073\/pnas.86.22.8922","article-title":"Animal model for ultraviolet radiation-induced melanoma: Platyfish-swordtail hybrid","volume":"86","author":"Setlow","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3780333_bib30","article-title":"Factors responsible for platyfish-swordtail hybrid melanomas \u2013 many or few","author":"Siciliano","year":"1976","journal-title":"Pigment cell"},{"key":"10.1038\/labinvest.3780333_bib31","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1159\/000398713","article-title":"Biochemical genetics of the platyfish-swordtail hybrid melanoma system","volume":"20","author":"Siciliano","year":"1976","journal-title":"Prog Exp Tumor Res"},{"key":"10.1038\/labinvest.3780333_bib32","series-title":"The pathology of fishes","first-page":"945","article-title":"Melanomas in platy\/swordtail hybrids","author":"Sobel","year":"1975"},{"key":"10.1038\/labinvest.3780333_bib33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1577\/1548-8667(1989)001<0069:GOMIXF>2.3.CO;2","article-title":"Genetics of melanomas in Xiphophorus fishes","volume":"1","author":"Vielkind","year":"1989","journal-title":"J Aquat Anim Health"},{"key":"10.1038\/labinvest.3780333_bib34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/jez.1401960207","article-title":"Genetic control of cell differentiation in platyfish-swordtail melanomas","volume":"196","author":"Vielkind","year":"1976","journal-title":"J Exp Zool"},{"key":"10.1038\/labinvest.3780333_bib35","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/315382a0","article-title":"Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats","volume":"315","author":"Zarbl","year":"1985","journal-title":"Nature"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3780333.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3780333","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722031725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722031725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3780333.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:54:44Z","timestamp":1758398084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722031725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["S0023683722031725"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.3780333","relation":{},"ISSN":["0023-6837"],"issn-type":[{"type":"print","value":"0023-6837"}],"subject":[],"published":{"date-parts":[[2001,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MNU Induction of Neoplasia in a Platyfish Model","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.3780333","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2001 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}