{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:48:12Z","timestamp":1787500092598,"version":"build-2736575974"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2009,7,30]],"date-time":"2009-07-30T00:00:00Z","timestamp":1248912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2009,7,30]],"date-time":"2009-07-30T00:00:00Z","timestamp":1248912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1038\/leu.2009.137","type":"journal-article","created":{"date-parts":[[2009,7,30]],"date-time":"2009-07-30T05:43:29Z","timestamp":1248932609000},"page":"2160-2167","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["B-cell prolymphocytic leukemia and chronic lymphocytic leukemia have distinctive gene expression signatures"],"prefix":"10.1038","volume":"23","author":[{"given":"I","family":"Del Giudice","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Osuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Dexter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Brito-Babapulle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Parry-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Chiaretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Messina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Catovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Matutes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,7,30]]},"reference":[{"key":"BFleu2009137_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1365-2141.1974.tb06769.x","volume":"27","author":"DA Galton","year":"1974","unstructured":"Galton DA, Goldman JM, Wiltshaw E, Catovsky D, Henry K, Goldenberg GJ . Prolymphocytic leukaemia. Br J Haematol 1974; 27: 7\u201323.","journal-title":"Br J Haematol"},{"key":"BFleu2009137_CR2","first-page":"183","volume-title":"World Health Organization Classification of Tumours of Hematopoietic and Lymphoid Tissues","author":"E Campo","year":"2008","unstructured":"Campo E, Catovsky D, Montserrat E, Muller-Hermelink HK, Harris NL, Stein H . B-Prolymphocytic leucemia. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (eds). World Health Organization Classification of Tumours of Hematopoietic and Lymphoid Tissues. IARC Press: Lyon, France, 2008, pp 183\u2013184."},{"key":"BFleu2009137_CR3","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1182\/blood.V89.6.2015","volume":"89","author":"D Lens","year":"1997","unstructured":"Lens D, De Schouwer PJ, Hamoudi RA, Abdul-Rauf M, Farahat N, Matutes E et al. p53 abnormalities in B-cell prolymphocytic leukemia. Blood 1997; 89: 2015\u20132023.","journal-title":"Blood"},{"key":"BFleu2009137_CR4","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1038\/sj.leu.2404238","volume":"20","author":"I Del Giudice","year":"2006","unstructured":"Del Giudice I, Davis Z, Matutes E, Osuji N, Parry-Jones N, Morilla A et al. IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL). Leukemia 2006; 20: 1231\u20131237.","journal-title":"Leukemia"},{"key":"BFleu2009137_CR5","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/j.1365-2141.2004.04913.x","volume":"125","author":"R Ruchlemer","year":"2004","unstructured":"Ruchlemer R, Parry-Jones N, Brito-Babapulle V, Attolico I, Wotherspoon AC, Matutes E et al. B-prolymphocytic leukaemia with t(11;14) revisited: a splenomegalic form of mantle cell lymphoma evolving with leukaemia. Br J Haematol 2004; 125: 330\u2013336.","journal-title":"Br J Haematol"},{"key":"BFleu2009137_CR6","doi-asserted-by":"publisher","first-page":"5116","DOI":"10.1073\/pnas.091062498","volume":"98","author":"VG Tusher","year":"2001","unstructured":"Tusher VG, Tibshirani R, Chu G . Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001; 98: 5116\u20135121.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2009137_CR7","doi-asserted-by":"publisher","first-page":"6567","DOI":"10.1073\/pnas.082099299","volume":"99","author":"R Tibshirani","year":"2002","unstructured":"Tibshirani R, Hastie T, Narasimhan B, Chu G . Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proc Natl Acad Sci USA 2002; 99: 6567\u20136572.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2009137_CR8","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/nrm1703","volume":"6","author":"S Adhikary","year":"2005","unstructured":"Adhikary S, Eilers M . Transcriptional regulation and transformation by myc proteins. Nat Rev Mol Cell Biol 2005; 6: 635\u2013645.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFleu2009137_CR9","first-page":"897","volume":"8","author":"U Brennscheidt","year":"1994","unstructured":"Brennscheidt U, Eick D, Kunzmann R, Martens U, Kiehntopf M, Mertelsmann R et al. Burkitt-like mutations in the c-myc gene locus in prolymphocytic leukaemia. Leukemia 1994; 8: 897\u2013902.","journal-title":"Leukemia"},{"key":"BFleu2009137_CR10","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/sj.leu.2401416","volume":"13","author":"D Lens","year":"1999","unstructured":"Lens D, Coignet LJ, Brito-Babapulle V, Lima CS, Matutes E, Dyer MJ et al. B cell prolymphocytic leukaemia (B-PLL) with complex karyotype and concurrent abnormalities of the p53 and c-Myc gene. Leukemia 1999; 13: 873\u2013876.","journal-title":"Leukemia"},{"key":"BFleu2009137_CR11","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1309\/PPK0-TJUK-1UAR-3194","volume":"115","author":"E Schlette","year":"2001","unstructured":"Schlette E, Bueso-Ramos C, Giles F, Glassmann A, Hayes K, Medeiros J . Mature B-cell leukemias with more than 55% prolymphocytes. Am J Clin Pathol 2001; 115: 571\u2013581.","journal-title":"Am J Clin Pathol"},{"key":"BFleu2009137_CR12","doi-asserted-by":"crossref","first-page":"305","DOI":"10.5858\/2003-127-0305-MBCLWM","volume":"127","author":"S Merchant","year":"2003","unstructured":"Merchant S, Schlette E, Sanger W, Lai R, Medeiros LJ . Mature B-cell leukemias with more than 55% prolymphocytes. Report of 2 cases with Burkitt lymphoma-type chromosomal translocations involving c-myc. Arch Pathol Lab Med 2003; 127: 305\u2013309.","journal-title":"Arch Pathol Lab Med"},{"key":"BFleu2009137_CR13","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.cancergencyto.2003.09.009","volume":"150","author":"P Kuriakose","year":"2004","unstructured":"Kuriakose P, Perveen N, Maeda K, Wiktor A, Van Dyke D . Translocation (8;14)(q24;q32) as the sole cytogenetic abnormality in B-cell prolymphocytic leukaemia. Cancer Genet Cytogenet 2004; 150: 156\u2013158.","journal-title":"Cancer Genet Cytogenet"},{"key":"BFleu2009137_CR14","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.leukres.2006.06.010","volume":"31","author":"RH Crisostomo","year":"2007","unstructured":"Crisostomo RH, Fernandez JA, Caceres W . Complex karyotype including chromosomal translocation (8;14)(q24;q32) in one case with B-cell prolymphocytic leukemia. Leuk Res 2007; 31: 699\u2013701.","journal-title":"Leuk Res"},{"key":"BFleu2009137_CR15","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0301-472X(02)01046-9","volume":"31","author":"A Zaninoni","year":"2003","unstructured":"Zaninoni A, Imperiali FG, Pasquini C, Zanella A, Barcellini W . Cytokine modulation of nuclear factor-kappaB activity in B-chronic lymphocytic leukemia. Exp Hematol 2003; 31: 185\u2013190.","journal-title":"Exp Hematol"},{"key":"BFleu2009137_CR16","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1182\/blood-2003-06-2160","volume":"103","author":"C Thieblemont","year":"2004","unstructured":"Thieblemont C, Nasser V, Felman P, Leroy K, Gazzo S, Callet-Bauchu E et al. Small lymphocytic lymphoma, marginal zone B-cell lymphoma, and mantle cell lymphoma exhibit distinct gene-expression profiles allowing molecular diagnosis. Blood 2004; 103: 2727\u20132737.","journal-title":"Blood"},{"key":"BFleu2009137_CR17","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1084\/jem.194.11.1625","volume":"194","author":"U Klein","year":"2001","unstructured":"Klein U, Tu Y, Stolovitzky GA, Mattioli M, Cattoretti G, Husson H et al. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med 2001; 194: 1625\u20131638.","journal-title":"J Exp Med"},{"key":"BFleu2009137_CR18","doi-asserted-by":"publisher","first-page":"3118","DOI":"10.1073\/pnas.0308648100","volume":"101","author":"D Lu","year":"2004","unstructured":"Lu D, Zhao Y, Tawatao R, Cottam HB, Sen M, Leoni LM et al. Activation of the Wnt signalling pathway in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2004; 101: 3118\u20133123.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2009137_CR19","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1182\/blood-2004-10-3898","volume":"106","author":"E Ruiz-Ballesteros","year":"2005","unstructured":"Ruiz-Ballesteros E, Mollejo M, Rodriguez A, Camacho FI, Algara P, Martinez N et al. Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis. Blood 2005; 106: 1831\u20131838.","journal-title":"Blood"},{"key":"BFleu2009137_CR20","first-page":"8226","volume":"63","author":"N Mart\u00ednez","year":"2003","unstructured":"Mart\u00ednez N, Camacho FI, Algara P, Rodr\u00edguez A, Dopazo A, Ru\u00edz-Ballesteros E et al. The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survival. Cancer Res 2003; 63: 8226\u20138232.","journal-title":"Cancer Res"},{"key":"BFleu2009137_CR21","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S1535-6108(03)00028-X","volume":"3","author":"A Rosenwald","year":"2003","unstructured":"Rosenwald A, Wright G, Wiestner A, Chan WC, Connors JM, Campo E et al. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 2003; 3: 185\u2013197.","journal-title":"Cancer Cell"},{"key":"BFleu2009137_CR22","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1182\/blood-2006-04-015586","volume":"108","author":"M Rudelius","year":"2006","unstructured":"Rudelius M, Pittaluga S, Nishizuka S, Pham TH, Fend F, Jaffe ES et al. Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma. Blood 2006; 108: 1668\u20131676.","journal-title":"Blood"},{"key":"BFleu2009137_CR23","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1007\/s00277-004-0879-2","volume":"83","author":"L Michaux","year":"2004","unstructured":"Michaux L, Wlodarska I, Theate I, Stul M, Scheiff JM, Deneys V et al. Coexistence of BCL1\/CCND1 and c-Myc aberrations in blastoid mantle cell lymphoma: a rare finding associated with very poor outcome. Ann Hematol 2004; 83: 578\u2013583.","journal-title":"Ann Hematol"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2009137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2009137","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2009137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T08:30:58Z","timestamp":1648715458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2009137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,30]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["BFleu2009137"],"URL":"https:\/\/doi.org\/10.1038\/leu.2009.137","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,30]]},"assertion":[{"value":"30 July 2009","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}