{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:54:30Z","timestamp":1790009670166,"version":"4.0.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T00:00:00Z","timestamp":1257379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T00:00:00Z","timestamp":1257379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1038\/leu.2009.224","type":"journal-article","created":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T14:58:47Z","timestamp":1257433127000},"page":"177-186","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["WAVE1 regulates Bcl-2 localization and phosphorylation in leukemia cells"],"prefix":"10.1038","volume":"24","author":[{"given":"R","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,11,5]]},"reference":[{"key":"BFleu2009224_CR1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/nrc776","volume":"2","author":"FH Igney","year":"2002","unstructured":"Igney FH, Krammer PH . Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer 2002; 2: 277\u2013288.","journal-title":"Nat Rev Cancer"},{"key":"BFleu2009224_CR2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev.physiol.70.021507.105852","volume":"70","author":"Y Rong","year":"2008","unstructured":"Rong Y, Distelhorst CW . Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis. Annu Rev Physiol 2008; 70: 73\u201391.","journal-title":"Annu Rev Physiol"},{"key":"BFleu2009224_CR3","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/348334a0","volume":"348","author":"D Hockenbery","year":"1990","unstructured":"Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ . Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990; 348: 334\u2013336.","journal-title":"Nature"},{"key":"BFleu2009224_CR4","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1242\/jcs.114.23.4161","volume":"114","author":"J Rudner","year":"2001","unstructured":"Rudner J, Lepple-Wienhues A, Budach W, Berschauer J, Friedrich B, Wesselborg S et al. Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis. J Cell Sci 2001; 114: 4161\u20134172.","journal-title":"J Cell Sci"},{"key":"BFleu2009224_CR5","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.cell.2005.07.002","volume":"122","author":"S Pattingre","year":"2005","unstructured":"Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122: 927\u2013939.","journal-title":"Cell"},{"key":"BFleu2009224_CR6","doi-asserted-by":"publisher","first-page":"44117","DOI":"10.1074\/jbc.M101958200","volume":"276","author":"NS Wang","year":"2001","unstructured":"Wang NS, Unkila MT, Reineks EZ, Distelhorst CW . Transient expression of wild-type or mitochondrially targeted Bcl-2 induces apoptosis, whereas transient expression of endoplasmic reticulum-targeted Bcl-2 is protective against Bax-induced cell death. J Biol Chem 2001; 276: 44117\u201344128.","journal-title":"J Biol Chem"},{"key":"BFleu2009224_CR7","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nrm2069","volume":"8","author":"T Takenawa","year":"2007","unstructured":"Takenawa T, Suetsugu S . The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nat Rev Mol Cell Biol 2007; 8: 37\u201348.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFleu2009224_CR8","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1083\/jcb.200310148","volume":"164","author":"CW Gourlay","year":"2004","unstructured":"Gourlay CW, Carpp LN, Timpson P, Winder SJ, Ayscough KR . A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol 2004; 164: 803\u2013809.","journal-title":"J Cell Biol"},{"key":"BFleu2009224_CR9","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1006\/bbrc.1999.0894","volume":"260","author":"S Suetsugu","year":"1999","unstructured":"Suetsugu S, Miki H, Takenawa T . Identification of two human WAVE\/SCAR homologues as general actin regulatory molecules which associate with the Arp2\/3 complex. Biochem Biophys Res Commun 1999; 260: 296\u2013302.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFleu2009224_CR10","doi-asserted-by":"publisher","first-page":"3343","DOI":"10.1523\/JNEUROSCI.23-08-03343.2003","volume":"23","author":"JP Dahl","year":"2003","unstructured":"Dahl JP, Wang-Dunlop J, Gonzales C, Goad ME, Mark RJ, Kwak SP . Characterization of the WAVE1 knock-out mouse: implications for CNS development. J Neurosci 2003; 23: 3343\u20133352.","journal-title":"J Neurosci"},{"key":"BFleu2009224_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.ydbio.2004.07.043","volume":"276","author":"VY Rawe","year":"2004","unstructured":"Rawe VY, Payne C, Navara C, Schatten G . WAVE1 intranuclear trafficking is essential for genomic and cytoskeletal dynamics during fertilization: cell-cycle-dependent shuttling between M-phase and interphase nuclei. Dev Biol 2004; 276: 253\u2013267.","journal-title":"Dev Biol"},{"key":"BFleu2009224_CR12","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/nature01825","volume":"424","author":"NN Danial","year":"2003","unstructured":"Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM et al. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 2003; 424: 952\u2013956.","journal-title":"Nature"},{"key":"BFleu2009224_CR13","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1523\/JNEUROSCI.5154-06.2007","volume":"27","author":"A Cheng","year":"2007","unstructured":"Cheng A, Arumugam TV, Liu D, Khatri RG, Mustafa K, Kwak S et al. Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death. J Neurosci 2007; 27: 1519\u20131528.","journal-title":"J Neurosci"},{"key":"BFleu2009224_CR14","doi-asserted-by":"publisher","first-page":"3112","DOI":"10.1073\/pnas.0712180105","volume":"105","author":"JY Sung","year":"2008","unstructured":"Sung JY, Engmann O, Teylan MA, Nairn AC, Greengard P, Kim Y . WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines. Proc Natl Acad Sci USA 2008; 105: 3112\u20133116.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2009224_CR15","first-page":"379","volume":"28","author":"R Kang","year":"2007","unstructured":"Kang R, Cao LZ, Yu Y, Hu T, Wang Z, Xu WQ et al. Role of WAVE1 in drug resistance of K562\/A02 leukemia cells. Zhonghua Xue Ye Xue Za Zhi 2007; 28: 379\u2013382.","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"BFleu2009224_CR16","first-page":"88","volume":"11","author":"YL He","year":"2009","unstructured":"He YL, Cao LZ, Yang J, Yang MH, Xu WQ, Xie M et al. Expression of WAVE1 and p22phox in children with acute lymphocytic leukemia and the relationship of WAVE1 with oxidative stress. Zhongguo Dang Dai Er Ke Za Zhi 2009; 11: 88\u201392.","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"BFleu2009224_CR17","doi-asserted-by":"publisher","first-page":"3141","DOI":"10.1182\/blood-2003-04-1319","volume":"105","author":"A Oda","year":"2005","unstructured":"Oda A, Miki H, Wada I, Yamaguchi H, Yamazaki D, Suetsugu S et al. WAVE\/Scars in platelets. Blood 2005; 105: 3141\u20133148.","journal-title":"Blood"},{"key":"BFleu2009224_CR18","doi-asserted-by":"publisher","first-page":"8469","DOI":"10.1128\/MCB.19.12.8469","volume":"19","author":"K Yamamoto","year":"1999","unstructured":"Yamamoto K, Ichijo H, Korsmeyer SJ . BCL-2 is phosphorylated and inactivated by an ASK1\/Jun N-terminal protein kinase pathway normally activated at G(2)\/M. Mol Cell Biol 1999; 19: 8469\u20138478.","journal-title":"Mol Cell Biol"},{"key":"BFleu2009224_CR19","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1182\/blood.V94.10.3583.422k31_3583_3592","volume":"94","author":"O Cuvillier","year":"1999","unstructured":"Cuvillier O, Mayhew E, Janoff AS, Spiegel S . Liposomal ET-18-OCH(3) induces cytochrome c-mediated apoptosis independently of CD95 (APO-1\/Fas) signaling. Blood 1999; 94: 3583\u20133592.","journal-title":"Blood"},{"key":"BFleu2009224_CR20","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.4049\/jimmunol.179.2.1236","volume":"179","author":"D Tang","year":"2007","unstructured":"Tang D, Kang R, Xiao W, Wang H, Calderwood SK, Xiao X . The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages. J Immunol 2007; 179: 1236\u20131244.","journal-title":"J Immunol"},{"key":"BFleu2009224_CR21","doi-asserted-by":"publisher","first-page":"7376","DOI":"10.4049\/jimmunol.178.11.7376","volume":"178","author":"D Tang","year":"2007","unstructured":"Tang D, Kang R, Xiao W, Jiang L, Liu M, Shi Y et al. Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release. J Immunol 2007; 178: 7376\u20137384.","journal-title":"J Immunol"},{"key":"BFleu2009224_CR22","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1189\/jlb.0806540","volume":"81","author":"D Tang","year":"2007","unstructured":"Tang D, Shi Y, Kang R, Li T, Xiao W, Wang H et al. Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1. J Leukoc Biol 2007; 81: 741\u2013747.","journal-title":"J Leukoc Biol"},{"key":"BFleu2009224_CR23","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1097\/01.shk.0000159556.95285.df","volume":"23","author":"D Tang","year":"2005","unstructured":"Tang D, Shi Y, Jang L, Wang K, Xiao W, Xiao X . Heat shock response inhibits release of high mobility group box 1 protein induced by endotoxin in murine macrophages. Shock 2005; 23: 434\u2013440.","journal-title":"Shock"},{"key":"BFleu2009224_CR24","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1146\/annurev.physiol.68.040104.110001","volume":"68","author":"MP Lesser","year":"2006","unstructured":"Lesser MP . Oxidative stress in marine environments: biochemistry and physiological ecology. Annu Rev Physiol 2006; 68: 253\u2013278.","journal-title":"Annu Rev Physiol"},{"key":"BFleu2009224_CR25","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1161\/01.RES.86.1.8","volume":"86","author":"M Arai","year":"2000","unstructured":"Arai M, Yoguchi A, Takizawa T, Yokoyama T, Kanda T, Kurabayashi M et al. Mechanism of doxorubicin-induced inhibition of sarcoplasmic reticulum Ca(2+)-ATPase gene transcription. Circ Res 2000; 86: 8\u201314.","journal-title":"Circ Res"},{"key":"BFleu2009224_CR26","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.1073\/pnas.0438041100","volume":"100","author":"J Nilsen","year":"2003","unstructured":"Nilsen J, Diaz Brinton R . Mechanism of estrogen-mediated neuroprotection: regulation of mitochondrial calcium and Bcl-2 expression. Proc Natl Acad Sci USA 2003; 100: 2842\u20132847.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFleu2009224_CR27","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1126\/science.8235659","volume":"262","author":"DJ Kane","year":"1993","unstructured":"Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS et al. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 1993; 262: 1274\u20131277.","journal-title":"Science"},{"key":"BFleu2009224_CR28","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/374811a0","volume":"374","author":"S Shimizu","year":"1995","unstructured":"Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H, Tsujimoto Y . Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature 1995; 374: 811\u2013813.","journal-title":"Nature"},{"key":"BFleu2009224_CR29","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0092-8674(93)80066-N","volume":"75","author":"DM Hockenbery","year":"1993","unstructured":"Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ . Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993; 75: 241\u2013251.","journal-title":"Cell"},{"key":"BFleu2009224_CR30","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1038\/sj.emboj.7600104","volume":"23","author":"MC Bassik","year":"2004","unstructured":"Bassik MC, Scorrano L, Oakes SA, Pozzan T, Korsmeyer SJ . Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J 2004; 23: 1207\u20131216.","journal-title":"EMBO J"},{"key":"BFleu2009224_CR31","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.molcel.2008.06.001","volume":"30","author":"Y Wei","year":"2008","unstructured":"Wei Y, Pattingre S, Sinha S, Bassik M, Levine B . JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 2008; 30: 678\u2013688.","journal-title":"Mol Cell"},{"key":"BFleu2009224_CR32","doi-asserted-by":"publisher","first-page":"4589","DOI":"10.1093\/emboj\/19.17.4589","volume":"19","author":"RS Westphal","year":"2000","unstructured":"Westphal RS, Soderling SH, Alto NM, Langeberg LK, Scott JD . Scar\/WAVE-1, a Wiskott\u2013Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. EMBO J 2000; 19: 4589\u20134600.","journal-title":"EMBO J"},{"key":"BFleu2009224_CR33","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1002\/jps.20874","volume":"96","author":"T Ozben","year":"2007","unstructured":"Ozben T . Oxidative stress and apoptosis: impact on cancer therapy. J Pharm Sci 2007; 96: 2181\u20132196.","journal-title":"J Pharm Sci"},{"key":"BFleu2009224_CR34","doi-asserted-by":"publisher","first-page":"4098","DOI":"10.1182\/blood-2002-08-2512","volume":"101","author":"Y Zhou","year":"2003","unstructured":"Zhou Y, Hileman EO, Plunkett W, Keating MJ, Huang P . Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents. Blood 2003; 101: 4098\u20134104.","journal-title":"Blood"},{"key":"BFleu2009224_CR35","doi-asserted-by":"publisher","first-page":"8608","DOI":"10.1038\/sj.onc.1207108","volume":"22","author":"DG Breckenridge","year":"2003","unstructured":"Breckenridge DG, Germain M, Mathai JP, Nguyen M, Shore GC . Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 2003; 22: 8608\u20138618.","journal-title":"Oncogene"},{"key":"BFleu2009224_CR36","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1126\/science.1081208","volume":"300","author":"L Scorrano","year":"2003","unstructured":"Scorrano L, Oakes SA, Opferman JT, Cheng EH, Sorcinelli MD, Pozzan T et al. BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science 2003; 300: 135\u2013139.","journal-title":"Science"},{"key":"BFleu2009224_CR37","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1038\/sj.cdd.4401960","volume":"13","author":"P Pinton","year":"2006","unstructured":"Pinton P, Rizzuto R . Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulum. Cell Death Differ 2006; 13: 1409\u20131418.","journal-title":"Cell Death Differ"},{"key":"BFleu2009224_CR38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nrm2308","volume":"9","author":"RJ Youle","year":"2008","unstructured":"Youle RJ, Strasser A . The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008; 9: 47\u201359.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFleu2009224_CR39","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1101\/gad.992302","volume":"16","author":"H Nishitoh","year":"2002","unstructured":"Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K et al. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev 2002; 16: 1345\u20131355.","journal-title":"Genes Dev"},{"key":"BFleu2009224_CR40","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1046\/j.1365-2796.2001.00807.x","volume":"249","author":"MK Brenner","year":"2001","unstructured":"Brenner MK . Gene transfer and the treatment of haematological malignancy. J Intern Med 2001; 249: 345\u2013358.","journal-title":"J Intern Med"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/leu2009224.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2009224","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/leu2009224.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T12:16:17Z","timestamp":1648728977000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/leu2009224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,5]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["BFleu2009224"],"URL":"https:\/\/doi.org\/10.1038\/leu.2009.224","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,5]]},"assertion":[{"value":"23 March 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2009","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2009","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2009","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}