{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:38:12Z","timestamp":1790491092957,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T00:00:00Z","timestamp":1247702400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T00:00:00Z","timestamp":1247702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1038\/leu.2009.138","type":"journal-article","created":{"date-parts":[[2009,7,18]],"date-time":"2009-07-18T02:55:07Z","timestamp":1247885707000},"page":"1818-1824","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Characterization of BAX inhibitor-1 as a novel leukemia-associated antigen"],"prefix":"10.1038","volume":"23","author":[{"given":"S M","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bringmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Held","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"von Schwarzenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Heine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T A W","family":"Holderried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Stevanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Gr\u00fcnebach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Brossart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,7,16]]},"reference":[{"key":"BFleu2009138_CR1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/32588","volume":"392","author":"J Banchereau","year":"1998","unstructured":"Banchereau J, Steinman RM . Dendritic cells and the control of immunity. Nature 1998; 392: 245\u2013252.","journal-title":"Nature"},{"key":"BFleu2009138_CR2","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","volume":"18","author":"J Banchereau","year":"2000","unstructured":"Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000; 18: 767\u2013811.","journal-title":"Annu Rev Immunol"},{"key":"BFleu2009138_CR3","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/351290a0","volume":"351","author":"K Falk","year":"1991","unstructured":"Falk K, Rotzschke O, Stevanovic S, Jung G, Rammensee HG . Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 1991; 351: 290\u2013296.","journal-title":"Nature"},{"key":"BFleu2009138_CR4","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1084\/jem.183.3.725","volume":"183","author":"T Boon","year":"1996","unstructured":"Boon T, van der BP . Human tumor antigens recognized by T lymphocytes. J Exp Med 1996; 183: 725\u2013729.","journal-title":"J Exp Med"},{"key":"BFleu2009138_CR5","doi-asserted-by":"publisher","first-page":"11810","DOI":"10.1073\/pnas.92.25.11810","volume":"92","author":"U Sahin","year":"1995","unstructured":"Sahin U, Tureci O, Schmitt H, Cochlovius B, Johannes T, Schmits R et al. Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci USA 1995; 92: 11810\u201311813.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2009138_CR6","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1073\/pnas.94.5.1914","volume":"94","author":"YT Chen","year":"1997","unstructured":"Chen YT, Scanlan MJ, Sahin U, Tureci O, Gure AO, Tsang S et al. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc Natl Acad Sci USA 1997; 94: 1914\u20131918.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2009138_CR7","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1007\/s00262-004-0650-5","volume":"54","author":"T Kruger","year":"2005","unstructured":"Kruger T, Schoor O, Lemmel C, Kraemer B, Reichle C, Dengjel J et al. Lessons to be learned from primary renal cell carcinomas: novel tumor antigens and HLA ligands for immunotherapy. Cancer Immunol Immunother 2005; 54: 826\u2013836.","journal-title":"Cancer Immunol Immunother"},{"key":"BFleu2009138_CR8","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1002\/1521-4141(2000)30:8<2216::AID-IMMU2216>3.0.CO;2-7","volume":"30","author":"M Schirle","year":"2000","unstructured":"Schirle M, Keilholz W, Weber B, Gouttefangeas C, Dumrese T, Becker HD et al. Identification of tumor-associated MHC class I ligands by a novel T cell-independent approach. Eur J Immunol 2000; 30: 2216\u20132225.","journal-title":"Eur J Immunol"},{"key":"BFleu2009138_CR9","first-page":"5818","volume":"62","author":"T Weinschenk","year":"2002","unstructured":"Weinschenk T, Gouttefangeas C, Schirle M, Obermayr F, Walter S, Schoor O et al. Integrated functional genomics approach for the design of patient-individual antitumor vaccines. Cancer Res 2002; 62: 5818\u20135827.","journal-title":"Cancer Res"},{"issue":"4","key":"BFleu2009138_CR10","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/BF00360548","volume":"5","author":"L Walter","year":"1994","unstructured":"Walter L, Dirks B, Rothermel E, Heyens M, Szpirer C, Levan G et al. A novel, conserved gene of the rat that is developmentally regulated in the testis. Mamm Genome Apr 1994; 5 (4): 216\u2013221.","journal-title":"Mamm Genome Apr"},{"key":"BFleu2009138_CR11","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S1097-2765(00)80034-9","volume":"1","author":"QL Xu","year":"1998","unstructured":"Xu QL, Reed JC . Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Mol Cell 1998; 1: 337\u2013346.","journal-title":"Mol Cell"},{"key":"BFleu2009138_CR12","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/ijc.10170","volume":"98","author":"R Schmits","year":"2002","unstructured":"Schmits R, Cochlovius B, Treitz G, Regitz E, Ketter R, Preuss KD et al. Analysis of the antibody repertoire of astrocytoma patients against antigens expressed by gliomas. Int J Cancer 2002; 98: 73\u201377.","journal-title":"Int J Cancer"},{"key":"BFleu2009138_CR13","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1006\/geno.1999.5761","volume":"57","author":"JC Jean","year":"1999","unstructured":"Jean JC, Oakes SM, Joyce-Brady M . The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters. Genomics 1999; 57: 201\u2013208.","journal-title":"Genomics"},{"key":"BFleu2009138_CR14","first-page":"5974","volume":"61","author":"JB Welsh","year":"2001","unstructured":"Welsh JB, Sapinoso LM, Su AI, Kern SG, Wang-Rodriguez J, Moskaluk CA et al. Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Res 2001; 61: 5974\u20135978.","journal-title":"Cancer Res"},{"key":"BFleu2009138_CR15","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/415530a","volume":"415","author":"LJ van't Veer","year":"2002","unstructured":"van't Veer LJ, Dai HY, van de Vijver MJ, He YDD, Hart AAM, Mao M et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002; 415: 530\u2013536.","journal-title":"Nature"},{"key":"BFleu2009138_CR16","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S0002-9440(10)63682-6","volume":"163","author":"M Grzmil","year":"2003","unstructured":"Grzmil M, Thelen P, Hemmerlein B, Schweyer S, Voigt S, Mury D et al. Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells. Am J Pathol 2003; 163: 543\u2013552.","journal-title":"Am J Pathol"},{"key":"BFleu2009138_CR17","doi-asserted-by":"publisher","first-page":"21618","DOI":"10.1074\/jbc.M700053200","volume":"282","author":"GH Lee","year":"2007","unstructured":"Lee GH, Kim HK, Chae SW, Kim DS, Ha KC, Cuddy M et al. Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression. J Biol Chem 2007; 282: 21618\u201321628.","journal-title":"J Biol Chem"},{"key":"BFleu2009138_CR18","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1182\/blood.V92.11.4238","volume":"92","author":"P Brossart","year":"1998","unstructured":"Brossart P, Gr\u00fcnebach F, Stuhler G, Reichardt VL, Mohle R, Kanz L et al. Generation of functional human dendritic cells from adherent peripheral blood monocytes by CD40 ligation in the absence of granulocyte-macrophage colony-stimulating factor. Blood 1998; 92: 4238\u20134247.","journal-title":"Blood"},{"key":"BFleu2009138_CR19","first-page":"6846","volume":"61","author":"P Brossart","year":"2001","unstructured":"Brossart P, Schneider A, Dill P, Schammann T, Gr\u00fcnebach F, Wirths S et al. The epithelial tumor antigen MUC1 is expressed in hematological malignancies and is recognized by MUC1-specific cytotoxic T-lymphocytes. Cancer Res 2001; 61: 6846\u20136850.","journal-title":"Cancer Res"},{"key":"BFleu2009138_CR20","first-page":"47","volume":"109","author":"F Gr\u00fcnebach","year":"2005","unstructured":"Gr\u00fcnebach F, M\u00fcller MR, Brossart P . RNA transfection of dendritic cells. Methods Mol Med 2005; 109: 47\u201354.","journal-title":"Methods Mol Med"},{"key":"BFleu2009138_CR21","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1038\/sj.gt.3301252","volume":"7","author":"VF Van Tendeloo","year":"2000","unstructured":"Van Tendeloo VF, Willems R, Ponsaerts P, Lenjou M, Nijs G, Vanhove M et al. High-level transgene expression in primary human T lymphocytes and adult bone marrow CD34+ cells via electroporation-mediated gene delivery. Gene Ther 2000; 7: 1431\u20131437.","journal-title":"Gene Ther"},{"key":"BFleu2009138_CR22","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1182\/blood-2004-09-3556","volume":"105","author":"D D\u00f6rfel","year":"2004","unstructured":"D\u00f6rfel D, Appel S, Gr\u00fcnebach F, Weck MM, M\u00fcller MR, Heine A et al. Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro transcribed MUC1 RNA. Blood 2004; 105: 3199\u20133205.","journal-title":"Blood"},{"key":"BFleu2009138_CR23","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s00262-004-0560-6","volume":"54","author":"L Novellino","year":"2005","unstructured":"Novellino L, Castelli C, Parmiani G . A listing of human tumor antigens recognized by T cells: March 2004 update. Cancer Immunol Immunother 2005; 54: 187\u2013207.","journal-title":"Cancer Immunol Immunother"},{"key":"BFleu2009138_CR24","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1146\/annurev.iy.09.040191.001415","volume":"9","author":"RM Steinman","year":"1991","unstructured":"Steinman RM . The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991; 9: 271\u2013296.","journal-title":"Annu Rev Immunol"},{"key":"BFleu2009138_CR25","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/leu.2008.301","volume":"23","author":"A Kn\u00f6dler","year":"2009","unstructured":"Kn\u00f6dler A, Schmidt SM, Bringmann A, Weck MM, Brauer KM, Holderried TA et al. Post-transcriptional regulation of adapter molecules by IL-10 inhibits TLR-mediated activation of antigen-presenting cells. Leukemia 2009; 23: 535\u2013544.","journal-title":"Leukemia"},{"key":"BFleu2009138_CR26","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/sj.leu.2404556","volume":"21","author":"A Bringmann","year":"2007","unstructured":"Bringmann A, Schmidt SM, Weck MM, Brauer KM, von Schwarzenberg K, Werth D et al. Zoledronic acid inhibits the function of Toll-like receptor 4 ligand activated monocyte-derived dendritic cells. Leukemia 2007; 21: 732\u2013738.","journal-title":"Leukemia"},{"key":"BFleu2009138_CR27","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev.immunol.20.100301.064828","volume":"20","author":"P Guermonprez","year":"2002","unstructured":"Guermonprez P, Valladeau J, Zitvogel L, Thery C, Amigorena S . Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol 2002; 20: 621\u2013667.","journal-title":"Annu Rev Immunol"},{"key":"BFleu2009138_CR28","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nri1256","volume":"4","author":"H Hackstein","year":"2004","unstructured":"Hackstein H, Thomson AW . Dendritic cells: emerging pharmacological targets of immunosuppressive drugs. Nat Rev Immunol 2004; 4: 24\u201334.","journal-title":"Nat Rev Immunol"},{"key":"BFleu2009138_CR29","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/418252a","volume":"418","author":"BA Sullenger","year":"2002","unstructured":"Sullenger BA, Gilboa E . Emerging clinical applications of RNA. Nature 2002; 418: 252\u2013258.","journal-title":"Nature"},{"key":"BFleu2009138_CR30","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1046\/j.1365-2141.2002.03671.x","volume":"118","author":"C Villalva","year":"2002","unstructured":"Villalva C, Trempat P, Greenland C, Thomas C, Girard JP, Moebius F et al. Isolation of differentially expressed genes in NPM-ALK-positive anaplastic large cell lymphoma. Br J Haematol 2002; 118: 791\u2013798.","journal-title":"Br J Haematol"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2009138.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2009138","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2009138.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T12:07:00Z","timestamp":1648728420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2009138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,16]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["BFleu2009138"],"URL":"https:\/\/doi.org\/10.1038\/leu.2009.138","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,16]]},"assertion":[{"value":"12 May 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}