{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:17:32Z","timestamp":1791080252703,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":7560,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2002,5]]},"DOI":"10.1038\/labinvest.3780456","type":"journal-article","created":{"date-parts":[[2004,11,2]],"date-time":"2004-11-02T16:41:38Z","timestamp":1099413698000},"page":"619-628","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Cellular Retinol-Binding Protein-1 Expression and Modulation during In Vivo and In Vitro Myofibroblastic Differentiation of Rat Hepatic Stellate Cells and Portal Fibroblasts"],"prefix":"10.1016","volume":"82","author":[{"given":"Kozue","family":"Uchio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Tuchweber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Gabbiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Rosenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Desmouli\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/labinvest.3780456_bib1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF02899251","article-title":"Tumor necrosis factor alpha (TNF alpha) and transforming growth factor beta 1 (TGF beta 1) stimulate fibronectin synthesis and the transdifferentiation of fat-storing cells in the rat liver into myofibroblasts","volume":"63","author":"Bachem","year":"1993","journal-title":"Virchows Arch B Cell Pathol"},{"key":"10.1038\/labinvest.3780456_bib2","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/hep.1840160623","article-title":"Role of mesenchymal cell populations in porcine serum-induced rat liver fibrosis","volume":"16","author":"Bhunchet","year":"1992","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.3780456_bib3","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0022-2275(20)34272-3","article-title":"Retinoids, retinoid-binding proteins, and retinyl palmitate hydrolase distributions in different types of rat liver cells","volume":"26","author":"Blaner","year":"1985","journal-title":"J Lipid Res"},{"key":"10.1038\/labinvest.3780456_bib4","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1111\/j.1753-4887.1994.tb01382.x","article-title":"Transport and metabolism of vitamin A","volume":"52","author":"Blomhoff","year":"1994","journal-title":"Nutr Rev"},{"key":"10.1038\/labinvest.3780456_bib5","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1126\/science.2218545","article-title":"Transport and storage of vitamin A","volume":"250","author":"Blomhoff","year":"1990","journal-title":"Science"},{"key":"10.1038\/labinvest.3780456_bib6","doi-asserted-by":"crossref","first-page":"13560","DOI":"10.1016\/S0021-9258(17)38759-8","article-title":"Hepatic retinol metabolism. Distribution of retinoids, enzymes, and binding proteins in isolated rat liver cells","volume":"260","author":"Blomhoff","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.3780456_bib7","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1083\/jcb.104.3.595","article-title":"Monoclonal antibodies in the analysis of fibronectin isoforms generated by alternative splicing of mRNA precursors in normal and transformed human cells","volume":"104","author":"Borsi","year":"1987","journal-title":"J Cell Biol"},{"key":"10.1038\/labinvest.3780456_bib8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1038\/labinvest.3780456_bib9","doi-asserted-by":"crossref","first-page":"10280","DOI":"10.1016\/S0021-9258(18)61109-3","article-title":"Retinol and extracellular collagen matrices modulate hepatic Ito cell collagen phenotype and cellular retinol binding protein levels","volume":"262","author":"Davis","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1038\/labinvest.3780456_bib10","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0168-8278(97)80257-7","article-title":"Transforming growth factor-beta gene expression in normal and fibrotic rat liver","volume":"26","author":"PJ","year":"1997","journal-title":"J Hepatol"},{"key":"10.1038\/labinvest.3780456_bib11","first-page":"765","article-title":"Extracellular matrix deposition, lysyl oxidase expression, and myofibroblastic differentiation during the initial stages of cholestatic fibrosis in the rat","volume":"76","author":"Desmouli\u00e8re","year":"1997","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3780456_bib12","first-page":"485","article-title":"Activation of cultured rat hepatic stellate cells by tumoral hepatocytes","volume":"79","author":"Faouzi","year":"1999","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3780456_bib13","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/BF01078355","article-title":"Abnormal liver function in chronic hypervitaminosis A","volume":"22","author":"Farrell","year":"1977","journal-title":"Am J Dig Dis"},{"key":"10.1038\/labinvest.3780456_bib14","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/nar\/13.5.1431","article-title":"Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family","volume":"13","author":"Fort","year":"1985","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/labinvest.3780456_bib15","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0014-4827(85)90243-5","article-title":"Perisinusoidal fat-storing cells are the main vitamin A storage sites in rat liver","volume":"160","author":"Hendriks","year":"1985","journal-title":"Exp Cell Res"},{"key":"10.1038\/labinvest.3780456_bib16","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/0016-5085(89)91695-8","article-title":"Isolation and morphologic characterization of bile duct epithelial cells from normal rat liver","volume":"97","author":"Ishii","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.3780456_bib17","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1083\/jcb.98.5.1696","article-title":"Immunocytochemical studies on the localization of plasma and of cellular retinol-binding proteins and of transthyretin (prealbumin) in rat liver and kidney","volume":"98","author":"Kato","year":"1984","journal-title":"J Cell Biol"},{"key":"10.1038\/labinvest.3780456_bib18","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1073\/pnas.73.10.3719","article-title":"Vitamin A-containing lipocytes and formation of type III collagen in liver injury","volume":"73","author":"Kent","year":"1976","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3780456_bib19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s004180050421","article-title":"Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair","volume":"112","author":"Knittel","year":"1999","journal-title":"Histochem Cell Biol"},{"key":"10.1038\/labinvest.3780456_bib20","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0016-5085(99)70407-5","article-title":"Rat liver myofibroblasts and hepatic stellate cells: Different cell populations of the fibroblast lineage with fibrogenic potential","volume":"117","author":"Knittel","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1038\/labinvest.3780456_bib21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1600-0676.1986.tb00306.x","article-title":"Isolation and culture of biliary epithelial cells from the biliary tract fraction of normal rats","volume":"6","author":"Kumar","year":"1986","journal-title":"Liver"},{"key":"10.1038\/labinvest.3780456_bib22","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1002\/hep.1840180610","article-title":"Interferon-alpha 2b therapy reduces liver fibrosis in chronic non-A, non-B hepatitis: A quantitative histological evaluation","volume":"18","author":"Manabe","year":"1993","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.3780456_bib23","first-page":"1221","article-title":"Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease","volume":"139","author":"Milani","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3780456_bib24","first-page":"509","article-title":"Cellular retinol-binding protein-1 is expressed by distinct subsets of rat arterial smooth muscle cells in vitroin vivo","volume":"150","author":"Neuville","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3780456_bib25","first-page":"G589","article-title":"Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis","volume":"272","author":"Ohata","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1038\/labinvest.3780456_bib26","first-page":"283","article-title":"Cellular retinoid-binding proteins","author":"Ong","year":"1994","journal-title":"The Retinoids: Biology, Chemistry and Medicine"},{"key":"10.1038\/labinvest.3780456_bib27","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1055\/s-2007-1007128","article-title":"Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis","volume":"19","author":"Pinzani","year":"1999","journal-title":"Semin Liver Dis"},{"key":"10.1038\/labinvest.3780456_bib28","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF02899424","article-title":"Expression of the gene of the alpha-smooth muscle-actin isoform in rat liver and in rat fat-storing (ITO) cells","volume":"59","author":"Ramadori","year":"1990","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"10.1038\/labinvest.3780456_bib29","first-page":"193","article-title":"Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture","volume":"24","author":"Rockey","year":"1992","journal-title":"J Submicrosc Cytol Pathol"},{"key":"10.1038\/labinvest.3780456_bib30","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1096\/fasebj.7.2.8440409","article-title":"Cellular metabolism and activation of retinoids: Roles of cellular retinoid-binding proteins","volume":"7","author":"Ross","year":"1993","journal-title":"Faseb J"},{"key":"10.1038\/labinvest.3780456_bib31","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/jn\/123.suppl_2.346","article-title":"Overview of retinoid metabolism","volume":"123","author":"Ross","year":"1993","journal-title":"J Nutr"},{"key":"10.1038\/labinvest.3780456_bib32","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1056\/NEJM197408292910903","article-title":"Hepatic injury from chronic hypervitaminosis A resulting in portal hypertension and ascites","volume":"291","author":"Russell","year":"1974","journal-title":"N Engl J Med"},{"key":"10.1038\/labinvest.3780456_bib33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/hep.1840190129","article-title":"Vitamin A deficiency potentiates carbon tetrachloride-induced liver fibrosis in rats","volume":"19","author":"Seifert","year":"1994","journal-title":"Hepatology"},{"key":"10.1038\/labinvest.3780456_bib34","first-page":"182","article-title":"Suppression of experimental hepatic fibrosis by administration of vitamin A","volume":"52","author":"Senoo","year":"1985","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3780456_bib35","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1073\/pnas.84.10.3209","article-title":"Rat cellular retinol-binding protein: cDNA sequence and rapid retinol-dependent accumulation of mRNA","volume":"84","author":"Sherman","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/labinvest.3780456_bib36","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/BF01296379","article-title":"Modulation of collagen synthesis by fat-storing cells, isolated from CCl4- or vitamin A-treated rats","volume":"32","author":"Shiratori","year":"1987","journal-title":"Dig Dis Sci"},{"key":"10.1038\/labinvest.3780456_bib37","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1083\/jcb.103.6.2787","article-title":"A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation","volume":"103","author":"Skalli","year":"1986","journal-title":"J Cell Biol"},{"key":"10.1038\/labinvest.3780456_bib38","first-page":"265","article-title":"Proliferation and phenotypic modulation of portal fibroblasts in the early stages of cholestatic fibrosis in the rat","volume":"74","author":"Tuchweber","year":"1996","journal-title":"Lab Invest"},{"key":"10.1038\/labinvest.3780456_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1023\/A:1006886308490","article-title":"Retinol uptake and metabolism, and cellular retinol binding protein expression in an in vitro model of hepatic stellate cells","volume":"187","author":"Vicente","year":"1998","journal-title":"Mol Cell Biochem"},{"key":"10.1038\/labinvest.3780456_bib40","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0022-2275(20)32030-7","article-title":"An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro","volume":"41","author":"Vogel","year":"2000","journal-title":"J Lipid Res"},{"key":"10.1038\/labinvest.3780456_bib41","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/jcp.1078","article-title":"Regulation of alpha-smooth muscle actin and CRBP-1 expression by retinoic acid and TGF-beta in cultured fibroblasts","volume":"187","author":"Xu","year":"2001","journal-title":"J Cell Physiol"},{"key":"10.1038\/labinvest.3780456_bib42","first-page":"1741","article-title":"Cellular retinol-binding protein-1 is transiently expressed in granulation tissue fibroblasts and differentially expressed in fibroblasts cultured from different organs","volume":"151","author":"Xu","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1038\/labinvest.3780456_bib43","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1600-0676.1993.tb00646.x","article-title":"Role of hepatic vitamin A and lipocyte distribution in experimental hepatic fibrosis","volume":"13","author":"Yamane","year":"1993","journal-title":"Liver"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3780456.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3780456","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372203077X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372203077X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3780456.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:54:38Z","timestamp":1758398078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002368372203077X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["S002368372203077X"],"URL":"https:\/\/doi.org\/10.1038\/labinvest.3780456","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2002,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular Retinol-Binding Protein-1 Expression and Modulation during In Vivo and In Vitro Myofibroblastic Differentiation of Rat Hepatic Stellate Cells and Portal Fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/labinvest.3780456","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2002 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}