{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:55:25Z","timestamp":1760244925284,"version":"3.44.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":7560,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2002,5]]},"DOI":"10.1038\/labinvest.3780447","type":"journal-article","created":{"date-parts":[[2004,11,2]],"date-time":"2004-11-02T16:41:38Z","timestamp":1099413698000},"page":"535-541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Molecular Phenotype Distinguishes Two Subsets of Gastric Low-Grade Mucosa-Associated Lymphoid Tissue Lymphomas"],"prefix":"10.1016","volume":"82","author":[{"given":"Elena","family":"Nardini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Rizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"M\u00e9nard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Balsari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.3780447_bib1","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1182\/blood.V78.6.1561.1561","article-title":"Ig VH gene expression among human follicular lymphomas","volume":"78","author":"Bahler","year":"1991","journal-title":"Blood"},{"key":"10.1038\/labinvest.3780447_bib2","first-page":"5547s","article-title":"Antigen selection in human lymphomagenesis","volume":"52","author":"Bahler","year":"1992","journal-title":"Cancer Res"},{"key":"10.1038\/labinvest.3780447_bib3","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0140-6736(95)90113-2","article-title":"Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT Lymphoma Study Group","volume":"345","author":"Bayerdorffer","year":"1995","journal-title":"Lancet"},{"key":"10.1038\/labinvest.3780447_bib4","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/0092-8674(91)90289-B","article-title":"Maturation of the immune response in germinal centers","volume":"67","author":"Berek","year":"1991","journal-title":"Cell"},{"key":"10.1038\/labinvest.3780447_bib5","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1046\/j.1365-2141.1997.1392954.x","article-title":"Immunoglobulin heavy chain diversity genes rearrangement pattern indicates that MALT-type gastric lymphoma B cells have undergone an antigen selection process","volume":"97","author":"Bertoni","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1038\/labinvest.3780447_bib6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0167-5699(94)90175-9","article-title":"The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement","volume":"15","author":"Chang","year":"1994","journal-title":"Immunol Today"},{"key":"10.1038\/labinvest.3780447_bib7","first-page":"1190","article-title":"Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion","volume":"10","author":"Du","year":"1996","journal-title":"Leukemia"},{"key":"10.1038\/labinvest.3780447_bib8","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1084\/jem.174.3.525","article-title":"The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma","volume":"174","author":"Friedman","year":"1991","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3780447_bib9","first-page":"572","article-title":"Idiotype identity in a MALT-type lymphoma and B cells in Helicobacter pylori associated chronic gastritis","volume":"70","author":"Greiner","year":"1994","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3780447_bib10","first-page":"277","article-title":"Immunoglobulin VH genes of high-grade mucosa-associated lymphoid tissue lymphomas show a high load of somatic mutations and evidence of antigen-dependent affinity maturation","volume":"78","author":"Hallas","year":"1998","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3780447_bib11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1182\/blood.V84.2.403.403","article-title":"Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle","volume":"84","author":"Hummel","year":"1994","journal-title":"Blood"},{"key":"10.1038\/labinvest.3780447_bib12","first-page":"285","article-title":"Immunoglobulin specificity of low-grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type","volume":"142","author":"Hussell","year":"1993","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3780447_bib13","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1056\/NEJM199911113412007","article-title":"Cellular origin of human B cell lymphomas","volume":"341","author":"Kuppers","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1038\/labinvest.3780447_bib14","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1002\/j.1460-2075.1993.tb06189.x","article-title":"Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections","volume":"12","author":"Kuppers","year":"1993","journal-title":"EMBO J"},{"key":"10.1038\/labinvest.3780447_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1600-065X.1987.tb00508.x","article-title":"Somatic mutation in human B cell tumors","volume":"96","author":"Levy","year":"1987","journal-title":"Immunol Rev"},{"key":"10.1038\/labinvest.3780447_bib16","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1182\/blood.V89.5.1732","article-title":"Molecular characterization of IgA- and\/or IgG-switched chronic lymphocytic leukemia B cells","volume":"89","author":"Matolcsy","year":"1997","journal-title":"Blood"},{"key":"10.1038\/labinvest.3780447_bib17","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1182\/blood.V95.12.3878.012k26_3878_3884","article-title":"Salivary gland mucosa-associated lymphoid tissue lymphoma immunoglobulin V(H) genes show frequent use of V1-69 with distinctive CDR3 features","volume":"95","author":"Miklos","year":"2000","journal-title":"Blood"},{"key":"10.1038\/labinvest.3780447_bib18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/annonc\/8.suppl_2.S37","article-title":"Helicobacter pylori eradication for the treatment of gastric low-grade MALT lymphoma: follow-up together with sequential molecular studies","volume":"8","author":"Montalban","year":"1997","journal-title":"Ann Oncol"},{"key":"10.1038\/labinvest.3780447_bib19","first-page":"1271","article-title":"B cell monoclonality precedes the development of gastric MALT lymphoma in Helicobacter pylori-associated chronic gastritis","volume":"152","author":"Nakamura","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3780447_bib20","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1182\/blood.V95.3.1032.003k38_1032_1038","article-title":"Detection of aberrant isotype switch recombination in low-grade and high grade gastric MALT lymphomas","volume":"95","author":"Nardini","year":"2000","journal-title":"Blood"},{"key":"10.1038\/labinvest.3780447_bib21","first-page":"477","article-title":"Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis","volume":"76","author":"Qin","year":"1997","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3780447_bib22","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1182\/blood.V86.9.3528.bloodjournal8693528","article-title":"Somatic hypermutation in low-grade mucosa-associated lymphoid tissue-type B cell lymphoma","volume":"86","author":"Qin","year":"1995","journal-title":"Blood"},{"key":"10.1038\/labinvest.3780447_bib23","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/381751a0","article-title":"Clonal selection and learning in the antibody system","volume":"381","author":"Rajewsky","year":"1996","journal-title":"Nature"},{"key":"10.1038\/labinvest.3780447_bib24","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1084\/jem.185.8.1435","article-title":"Lack of allelic exclusion in B cell chronic lymphocytic leukemia","volume":"185","author":"Rassenti","year":"1997","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3780447_bib25","doi-asserted-by":"crossref","first-page":"767","DOI":"10.7326\/0003-4819-122-10-199505150-00006","article-title":"Eradication of Helicobacter pylori infection in primary low-grade gastric lymphoma of mucosa-associated lymphoid tissue","volume":"122","author":"Roggero","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1038\/labinvest.3780447_bib26","doi-asserted-by":"crossref","first-page":"88","DOI":"10.7326\/0003-4819-131-2-199907200-00003","article-title":"Antibiotic treatment of gastric lymphoma of mucosa-associated lymphoid tissue: An uncontrolled trial","volume":"131","author":"Steinbach","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1038\/labinvest.3780447_bib27","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1200\/JCO.1998.16.12.3822","article-title":"Ongoing somatic mutations and clonal expansions after cure of Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue B cell lymphoma","volume":"16","author":"Thiede","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1038\/labinvest.3780447_bib28","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/0140-6736(91)92035-Z","article-title":"Helicobacter pylori-associated gastritis and primary B cell gastric lymphoma","volume":"338","author":"Wotherspoon","year":"1991","journal-title":"Lancet"},{"key":"10.1038\/labinvest.3780447_bib29","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1349-7006.1999.tb00826.x","article-title":"CDR3 sequences of MALT lymphoma show homology with those of autoreactive B cell lines","volume":"90","author":"Yumoto","year":"1999","journal-title":"Jpn J Cancer Res"},{"key":"10.1038\/labinvest.3780447_bib30","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1084\/jem.176.4.1137","article-title":"Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection","volume":"176","author":"Zelenetz","year":"1992","journal-title":"J Exp Med"},{"key":"10.1038\/labinvest.3780447_bib31","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1056\/NEJM199803193381205","article-title":"Molecular analysis of the progression from Helicobacter pylori-associated chronic gastritis to mucosa-associated lymphoid-tissue lymphoma of the stomach","volume":"338","author":"Zucca","year":"1998","journal-title":"N Engl J Med"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3780447.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3780447","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722030689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722030689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3780447.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:55:03Z","timestamp":1758398103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722030689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["S0023683722030689"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.3780447","relation":{},"ISSN":["0023-6837"],"issn-type":[{"type":"print","value":"0023-6837"}],"subject":[],"published":{"date-parts":[[2002,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular Phenotype Distinguishes Two Subsets of Gastric Low-Grade Mucosa-Associated Lymphoid Tissue Lymphomas","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.3780447","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2002 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}