{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T01:05:45Z","timestamp":1779152745931,"version":"3.51.4"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1038\/leu.2008.371","type":"journal-article","created":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T10:49:05Z","timestamp":1233830945000},"page":"852-855","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["MPLW515L mutation in acute megakaryoblastic leukaemia"],"prefix":"10.1038","volume":"23","author":[{"given":"K","family":"Hussein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Bock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Theophile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Schulz-Bischof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Porwit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Schlue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Jonigk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Kreipe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,2,5]]},"reference":[{"key":"BFleu2008371_CR1","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1182\/blood-2005-06-2450","volume":"107","author":"Y Oki","year":"2006","unstructured":"Oki Y, Kantarjian HM, Zhou X, Cortes J, Faderl S, Verstovsek S et al. Adult acute megakaryocytic leukemia: an analysis of 37 patients treated at MD Anderson Cancer Center. Blood 2006; 107: 880\u2013884.","journal-title":"Blood"},{"key":"BFleu2008371_CR2","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1159\/000101709","volume":"74","author":"A Orazi","year":"2007","unstructured":"Orazi A . Histopathology in the diagnosis and classification of acute myeloid leukemia, myelodysplastic syndromes, and myelodysplastic\/myeloproliferative diseases. Pathobiology 2007; 74: 97\u2013114.","journal-title":"Pathobiology"},{"key":"BFleu2008371_CR3","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1038\/sj.leu.2404206","volume":"20","author":"DP Steensma","year":"2006","unstructured":"Steensma DP, McClure RF, Karp JE, Tefferi A, Lasho TL, Powell HL et al. JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained. Leukemia 2006; 20: 971\u2013978.","journal-title":"Leukemia"},{"key":"BFleu2008371_CR4","first-page":"1891","volume":"10","author":"S Schnittger","year":"1996","unstructured":"Schnittger S, de Sauvage FJ, Le Paslier D, Fonatsch C . Refined chromosomal localization of the human thrombopoietin gene to 3q27-q28 and exclusion as the responsible gene for thrombocytosis in patients with rearrangements of 3q21 and 3q26. Leukemia 1996; 10: 1891\u20131896.","journal-title":"Leukemia"},{"key":"BFleu2008371_CR5","doi-asserted-by":"publisher","first-page":"4220","DOI":"10.1182\/blood-2008-01-136366","volume":"112","author":"S Malinge","year":"2008","unstructured":"Malinge S, Ragu C, Della-Valle V, Pisani D, Constantinescu SN, Perez C et al. Activating mutations in human acute megakaryoblastic leukemia. Blood 2008; 112: 4220\u20134226; [e-pub ahead of print].","journal-title":"Blood"},{"key":"BFleu2008371_CR6","doi-asserted-by":"publisher","first-page":"3472","DOI":"10.1182\/blood-2006-04-018879","volume":"108","author":"AD Pardanani","year":"2006","unstructured":"Pardanani AD, Levine RL, Lasho T, Pikman Y, Mesa RA, Wadleigh M et al. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood 2006; 108: 3472\u20133476.","journal-title":"Blood"},{"key":"BFleu2008371_CR7","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/nature03546","volume":"434","author":"C James","year":"2005","unstructured":"James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, Lacout C et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005; 434: 1144\u20131148.","journal-title":"Nature"},{"key":"BFleu2008371_CR8","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.1182\/blood-2005-05-1800","volume":"106","author":"J Jelinek","year":"2005","unstructured":"Jelinek J, Oki Y, Gharibyan V, Bueso-Ramos C, Prchal JT, Verstovsek S et al. JAK2 mutation 1849G&gt;T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. Blood 2005; 106: 3370\u20133373.","journal-title":"Blood"},{"key":"BFleu2008371_CR9","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1038\/sj.leu.2404626","volume":"21","author":"K Nishii","year":"2007","unstructured":"Nishii K, Nanbu R, Lorenzo VF, Monma F, Kato K, Ryuu H et al. Expression of the JAK2 V617F mutation is not found in de novo AML and MDS but is detected in MDS-derived leukemia of megakaryoblastic nature. Leukemia 2007; 21: 1337\u20131338.","journal-title":"Leukemia"},{"key":"BFleu2008371_CR10","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1182\/blood-2005-09-3644","volume":"107","author":"S Fr\u00f6hling","year":"2006","unstructured":"Fr\u00f6hling S, Lipka DB, Kayser S, Scholl C, Schlenk RF, D\u00f6hner H et al. Rare occurrence of the JAK2 V617F mutation in AML subtypes M5, M6, and M7. Blood 2006; 107: 1242\u20131243.","journal-title":"Blood"},{"key":"BFleu2008371_CR11","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/S1525-1578(10)60452-7","volume":"5","author":"O Bock","year":"2003","unstructured":"Bock O, Lehmann U, Kreipe H . Quantitative intra-individual monitoring of BCR-ABL transcript levels in archival bone marrow trephines of patients with chronic myeloid leukemia. J Mol Diagn 2003; 5: 54\u201360.","journal-title":"J Mol Diagn"},{"key":"BFleu2008371_CR12","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1182\/blood-2007-03-080374","volume":"110","author":"A Norton","year":"2007","unstructured":"Norton A, Fisher C, Liu H, Wen Q, Mundschau G, Fuster JL et al. Analysis of JAK3, JAK2, and C-MPL mutations in transient myeloproliferative disorder and myeloid leukemia of Down syndrome blasts in children with Down syndrome. Blood 2007; 110: 1077\u20131079.","journal-title":"Blood"},{"key":"BFleu2008371_CR13","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/S1470-2045(07)70295-4","volume":"8","author":"M Bocchia","year":"2007","unstructured":"Bocchia M, Vannucchi AM, Gozzetti A, Guglielmelli P, Poli G, Crupi R et al. Insights into JAK2-V617F mutation in CML. Lancet Oncol 2007; 8: 864\u2013866.","journal-title":"Lancet Oncol"},{"key":"BFleu2008371_CR14","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1038\/sj.leu.2404993","volume":"22","author":"K Hussein","year":"2008","unstructured":"Hussein K, Bock O, Theophile K, Seegers A, Arps H, Basten O et al. Chronic myeloproliferative diseases with concurrent BCR-ABL junction and JAK2V617F mutation. Leukemia 2008; 22: 1059\u20131062.","journal-title":"Leukemia"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2008371.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2008371","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2008371.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T12:44:40Z","timestamp":1648730680000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2008371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["BFleu2008371"],"URL":"https:\/\/doi.org\/10.1038\/leu.2008.371","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,5]]},"assertion":[{"value":"4 August 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2009","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}