{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:30:18Z","timestamp":1787002218061,"version":"build-2736575974"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T00:00:00Z","timestamp":1229558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T00:00:00Z","timestamp":1229558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1038\/leu.2008.356","type":"journal-article","created":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T05:59:48Z","timestamp":1229579988000},"page":"994-997","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Therapeutic concentrations of dasatinib inhibit in vitro osteoclastogenesis"],"prefix":"10.1038","volume":"23","author":[{"given":"K","family":"Vandyke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A L","family":"Dewar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A N","family":"Farrugia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Fitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Bik To","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T P","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A C W","family":"Zannettino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,12,18]]},"reference":[{"key":"BFleu2008356_CR1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1126\/science.1099480","volume":"305","author":"NP Shah","year":"2004","unstructured":"Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL . Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004; 305: 399\u2013401.","journal-title":"Science"},{"key":"BFleu2008356_CR2","doi-asserted-by":"publisher","first-page":"3153","DOI":"10.1073\/pnas.0511292103","volume":"103","author":"JS Melnick","year":"2006","unstructured":"Melnick JS, Janes J, Kim S, Chang JY, Sipes DG, Gunderson D et al. An efficient rapid system for profiling the cellular activities of molecular libraries. Proc Natl Acad Sci USA 2006; 103: 3153\u20133158.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2008356_CR3","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1182\/blood-2006-09-047266","volume":"109","author":"A Hochhaus","year":"2007","unstructured":"Hochhaus A, Kantarjian HM, Baccarani M, Lipton JH, Apperley JF, Druker BJ et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 2007; 109: 2303\u20132309.","journal-title":"Blood"},{"key":"BFleu2008356_CR4","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1182\/blood-2004-10-3967","volume":"105","author":"AL Dewar","year":"2005","unstructured":"Dewar AL, Cambareri AC, Zannettino AC, Miller BL, Doherty KV, Hughes TP et al. Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib. Blood 2005; 105: 3127\u20133132.","journal-title":"Blood"},{"key":"BFleu2008356_CR5","doi-asserted-by":"publisher","first-page":"4334","DOI":"10.1182\/blood-2005-09-3568","volume":"107","author":"AL Dewar","year":"2006","unstructured":"Dewar AL, Farrugia AN, Condina MR, Bik To L, Hughes TP, Vernon-Roberts B et al. Imatinib as a potential antiresorptive therapy for bone disease. Blood 2006; 107: 4334\u20134337.","journal-title":"Blood"},{"key":"BFleu2008356_CR6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1182\/blood.V99.1.111","volume":"99","author":"XM Dai","year":"2002","unstructured":"Dai XM, Ryan GR, Hapel AJ, Dominguez MG, Russell RG, Kapp S et al. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood 2002; 99: 111\u2013120.","journal-title":"Blood"},{"issue":"15_suppl","key":"BFleu2008356_CR7","doi-asserted-by":"publisher","first-page":"3590","DOI":"10.1200\/jco.2008.26.15_suppl.3590","volume":"26","author":"X. Wang","year":"2008","unstructured":"Wang X, Hochhaus A, Kantarjian HM, Agrawal S, Roy A, Pfister M et al. Dasatinib pharmacokinetics and exposure-response (E-R): relationship to safety and efficacy in patients (pts) with chronic myeloid leukemia (CML). J Clin Oncol 2008; 26 (Suppl): 3590.","journal-title":"Journal of Clinical Oncology"},{"key":"BFleu2008356_CR8","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1101\/gad.840301","volume":"15","author":"L Xing","year":"2001","unstructured":"Xing L, Venegas AM, Chen A, Garrett-Beal L, Boyce BF, Varmus HE et al. Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival. Genes Dev 2001; 15: 241\u2013253.","journal-title":"Genes Dev"},{"key":"BFleu2008356_CR9","doi-asserted-by":"publisher","first-page":"4485","DOI":"10.1073\/pnas.90.10.4485","volume":"90","author":"C Lowe","year":"1993","unstructured":"Lowe C, Yoneda T, Boyce BF, Chen H, Mundy GR, Soriano P . Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts. Proc Natl Acad Sci USA 1993; 90: 4485\u20134489.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2008356_CR10","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1172\/JCI116032","volume":"90","author":"BF Boyce","year":"1992","unstructured":"Boyce BF, Yoneda T, Lowe C, Soriano P, Mundy GR . Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice. J Clin Invest 1992; 90: 1622\u20131627.","journal-title":"J Clin Invest"},{"key":"BFleu2008356_CR11","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1182\/blood-2007-07-104281","volume":"111","author":"S Fitter","year":"2008","unstructured":"Fitter S, Dewar AL, Kostakis P, To LB, Hughes TP, Roberts MM et al. Long-term imatinib therapy promotes bone formation in CML patients. Blood 2008; 111: 2538\u20132547.","journal-title":"Blood"},{"key":"BFleu2008356_CR12","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1056\/NEJMoa051140","volume":"354","author":"E Berman","year":"2006","unstructured":"Berman E, Nicolaides M, Maki RG, Fleisher M, Chanel S, Scheu K et al. Altered bone and mineral metabolism in patients receiving imatinib mesylate. N Engl J Med 2006; 354: 2006\u20132013.","journal-title":"N Engl J Med"},{"key":"BFleu2008356_CR13","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1056\/NEJMc062388","volume":"355","author":"A Grey","year":"2006","unstructured":"Grey A, O'Sullivan S, Reid IR, Browett P . Imatinib mesylate, increased bone formation, and secondary hyperparathyroidism. N Engl J Med 2006; 355: 2494\u20132495.","journal-title":"N Engl J Med"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2008356.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2008356","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2008356.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T08:45:09Z","timestamp":1648716309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2008356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,18]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["BFleu2008356"],"URL":"https:\/\/doi.org\/10.1038\/leu.2008.356","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,18]]},"assertion":[{"value":"18 December 2008","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}